Aanat (aralkylamine N-acetyltransferase) - Rat Genome Database

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Gene: Aanat (aralkylamine N-acetyltransferase) Rattus norvegicus
Analyze
Symbol: Aanat
Name: aralkylamine N-acetyltransferase
RGD ID: 2006
Description: Enables 14-3-3 protein binding activity and aralkylamine N-acetyltransferase activity. Involved in several processes, including response to copper ion; response to corticosterone; and response to prostaglandin E. Located in cytoplasm. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in advanced sleep phase syndrome and delayed sleep phase syndrome. Orthologous to human AANAT (aralkylamine N-acetyltransferase); PARTICIPATES IN tryptophan metabolic pathway; INTERACTS WITH ammonium chloride; bisphenol A; calyculin a.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AA-NAT; arylakylamine N-acetyltransferase; arylalkylamine N - acetyltransferase ; Arylalkylamine N - acetyltransferase (Serotonin N - acetyltransferase); arylalkylamine N-acetyltransferase; Nat4; seretonin N-acetyltransferase; serotonin acetylase; serotonin N-acetyltransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210101,827,072 - 101,831,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,827,301 - 101,831,801 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10106,883,977 - 106,888,805 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.010106,347,070 - 106,351,898 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.010101,748,363 - 101,752,675 (+)NCBIRnor_WKY
Rnor_6.010105,568,091 - 105,572,407 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,568,091 - 105,572,403 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010105,231,006 - 105,235,322 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,709,371 - 106,713,683 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,723,787 - 106,728,187 (+)NCBI
Celera10100,399,613 - 100,403,925 (+)NCBICelera
Cytogenetic Map10q32.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA)
cytosol  (IEA,ISO)
perinuclear region of cytoplasm  (ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Daily oscillation of gene expression in the retina is phase-advanced with respect to the pineal gland. Bai L, etal., Brain Res. 2008 Apr 8;1203:89-96. Epub 2008 Feb 9.
2. Circadian expression of transcription factor Fra-2 in the rat pineal gland. Baler R and Klein DC, J Biol Chem 1995 Nov 10;270(45):27319-25.
3. The rat arylalkylamine N-acetyltransferase gene promoter. cAMP activation via a cAMP-responsive element-CCAAT complex. Baler R, etal., J Biol Chem 1997 Mar 14;272(11):6979-85.
4. Diurnal variation in mRNA encoding serotonin N-acetyltransferase in pineal gland. Borjigin J, etal., Nature 1995 Dec 21-28;378(6559):783-5.
5. Regulation of cAMP-induced arylalkylamine N-acetyltransferase, Period1, and MKP-1 gene expression by mitogen-activated protein kinases in the rat pineal gland. Chansard M, etal., Brain Res Mol Brain Res. 2005 Oct 3;139(2):333-40.
6. Pineal serotonin N-acetyltransferase: expression cloning and molecular analysis. Coon SL, etal., Science 1995 Dec 8;270(5242):1681-3.
7. Effect of TNF-alpha on the melatonin synthetic pathway in the rat pineal gland: basis for a 'feedback' of the immune response on circadian timing. Fernandes PA, etal., J Pineal Res. 2006 Nov;41(4):344-50.
8. Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. Ganguly S, etal., Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):8083-8. Epub 2001 Jun 26.
9. Insulin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal gland. Garcia RA, etal., Life Sci. 2008 Jan 2;82(1-2):108-14. Epub 2007 Nov 1.
10. In vivo observation of a non-noradrenergic regulation of arylalkylamine N-acetyltransferase gene expression in the rat pineal complex. Garidou ML, etal., Neuroscience 2001;105(3):721-9.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Adrenergic inducibility of AP-1 binding in the rat pineal gland depends on prior photoperiod. Guillaumond F, etal., J Neurochem 2002 Oct;83(1):157-66.
14. Rhythmic expression of adenylyl cyclase VI contributes to the differential regulation of serotonin N-acetyltransferase by bradykinin in rat pineal glands. Han S, etal., J Biol Chem. 2005 Nov 18;280(46):38228-34. Epub 2005 Sep 15.
15. Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome. Hohjoh H, etal., Neurogenetics 2003 Apr;4(3):151-3. Epub 2002 Nov 29.
16. Expression and cellular localization of melatonin-synthesizing enzymes in the rat lens. Itoh MT, etal., J Pineal Res. 2007 Jan;42(1):92-6.
17. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
18. Arylalkylamine N-acetyltransferase: "the Timezyme". Klein DC J Biol Chem. 2007 Feb 16;282(7):4233-7. Epub 2006 Dec 12.
19. Cannabinoids attenuate norepinephrine-induced melatonin biosynthesis in the rat pineal gland by reducing arylalkylamine N-acetyltransferase activity without involvement of cannabinoid receptors. Koch M, etal., J Neurochem. 2006 Jul;98(1):267-78.
20. Norepinephrine activates store-operated Ca2+ entry coupled to large-conductance Ca2+-activated K+ channels in rat pinealocytes. Lee SY, etal., Am J Physiol Cell Physiol. 2006 Apr;290(4):C1060-6. Epub 2005 Nov 9.
21. Daily profile in melanopsin transcripts depends on seasonal lighting conditions in the rat retina. Mathes A, etal., J Neuroendocrinol. 2007 Dec;19(12):952-7.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Diabetic Goto Kakizaki rats as well as type 2 diabetic patients show a decreased diurnal serum melatonin level and an increased pancreatic melatonin-receptor status. Peschke E, etal., J Pineal Res. 2006 Mar;40(2):135-43.
25. Increased melatonin synthesis in pineal glands of rats in streptozotocin induced type 1 diabetes. Peschke E, etal., J Pineal Res. 2008 Jul 1.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
28. RefSeq and LocusLink: NCBI gene-centered resources Pruitt KD and Maglott DR, Nucleic Acids Res. 2001 Jan 1;29(1):137-40.
29. Accumulation of rat pineal serotonin N-acetyltransferase mRNA induced by pituitary adenylate cyclase activating polypeptide and vasoactive intestinal peptide in vitro. Rekasi Z and Czompoly T, J Mol Endocrinol 2002 Feb;28(1):19-31.
30. GOA pipeline RGD automated data pipeline
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Prostaglandin E2 increases adenosine 3',5'-monophosphate concentration and binding-site occupancy, and stimulates serotonin-N-acetyltransferase activity in rat pineal glands in vitro. Ritta MN and Cardinali DP, Mol Cell Endocrinol. 1981 Aug;23(2):151-9.
33. Melatonin synthesis: analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland. Roseboom PH, etal., Endocrinology 1996 Jul;137(7):3033-45.
34. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
35. Biochemical characterization of recombinant serotonin N-acetyltransferase. Zhan-Poe X and Craft CM, J Pineal Res. 1999 Aug;27(1):49-58.
Additional References at PubMed
PMID:7545952   PMID:11313340   PMID:14617573   PMID:15046865   PMID:15193530   PMID:15228600   PMID:15798208   PMID:16099857   PMID:16687309   PMID:17363136   PMID:17364576   PMID:17403780  
PMID:20210853   PMID:21437622   PMID:22908386   PMID:23080076   PMID:23513468   PMID:24877634   PMID:25594545   PMID:27339900   PMID:28502584   PMID:30890428   PMID:31124080  


Genomics

Comparative Map Data
Aanat
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.210101,827,072 - 101,831,805 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,827,301 - 101,831,801 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10106,883,977 - 106,888,805 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.010106,347,070 - 106,351,898 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.010101,748,363 - 101,752,675 (+)NCBIRnor_WKY
Rnor_6.010105,568,091 - 105,572,407 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,568,091 - 105,572,403 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010105,231,006 - 105,235,322 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,709,371 - 106,713,683 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,723,787 - 106,728,187 (+)NCBI
Celera10100,399,613 - 100,403,925 (+)NCBICelera
Cytogenetic Map10q32.2NCBI
AANAT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381776,453,351 - 76,470,117 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1776,453,351 - 76,470,117 (+)EnsemblGRCh38hg38GRCh38
GRCh371774,449,433 - 74,466,199 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361771,975,246 - 71,977,794 (+)NCBINCBI36Build 36hg18NCBI36
Build 341771,975,245 - 71,977,793NCBI
Celera1771,041,811 - 71,058,583 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1769,877,340 - 69,894,101 (+)NCBIHuRef
CHM1_11774,514,431 - 74,531,198 (+)NCBICHM1_1
T2T-CHM13v2.01777,349,932 - 77,366,693 (+)NCBIT2T-CHM13v2.0
Aanat
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911116,482,547 - 116,489,022 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11116,477,258 - 116,488,506 (+)EnsemblGRCm39 Ensembl
GRCm3811116,591,721 - 116,597,680 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,586,432 - 116,597,680 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711116,455,001 - 116,458,994 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611116,409,777 - 116,413,634 (+)NCBIMGSCv36mm8
Celera11128,363,982 - 128,367,985 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1181.43NCBI
Aanat
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555065,828,659 - 5,834,812 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555065,828,666 - 5,834,812 (-)NCBIChiLan1.0ChiLan1.0
AANAT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11775,951,915 - 75,967,411 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1775,951,915 - 75,967,411 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01770,401,103 - 70,418,551 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
AANAT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,238,814 - 4,245,660 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,239,284 - 4,240,707 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha94,920,559 - 4,921,982 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.094,914,638 - 4,921,709 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl94,914,649 - 4,921,521 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.194,940,312 - 4,941,735 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,060,146 - 5,061,569 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,141,399 - 5,142,822 (-)NCBIUU_Cfam_GSD_1.0
Aanat
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056024,852,759 - 4,869,231 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365941,556,285 - 1,559,400 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365941,556,303 - 1,559,198 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100518330
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,042,897 - 5,044,505 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,042,897 - 5,047,626 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2124,887,637 - 4,897,028 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AANAT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11645,206,233 - 45,215,761 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1645,206,377 - 45,207,591 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607715,946,938 - 15,949,113 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aanat
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248016,331,505 - 6,333,599 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248016,329,090 - 6,333,290 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aanat
49 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:70
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000015221
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1558652Bw57Body weight QTL 574.20.0008body mass (VT:0001259)body weight (CMO:0000012)1090910316107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat

Markers in Region
Aanat  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,831,462 - 101,831,692 (+)MAPPERmRatBN7.2
Rnor_6.010105,572,065 - 105,572,294NCBIRnor6.0
Rnor_5.010105,234,980 - 105,235,209UniSTSRnor5.0
RGSC_v3.410106,713,345 - 106,713,574UniSTSRGSC3.4
Celera10100,403,587 - 100,403,816UniSTS
Cytogenetic Map10q32.3UniSTS
D10Wox52  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,827,515 - 101,827,789 (+)MAPPERmRatBN7.2
Rnor_6.010105,568,118 - 105,568,391NCBIRnor6.0
Rnor_5.010105,231,033 - 105,231,306UniSTSRnor5.0
RGSC_v3.410106,709,398 - 106,709,671UniSTSRGSC3.4
Celera10100,399,640 - 100,399,913UniSTS
Cytogenetic Map10q32.3UniSTS
D11Mit102  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,826,812 - 101,826,964 (+)MAPPERmRatBN7.2
Rnor_6.010105,567,415 - 105,567,566NCBIRnor6.0
Rnor_5.010105,230,330 - 105,230,481UniSTSRnor5.0
RGSC_v3.410106,708,695 - 106,708,846UniSTSRGSC3.4
Celera10100,398,937 - 100,399,088UniSTS
Cytogenetic Map10q32.3UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 7 18 13 1
Below cutoff 3 11 16 4 10 4 7 8 32 15 19 10 7

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000015221   ⟹   ENSRNOP00000015221
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,827,301 - 101,831,801 (+)Ensembl
Rnor_6.0 Ensembl10105,568,091 - 105,572,403 (+)Ensembl
RefSeq Acc Id: NM_012818   ⟹   NP_036950
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210101,827,489 - 101,831,801 (+)NCBI
Rnor_6.010105,568,091 - 105,572,403 (+)NCBI
Rnor_5.010105,231,006 - 105,235,322 (+)NCBI
RGSC_v3.410106,709,371 - 106,713,683 (+)RGD
Celera10100,399,613 - 100,403,925 (+)RGD
Sequence:
RefSeq Acc Id: XM_006247792   ⟹   XP_006247854
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210101,828,880 - 101,831,805 (+)NCBI
Rnor_6.010105,568,316 - 105,572,407 (+)NCBI
Rnor_5.010105,231,006 - 105,235,322 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085255   ⟹   XP_038941183
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.210101,827,072 - 101,830,471 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_036950   ⟸   NM_012818
- UniProtKB: Q64553 (UniProtKB/Swiss-Prot),   Q64666 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006247854   ⟸   XM_006247792
- Peptide Label: isoform X1
- UniProtKB: Q64553 (UniProtKB/Swiss-Prot),   Q64666 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015221   ⟸   ENSRNOT00000015221
RefSeq Acc Id: XP_038941183   ⟸   XM_039085255
- Peptide Label: isoform X2
Protein Domains
N-acetyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64666-F1-model_v2 AlphaFold Q64666 1-205 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2006 AgrOrtholog
BioCyc Gene G2FUF-22594 BioCyc
BioCyc Pathway PWY-6030 [serotonin and melatonin biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000011182 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000015221 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015221 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro Acyl_CoA_acyltransferase UniProtKB/Swiss-Prot
  GNAT_dom UniProtKB/Swiss-Prot
KEGG Report rno:25120 UniProtKB/Swiss-Prot
NCBI Gene 25120 ENTREZGENE
Pfam Acetyltransf_1 UniProtKB/Swiss-Prot
PhenoGen Aanat PhenoGen
PROSITE GNAT UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55729 UniProtKB/Swiss-Prot
TIGR TC222688
UniProt Q64553 ENTREZGENE
  Q64666 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q4JL74 UniProtKB/Swiss-Prot
  Q64553 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-07-28 Aanat  aralkylamine N-acetyltransferase  Aanat  arylalkylamine N-acetyltransferase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Aanat  arylalkylamine N-acetyltransferase    arylalkylamine N - acetyltransferase   Name updated 1299863 APPROVED
2002-06-10 Aanat  arylalkylamine N - acetyltransferase       Symbol and Name status set to approved 70586 APPROVED
2001-06-20 Nat4  Seretonin N-acetyltransferase      Symbol withdrawn, duplicate entry of Aanat (RGD:2006) 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_drugs gene expression and activity are greatly stimulated by norepinephrine induced increase in cAMP and calcium levels 70285
gene_drugs circulating catecholamines have no effect on mRNA in ganglionectomized rats 70285
gene_expression expressed in the rat pineal gland 628397
gene_process penultimate enzyme in the melatonin biosynthetic pathway 67926
gene_process activity depends on the photoperiodic schedule 628397
gene_process mRNA level increases during the night and helps in the release of melatonin 628397
gene_process responsible for the N-acetylation of serotonin 70285
gene_process may act as the melatonin rhythm-generating enzyme 70285