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Gene: Nt5c (5', 3'-nucleotidase, cytosolic) Rattus norvegicus
Symbol: Nt5c
Name: 5', 3'-nucleotidase, cytosolic
RGD ID: 2321875
Description: Predicted to have 5'-nucleotidase activity; identical protein binding activity; and pyrimidine nucleotide binding activity. Predicted to be involved in dephosphorylation and pyrimidine deoxyribonucleotide catabolic process. Predicted to localize to cytosol and nucleus. Orthologous to human NT5C (5', 3'-nucleotidase, cytosolic); PARTICIPATES IN gemcitabine pharmacodynamics pathway; gemcitabine pharmacokinetics pathway; lamivudine pharmacokinetics pathway; INTERACTS WITH 3-chloropropane-1,2-diol; Triptolide; (+)-catechin (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5'(3')-deoxyribonucleotidase, cytosolic type; 5',3'-nucleotidase, cytosolic; 5,3-nucleotidase, cytosolic; LOC100360582; Umph2; uridine 5-monophosphate phosphohydrolase 2
Homo sapiens (human) : NT5C (5', 3'-nucleotidase, cytosolic)  HGNC  Alliance
Mus musculus (house mouse) : Nt5c (5',3'-nucleotidase, cytosolic)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nt5c (5', 3'-nucleotidase, cytosolic)
Pan paniscus (bonobo/pygmy chimpanzee) : NT5C (5', 3'-nucleotidase, cytosolic)
Canis lupus familiaris (dog) : NT5C (5', 3'-nucleotidase, cytosolic)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nt5c (5', 3'-nucleotidase, cytosolic)
Sus scrofa (pig) : NT5C (5', 3'-nucleotidase, cytosolic)
Chlorocebus sabaeus (African green monkey) : NT5C (5', 3'-nucleotidase, cytosolic)
Heterocephalus glaber (naked mole-rat) : Nt5c (5', 3'-nucleotidase, cytosolic)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.010104,052,807 - 104,054,805 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10104,052,831 - 104,054,805 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010104,225,988 - 104,227,164 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410105,574,754 - 105,576,848 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1099,314,518 - 99,316,243 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Nt5c
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2321875
Created: 2010-05-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.