Abr (ABR activator of RhoGEF and GTPase) - Rat Genome Database

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Gene: Abr (ABR activator of RhoGEF and GTPase) Rattus norvegicus
Analyze
Symbol: Abr
Name: ABR activator of RhoGEF and GTPase
RGD ID: 1306279
Description: Predicted to enable GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including activation of GTPase activity; negative regulation of blood vessel remodeling; and negative regulation of cellular extravasation. Predicted to act upstream of or within several processes, including negative regulation of macrophage migration; regulation of vesicle-mediated transport; and response to lipopolysaccharide. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Orthologous to human ABR (ABR activator of RhoGEF and GTPase); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ABR, RhoGEF and GTPase activating protein; active BCR-related; active BCR-related gene; active breakpoint cluster region-related protein; breakpoint cluster region protein-like; LOC103693389; LOC287537; LOC687983; similar to Breakpoint cluster region protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81061,760,743 - 61,959,526 (-)NCBIGRCr8
mRatBN7.21061,262,516 - 61,461,331 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1061,262,516 - 61,461,505 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1065,908,046 - 66,051,300 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01065,413,502 - 65,556,758 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01060,883,717 - 61,026,573 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01064,565,121 - 64,657,079 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1064,567,268 - 64,657,089 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01063,250,866 - 63,449,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41067,617,776 - 67,760,961 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11067,631,103 - 67,774,585 (+)NCBI
Celera1060,277,504 - 60,420,210 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AbrRatchromosome 17p13.3 duplication syndrome  ISOABR (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 17p13.3 duplication syndromeClinVarPMID:21681106
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
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Original Reference(s)
AbrRatProstatic Neoplasms  ISOABR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24763052

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Object Symbol
Species
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Reference
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Original Reference(s)
AbrRat(-)-epigallocatechin 3-gallate multiple interactionsISOABR (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ABR mRNACTDPMID:22079256
AbrRat(1->4)-beta-D-glucan multiple interactionsISOAbr (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ABR mRNACTDPMID:36331819
AbrRat1,2-dimethylhydrazine multiple interactionsISOAbr (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of ABR mRNACTDPMID:22206623
AbrRat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of ABR mRNACTDPMID:29097150
AbrRat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOAbr (Mus musculus)6480464[2 more ...CTDPMID:25510870
AbrRat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISOAbr (Mus musculus)6480464[2 more ...CTDPMID:25510870
AbrRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOAbr (Mus musculus)6480464Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ABR gene]CTDPMID:20819909
AbrRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of ABR mRNACTDPMID:32109520
AbrRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOAbr (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of ABR mRNACTDPMID:21570461
AbrRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOAbr (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of ABR mRNACTDPMID:20819909
AbrRat2-methylcholine affects expressionISOABR (Homo sapiens)6480464beta-methylcholine affects the expression of ABR mRNACTDPMID:21179406
AbrRat2-palmitoylglycerol increases expressionISOABR (Homo sapiens)64804642-palmitoylglycerol results in increased expression of ABR mRNACTDPMID:37199045
AbrRat3,4-methylenedioxymethamphetamine decreases expressionISOAbr (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of ABR mRNACTDPMID:26251327
AbrRat3,4-methylenedioxymethamphetamine increases methylationISOAbr (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased methylation of ABR promoterCTDPMID:26251327
AbrRat3-chloropropane-1,2-diol decreases expressionEXP 6480464alpha-Chlorohydrin results in decreased expression of ABR mRNACTDPMID:28522335
AbrRat4,4'-sulfonyldiphenol decreases methylationISOABR (Homo sapiens)6480464bisphenol S results in decreased methylation of ABR geneCTDPMID:31601247
AbrRat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of ABR mRNACTDPMID:24780913
AbrRatacetamide increases expressionEXP 6480464acetamide results in increased expression of ABR mRNACTDPMID:31881176
AbrRataflatoxin B1 increases methylationISOABR (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of ABR promoterCTDPMID:30157460
AbrRataflatoxin B1 affects methylationISOABR (Homo sapiens)6480464Aflatoxin B1 affects the methylation of ABR intronCTDPMID:30157460

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Biological Process
1 to 20 of 23 rows

  
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Original Reference(s)
AbrRatactin cytoskeleton organization acts_upstream_of_or_withinISOAbr (Mus musculus)1624291MGI:88141 PMID:17116687RGDPMID:17116687
AbrRatactivation of GTPase activity involved_inISOABR (Homo sapiens)1624291 PMID:7479768RGDPMID:7479768
AbrRatbrain development acts_upstream_of_or_withinISOAbr (Mus musculus)1624291MGI:88141 PMID:11684658RGDPMID:11684658
AbrRatcell migration acts_upstream_ofISOAbr (Mus musculus)1624291MGI:88141 PMID:17116687RGDPMID:17116687
AbrRatestablishment of localization in cell acts_upstream_ofISOAbr (Mus musculus)1624291MGI:88141 PMID:17116687RGDPMID:17116687
AbrRatinner ear morphogenesis acts_upstream_of_or_withinISOAbr (Mus musculus)1624291MGI:88141 PMID:11921339RGDPMID:11921339
AbrRatintracellular signal transduction involved_inIEAInterPro:IPR0013311600115GO_REF:0000002InterProGO_REF:0000002
AbrRatmacrophage migration acts_upstream_ofISOAbr (Mus musculus)1624291MGI:88141 PMID:17116687RGDPMID:17116687
AbrRatmodulation of chemical synaptic transmission involved_inISSUniProtKB:Q5SSL41600115GO_REF:0000024UniProtGO_REF:0000024
AbrRatmodulation of chemical synaptic transmission involved_inISOAbr (Mus musculus)1624291 PMID:20962234RGDPMID:20962234
AbrRatnegative regulation of blood vessel remodeling involved_inISOAbr (Mus musculus)1624291 PMID:23152932RGDPMID:23152932
AbrRatnegative regulation of cellular extravasation involved_inISOAbr (Mus musculus)1624291 PMID:23152932RGDPMID:23152932
AbrRatnegative regulation of inflammatory response acts_upstream_of_or_withinISOAbr (Mus musculus)1624291MGI:2388713 PMID:19703997RGDPMID:19703997
AbrRatnegative regulation of macrophage migration acts_upstream_of_or_withinISOAbr (Mus musculus)1624291MGI:88141 PMID:17116687RGDPMID:17116687
AbrRatnegative regulation of neutrophil degranulation acts_upstream_of_or_withinISOAbr (Mus musculus)1624291MGI:88141 PMID:19703997RGDPMID:19703997
AbrRatneuromuscular process controlling balance acts_upstream_of_or_withinISOAbr (Mus musculus)1624291MGI:88141 PMID:11921339RGDPMID:11921339
AbrRatneutrophil degranulation acts_upstream_ofISOAbr (Mus musculus)1624291MGI:88141 PMID:19703997RGDPMID:19703997
AbrRatphagocytosis acts_upstream_ofISOAbr (Mus musculus)1624291MGI:88141 PMID:17116687RGDPMID:17116687
AbrRatpositive regulation of phagocytosis acts_upstream_of_or_withinISOAbr (Mus musculus)1624291MGI:88141 PMID:17116687RGDPMID:17116687
AbrRatregulation of vascular permeability involved_inISOAbr (Mus musculus)1624291 PMID:23152932RGDPMID:23152932
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Cellular Component
1 to 14 of 14 rows

  
Object Symbol
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Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
AbrRataxon located_inIEAUniProtKB-SubCell:SL-02791600115GO_REF:0000044UniProtGO_REF:0000044
AbrRatcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
AbrRatcytosol located_inISOAbr (Mus musculus)1624291 PMID:17116687RGDPMID:17116687
AbrRatdendritic spine located_inIEAUniProtKB-SubCell:SL-02841600115GO_REF:0000044UniProtGO_REF:0000044
AbrRatglutamatergic synapse is_active_inIDA 13702252PMID:20962234SynGO 
AbrRatglutamatergic synapse is_active_inISOAbr (Mus musculus)1624291 PMID:20962234RGDPMID:20962234
AbrRatglutamatergic synapse part_ofISSUniProtKB:Q5SSL41600115GO_REF:0000024UniProtGO_REF:0000024
AbrRatmembrane is_active_inIBAMGI:107771 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
AbrRatplasma membrane located_inISOAbr (Mus musculus)1624291 PMID:17116687RGDPMID:17116687
AbrRatpostsynaptic density, intracellular component is_active_inIDA 13702252PMID:20962234SynGO 
AbrRatSchaffer collateral - CA1 synapse part_ofISSUniProtKB:Q5SSL41600115GO_REF:0000024UniProtGO_REF:0000024
AbrRatSchaffer collateral - CA1 synapse is_active_inISOAbr (Mus musculus)1624291 PMID:20962234RGDPMID:20962234
AbrRatsynapse located_inIEAUniProtKB-KW:KW-07701600115GO_REF:0000043UniProtGO_REF:0000043
AbrRatsynapse located_inIEAUniProtKB-SubCell:SL-02581600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function
1 to 14 of 14 rows

  
Object Symbol
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Reference
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Original Reference(s)
AbrRatGTPase activator activity enablesIEAUniProtKB:Q12979 and ensembl:ENSP000003039091600115GO_REF:0000107EnsemblGO_REF:0000107
AbrRatGTPase activator activity enablesIEAInterPro:IPR015123 and InterPro:IPR0377691600115GO_REF:0000002InterProGO_REF:0000002
AbrRatGTPase activator activity enablesIEAInterPro:IPR0377691600115GO_REF:0000002InterProGO_REF:0000002
AbrRatGTPase activator activity enablesISOAbr (Mus musculus)1624291MGI:88141 PMID:17116687 and PMID:19703997RGDPMID:17116687 and PMID:19703997
AbrRatGTPase activator activity enablesIEAUniProtKB-KW:KW-03431600115GO_REF:0000043UniProtGO_REF:0000043
AbrRatGTPase activator activity enablesISOABR (Homo sapiens)1624291 PMID:7479768RGDPMID:7479768
AbrRatguanyl-nucleotide exchange factor activity enablesISOABR (Homo sapiens)1624291 PMID:7479768RGDPMID:7479768
AbrRatguanyl-nucleotide exchange factor activity enablesIEAInterPro:IPR0002191600115GO_REF:0000002InterProGO_REF:0000002
AbrRatguanyl-nucleotide exchange factor activity enablesIEAInterPro:IPR000219 and InterPro:IPR0013311600115GO_REF:0000002InterProGO_REF:0000002
AbrRatguanyl-nucleotide exchange factor activity enablesIEAUniProtKB:Q12979 and ensembl:ENSP000003039091600115GO_REF:0000107EnsemblGO_REF:0000107
AbrRatguanyl-nucleotide exchange factor activity enablesIEAUniProtKB-KW:KW-03441600115GO_REF:0000043UniProtGO_REF:0000043
AbrRatprotein binding enablesIPIUniProtKB:P3101613702252PMID:20962234UniProt 
AbrRatprotein binding enablesISOABR (Homo sapiens)1624291UniProtKB:P78352 and PMID:20962234RGDPMID:20962234
AbrRatprotein serine/threonine kinase activity enablesIEAInterPro:IPR0151231600115GO_REF:0000002InterProGO_REF:0000002
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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins. Oh D, etal., J Neurosci. 2010 Oct 20;30(42):14134-44. doi: 10.1523/JNEUROSCI.1711-10.2010.
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:7479768   PMID:11684658   PMID:11921339   PMID:17116687   PMID:19703997   PMID:19946888   PMID:23152932  



Abr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81061,760,743 - 61,959,526 (-)NCBIGRCr8
mRatBN7.21061,262,516 - 61,461,331 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1061,262,516 - 61,461,505 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1065,908,046 - 66,051,300 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01065,413,502 - 65,556,758 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01060,883,717 - 61,026,573 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01064,565,121 - 64,657,079 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1064,567,268 - 64,657,089 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01063,250,866 - 63,449,251 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41067,617,776 - 67,760,961 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11067,631,103 - 67,774,585 (+)NCBI
Celera1060,277,504 - 60,420,210 (-)NCBICelera
Cytogenetic Map10q24NCBI
ABR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38171,003,519 - 1,229,722 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl171,003,519 - 1,229,738 (-)EnsemblGRCh38hg38GRCh38
GRCh3717906,759 - 1,133,016 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3617853,509 - 1,029,881 (-)NCBINCBI36Build 36hg18NCBI36
Build 3417853,509 - 1,029,881NCBI
Celera17918,106 - 1,102,463 (-)NCBICelera
Cytogenetic Map17p13.3NCBI
HuRef17813,353 - 993,409 (-)NCBIHuRef
CHM1_117914,146 - 1,097,251 (-)NCBICHM1_1
T2T-CHM13v2.017890,209 - 1,120,740 (-)NCBIT2T-CHM13v2.0
Abr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391176,307,560 - 76,468,515 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1176,307,560 - 76,514,384 (-)EnsemblGRCm39 Ensembl
GRCm381176,416,732 - 76,623,324 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1176,416,734 - 76,623,558 (-)EnsemblGRCm38mm10GRCm38
MGSCv371176,230,236 - 76,391,229 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361176,232,929 - 76,393,922 (-)NCBIMGSCv36mm8
Celera1183,928,368 - 84,081,980 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.92NCBI
Abr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554812,503,315 - 2,654,244 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554812,503,309 - 2,710,667 (-)NCBIChiLan1.0ChiLan1.0
ABR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2198,556,006 - 8,755,510 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11710,527,138 - 10,731,505 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v017972,009 - 1,174,953 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.117893,413 - 1,116,064 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl17895,013 - 1,069,973 (-)Ensemblpanpan1.1panPan2
ABR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1944,634,117 - 44,821,454 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl944,681,411 - 44,819,249 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha943,785,466 - 43,972,043 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0945,451,750 - 45,638,302 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl945,451,864 - 45,638,282 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1944,278,129 - 44,417,777 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0944,517,664 - 44,703,775 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0944,604,307 - 44,790,569 (+)NCBIUU_Cfam_GSD_1.0
Abr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560243,750,170 - 43,941,125 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365386,674,907 - 6,816,674 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365386,674,595 - 6,819,511 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1246,709,880 - 46,895,808 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11246,709,840 - 46,895,819 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21248,950,856 - 49,028,680 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116732,556 - 947,329 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl16735,211 - 847,690 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605921,070,415 - 21,348,246 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247863,174,989 - 3,319,804 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247863,121,282 - 3,319,804 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Abr
882 total Variants

Predicted Target Of
Summary Value
Count of predictions:372
Count of miRNA genes:198
Interacting mature miRNAs:264
Transcripts:ENSRNOT00000032861
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat

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D10Mgh6  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81061,843,496 - 61,843,633 (+)Marker Load Pipeline
mRatBN7.21061,345,276 - 61,345,413 (+)MAPPERmRatBN7.2
Rnor_6.01064,648,175 - 64,648,311NCBIRnor6.0
Rnor_5.01063,366,082 - 63,366,218UniSTSRnor5.0
RGSC_v3.41067,677,924 - 67,678,060UniSTSRGSC3.4
Celera1060,360,352 - 60,360,488UniSTS
RH 2.0 Map10641.2RGD
SHRSP x BN Map1045.5399RGD
Cytogenetic Map10q26UniSTS
AU042359  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81061,760,947 - 61,761,059 (+)Marker Load Pipeline
mRatBN7.21061,262,719 - 61,262,832 (+)MAPPERmRatBN7.2
Rnor_6.01064,565,325 - 64,565,437NCBIRnor6.0
Rnor_5.01063,448,935 - 63,449,047UniSTSRnor5.0
RGSC_v3.41067,760,646 - 67,760,758UniSTSRGSC3.4
Celera1060,277,708 - 60,277,820UniSTS
Cytogenetic Map10q26UniSTS
BE104553  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21061,287,604 - 61,287,756 (+)MAPPERmRatBN7.2
Rnor_6.01064,590,209 - 64,590,360NCBIRnor6.0
Rnor_5.01063,424,012 - 63,424,163UniSTSRnor5.0
RGSC_v3.41067,735,722 - 67,735,873UniSTSRGSC3.4
Celera1060,302,593 - 60,302,744UniSTS
Cytogenetic Map10q26UniSTS
Abr  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21061,262,558 - 61,262,725 (+)MAPPERmRatBN7.2
Rnor_6.01064,565,164 - 64,565,330NCBIRnor6.0
Rnor_5.01063,449,042 - 63,449,208UniSTSRnor5.0
RGSC_v3.41067,760,753 - 67,760,919UniSTSRGSC3.4
Celera1060,277,547 - 60,277,713UniSTS
Cytogenetic Map10q26UniSTS
d10mgh6  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01063,366,082 - 63,366,219UniSTSRnor5.0
RGSC_v3.41067,677,924 - 67,678,061UniSTSRGSC3.4
Cytogenetic Map10q26UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000080703   ⟹   ENSRNOP00000068811
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1061,262,516 - 61,376,496 (-)Ensembl
Rnor_6.0 Ensembl1064,567,466 - 64,657,089 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000084670   ⟹   ENSRNOP00000071246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1061,264,810 - 61,339,976 (-)Ensembl
Rnor_6.0 Ensembl1064,567,268 - 64,642,292 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098977   ⟹   ENSRNOP00000085893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1061,262,516 - 61,406,014 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105253   ⟹   ENSRNOP00000090388
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1061,262,516 - 61,313,583 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109843   ⟹   ENSRNOP00000085287
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1061,262,516 - 61,461,505 (-)Ensembl
RefSeq Acc Id: NM_001105814   ⟹   NP_001099284
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81061,760,743 - 61,903,937 (-)NCBI
mRatBN7.21061,262,516 - 61,405,721 (-)NCBI
Rnor_6.01064,565,121 - 64,657,079 (-)NCBI
Rnor_5.01063,250,866 - 63,449,251 (+)NCBI
RGSC_v3.41067,617,776 - 67,760,961 (+)RGD
Celera1060,277,504 - 60,420,210 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085523   ⟹   XP_038941451
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81061,760,743 - 61,959,526 (-)NCBI
mRatBN7.21061,262,516 - 61,461,331 (-)NCBI
RefSeq Acc Id: XM_039085524   ⟹   XP_038941452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81061,760,743 - 61,958,441 (-)NCBI
mRatBN7.21061,264,726 - 61,460,247 (-)NCBI
RefSeq Acc Id: XM_039085527   ⟹   XP_038941455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81061,760,743 - 61,910,652 (-)NCBI
mRatBN7.21061,264,726 - 61,412,400 (-)NCBI
RefSeq Acc Id: XM_039085528   ⟹   XP_038941456
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81061,760,743 - 61,957,513 (-)NCBI
mRatBN7.21061,264,726 - 61,459,311 (-)NCBI
RefSeq Acc Id: XM_039085529   ⟹   XP_038941457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81061,760,743 - 61,838,920 (-)NCBI
mRatBN7.21061,264,861 - 61,339,626 (-)NCBI
RefSeq Acc Id: XM_039085530   ⟹   XP_038941458
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81061,760,743 - 61,910,627 (-)NCBI
mRatBN7.21061,264,861 - 61,412,343 (-)NCBI
RefSeq Acc Id: XM_039085531   ⟹   XP_038941459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81061,760,743 - 61,957,511 (-)NCBI
mRatBN7.21061,264,861 - 61,459,311 (-)NCBI
RefSeq Acc Id: XM_039085532   ⟹   XP_038941460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81061,760,743 - 61,812,110 (-)NCBI
mRatBN7.21061,264,861 - 61,313,879 (-)NCBI
RefSeq Acc Id: XM_039085533   ⟹   XP_038941461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81061,760,743 - 61,789,509 (-)NCBI
mRatBN7.21061,264,861 - 61,283,114 (-)NCBI
1 to 5 of 15 rows
1 to 5 of 15 rows
RefSeq Acc Id: NP_001099284   ⟸   NM_001105814
- UniProtKB: A0A0G2JTR4 (UniProtKB/Swiss-Prot),   A6HGV7 (UniProtKB/TrEMBL),   A0A4X0W8E9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068811   ⟸   ENSRNOT00000080703
Ensembl Acc Id: ENSRNOP00000071246   ⟸   ENSRNOT00000084670
RefSeq Acc Id: XP_038941451   ⟸   XM_039085523
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A3Q6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038941452   ⟸   XM_039085524
- Peptide Label: isoform X2
- UniProtKB: A0A4X0W8E9 (UniProtKB/TrEMBL)
C2   DH   PH   Rho-GAP

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JTR4-F1-model_v2 AlphaFold A0A0G2JTR4 1-859 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 55 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-24155 BioCyc
Ensembl Genes ENSRNOG00000056837 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000080703 ENTREZGENE
  ENSRNOT00000084670 ENTREZGENE
  ENSRNOT00000098977 ENTREZGENE
  ENSRNOT00000105253 ENTREZGENE
  ENSRNOT00000109843 ENTREZGENE
  ENSRNOT00000138045 ENTREZGENE
  ENSRNOT00000139836 ENTREZGENE
Gene3D-CATH 1.10.555.10 UniProtKB/Swiss-Prot
  1.20.900.10 UniProtKB/Swiss-Prot
  2.30.29.30 UniProtKB/Swiss-Prot
  2.60.40.150 UniProtKB/Swiss-Prot
InterPro Abr/Bcr UniProtKB/Swiss-Prot
  ABR_PH UniProtKB/Swiss-Prot
  C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  DBL_dom_sf UniProtKB/Swiss-Prot
  DH-domain UniProtKB/Swiss-Prot
  GDS_CDC24_CS UniProtKB/Swiss-Prot
  PH-like_dom_sf UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
  Rho_GTPase_activation_prot UniProtKB/Swiss-Prot
  RhoGAP_dom UniProtKB/Swiss-Prot
KEGG Report rno:287537 UniProtKB/Swiss-Prot
NCBI Gene 287537 ENTREZGENE
PANTHER ACTIVE BREAKPOINT CLUSTER REGION-RELATED PROTEIN UniProtKB/Swiss-Prot
  PTHR23182 UniProtKB/Swiss-Prot
Pfam PF00168 UniProtKB/Swiss-Prot
  PH_19 UniProtKB/Swiss-Prot
  RhoGAP UniProtKB/Swiss-Prot
  RhoGEF UniProtKB/Swiss-Prot
PhenoGen Abr PhenoGen
PROSITE DH_1 UniProtKB/Swiss-Prot
  DH_2 UniProtKB/Swiss-Prot
  PH_DOMAIN UniProtKB/Swiss-Prot
  PS50004 UniProtKB/Swiss-Prot
  RHOGAP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000056837 RatGTEx
SMART RhoGAP UniProtKB/Swiss-Prot
1 to 40 of 55 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Abr  ABR activator of RhoGEF and GTPase  LOC103693389  breakpoint cluster region protein-like  Data merged from RGD:9174117 737654 PROVISIONAL
2019-03-25 Abr  ABR activator of RhoGEF and GTPase  Abr  ABR, RhoGEF and GTPase activating protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2018-02-23 Abr  ABR, RhoGEF and GTPase activating protein  Abr  active BCR-related  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 LOC103693389  breakpoint cluster region protein-like  LOC687983  similar to Breakpoint cluster region protein  Data merged from RGD:1594868 737654 PROVISIONAL
2014-08-25 LOC103693389  breakpoint cluster region protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-13 Abr  active BCR-related  Abr  active BCR-related gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Abr  active BCR-related gene   Abr_predicted  active BCR-related gene (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC687983  similar to Breakpoint cluster region protein      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Abr_predicted  active BCR-related gene (predicted)      Symbol and Name status set to approved 70820 APPROVED