Slc4a1 (solute carrier family 4 member 1 (Diego blood group)) - Rat Genome Database

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Gene: Slc4a1 (solute carrier family 4 member 1 (Diego blood group)) Rattus norvegicus
Analyze
Symbol: Slc4a1
Name: solute carrier family 4 member 1 (Diego blood group)
RGD ID: 3710
Description: Enables actin binding activity; enzyme binding activity; and protein C-terminus binding activity. Involved in several processes, including positive regulation of T cell proliferation; response to alkaline pH; and response to carbon dioxide. Located in several cellular components, including Z disc; basolateral plasma membrane; and intercalated disc. Biomarker of iron deficiency anemia; metabolic acidosis; and renal tubular acidosis. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; hereditary spherocytosis type 4; malaria; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)); INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AE 1; anion exchange protein 1; anion exchanger 1; band 3 anion transport protein; MGC93554; solute carrier family 4 (anion exchanger), member 1; solute carrier family 4 member 1; Solute carrier family 4 member 1 anion exchange protein 1 (kidney band 3); solute carrier family 4, member 1; Solute carrier family 4, member 1, anion exchange protein 1 (kidney band 3)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: QTLs:   BpQTLcluster1   BpQTLcluster9  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21087,306,865 - 87,323,132 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1087,306,872 - 87,323,117 (-)Ensembl
Rnor_6.01090,296,144 - 90,312,401 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,296,141 - 90,312,386 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,084,734 - 90,101,181 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,454,824 - 91,471,072 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11091,470,679 - 91,479,502 (-)NCBI
Celera1086,018,849 - 86,032,669 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-dinitrostilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aconitine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid  (ISO)
atorvastatin calcium  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
Benzo[ghi]perylene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
C60 fullerene  (EXP)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
cholesterol  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
D-glucose  (ISO)
D-penicillamine  (EXP)
dexamethasone  (EXP)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (ISO)
dioxygen  (EXP,ISO)
dipyridamole  (ISO)
folic acid  (ISO)
furan  (EXP)
furans  (ISO)
gentamycin  (EXP)
glucose  (ISO)
hydrogen peroxide  (EXP)
lead diacetate  (EXP)
metformin  (EXP)
methapyrilene  (ISO)
methotrexate  (EXP)
methoxychlor  (EXP)
methyl isocyanate  (EXP)
monosodium L-glutamate  (EXP)
N-acetyl-L-cysteine  (EXP)
N-ethyl-N-nitrosourea  (ISO)
Niflumic acid  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenformin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium atom  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
selenous acid  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
sodium atom  (ISO)
sodium hydrogencarbonate  (EXP)
sulfates  (ISO)
tebuconazole  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP)
tetrachloromethane  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
triptonide  (ISO)
tungsten  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Modulation of clinical expression and band 3 deficiency in hereditary spherocytosis. Alloisio N, etal., Blood. 1997 Jul 1;90(1):414-20.
2. Cardiac hypertrophy in anion exchanger 1-null mutant mice with severe hemolytic anemia. Alvarez BV, etal., Am J Physiol Heart Circ Physiol. 2007 Mar;292(3):H1301-12. Epub 2006 Oct 20.
3. T-cell specificity in murine autoimmune haemolytic anaemia induced by rat red blood cells. Barker RN, etal., Clin Exp Immunol. 2002 Aug;129(2):208-13.
4. Pathogenic autoantibodies in the NZB mouse are specific for erythrocyte band 3 protein. Barker RN, etal., Eur J Immunol. 1993 Jul;23(7):1723-6.
5. Differential regulation of basolateral Cl-/HCO3- exchangers SLC26A7 and AE1 in kidney outer medullary collecting duct. Barone S, etal., J Am Soc Nephrol. 2004 Aug;15(8):2002-11.
6. Regulation of the basolateral chloride/base exchangers AE1 and SLC26A7 in the kidney collecting duct in potassium depletion. Barone S, etal., Nephrol Dial Transplant. 2007 Dec;22(12):3462-70. Epub 2007 Sep 5.
7. Reduced cellular redox status induces 4-hydroxynonenal-mediated caspase 3 activation leading to erythrocyte death during chronic arsenic exposure in rats. Biswas D, etal., Toxicol Appl Pharmacol. 2010 May 1;244(3):315-27. doi: 10.1016/j.taap.2010.01.009. Epub 2010 Jan 28.
8. Atorvastatin acts synergistically with N-acetyl cysteine to provide therapeutic advantage against Fas-activated erythrocyte apoptosis during chronic arsenic exposure in rats. Biswas D, etal., Toxicol Appl Pharmacol. 2011 Jan 1;250(1):39-53. doi: 10.1016/j.taap.2010.10.002. Epub 2010 Oct 12.
9. Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1. Bruce LJ, etal., Nat Genet. 2005 Nov;37(11):1258-63. Epub 2005 Oct 9.
10. Acid-base effects on intestinal Cl- absorption and vesicular trafficking. Charney AN, etal., Am J Physiol Cell Physiol. 2004 May;286(5):C1062-70. Epub 2003 Dec 24.
11. dRTA and hemolytic anemia: first detailed description of SLC4A1 A858D mutation in homozygous state. Fawaz NA, etal., Eur J Haematol. 2012 Apr;88(4):350-5. doi: 10.1111/j.1600-0609.2011.01739.x. Epub 2012 Jan 4.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
14. Mature erythrocyte membrane homeostasis is compromised by loss of the GATA1-FOG1 interaction. Hasegawa A, etal., Blood. 2012 Mar 15;119(11):2615-23. doi: 10.1182/blood-2011-09-382473. Epub 2012 Jan 25.
15. Expression of rat kidney anion exchanger 1 in type A intercalated cells in metabolic acidosis and alkalosis. Huber S, etal., Am J Physiol. 1999 Dec;277(6 Pt 2):F841-9.
16. Duplication of 10 nucleotides in the erythroid band 3 (AE1) gene in a kindred with hereditary spherocytosis and band 3 protein deficiency (band 3PRAGUE). Jarolim P, etal., J Clin Invest. 1994 Jan;93(1):121-30.
17. Deletion in erythrocyte band 3 gene in malaria-resistant Southeast Asian ovalocytosis. Jarolim P, etal., Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11022-6.
18. Oxidation as a possible mechanism of cellular aging: vitamin E deficiency causes premature aging and IgG binding to erythrocytes. Kay MM, etal., Proc Natl Acad Sci U S A. 1986 Apr;83(8):2463-7.
19. Tropical distal renal tubular acidosis: clinical and epidemiological studies in 78 patients. Khositseth S, etal., QJM. 2012 Sep;105(9):861-77. doi: 10.1093/qjmed/hcs139.
20. Primary structure of the rat kidney band 3 anion exchange protein deduced from a cDNA. Kudrycki KE and Shull GE, J Biol Chem 1989 May 15;264(14):8185-92.
21. Abnormalities of ion-exchange proteins of the red cell membrane in iron deficiency anemia. Li JY, etal., Chin Med J (Engl). 1992 Feb;105(2):116-9.
22. Band 3 Campinas: a novel splicing mutation in the band 3 gene (AE1) associated with hereditary spherocytosis, hyperactivity of Na+/Li+ countertransport and an abnormal renal bicarbonate handling. Lima PR, etal., Blood. 1997 Oct 1;90(7):2810-8.
23. Band 3 Chur: a variant associated with band 3-deficient hereditary spherocytosis and substitution in a highly conserved position of transmembrane segment 11. Maillet P, etal., Br J Haematol. 1995 Dec;91(4):804-10.
24. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
25. The calcineurin inhibitor FK506 (tacrolimus) is associated with transient metabolic acidosis and altered expression of renal acid-base transport proteins. Mohebbi N, etal., Am J Physiol Renal Physiol. 2009 Aug;297(2):F499-509. doi: 10.1152/ajprenal.90489.2008. Epub 2009 May 13.
26. Interactions of transmembrane carbonic anhydrase, CAIX, with bicarbonate transporters. Morgan PE, etal., Am J Physiol Cell Physiol. 2007 Aug;293(2):C738-48. Epub 2007 Jul 25.
27. alpha-cardiac actin (ACTC) binds to the band 3 (AE1) cardiac isoform. Moura Lima PR, etal., J Cell Biochem. 2003 Aug 15;89(6):1215-21.
28. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
29. Characterization of anion exchangers in an inner medullary collecting duct cell line. Obrador G, etal., J Am Soc Nephrol. 1998 May;9(5):746-54.
30. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
31. Irreversible AE1 tyrosine phosphorylation leads to membrane vesiculation in G6PD deficient red cells. Pantaleo A, etal., PLoS One. 2011 Jan 5;6(1):e15847. doi: 10.1371/journal.pone.0015847.
32. Vasopressin induces expression of the Cl-/HCO3- exchanger SLC26A7 in kidney medullary collecting ducts of Brattleboro rats. Petrovic S, etal., Am J Physiol Renal Physiol. 2006 May;290(5):F1194-201. Epub 2005 Dec 13.
33. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Renal expression of the ammonia transporters, Rhbg and Rhcg, in response to chronic metabolic acidosis. Seshadri RM, etal., Am J Physiol Renal Physiol. 2006 Feb;290(2):F397-408. Epub 2005 Sep 6.
36. Chromosomal mapping of the rat Slc4a family of anion exchanger genes, Ae1, Ae2, and Ae3. Simon JS, etal., Mamm Genome 1996 May;7(5):380-2.
37. Monoclonal antibodies recognizing epitopes on the extracellular face and intracellular N-terminus of the human erythrocyte anion transporter (band 3) and their application to the analysis of South East Asian ovalocytes. Smythe JS, etal., Blood. 1995 May 15;85(10):2929-36.
38. Circadian regulation of electrolyte absorption in the rat colon. Sotak M, etal., Am J Physiol Gastrointest Liver Physiol. 2011 Dec;301(6):G1066-74. doi: 10.1152/ajpgi.00256.2011. Epub 2011 Sep 8.
39. Targeted disruption of the murine erythroid band 3 gene results in spherocytosis and severe haemolytic anaemia despite a normal membrane skeleton. Southgate CD, etal., Nat Genet. 1996 Oct;14(2):227-30.
40. Distal renal tubular acidosis in mice lacking the AE1 (band3) Cl-/HCO3- exchanger (slc4a1). Stehberger PA, etal., J Am Soc Nephrol. 2007 May;18(5):1408-18. Epub 2007 Apr 4.
41. Glyceraldehyde 3-phosphate dehydrogenase is required for band 3 (anion exchanger 1) membrane residency in the mammalian kidney. Su Y, etal., Am J Physiol Renal Physiol. 2011 Jan;300(1):F157-66. doi: 10.1152/ajprenal.00228.2010. Epub 2010 Oct 27.
42. Natural antiband 3 antibodies in patients with sickle cell disease. Villaescusa R, etal., C R Biol. 2013 Mar;336(3):173-6. doi: 10.1016/j.crvi.2012.09.002. Epub 2012 Oct 12.
43. Promoter polymorphism of the anion-exchange protein 1 associated with severe malarial anemia and fatality. von Kalckreuth V, etal., J Infect Dis. 2006 Oct 1;194(7):949-57. Epub 2006 Aug 30.
44. Cluster of erythrocyte band 3: a potential molecular target of exhaustive exercise-induced dysfunction of erythrocyte deformability. Xiong Y, etal., Can J Physiol Pharmacol. 2013 Dec;91(12):1127-34. doi: 10.1139/cjpp-2013-0145. Epub 2013 Jul 26.
Additional References at PubMed
PMID:379653   PMID:8456965   PMID:9716609   PMID:12388412   PMID:12477932   PMID:12539048   PMID:14734552   PMID:16077082   PMID:16669616   PMID:17690150   PMID:17715300   PMID:18698006  
PMID:18723693   PMID:19056867   PMID:22452706   PMID:22516433   PMID:23878365   PMID:24121512  


Genomics

Comparative Map Data
Slc4a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21087,306,865 - 87,323,132 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1087,306,872 - 87,323,117 (-)Ensembl
Rnor_6.01090,296,144 - 90,312,401 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1090,296,141 - 90,312,386 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01090,084,734 - 90,101,181 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41091,454,824 - 91,471,072 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11091,470,679 - 91,479,502 (-)NCBI
Celera1086,018,849 - 86,032,669 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
SLC4A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381744,248,390 - 44,268,135 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1744,248,390 - 44,268,141 (-)EnsemblGRCh38hg38GRCh38
GRCh371742,325,758 - 42,345,503 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361739,682,566 - 39,700,993 (-)NCBINCBI36hg18NCBI36
Build 341739,682,565 - 39,700,993NCBI
Celera1739,034,465 - 39,054,210 (-)NCBI
Cytogenetic Map17q21.31NCBI
HuRef1738,089,106 - 38,108,850 (-)NCBIHuRef
CHM1_11742,561,259 - 42,581,020 (-)NCBICHM1_1
T2T-CHM13v2.01745,101,499 - 45,121,240 (-)NCBI
Slc4a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911102,239,646 - 102,256,107 (-)NCBIGRCm39mm39
GRCm39 Ensembl11102,239,650 - 102,257,029 (-)Ensembl
GRCm3811102,348,820 - 102,365,281 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11102,348,824 - 102,366,203 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711102,210,134 - 102,226,595 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611102,164,917 - 102,181,205 (-)NCBImm8
Celera11114,058,195 - 114,074,658 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1166.29NCBI
Slc4a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545117,315,024 - 17,328,103 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545117,318,600 - 17,330,943 (-)NCBIChiLan1.0ChiLan1.0
SLC4A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11713,302,796 - 13,317,312 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1713,302,796 - 13,317,312 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01713,131,851 - 13,150,872 (+)NCBIMhudiblu_PPA_v0panPan3
SLC4A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1919,142,884 - 19,159,449 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl919,146,480 - 19,157,915 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha918,535,326 - 18,546,756 (+)NCBI
ROS_Cfam_1.0919,836,393 - 19,852,954 (+)NCBI
ROS_Cfam_1.0 Ensembl919,839,985 - 19,851,420 (+)Ensembl
UMICH_Zoey_3.1918,693,717 - 18,705,143 (+)NCBI
UNSW_CanFamBas_1.0918,877,006 - 18,888,427 (+)NCBI
UU_Cfam_GSD_1.0919,021,401 - 19,032,836 (+)NCBI
Slc4a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560218,460,919 - 18,477,383 (+)NCBI
SpeTri2.0NW_004936541718,577 - 727,420 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC4A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1218,957,807 - 18,974,208 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11218,957,813 - 18,975,266 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21219,180,392 - 19,196,592 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC4A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11662,126,370 - 62,146,192 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1662,131,709 - 62,146,182 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607732,895,386 - 32,915,473 (+)NCBIVero_WHO_p1.0
Slc4a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624795743,646 - 752,103 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_004624795739,821 - 752,773 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D10Wox20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,307,617 - 87,307,728 (+)MAPPERmRatBN7.2
Rnor_6.01090,296,897 - 90,297,007NCBIRnor6.0
Rnor_5.01090,085,487 - 90,085,597UniSTSRnor5.0
RGSC_v3.41091,455,572 - 91,455,683RGDRGSC3.4
RGSC_v3.41091,455,573 - 91,455,683UniSTSRGSC3.4
RGSC_v3.11091,469,942 - 91,470,053RGD
Celera1086,019,596 - 86,019,706UniSTS
RH 3.4 Map10880.59UniSTS
RH 3.4 Map10880.59RGD
RH 2.0 Map101017.0RGD
Cytogenetic Map10q32UniSTS
D10Arb13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,307,584 - 87,307,853 (+)MAPPERmRatBN7.2
Rnor_6.01090,296,864 - 90,297,132NCBIRnor6.0
Rnor_5.01090,085,454 - 90,085,722UniSTSRnor5.0
RGSC_v3.41091,455,539 - 91,455,808RGDRGSC3.4
RGSC_v3.41091,455,540 - 91,455,808UniSTSRGSC3.4
RGSC_v3.11091,469,909 - 91,470,178RGD
Celera1086,019,563 - 86,019,831UniSTS
FHH x ACI Map1071.36UniSTS
FHH x ACI Map1071.36RGD
Cytogenetic Map10q32UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:253
Count of miRNA genes:172
Interacting mature miRNAs:192
Transcripts:ENSRNOT00000028445
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 12 12 1 12
Medium 24 12 12 10 12 27 35 19 5
Low 2 19 33 17 8 17 5 5 44 15 6 5
Below cutoff 1 3 6 3 7 3

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000028445   ⟹   ENSRNOP00000028445
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,306,872 - 87,323,117 (-)Ensembl
Rnor_6.0 Ensembl1090,296,141 - 90,312,386 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092102   ⟹   ENSRNOP00000074568
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1087,306,872 - 87,323,117 (-)Ensembl
Rnor_6.0 Ensembl1090,296,151 - 90,307,658 (-)Ensembl
RefSeq Acc Id: NM_012651   ⟹   NP_036783
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21087,306,869 - 87,323,117 (-)NCBI
Rnor_6.01090,296,148 - 90,312,396 (-)NCBI
Rnor_5.01090,084,734 - 90,101,181 (-)NCBI
RGSC_v3.41091,454,824 - 91,471,072 (-)RGD
Celera1086,018,849 - 86,032,669 (-)RGD
Sequence:
RefSeq Acc Id: XM_008767946   ⟹   XP_008766168
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21087,306,865 - 87,323,132 (-)NCBI
Rnor_6.01090,296,144 - 90,312,401 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036783   ⟸   NM_012651
- UniProtKB: P23562 (UniProtKB/Swiss-Prot),   F8WFT7 (UniProtKB/TrEMBL),   Q5U329 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008766168   ⟸   XM_008767946
- Peptide Label: isoform X1
- UniProtKB: P23562 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074568   ⟸   ENSRNOT00000092102
RefSeq Acc Id: ENSRNOP00000028445   ⟸   ENSRNOT00000028445

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P23562-F1-model_v2 AlphaFold P23562 1-927 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697789
Promoter ID:EPDNEW_R8308
Type:single initiation site
Name:Slc4a1_2
Description:solute carrier family 4 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8309  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01090,307,676 - 90,307,736EPDNEW
RGD ID:13697785
Promoter ID:EPDNEW_R8309
Type:multiple initiation site
Name:Slc4a1_1
Description:solute carrier family 4 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8308  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01090,312,336 - 90,312,396EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
10 90087257 90087258 G A snv Crl:SD (UDEL)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3710 AgrOrtholog
BioCyc Gene G2FUF-23111 BioCyc
Ensembl Genes ENSRNOG00000020951 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000028445 ENTREZGENE
  ENSRNOP00000028445.6 UniProtKB/TrEMBL
  ENSRNOP00000074568.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000028445 ENTREZGENE
  ENSRNOT00000028445.7 UniProtKB/TrEMBL
  ENSRNOT00000092102.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.930.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126960 IMAGE-MGC_LOAD
InterPro Anion_exchange UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anion_exchange_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anion_exchange_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Band3_cytoplasmic_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCO3_transpt_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCO3_transpt_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTrfase/Anion_transptr UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24779 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93554 IMAGE-MGC_LOAD
NCBI Gene 24779 ENTREZGENE
PANTHER PTHR11453 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Band_3_cyto UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCO3_cotransp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc4a1 PhenoGen
PRINTS ANIONEXCHNGR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANIONEXHNGR1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HCO3TRNSPORT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANION_EXCHANGER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANION_EXCHANGER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55804 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs TIGR00834 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K8D8_RAT UniProtKB/TrEMBL
  B3AT_RAT UniProtKB/Swiss-Prot
  F8WFT7 ENTREZGENE, UniProtKB/TrEMBL
  P23562 ENTREZGENE
  Q5U329 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-02 Slc4a1  solute carrier family 4 member 1 (Diego blood group)  Slc4a1  solute carrier family 4 member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-01-17 Slc4a1  solute carrier family 4 member 1  Slc4a1  solute carrier family 4 (anion exchanger), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Slc4a1  solute carrier family 4 (anion exchanger), member 1  Slc4a1  solute carrier family 4, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Slc4a1  solute carrier family 4, member 1    Solute carrier family 4, member 1, anion exchange protein 1 (kidney band 3)  Name updated 629478 APPROVED
2002-06-10 Slc4a1  Solute carrier family 4, member 1, anion exchange protein 1 (kidney band 3)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mapping segregates on chr 10 within the Bp1 QTL region which has a major effect on systolic and diastolic blood pressure 1342444
gene_protein 848 amino acids 729968