Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Vtn (vitronectin) Rattus norvegicus
Analyze
Symbol: Vtn
Name: vitronectin
Description: Exhibits collagen binding activity; heparin binding activity; and identical protein binding activity. Involved in liver regeneration and protein polymerization. Localizes to the basement membrane; extracellular space; and intracellular organelle lumen. Used to study proteinuria. Biomarker of diabetic retinopathy and visual epilepsy. Human ortholog(s) of this gene implicated in Churg-Strauss syndrome; granulomatosis with polyangiitis; and thrombosis. Orthologous to human VTN (vitronectin); PARTICIPATES IN forkhead class A signaling pathway; vascular endothelial growth factor signaling pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Aa1018; MGC124961; Vn
Orthologs:
Homo sapiens (human) : VTN (vitronectin)  HGNC  Alliance
Mus musculus (house mouse) : Vtn (vitronectin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vtn (vitronectin)
Pan paniscus (bonobo/pygmy chimpanzee) : VTN (vitronectin)
Canis lupus familiaris (dog) : VTN (vitronectin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vtn (vitronectin)
Sus scrofa (pig) : VTN (vitronectin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01065,767,960 - 65,771,040 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01065,872,580 - 65,875,660 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41064,609,242 - 64,612,322 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11064,622,874 - 64,625,943 (+)NCBI
Celera1062,371,307 - 62,374,387 (+)NCBICelera
Cytogenetic Map10q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Vtn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3967
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.