Gjc1 (gap junction protein, gamma 1)

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Gene: Gjc1 (gap junction protein, gamma 1) Rattus norvegicus

Analyze

Symbol:

Gjc1

Name:

gap junction protein, gamma 1

RGD ID:

628889

Description:

Enables gap junction channel activity. Involved in cell-cell signaling. Located in gap junction. Orthologous to human GJC1 (gap junction protein gamma 1); PARTICIPATES IN connexin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

connexin 45; connexin q; connexin-45; Cx45; Cxnq; gap junction alpha-7 protein; gap junction channel protein connexin 45; gap junction gamma-1 protein; gap junction membrane channel protein alpha 7; Gja7

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GJC1 (gap junction protein gamma 1)	RGD	RGD
Mus musculus (house mouse):	Gjc1 (gap junction protein, gamma 1)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	Gjc1 (gap junction protein gamma 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GJC1 (gap junction protein gamma 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GJC1 (gap junction protein gamma 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gjc1 (gap junction protein gamma 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GJC1 (gap junction protein gamma 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GJC1 (gap junction protein gamma 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gjc1 (gap junction protein gamma 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	TMEM45A (transmembrane protein 45A)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	GJC1 (gap junction protein gamma 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gjc1 (gap junction protein, gamma 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	cx47.1 (connexin 47.1)	Alliance	DIOPT (InParanoid\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gjc1	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

NCBI Annotation Information:

Note: There is an assembly problem in the Rnor_6.0 reference genome assembly, and therefore, annotation of this gene is split across NW_007905923.1 and NW_007905924.1 in NCBI's Rattus norvegicus Annotation Release 105. [18 Jun 2015]

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	87,758,192 - 87,785,443 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	87,760,528 - 87,785,867 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	92,799,858 - 92,820,614 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	92,266,006 - 92,286,621 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	87,659,342 - 87,679,956 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	90,781,408 - 90,912,440 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	90,781,402 - 90,912,287 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	90,573,861 - 90,576,546 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	10	90,684,903 - 90,685,231 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	10	86,466,836 - 86,488,023 (-)	NCBI		Celera
Cytogenetic Map	10	q32.1	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

hypertension (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-methylcholine (ISO)

4-hydroperoxycyclophosphamide (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amitrole (EXP)

antirheumatic drug (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

CGP 52608 (ISO)

chloropicrin (ISO)

choline (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

cyclosporin A (ISO)

dibenzo[a,l]pyrene (ISO)

dorsomorphin (ISO)

enalapril (ISO)

folic acid (ISO)

fonofos (ISO)

formaldehyde (ISO)

furan (EXP)

gallic acid (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

L-methionine (ISO)

lead(0) (ISO)

leflunomide (ISO)

methylmercury chloride (ISO)

nickel atom (ISO)

omega-6 fatty acid (ISO)

ozone (ISO)

paracetamol (ISO)

parathion (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

SB 431542 (ISO)

sodium dodecyl sulfate (ISO)

sunitinib (ISO)

terbufos (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triclocarban (ISO)

urethane (ISO)

valproic acid (ISO)

vincristine (ISO)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

AV node cell to bundle of His cell communication by electrical coupling (ISO)

cardiac muscle tissue development (ISO)

cell development (ISO)

cell-cell signaling (IBA,IDA,ISO)

chemical synaptic transmission (ISO)

gap junction assembly (ISO)

heart development (ISO)

monoatomic ion transmembrane transport (IEA,ISO)

vasculogenesis (ISO)

visual perception (ISO)

Cellular Component

connexin complex (IBA,ISO)

endoplasmic reticulum (IEA,ISO)

gap junction (IDA,ISO)

nucleoplasm (IEA,ISO)

plasma membrane (ISO)

synapse (IEA)

Molecular Function

gap junction channel activity (IBA,IDA)

gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling (ISO)

monoatomic ion channel activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

connexin signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Cellular expression of connexins in the rat brain: neuronal localization, effects of kainate-induced seizures and expression in apoptotic neuronal cells.	Condorelli DF, etal., Eur J Neurosci 2003 Oct;18(7):1807-27.
2.	Connexins: gaps in our knowledge of vascular function.	Figueroa XF, etal., Physiology (Bethesda). 2004 Oct;19:277-84.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Connexin45 interacts with zonula occludens-1 in osteoblastic cells.	Laing JG, etal., Cell Commun Adhes 2001;8(4-6):209-12.
5.	Connexin45 gap junction channels in rat cerebral vascular smooth muscle cells.	Li X and Simard JM, Am J Physiol Heart Circ Physiol 2001 Nov;281(5):H1890-8.
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7930207	PMID:10976050	PMID:11922902	PMID:12477932	PMID:14681043	PMID:15659592	PMID:15879306	PMID:16194882	PMID:17328669	PMID:17546509	PMID:17584645	PMID:17632690
PMID:19129462	PMID:20819514	PMID:22982984	PMID:24043768	PMID:24883012	PMID:27913256	PMID:28561933	PMID:34808525

Genomics

Comparative Map Data

Gjc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	87,758,192 - 87,785,443 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	87,760,528 - 87,785,867 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	92,799,858 - 92,820,614 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	92,266,006 - 92,286,621 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	87,659,342 - 87,679,956 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	90,781,408 - 90,912,440 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	90,781,402 - 90,912,287 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	90,573,861 - 90,576,546 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	10	90,684,903 - 90,685,231 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	10	86,466,836 - 86,488,023 (-)	NCBI		Celera
Cytogenetic Map	10	q32.1	NCBI

GJC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	44,794,104 - 44,831,364 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	44,798,448 - 44,830,816 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	42,875,816 - 42,908,202 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	40,231,342 - 40,263,705 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	40,237,520 - 40,238,711	NCBI
Celera	17	39,586,320 - 39,618,684 (-)	NCBI		Celera
Cytogenetic Map	17	q21.31	NCBI
HuRef	17	38,640,950 - 38,673,263 (-)	NCBI		HuRef
CHM1_1	17	43,111,947 - 43,144,318 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	45,648,941 - 45,685,306 (-)	NCBI		T2T-CHM13v2.0

Gjc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	102,690,303 - 102,710,512 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	102,690,405 - 102,710,526 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	102,799,477 - 102,819,686 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	102,799,579 - 102,819,700 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	102,660,792 - 102,681,000 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	102,615,669 - 102,620,731 (-)	NCBI		MGSCv36	mm8
Celera	11	114,511,245 - 114,530,176 (-)	NCBI		Celera
Cytogenetic Map	11	E1	NCBI
cM Map	11	66.48	NCBI

Gjc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955451	17,626,859 - 17,630,247 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955451	17,626,859 - 17,639,002 (-)	NCBI	ChiLan1.0	ChiLan1.0

GJC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	17	21,971,082 - 22,003,446 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	12,492,285 - 12,524,615 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	12,663,614 - 12,696,618 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	12,689,251 - 12,690,441 (+)	Ensembl	panpan1.1		panPan2

GJC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	18,642,359 - 18,688,128 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	18,686,527 - 18,687,717 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	18,071,974 - 18,073,164 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	19,336,722 - 19,382,385 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	19,337,429 - 19,382,482 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	18,234,973 - 18,235,559 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	18,416,349 - 18,417,539 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	18,573,413 - 18,574,603 (+)	NCBI		UU_Cfam_GSD_1.0

Gjc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	17,990,495 - 18,016,917 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936541	1,178,493 - 1,182,967 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936541	1,177,581 - 1,182,967 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GJC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	18,526,595 - 18,560,218 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	18,526,060 - 18,560,221 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	18,770,695 - 18,795,440 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GJC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	61,575,851 - 61,596,488 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	61,594,885 - 61,596,075 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	32,322,168 - 32,350,709 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gjc1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624795	461,691 - 464,454 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624795	443,234 - 466,222 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gjc1
151 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	200
Count of miRNA genes:	153
Interacting mature miRNAs:	168
Transcripts:	ENSRNOT00000073372
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6357896	96121100	Rat
2303118	Mamtr7	Mammary tumor resistance QTL 7		0.003	mammary gland integrity trait (VT:0010552)	mammary tumor growth rate (CMO:0000344)	10	9658275	104670812	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14487011	89062041	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14487011	104060283	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14487011	107057807	Rat
1554317	Bmd4	Bone mineral density QTL 4	9.4	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	19816042	99406971	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22427500	90627625	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23444813	104060283	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	26521957	98003205	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	26521957	98952741	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29299504	107211142	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40035094	102359817	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40035094	104060283	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42045676	104670812	Rat
9589030	Epfw9	Epididymal fat weight QTL 9	19.24	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	10	44441699	89441699	Rat
7411614	Foco18	Food consumption QTL 18		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	44441699	89441699	Rat
8694173	Bw149	Body weight QTL 149	4.38	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	10	44441699	89441699	Rat
2300218	Hpcl2	Hepatic cholesterol level QTL 2			liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	45029650	95600334	Rat
631547	Bp87	Blood pressure QTL 87	4.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	47369470	92369470	Rat
1549846	Scl47	Serum cholesterol level QTL 47	3.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	50574707	95574707	Rat
70364	Bp72	Blood pressure QTL 72			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	51121100	96121100	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	51770177	107211142	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	51770177	107211142	Rat
1359017	Hrtrt21	Heart rate QTL 21	2.4		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	10	51772940	96772940	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	51774612	95600334	Rat
631535	Cm51	Cardiac mass QTL 51	3		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	51786282	91669536	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	53797385	107211142	Rat
70164	Bw21	Body weight QTL 21	4.36	0.00005	body mass (VT:0001259)	body weight (CMO:0000012)	10	53797494	98952626	Rat
1354608	Cm33	Cardiac mass QTL 33	2.8		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	10	54809292	99809292	Rat
2312662	Slep8	Serum leptin concentration QTL 8		0.05	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	10	57134272	102134272	Rat
2312668	Scl65	Serum cholesterol level QTL 65		0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	57134272	102134272	Rat
2312672	Insul15	Insulin level QTL 15		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	10	57134272	102134272	Rat
1549831	Bss6	Bone structure and strength QTL 6	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	10	57576521	102576521	Rat
2293698	Bss43	Bone structure and strength QTL 43	5.33	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra cross-sectional area (CMO:0001689)	10	59209888	104209888	Rat
2306970	Anxrr22	Anxiety related response QTL 22	5.95		fear/anxiety-related behavior trait (VT:1000241)	number of periods of voluntary immobility (CMO:0001045)	10	61345276	98211570	Rat
6893336	Cm75	Cardiac mass QTL 75	0.1	0.87	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	61345276	99703528	Rat
1558643	Cm44	Cardiac mass QTL 44	4.8	0.0000368	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	61345276	99703528	Rat
2313103	Bss80	Bone structure and strength QTL 80	2	0.0001	tibia strength trait (VT:1000284)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	10	62057807	107057807	Rat
2313105	Bss79	Bone structure and strength QTL 79	1.8	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	10	62057807	107057807	Rat
61449	Ciaa2	CIA Autoantibody QTL 2	7.1		blood autoantibody amount (VT:0003725)	calculated serum anti-type 2 collagen antibody titer (CMO:0001279)	10	63221094	107211142	Rat
1357344	Bp249	Blood pressure QTL 249		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	66743655	98003205	Rat
2317029	Aia19	Adjuvant induced arthritis QTL 19	2.98		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	10	66978955	107211142	Rat
2317039	Aia6	Adjuvant induced arthritis QTL 6	4.31		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	10	66978955	107211142	Rat
10450498	Bp384	Blood pressure QTL 384		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	67750049	107211142	Rat
1642980	Bp300	Blood pressure QTL 300			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68383129	107211142	Rat
61396	Bp9	Blood pressure QTL 9	4.8	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	68420376	107211142	Rat
2300172	Bmd57	Bone mineral density QTL 57	9.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	10	69738412	107211142	Rat
2293646	Bss25	Bone structure and strength QTL 25	10.96	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	10	69738412	107211142	Rat
2293663	Bss33	Bone structure and strength QTL 33	9.34	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	10	69738412	107211142	Rat
6893366	Bw106	Body weight QTL 106	0.3	0.47	body mass (VT:0001259)	body weight (CMO:0000012)	10	70199100	107211142	Rat
70193	Mcs7	Mammary carcinoma susceptibility QTL 7	2.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	72224939	107211142	Rat
2298548	Neuinf7	Neuroinflammation QTL 7	3.4		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	10	72224939	107211142	Rat
2306793	Ean5	Experimental allergic neuritis QTL 5	4.7		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	72552416	93995749	Rat
1358188	Ept9	Estrogen-induced pituitary tumorigenesis QTL 9	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	73453136	96120911	Rat
2292617	Ept18	Estrogen-induced pituitary tumorigenesis QTL 18	3.9		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	10	73453136	96120911	Rat
1579919	Bp281	Blood pressure QTL 281		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	74372084	94965338	Rat
10450495	Bp383	Blood pressure QTL 383		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76246085	94965338	Rat
2292438	Bp311	Blood pressure QTL 311			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	76246085	107211142	Rat
1302404	Cia27	Collagen induced arthritis QTL 27	2.6	0.0045	joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	10	76452683	107211142	Rat
4889492	Pancm2	Pancreatic morphology QTL 2	3.2		pancreatic beta cell morphology trait (VT:0005217)	ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)	10	76748906	107211142	Rat
1300107	Rf18	Renal function QTL 18	3.41		urine output (VT:0003620)	timed urine volume (CMO:0000260)	10	78775516	98279596	Rat
631555	Bp134	Blood pressure QTL 134		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	80515287	91230079	Rat
6893357	Bw102	Body weight QTL 102	0.5	0.36	body mass (VT:0001259)	body weight (CMO:0000012)	10	80515287	101325465	Rat
2303589	Bw87	Body weight QTL 87	2		body mass (VT:0001259)	body weight (CMO:0000012)	10	81285008	107211142	Rat
4889948	Bss91	Bone structure and strength QTL 91	4		tibia area (VT:1000281)	tibia midshaft total cross-sectional area (CMO:0001715)	10	82564856	92369470	Rat
2317754	Glom25	Glomerulus QTL 25	3.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	82685200	107211142	Rat
12880055	Am11	Aortic mass QTL 11		0.004	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	84007272	95933025	Rat
2301398	Kidm38	Kidney mass QTL 38		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	10	84007272	95933025	Rat
2306792	Ean4	Experimental allergic neuritis QTL 4	4		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	84022321	93995963	Rat
1600367	Mcs15	Mammary carcinoma susceptibility QTL 15	4.5		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	10	85565469	103884409	Rat
631538	Oia5	Oil induced arthritis QTL 5			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	87055121	107211142	Rat
2313856	Bp342	Blood pressure QTL 342	4.4	0.0001	life span trait (VT:0005372)	age at time of death (CMO:0001193)	10	87307617	96121100	Rat
61363	Oia3	Oil induced arthritis QTL 3		0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	87307617	107211142	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		35	6	6		6	6	9	56	21	34	11	6
Low	3	8	42	26	19	26	2	2	18	14	7		2
Below cutoff			9	9		9

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001085381	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597049	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597050	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085309	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085310	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085311	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039085312	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF536559	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC166405	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ871218	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000220	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	LT990408	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000073372 ⟹ ENSRNOP00000066371

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	10	90,781,674 - 90,909,572 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000093570 ⟹ ENSRNOP00000076255

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	87,761,961 - 87,768,364 (-)	Ensembl
Rnor_6.0 Ensembl	10	90,781,402 - 90,912,287 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000096574 ⟹ ENSRNOP00000081758

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	87,760,528 - 87,784,506 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000108179 ⟹ ENSRNOP00000087322

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	87,760,528 - 87,785,867 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000116881 ⟹ ENSRNOP00000096467

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	87,760,528 - 87,785,064 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000117898 ⟹ ENSRNOP00000094267

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	87,760,528 - 87,785,867 (-)	Ensembl

RefSeq Acc Id:

NM_001085381 ⟹ NP_001078850

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	87,763,150 - 87,784,150 (-)	NCBI
Rnor_6.0	10	90,781,674 - 90,909,572 (-)	NCBI
Rnor_5.0	10	90,573,861 - 90,576,546 (-)	NCBI
Rnor_5.0	10	90,684,903 - 90,685,231 (-)	NCBI
Celera	10	86,466,836 - 86,488,023 (-)	RGD

Sequence:

show sequence

TTGTTCTTCGTTGACTCTCCAGATTGAAAATAGAGAGGAGGCGCTAATGCTGTGATTGGGCTGG
CTGCTGCGTTTGGATTTTCGAGTTGAAAAGATTTACGTGACTTGTGTTTAGAATTTGGGGTCCT
TCCTCCCCGCTTTTCGGATTATTTGGGATTGCTTTTCTTTTTGCGAAGTGGGTGAATTTGTTTT
TTTTTTTTTTGTCATTTGAAGTCATTTTTGGTCCTCGGGGACTGGCAGCGCTACAGATTTCATT
GTGCTCGTGCTTTATTTTTTTTCTCATCCACACTGGGTGCCATCGAGGAACTCAAGAGAGAATT
TGGGAAAGTAACAAACACAGCACAGAATCTGAAAGGAGGTTTTGGGTAACGGAGGTTCTGGTTA
ACAGGGCAAACCAATTCCACCACCATGAGTTGGAGCTTCCTGACTCGCCTGCTAGAGGAGATAC
ACAACCATTCGACGTTTGTAGGGAAGATCTGGCTCACTGTGCTGATTGTCTTTCGAATTGTCCT
AACTGCGGTAGGAGGAGAGTCCATCTACTATGATGAGCAAAGCAAATTTGTGTGCAACACAGAG
CAGCCGGGCTGTGAGAACGTCTGCTATGATGCCTTTGCCCCGCTCTCCCACGTGCGCTTCTGGG
TATTCCAGATCATCCTGGTTGCTACTCCCTCGGTGATGTACCTGGGATATGCTATTCACAAGAT
TGCCAAAATGGAGCACGGCGAGGCAGACAAGAAGGCAGCTCGGAGCAAACCCTATGCCATGCGT
TGGAAGCAGCACCGGGCTCTGGAAGAAACGGAAGAGGACCATGAAGAGGATCCTATGATGTACC
CAGAGATGGAGTTAGAAAGCGAGAAAGAAAATAAAGAGCAGAGCCAACCAAAACCCAAGCATGA
TGGCCGCCGACGCATTCGTGAGGATGGGCTCATGAAAATCTATGTGTTGCAGCTGCTAGCCAGG
ACTGTGTTTGAGGTGGGCTTTCTCATAGGGCAGTATTTCCTGTATGGCTTCCAAGTACACCCAT
TTTATGTGTGCAGCAGACTTCCTTGTCCTCATAAGATAGACTGCTTTATTTCTAGACCCACTGA
AAAGACCATCTTCCTTCTGATAATGTATGGTGTCACAGGCCTCTGCCTATTGCTTAACATTTGG
GAGATGCTTCATCTAGGGTTTGGGACCATTCGAGACTCACTAAACAGTAAAAGGAGGGAACTTG
ATGATCCGGGTGCTTATAATTATCCTTTCACTTGGAATACACCATCTGCTCCCCCAGGCTATAA
CATTGCTGTCAAACCAGATCAAATCCAGTACACTGAGTTGTCCAATGCTAAGATTGCCTACAAG
CAGAACAAAGCCAATATCGCCCAGGAGCAGCAGTATGGCAGCCACGAGGAGCACCTCCCGGCCG
ATCTGGAGACCCTGCAGCGGGAGATCAGAATGGCCCAGGAACGCTTGGATCTAGCAATCCAGGC
CTACCATCACCAGAACAACCCCCATGGTCCTCGGGAAAAGAAGGCCAAAGTGGGGTCCAAATCT
GGGTCCAACAAAAGCAGTATTAGTAGCAAATCAGGAGATGGGAAGACCTCCGTCTGGATTTAA

hide sequence

RefSeq Acc Id:

XM_017597049 ⟹ XP_017452538

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	87,758,192 - 87,785,443 (-)	NCBI
Rnor_6.0	10	90,781,408 - 90,912,440 (-)	NCBI

Sequence:

show sequence

CTTAACAGGCAGTTTCAACCAGGGGAATTCCTGTCCATGTGCATTTCAAAAGTCTTCTAATTGG
GATCCTGCTGGGATGCAAGGAGTTAAGAGGAAATGGCCTATTAGGGTCTTACTAATCCGAGAAA
TCCAGGACCTCAAAACTACGTAGACCGCCTGTAAAAATCATGATTCCACCAGGCGGGGATGGTT
GGCCGAGAAGCCCCGGAGGTTCTTCGAGTTACTGCAGAGCAGAGCCTAGACCGGCCATGAGCAT
CCCGAGATCCGCTGGACCAAGGCCCTGACCTAGCGCACCAGATAACGGTGGAGCTCTACAGTCG
GACCCTGGAAACTCAGAGAGAATTTGGGAAAGTAACAAACACAGCACAGAGTCTGAAAGGAGGT
TTTGGGTAACGGAGGTTCTGGTTAACAGGGCAAACCAATTCCACCACCATGAGTTGGAGCTTCC
TGACTCGCCTGCTAGAGGAGATACACAACCATTCGACGTTTGTAGGGAAGATCTGGCTCACTGT
GCTGATTGTCTTTCGAATTGTCCTAACTGCGGTAGGAGGAGAGTCCATCTACTATGATGAGCAA
AGCAAATTTGTGTGCAACACAGAGCAGCCGGGCTGTGAGAACGTCTGCTATGATGCCTTTGCCC
CGCTCTCCCACGTGCGCTTCTGGGTATTCCAGATCATCCTGGTTGCTACTCCCTCTGTGATGTA
CCTGGGATATGCTATTCACAAGATTGCCAAAATGGAGCACGGCGAGGCAGACAAGAAGGCAGCT
CGGAGCAAACCCTATGCCATGCGTTGGAAGCAGCACCGGGCTCTGGAAGAAACGGAAGAGGACC
ATGAAGAGGATCCTATGATGTACCCAGAGATGGAGTTAGAAAGCGAGAAAGAAAATAAAGAGCA
GAGCCAACCAAAACCCAAGCATGATGGCCGCCGACGCATTCGTGAGGATGGGCTCATGAAAATC
TATGTGTTGCAGCTGCTAGCCAGGACTGTGTTTGAGGTGGGCTTTCTCATAGGGCAGTATTTCC
TGTATGGCTTCCAAGTACACCCATTTTATGTGTGCAGCAGACTTCCTTGTCCTCATAAGATAGA
CTGCTTTATTTCTAGACCCACTGAAAAGACCATCTTCCTTCTGATAATGTATGGTGTCACAGGC
CTCTGCCTATTGCTTAACATTTGGGAGATGCTTCATCTAGGGTTTGGGACCATTCGAGACTCAC
TAAACAGTAAAAGGAGGGAACTTGATGATCCGGGTGCTTATAATTATCCTTTCACTTGGAATAC
ACCATCTGCTCCCCCAGGCTATAACATTGCTGTCAAACCAGATCAAATCCAGTACACTGAGTTG
TCCAATGCTAAGATTGCCTACAAGCAGAACAAAGCCAATATCGCCCAGGAGCAGCAGTACGGCA
GCCACGAGGAGCACCTCCCGGCCGATCTGGAGACCCTGCAGCGGGAGATCAGAATGGCCCAGGA
ACGCTTGGATCTAGCAATCCAGGCCTACCATCACCAGAACAACCCCCATGGTCCTCGGGAAAAG
AAGGCCAAAGTGGGGTCCAAATCTGGGTCCAACAAAAGCAGTATTAGTAGCAAATCAGGAGATG
GGAAGACCTCCGTCTGGATTTAATCTTGGTTGGGCTTAAAGCTTGGGTTTCCATAGTTTATGGT
AAGCAGCAACTTGCTGAATGATGACTCCCATTGAGTAAACATCTGGCTCTGGTTATCTTCAGGG
ATGCTGTTGGCTCGTGATCCAAACTCAGGGGACTGAAAGTGGATCTGGGATGAGTCCGGAGCGG
GAAACACAGTGTTCCCAGGCACAGGTTCTCAGCAATAATGCAGTTGCAGAACTCTAAGCTGTGT
CTTCCAGATCCGGAGAAGAACAGATATATTTAA

hide sequence

RefSeq Acc Id:

XM_039085309 ⟹ XP_038941237

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	87,758,192 - 87,784,890 (-)	NCBI

RefSeq Acc Id:

XM_039085310 ⟹ XP_038941238

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	87,758,192 - 87,784,837 (-)	NCBI

RefSeq Acc Id:

XM_039085311 ⟹ XP_038941239

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	87,758,192 - 87,784,837 (-)	NCBI

RefSeq Acc Id:

XM_039085312 ⟹ XP_038941240

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	10	87,758,192 - 87,784,915 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001078850	(Get FASTA)	NCBI Sequence Viewer
	XP_017452538	(Get FASTA)	NCBI Sequence Viewer
	XP_038941237	(Get FASTA)	NCBI Sequence Viewer
	XP_038941238	(Get FASTA)	NCBI Sequence Viewer
	XP_038941239	(Get FASTA)	NCBI Sequence Viewer
	XP_038941240	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	A4GG66	(Get FASTA)	NCBI Sequence Viewer
	AAI66405	(Get FASTA)	NCBI Sequence Viewer
	AAN17802	(Get FASTA)	NCBI Sequence Viewer
	ABI54096	(Get FASTA)	NCBI Sequence Viewer
	ABI54097	(Get FASTA)	NCBI Sequence Viewer
	ABI54098	(Get FASTA)	NCBI Sequence Viewer
	ABI54099	(Get FASTA)	NCBI Sequence Viewer
	EDM06232	(Get FASTA)	NCBI Sequence Viewer
	VZP20208	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001078850 ⟸ NM_001085381

- UniProtKB:

A4GG66 (UniProtKB/Swiss-Prot), A0A654ICN4 (UniProtKB/TrEMBL), Q8CJ21 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVC
YDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALE
ETEEDHEEDPMMYPEMELESEKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFL
IGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFG
TIRDSLNSKRRELDDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANIAQ
EQQYGSHEEHLPADLETLQREIRMAQERLDLAIQAYHHQNNPHGPREKKAKVGSKSGSNKSSIS
SKSGDGKTSVWI

hide sequence

RefSeq Acc Id:	XP_017452538 ⟸ XM_017597049
- Peptide Label:	isoform X1
- UniProtKB:	A4GG66 (UniProtKB/Swiss-Prot), A0A654ICN4 (UniProtKB/TrEMBL), Q8CJ21 (UniProtKB/TrEMBL)
- Sequence:	show sequence MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVC YDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALE ETEEDHEEDPMMYPEMELESEKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFL IGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFG TIRDSLNSKRRELDDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANIAQ EQQYGSHEEHLPADLETLQREIRMAQERLDLAIQAYHHQNNPHGPREKKAKVGSKSGSNKSSIS SKSGDGKTSVWI hide sequence

RefSeq Acc Id:

ENSRNOP00000066371 ⟸ ENSRNOT00000073372

RefSeq Acc Id:

ENSRNOP00000076255 ⟸ ENSRNOT00000093570

RefSeq Acc Id:	XP_038941240 ⟸ XM_039085312
- Peptide Label:	isoform X1
- UniProtKB:	A4GG66 (UniProtKB/Swiss-Prot), A0A654ICN4 (UniProtKB/TrEMBL), Q8CJ21 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038941237 ⟸ XM_039085309
- Peptide Label:	isoform X1
- UniProtKB:	A4GG66 (UniProtKB/Swiss-Prot), A0A654ICN4 (UniProtKB/TrEMBL), Q8CJ21 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038941239 ⟸ XM_039085311
- Peptide Label:	isoform X1
- UniProtKB:	A4GG66 (UniProtKB/Swiss-Prot), A0A654ICN4 (UniProtKB/TrEMBL), Q8CJ21 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038941238 ⟸ XM_039085310
- Peptide Label:	isoform X1
- UniProtKB:	A4GG66 (UniProtKB/Swiss-Prot), A0A654ICN4 (UniProtKB/TrEMBL), Q8CJ21 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000081758 ⟸ ENSRNOT00000096574

RefSeq Acc Id:

ENSRNOP00000094267 ⟸ ENSRNOT00000117898

RefSeq Acc Id:

ENSRNOP00000096467 ⟸ ENSRNOT00000116881

RefSeq Acc Id:

ENSRNOP00000087322 ⟸ ENSRNOT00000108179

Protein Domains

Connexin N-terminal Gap junction protein cysteine-rich

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A4GG66-F1-model_v2	AlphaFold	A4GG66	1-396	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628889	AgrOrtholog
BioCyc Gene	G2FUF-23070	BioCyc
Ensembl Genes	ENSRNOG00000048838	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000076255	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000081758	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000087322	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000094267	UniProtKB/Swiss-Prot
	ENSRNOP00000096467	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000093570	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000096574	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000108179	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000116881	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000117898	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1440.80	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:9021864	IMAGE-MGC_LOAD
InterPro	Connexin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Connexin45	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Connexin_CCC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Connexin_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Connexin_N	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Connexin_N_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:266706	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:187215	IMAGE-MGC_LOAD
NCBI Gene	266706	ENTREZGENE
PANTHER	GAP JUNCTION GAMMA-1 PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR11984	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Connexin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Gjc1	PhenoGen
PRINTS	CONNEXIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CONNEXINA6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	CONNEXINS_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CONNEXINS_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	CNX	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Connexin_CCC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A654ICN4	ENTREZGENE, UniProtKB/TrEMBL
	A4GG66	ENTREZGENE, UniProtKB/Swiss-Prot
	Q8CJ21	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-03-13	Gjc1	gap junction protein, gamma 1	Gja7	gap junction membrane channel protein alpha 7	Name and Symbol changed	629549	APPROVED
2003-02-27	Gja7	gap junction membrane channel protein alpha 7			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in cerebral arterial smooth muscle	628534
gene_function	forms gap junction channels	628534
gene_function	interconnects adjacent cells, allowing exchange of ions and small molecules	628534
gene_protein	forms small-conductance channels (30-40 pS) and exhibits strong voltage dependence (V1/2 115 mV) with little nondeactivating current	628534

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations