Hic1 (HIC ZBTB transcriptional repressor 1) - Rat Genome Database

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Gene: Hic1 (HIC ZBTB transcriptional repressor 1) Rattus norvegicus
Analyze
Symbol: Hic1
Name: HIC ZBTB transcriptional repressor 1
RGD ID: 1307527
Description: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone deacetylase binding activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to DNA damage; regulation of gene expression; and regulation of signal transduction. Predicted to be part of chromatin. Predicted to be active in nucleoplasm. Orthologous to human HIC1 (HIC ZBTB transcriptional repressor 1); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypermethylated in cancer 1; hypermethylated in cancer 1 protein; hypermethylated in cancer 1 protein-like; LOC100912068; LOC303310
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81060,512,855 - 60,517,812 (-)NCBIGRCr8
mRatBN7.21060,014,520 - 60,019,475 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,011,528 - 60,019,475 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1064,661,147 - 64,666,097 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01064,166,728 - 64,171,679 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01059,629,108 - 59,634,061 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01062,007,150 - 62,010,774 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1062,007,150 - 62,009,582 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01061,721,540 - 61,725,164 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,470,736 - 62,476,506 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11062,485,182 - 62,492,086 (-)NCBI
Celera1059,044,464 - 59,049,428 (-)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzophenanthridine  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buta-1,3-diene  (ISO)
cadmium sulfate  (ISO)
carbon nanotube  (ISO)
chloroprene  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cypermethrin  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
etoposide  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
indometacin  (ISO)
lead(II) chloride  (ISO)
lipopolysaccharide  (ISO)
methylisothiazolinone  (ISO)
N-Nitrosopyrrolidine  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
Ptaquiloside  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sotorasib  (ISO)
testosterone  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12052894   PMID:15231840   PMID:16269335   PMID:16724116  


Genomics

Comparative Map Data
Hic1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81060,512,855 - 60,517,812 (-)NCBIGRCr8
mRatBN7.21060,014,520 - 60,019,475 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1060,011,528 - 60,019,475 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1064,661,147 - 64,666,097 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01064,166,728 - 64,171,679 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01059,629,108 - 59,634,061 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01062,007,150 - 62,010,774 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1062,007,150 - 62,009,582 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01061,721,540 - 61,725,164 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41062,470,736 - 62,476,506 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11062,485,182 - 62,492,086 (-)NCBI
Celera1059,044,464 - 59,049,428 (-)NCBICelera
Cytogenetic Map10q24NCBI
HIC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38172,055,103 - 2,063,241 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl172,054,154 - 2,063,241 (+)EnsemblGRCh38hg38GRCh38
GRCh37171,958,397 - 1,966,535 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36171,905,143 - 1,909,731 (+)NCBINCBI36Build 36hg18NCBI36
Build 34171,906,714 - 1,908,879NCBI
Celera171,974,408 - 1,978,996 (+)NCBICelera
Cytogenetic Map17p13.3NCBI
HuRef171,853,855 - 1,857,995 (+)NCBIHuRef
CHM1_1171,967,163 - 1,971,751 (+)NCBICHM1_1
T2T-CHM13v2.0171,942,378 - 1,950,518 (+)NCBIT2T-CHM13v2.0
Hic1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391175,052,203 - 75,059,970 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1175,055,391 - 75,060,345 (-)EnsemblGRCm39 Ensembl
GRCm381175,161,377 - 75,170,255 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1175,164,565 - 75,169,519 (-)EnsemblGRCm38mm10GRCm38
MGSCv371174,978,067 - 74,983,757 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361174,980,763 - 74,985,714 (-)NCBIMGSCv36mm8
Celera1182,671,336 - 82,677,017 (-)NCBICelera
Cytogenetic Map11B5NCBI
cM Map1145.76NCBI
Hic1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554811,179,015 - 1,181,825 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554811,179,015 - 1,182,936 (-)NCBIChiLan1.0ChiLan1.0
HIC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2199,635,373 - 9,640,053 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11711,602,754 - 11,607,442 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0172,045,960 - 2,051,483 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1171,935,628 - 1,937,474 (+)NCBIpanpan1.1PanPan1.1panPan2
HIC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1946,156,909 - 46,162,849 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl946,159,136 - 46,162,004 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha945,306,957 - 45,312,945 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0946,987,712 - 46,993,723 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl946,989,156 - 46,993,692 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1945,754,761 - 45,760,755 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0946,049,100 - 46,055,081 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0946,104,136 - 46,110,131 (+)NCBIUU_Cfam_GSD_1.0
Hic1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560245,241,606 - 45,248,219 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365388,122,749 - 8,125,306 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365388,122,557 - 8,126,157 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HIC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1248,168,900 - 48,172,636 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11248,167,861 - 48,172,540 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21250,021,109 - 50,025,558 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HIC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1161,687,560 - 1,697,888 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl161,694,341 - 1,697,023 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605920,267,675 - 20,271,313 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hic1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247864,724,806 - 4,729,714 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hic1
15 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:148
Count of miRNA genes:106
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000004143, ENSRNOT00000066972
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105379738566979128Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)105527369660677262Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat

Markers in Region
Hic1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01062,007,652 - 62,007,753NCBIRnor6.0
Rnor_5.01061,722,042 - 61,722,143UniSTSRnor5.0
RGSC_v3.41062,471,238 - 62,471,338UniSTSRGSC3.4
Celera1059,044,969 - 59,045,066UniSTS
Cytogenetic Map10q24UniSTS
BE100929  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21060,019,266 - 60,019,416 (+)MAPPERmRatBN7.2
Rnor_6.01062,010,566 - 62,010,715NCBIRnor6.0
Rnor_5.01061,724,956 - 61,725,105UniSTSRnor5.0
RGSC_v3.41062,476,298 - 62,476,447UniSTSRGSC3.4
Celera1059,049,220 - 59,049,369UniSTS
Cytogenetic Map10q24UniSTS
G54872  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21060,015,541 - 60,015,789 (+)MAPPERmRatBN7.2
Rnor_6.01062,480,957 - 62,481,204NCBIRnor6.0
Rnor_6.01062,008,171 - 62,008,418NCBIRnor6.0
Rnor_5.01061,722,561 - 61,722,808UniSTSRnor5.0
Rnor_5.01062,192,273 - 62,192,520UniSTSRnor5.0
RGSC_v3.41062,471,756 - 62,472,003UniSTSRGSC3.4
Celera1059,045,484 - 59,045,731UniSTS
Cytogenetic Map10q24UniSTS
RH124699  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21060,014,518 - 60,014,663 (+)MAPPERmRatBN7.2
Rnor_6.01062,007,149 - 62,007,293NCBIRnor6.0
Rnor_5.01061,721,539 - 61,721,683UniSTSRnor5.0
RGSC_v3.41062,470,735 - 62,470,879UniSTSRGSC3.4
Celera1059,044,466 - 59,044,610UniSTS
Cytogenetic Map10q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 10 16
Low 3 41 33 27 7 27 4 7 52 20 18 11 4
Below cutoff 2 24 14 12 14 4 4 22 5 7 4

Sequence


RefSeq Acc Id: ENSRNOT00000004143   ⟹   ENSRNOP00000004143
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1060,014,507 - 60,018,109 (-)Ensembl
Rnor_6.0 Ensembl1062,007,150 - 62,009,582 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079956   ⟹   ENSRNOP00000074161
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1060,014,520 - 60,019,475 (-)Ensembl
Rnor_6.0 Ensembl1062,480,767 - 62,483,342 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000115646   ⟹   ENSRNOP00000090248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1060,011,528 - 60,019,160 (-)Ensembl
RefSeq Acc Id: NM_001107021   ⟹   NP_001100491
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81060,512,858 - 60,517,812 (-)NCBI
mRatBN7.21060,014,520 - 60,019,475 (-)NCBI
Rnor_6.01062,007,150 - 62,010,774 (-)NCBI
Rnor_5.01061,721,540 - 61,725,164 (-)NCBI
RGSC_v3.41062,470,736 - 62,476,506 (-)RGD
Sequence:
RefSeq Acc Id: NM_001422893   ⟹   NP_001409822
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81060,512,855 - 60,517,445 (-)NCBI
RefSeq Acc Id: XM_063269069   ⟹   XP_063125139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81060,512,855 - 60,516,453 (-)NCBI
RefSeq Acc Id: XM_063269070   ⟹   XP_063125140
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81060,512,855 - 60,517,030 (-)NCBI
RefSeq Acc Id: NP_001100491   ⟸   NM_001107021
- Peptide Label: isoform 2
- UniProtKB: A6HGP3 (UniProtKB/TrEMBL),   A0A0G2K7D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004143   ⟸   ENSRNOT00000004143
RefSeq Acc Id: ENSRNOP00000074161   ⟸   ENSRNOT00000079956
RefSeq Acc Id: ENSRNOP00000090248   ⟸   ENSRNOT00000115646
RefSeq Acc Id: NP_001409822   ⟸   NM_001422893
- Peptide Label: isoform 1
- UniProtKB: A0A8I6ADF2 (UniProtKB/TrEMBL),   D4A974 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125140   ⟸   XM_063269070
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063125139   ⟸   XM_063269069
- Peptide Label: isoform X1
Protein Domains
BTB   C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A974-F1-model_v2 AlphaFold D4A974 1-535 view protein structure
AF-A0A0G2K7D6-F1-model_v2 AlphaFold A0A0G2K7D6 1-740 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307527 AgrOrtholog
BioCyc Gene G2FUF-24234 BioCyc
Ensembl Genes ENSRNOG00000046405 Ensembl
  ENSRNOG00000057619 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004143.5 UniProtKB/TrEMBL
  ENSRNOT00000079956 ENTREZGENE
  ENSRNOT00000079956.2 UniProtKB/TrEMBL
  ENSRNOT00000115646.1 UniProtKB/TrEMBL
Gene3D-CATH Classic Zinc Finger UniProtKB/TrEMBL
InterPro BTB/POZ_dom UniProtKB/TrEMBL
  SKP1/BTB/POZ_sf UniProtKB/TrEMBL
  Znf_C2H2/integrase_DNA-bd UniProtKB/TrEMBL
  Znf_C2H2_sf UniProtKB/TrEMBL
KEGG Report rno:303310 UniProtKB/TrEMBL
NCBI Gene 303310 ENTREZGENE
PANTHER HYPERMETHYLATED IN CANCER 1 PROTEIN UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/TrEMBL
Pfam BTB UniProtKB/TrEMBL
  zf-C2H2 UniProtKB/TrEMBL
PhenoGen Hic1 PhenoGen
PROSITE BTB UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000046405 RatGTEx
  ENSRNOG00000057619 RatGTEx
SMART BTB UniProtKB/TrEMBL
  ZnF_C2H2 UniProtKB/TrEMBL
Superfamily-SCOP SSF54695 UniProtKB/TrEMBL
  SSF57667 UniProtKB/TrEMBL
UniProt A0A0G2K7D6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ADF2 ENTREZGENE, UniProtKB/TrEMBL
  A6HGP3 ENTREZGENE, UniProtKB/TrEMBL
  D4A974 ENTREZGENE, UniProtKB/TrEMBL
  E5D4G5_RAT UniProtKB/TrEMBL
  E5D4G6_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Hic1  HIC ZBTB transcriptional repressor 1  LOC100912068  hypermethylated in cancer 1 protein-like  Data merged from RGD:6488990 737654 PROVISIONAL
2016-10-12 Hic1  HIC ZBTB transcriptional repressor 1  Hic1  hypermethylated in cancer 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100912068  hypermethylated in cancer 1 protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 Hic1  hypermethylated in cancer 1   Hic1_predicted  hypermethylated in cancer 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Hic1_predicted  hypermethylated in cancer 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED