Sphk1 (sphingosine kinase 1) - Rat Genome Database

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Gene: Sphk1 (sphingosine kinase 1) Rattus norvegicus
Analyze
Symbol: Sphk1
Name: sphingosine kinase 1
RGD ID: 620048
Description: Enables D-erythro-sphingosine kinase activity. Involved in several processes, including cellular response to phorbol 13-acetate 12-myristate; cyclooxygenase pathway; and regulation of macromolecule metabolic process. Located in axon and synaptic vesicle. Biomarker of adenocarcinoma and high grade glioma. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SPHK1 (sphingosine kinase 1); PARTICIPATES IN platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: acetyltransferase SPHK1; SK 1; SPK 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810102,257,413 - 102,263,086 (+)NCBIGRCr8
mRatBN7.210101,758,567 - 101,764,240 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,758,711 - 101,764,240 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10106,815,189 - 106,820,851 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010106,278,279 - 106,283,941 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,679,445 - 101,685,112 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010105,498,728 - 105,504,401 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,498,728 - 105,504,393 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010105,162,314 - 105,167,987 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,641,509 - 106,645,579 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,656,012 - 106,660,081 (+)NCBI
Celera10100,330,875 - 100,336,542 (+)NCBICelera
Cytogenetic Map10q32.1-q32.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-dihydromyricetin  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-palmitoylglycerol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrophenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
albendazole  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
apigenin  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
butan-1-ol  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
cefaloridine  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
dexamethasone  (ISO)
dextran sulfate  (EXP,ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
dioxygen  (ISO)
divanadium pentaoxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (EXP)
hesperidin  (EXP)
irinotecan  (EXP)
isobutanol  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
ketoconazole  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
Licochalcone B  (ISO)
lipopolysaccharide  (EXP,ISO)
menadione  (ISO)
methotrexate  (ISO)
methylmercury(1+)  (ISO)
methylparaben  (ISO)
mifepristone  (EXP)
N,N-dimethylsphingosine  (EXP,ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
naphthalene  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
onapristone  (EXP)
ouabain  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phosgene  (ISO)
pirinixic acid  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP)
prothioconazole  (ISO)
pyridoxamine  (EXP)
ranitidine  (EXP)
resveratrol  (EXP,ISO)
SB 431542  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sphingosine 1-phosphate  (ISO)
streptozocin  (EXP,ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel development  (ISO)
brain development  (ISO)
calcium-mediated signaling  (IEA,ISO)
cell population proliferation  (ISO)
cellular response to growth factor stimulus  (IBA,IEP)
cellular response to hydrogen peroxide  (IEP,ISO)
cellular response to phorbol 13-acetate 12-myristate  (IEP)
cellular response to starvation  (IEP)
cellular response to vascular endothelial growth factor stimulus  (IEA,ISO,ISS)
cyclooxygenase pathway  (IDA)
DNA biosynthetic process  (ISO)
female pregnancy  (IEP)
inflammatory response  (ISO)
lipid metabolic process  (IEA)
negative regulation of apoptotic process  (IBA,IEA,IMP,ISO,ISS)
negative regulation of ceramide biosynthetic process  (IEA,ISO,ISS)
phosphorylation  (ISO)
positive regulation of angiogenesis  (IEA,ISO)
positive regulation of cell growth  (IEA,ISO)
positive regulation of cell migration  (IEA,IMP,ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of interleukin-17 production  (IMP)
positive regulation of mitotic cell cycle  (IEA,ISO)
positive regulation of mitotic nuclear division  (ISO)
positive regulation of neuron projection development  (IMP)
positive regulation of neurotransmitter secretion  (IMP)
positive regulation of NF-kappaB transcription factor activity  (IMP,ISO,ISS)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA,ISO,ISS)
positive regulation of p38MAPK cascade  (IEA,ISO,ISS)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (IMP)
positive regulation of protein ubiquitination  (IEA,ISO,ISS)
positive regulation of smooth muscle contraction  (IEA,ISO)
protein acetylation  (ISO,ISS)
regulation of endocytosis  (IEA,ISO,ISS)
regulation of endosomal vesicle fusion  (ISO,ISS)
regulation of interleukin-1 beta production  (ISO)
regulation of microglial cell activation  (ISO,ISS)
regulation of neuroinflammatory response  (IMP,ISO,ISS)
regulation of phagocytosis  (ISO,ISS)
regulation of tumor necrosis factor-mediated signaling pathway  (IEA,IMP,ISO,ISS)
response to amine  (IEP)
response to ATP  (IEP)
response to interleukin-1  (IEP)
response to magnesium ion  (IEP)
response to progesterone  (IEP)
response to tumor necrosis factor  (IEA,ISO,ISS)
sphingolipid mediated signaling pathway  (ISO)
sphingosine biosynthetic process  (IBA,IEA,ISO)
sphingosine metabolic process  (IEA,ISO,ISS)
sphingosine-1-phosphate receptor signaling pathway  (IEA)

Cellular Component
axon  (IDA)
cilium  (IEA,ISO)
clathrin-coated pit  (IEA,ISO,ISS)
cytoplasm  (IBA,IEA,ISO,ISS)
early endosome membrane  (IEA,ISO,ISS)
endocytic vesicle  (ISO,ISS)
endosome  (IEA)
endosome membrane  (IEA)
membrane  (IBA,IEA)
nucleus  (IEA,ISO,ISS)
plasma membrane  (IEA,ISO)
presynapse  (IEA,ISO)
synapse  (IEA)
synaptic vesicle  (IDA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Extracellular release of newly synthesized sphingosine-1-phosphate by cerebellar granule cells and astrocytes. Anelli V, etal., J Neurochem. 2005 Mar;92(5):1204-15.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. CpG island of rat sphingosine kinase-1 gene: tissue-dependent DNA methylation status and multiple alternative first exons. Imamura T, etal., Genomics 2001 Aug;76(1-3):117-25.
4. Progesterone-induced sphingosine kinase-1 expression in the rat uterus during pregnancy and signaling consequences. Jeng YJ, etal., Am J Physiol Endocrinol Metab. 2007 Apr;292(4):E1110-21. Epub 2006 Dec 12.
5. Involvement of sphingosine-1-phosphate in glutamate secretion in hippocampal neurons. Kajimoto T, etal., Mol Cell Biol. 2007 May;27(9):3429-40. Epub 2007 Feb 26.
6. Sphingosine kinase 1 is up-regulated in colon carcinogenesis. Kawamori T, etal., FASEB J. 2006 Feb;20(2):386-8. Epub 2005 Nov 30.
7. Extracellular nucleotides induce migration of renal mesangial cells by upregulating sphingosine kinase-1 expression and activity. Klawitter S, etal., Br J Pharmacol. 2007 Feb;150(3):271-80. Epub 2007 Jan 2.
8. Sphingosine kinase 1 participates in insulin signalling and regulates glucose metabolism and homeostasis in KK/Ay diabetic mice. Ma MM, etal., Diabetologia. 2007 Apr;50(4):891-900. Epub 2007 Jan 31.
9. Sphingosine kinase activity and sphingosine-1 phosphate production in rat pancreatic islets and INS-1 cells: response to cytokines. Mastrandrea LD, etal., Diabetes. 2005 May;54(5):1429-36.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. SPHINGOSINE-1-PHOSPHATE IS A KEY REGULATOR OF PROLIFERATION AND DIFFERENTIATION IN RETINA PHOTORECEPTORS. Miranda GE, etal., Invest Ophthalmol Vis Sci. 2009 Apr 8.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Cloning and characterization of rat sphingosine kinase 1 with an N-terminal extension. Park CG, etal., Biochem Biophys Res Commun. 2007 Dec 21;364(3):702-7. Epub 2007 Oct 22.
14. Oxidative stress-dependent sphingosine kinase-1 inhibition mediates monoamine oxidase A-associated cardiac cell apoptosis. Pchejetski D, etal., Circ Res. 2007 Jan 5;100(1):41-9. Epub 2006 Dec 7.
15. Modulation of P-glycoprotein function by sphingosine kinase-1 in brain endothelial cells. Pilorget A, etal., J Neurochem. 2007 Mar;100(5):1203-10.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. Endothelin-1 inhibits apoptosis through a sphingosine kinase 1-dependent mechanism in uterine leiomyoma ELT3 cells. Raymond MN, etal., Endocrinology. 2006 Dec;147(12):5873-82. Epub 2006 Sep 7.
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Novel role of sphingosine kinase 1 as a mediator of neurotrophin-3 action in oligodendrocyte progenitors. Saini HS, etal., J Neurochem. 2005 Dec;95(5):1298-310.
22. Signaling pathways involved in sphingosine kinase activation and sphingosine-1-phosphate release in rat myometrium in late pregnancy: role in the induction of cyclooxygenase 2. Serrano-Sanchez M, etal., Endocrinology. 2008 Sep;149(9):4669-79.
23. Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor-induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12. Sobue S, etal., J Neurochem. 2005 Nov;95(4):940-9. Epub 2005 Aug 31.
24. Neurotrophic signalling pathway triggered by prosaposin in PC12 cells occurs through lipid rafts. Sorice M, etal., FEBS J. 2008 Oct;275(19):4903-12.
25. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
26. Sphk1 mediates neuroinflammation and neuronal injury via TRAF2/NF-κB pathways in activated microglia in cerebral ischemia reperfusion. Su D, etal., J Neuroimmunol. 2017 Apr 15;305:35-41. doi: 10.1016/j.jneuroim.2017.01.015. Epub 2017 Jan 26.
27. FHL2/SLIM3 decreases cardiomyocyte survival by inhibitory interaction with sphingosine kinase-1. Sun J, etal., Circ Res. 2006 Sep 1;99(5):468-76. Epub 2006 Aug 3.
28. Differential transactivation of sphingosine-1-phosphate receptors modulates NGF-induced neurite extension. Toman RE, etal., J Cell Biol. 2004 Aug 2;166(3):381-92.
Additional References at PubMed
PMID:9726979   PMID:10863092   PMID:10947957   PMID:11923095   PMID:12393916   PMID:12441135   PMID:12847068   PMID:15310762   PMID:15314148   PMID:15585953   PMID:15623571   PMID:15741218  
PMID:16118219   PMID:16314531   PMID:16956968   PMID:16980623   PMID:18305483   PMID:18552482   PMID:18675457   PMID:18805787   PMID:19797403   PMID:19854831   PMID:20371493   PMID:20577214  
PMID:21075214   PMID:21084291   PMID:21310085   PMID:21660956   PMID:21887342   PMID:21998146   PMID:22155656   PMID:22251137   PMID:23085271   PMID:23106337   PMID:23651497   PMID:23817990  
PMID:23935096   PMID:24342046   PMID:24929359   PMID:25399649   PMID:25417698   PMID:25575056   PMID:26334640   PMID:27002656   PMID:27467777   PMID:27806293   PMID:28049734   PMID:29233979  
PMID:29662056   PMID:29743513   PMID:30453304   PMID:31486506   PMID:31814336   PMID:33281190   PMID:33602274   PMID:35766986   PMID:38607078  


Genomics

Comparative Map Data
Sphk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810102,257,413 - 102,263,086 (+)NCBIGRCr8
mRatBN7.210101,758,567 - 101,764,240 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,758,711 - 101,764,240 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10106,815,189 - 106,820,851 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010106,278,279 - 106,283,941 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,679,445 - 101,685,112 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010105,498,728 - 105,504,401 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,498,728 - 105,504,393 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010105,162,314 - 105,167,987 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,641,509 - 106,645,579 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,656,012 - 106,660,081 (+)NCBI
Celera10100,330,875 - 100,336,542 (+)NCBICelera
Cytogenetic Map10q32.1-q32.2NCBI
SPHK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381776,383,204 - 76,387,855 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1776,376,584 - 76,387,860 (+)EnsemblGRCh38hg38GRCh38
GRCh371774,379,285 - 74,383,936 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361771,892,297 - 71,895,536 (+)NCBINCBI36Build 36hg18NCBI36
Build 341771,892,325 - 71,895,530NCBI
Celera1770,973,067 - 70,976,318 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1769,809,173 - 69,812,424 (+)NCBIHuRef
CHM1_11774,445,769 - 74,449,020 (+)NCBICHM1_1
T2T-CHM13v2.01777,279,777 - 77,284,428 (+)NCBIT2T-CHM13v2.0
Sphk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911116,421,662 - 116,427,502 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11116,421,751 - 116,427,501 (+)EnsemblGRCm39 Ensembl
GRCm3811116,530,836 - 116,536,675 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,530,925 - 116,536,674 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,530,925 - 116,536,675 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711116,393,225 - 116,397,989 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611116,349,437 - 116,352,760 (+)NCBIMGSCv36mm8
Celera11128,300,450 - 128,305,214 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1181.42NCBI
Sphk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555065,902,345 - 5,904,988 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555065,902,079 - 5,906,639 (-)NCBIChiLan1.0ChiLan1.0
SPHK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21992,424,277 - 92,430,882 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11797,251,477 - 97,256,099 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01770,331,370 - 70,336,043 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11775,875,530 - 75,886,481 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1775,883,329 - 75,886,481 (+)Ensemblpanpan1.1panPan2
SPHK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,311,698 - 4,314,773 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,311,683 - 4,314,483 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha94,992,955 - 4,996,576 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.094,984,498 - 4,988,116 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl94,984,483 - 4,987,049 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.195,012,727 - 5,016,344 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,132,520 - 5,136,143 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,213,806 - 5,217,418 (-)NCBIUU_Cfam_GSD_1.0
Sphk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056024,922,623 - 4,928,472 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365941,486,111 - 1,489,188 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365941,482,830 - 1,489,337 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPHK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,114,947 - 5,120,083 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,114,946 - 5,122,580 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2125,018,690 - 5,023,812 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPHK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11645,290,147 - 45,295,175 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1645,290,421 - 45,293,128 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607716,031,997 - 16,036,965 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sphk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248016,253,219 - 6,257,128 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sphk1
14 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:184
Count of miRNA genes:125
Interacting mature miRNAs:136
Transcripts:ENSRNOT00000032163
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1578672Bmd16Bone mineral density QTL 166.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)1096703043107057807Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
1578663Bss18Bone structure and strength QTL 183.6femur width (VT:1000666)femoral neck width (CMO:0001695)1096703043107057807Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
1576313Pia25Pristane induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1576307Cia28Collagen induced arthritis QTL 28joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1096120911104060283Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1094759759107211142Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631539Oia6Oil induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1097010147104670812Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
RH130570  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.210101,764,046 - 101,764,226 (+)MAPPERmRatBN7.2
Rnor_6.010105,504,208 - 105,504,387NCBIRnor6.0
Rnor_5.010105,167,794 - 105,167,973UniSTSRnor5.0
RGSC_v3.410106,645,392 - 106,645,571UniSTSRGSC3.4
Celera10100,336,355 - 100,336,534UniSTS
Cytogenetic Map10q32.3UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270808 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_133386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB049571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB049572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB049573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB049574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB049575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ486894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000032163   ⟹   ENSRNOP00000029296
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,758,711 - 101,764,240 (+)Ensembl
Rnor_6.0 Ensembl10105,498,728 - 105,504,393 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079080   ⟹   ENSRNOP00000073860
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl10105,500,290 - 105,504,393 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083593   ⟹   ENSRNOP00000072525
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl10101,760,129 - 101,764,239 (+)Ensembl
Rnor_6.0 Ensembl10105,500,290 - 105,504,393 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000088457   ⟹   ENSRNOP00000069849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl10105,499,569 - 105,504,393 (+)Ensembl
RefSeq Acc Id: NM_001270807   ⟹   NP_001257736
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,257,413 - 102,263,080 (+)NCBI
mRatBN7.210101,758,567 - 101,764,234 (+)NCBI
Rnor_6.010105,498,728 - 105,504,395 (+)NCBI
Rnor_5.010105,162,314 - 105,167,987 (+)NCBI
Celera10100,330,875 - 100,336,542 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270808   ⟹   NP_001257737
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,258,254 - 102,263,080 (+)NCBI
mRatBN7.210101,759,408 - 101,764,234 (+)NCBI
Rnor_6.010105,499,569 - 105,504,395 (+)NCBI
Rnor_5.010105,162,314 - 105,167,987 (+)NCBI
Celera10100,331,716 - 100,336,542 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270809   ⟹   NP_001257738
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,258,975 - 102,263,080 (+)NCBI
mRatBN7.210101,760,129 - 101,764,234 (+)NCBI
Rnor_6.010105,500,290 - 105,504,395 (+)NCBI
Rnor_5.010105,162,314 - 105,167,987 (+)NCBI
Celera10100,332,437 - 100,336,542 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270810   ⟹   NP_001257739
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,258,975 - 102,263,080 (+)NCBI
mRatBN7.210101,760,129 - 101,764,234 (+)NCBI
Rnor_6.010105,500,290 - 105,504,395 (+)NCBI
Rnor_5.010105,162,314 - 105,167,987 (+)NCBI
Celera10100,332,437 - 100,336,542 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001270811   ⟹   NP_001257740
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,258,975 - 102,263,080 (+)NCBI
mRatBN7.210101,760,129 - 101,764,234 (+)NCBI
Rnor_6.010105,500,290 - 105,504,395 (+)NCBI
Rnor_5.010105,162,314 - 105,167,987 (+)NCBI
Celera10100,332,437 - 100,336,542 (+)NCBI
Sequence:
RefSeq Acc Id: NM_133386   ⟹   NP_596877
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,258,975 - 102,263,080 (+)NCBI
mRatBN7.210101,760,129 - 101,764,234 (+)NCBI
Rnor_6.010105,500,290 - 105,504,395 (+)NCBI
Rnor_5.010105,162,314 - 105,167,987 (+)NCBI
RGSC_v3.410106,641,509 - 106,645,579 (+)RGD
Celera10100,332,437 - 100,336,542 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006247787   ⟹   XP_006247849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr810102,258,974 - 102,263,086 (+)NCBI
mRatBN7.210101,759,776 - 101,764,240 (+)NCBI
Rnor_6.010105,499,917 - 105,504,401 (+)NCBI
Rnor_5.010105,162,314 - 105,167,987 (+)NCBI
Sequence:
RefSeq Acc Id: NP_596877   ⟸   NM_133386
- Peptide Label: isoform b
- UniProtKB: Q642F6 (UniProtKB/Swiss-Prot),   Q91V26 (UniProtKB/Swiss-Prot),   A6HKX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257736   ⟸   NM_001270807
- Peptide Label: isoform b
- UniProtKB: Q642F6 (UniProtKB/Swiss-Prot),   Q91V26 (UniProtKB/Swiss-Prot),   A6HKX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257737   ⟸   NM_001270808
- Peptide Label: isoform b
- UniProtKB: Q642F6 (UniProtKB/Swiss-Prot),   Q91V26 (UniProtKB/Swiss-Prot),   A6HKX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257740   ⟸   NM_001270811
- Peptide Label: isoform a
- UniProtKB: A0A0G2K373 (UniProtKB/TrEMBL),   Q1HGK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257739   ⟸   NM_001270810
- Peptide Label: isoform b
- UniProtKB: Q642F6 (UniProtKB/Swiss-Prot),   Q91V26 (UniProtKB/Swiss-Prot),   A6HKX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257738   ⟸   NM_001270809
- Peptide Label: isoform b
- UniProtKB: Q642F6 (UniProtKB/Swiss-Prot),   Q91V26 (UniProtKB/Swiss-Prot),   A6HKX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247849   ⟸   XM_006247787
- Peptide Label: isoform X1
- UniProtKB: Q91V26 (UniProtKB/Swiss-Prot),   Q642F6 (UniProtKB/Swiss-Prot),   A0A140TAE3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073860   ⟸   ENSRNOT00000079080
Ensembl Acc Id: ENSRNOP00000029296   ⟸   ENSRNOT00000032163
Ensembl Acc Id: ENSRNOP00000072525   ⟸   ENSRNOT00000083593
Ensembl Acc Id: ENSRNOP00000069849   ⟸   ENSRNOT00000088457
Protein Domains
DAGKc

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91V26-F1-model_v2 AlphaFold Q91V26 1-383 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697917
Promoter ID:EPDNEW_R8442
Type:multiple initiation site
Name:Sphk1_1
Description:sphingosine kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8443  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010105,500,316 - 105,500,376EPDNEW
RGD ID:13697918
Promoter ID:EPDNEW_R8443
Type:single initiation site
Name:Sphk1_2
Description:sphingosine kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R8442  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.010105,501,182 - 105,501,242EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620048 AgrOrtholog
BioCyc Gene G2FUF-22599 BioCyc
BioCyc Pathway PWY-6483 [ceramide degradation (generic)] BioCyc
  PWY3DJ-11470 [sphingosine and sphingosine-1-phosphate metabolism] BioCyc
BioCyc Pathway Image PWY-6483 BioCyc
  PWY3DJ-11470 BioCyc
Ensembl Genes ENSRNOG00000010626 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000083593 ENTREZGENE
Gene3D-CATH 2.60.200.40 UniProtKB/Swiss-Prot
  Probable inorganic polyphosphate/atp-NAD kinase, domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7132896 IMAGE-MGC_LOAD
InterPro ATP-NAD_kinase_N UniProtKB/Swiss-Prot
  Diacylglycerol_kinase_cat_dom UniProtKB/Swiss-Prot
  Lipid_Phosphate_FormReg UniProtKB/Swiss-Prot
  NAD/diacylglycerol_kinase_sf UniProtKB/Swiss-Prot
KEGG Report rno:170897 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93229 IMAGE-MGC_LOAD
NCBI Gene 170897 ENTREZGENE
PANTHER SPHINGOSINE KINASE UniProtKB/Swiss-Prot
  SPHINGOSINE KINASE 1 UniProtKB/Swiss-Prot
Pfam DAGK_cat UniProtKB/Swiss-Prot
PhenoGen Sphk1 PhenoGen
PROSITE DAGK UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010626 RatGTEx
SMART DAGKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF111331 UniProtKB/Swiss-Prot
UniProt A0A0G2K373 ENTREZGENE, UniProtKB/TrEMBL
  A0A140TAE3 ENTREZGENE, UniProtKB/TrEMBL
  A6HKX2 ENTREZGENE, UniProtKB/TrEMBL
  Q1HGK5 ENTREZGENE, UniProtKB/TrEMBL
  Q642F6 ENTREZGENE
  Q91V26 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q642F6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Sphk1  sphingosine kinase 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Sphk1  sphingosine kinase 1      Symbol and Name status set to provisional 70820 PROVISIONAL