Sphk1 Rat (+)-dihydromyricetin decreases expression ISO SPHK1 (Homo sapiens) 6480464 ampelopsin results in decreased expression of SPHK1 protein CTD PMID:22251058 Sphk1 Rat (+)-dihydromyricetin decreases activity ISO SPHK1 (Homo sapiens) 6480464 ampelopsin results in decreased activity of SPHK1 protein CTD PMID:22251058 Sphk1 Rat 1,2-dimethylhydrazine increases expression EXP 6480464 1 and 2-Dimethylhydrazine results in increased expression of SPHK1 mRNA CTD PMID:27840820 Sphk1 Rat 1,2-dimethylhydrazine multiple interactions ISO Sphk1 (Mus musculus) 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SPHK1 mRNA CTD PMID:22206623 Sphk1 Rat 1,2-dimethylhydrazine increases expression ISO Sphk1 (Mus musculus) 6480464 1 and 2-Dimethylhydrazine results in increased expression of SPHK1 mRNA CTD PMID:22206623 Sphk1 Rat 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of SPHK1 mRNA CTD PMID:17351261 Sphk1 Rat 17beta-estradiol affects expression ISO SPHK1 (Homo sapiens) 6480464 Estradiol affects the expression of SPHK1 mRNA CTD PMID:22574217 Sphk1 Rat 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of SPHK1 mRNA CTD PMID:32145629 Sphk1 Rat 17beta-estradiol multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of SPHK1 mRNA CTD PMID:30165855 Sphk1 Rat 17beta-estradiol increases expression ISO SPHK1 (Homo sapiens) 6480464 Estradiol results in increased expression of SPHK1 mRNA CTD PMID:29654831 and PMID:31614463 Sphk1 Rat 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions EXP 6480464 2 more ... CTD PMID:27318803 Sphk1 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Sphk1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin results in increased expression of SPHK1 mRNA CTD PMID:19933214 Sphk1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of SPHK1 mRNA CTD PMID:34747641 Sphk1 Rat 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Sphk1 (Mus musculus) 6480464 Tetrachlorodibenzodioxin affects the expression of SPHK1 mRNA CTD PMID:21570461 Sphk1 Rat 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SPHK1 mRNA CTD PMID:16960034 and PMID:21964420 Sphk1 Rat 2-palmitoylglycerol increases expression ISO SPHK1 (Homo sapiens) 6480464 2-palmitoylglycerol results in increased expression of SPHK1 mRNA CTD PMID:37199045 Sphk1 Rat 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO Sphk1 (Mus musculus) 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SPHK1 mRNA CTD PMID:16054899 Sphk1 Rat 4-(ethoxymethylene)-2-phenyloxazol-5-one increases activity EXP 6480464 Oxazolone results in increased activity of SPHK1 protein CTD PMID:24055189 Sphk1 Rat 4-(ethoxymethylene)-2-phenyloxazol-5-one multiple interactions EXP 6480464 resveratrol inhibits the reaction [Oxazolone results in increased activity of SPHK1 protein] CTD PMID:24055189 Sphk1 Rat 4-hydroxy-17beta-estradiol increases expression ISO SPHK1 (Homo sapiens) 6480464 4-hydroxyestradiol results in increased expression of SPHK1 mRNA CTD PMID:29654831 Sphk1 Rat 4-hydroxyphenyl retinamide increases expression ISO Sphk1 (Mus musculus) 6480464 Fenretinide results in increased expression of SPHK1 mRNA CTD PMID:28973697 Sphk1 Rat 4-nitrophenol increases expression ISO Sphk1 (Mus musculus) 6480464 4-nitrophenol results in increased expression of SPHK1 mRNA CTD PMID:34673133 Sphk1 Rat 5-aza-2'-deoxycytidine increases expression ISO SPHK1 (Homo sapiens) 6480464 Decitabine results in increased expression of SPHK1 mRNA CTD PMID:19194470 Sphk1 Rat 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of SPHK1 mRNA CTD PMID:24780913 Sphk1 Rat acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of SPHK1 mRNA CTD PMID:28959563 Sphk1 Rat afimoxifene decreases response to substance ISO SPHK1 (Homo sapiens) 6480464 SPHK1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 Sphk1 Rat aflatoxin B1 increases expression ISO SPHK1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of SPHK1 mRNA CTD PMID:22100608 and PMID:27153756 Sphk1 Rat albendazole multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [Ivermectin co-treated with Albendazole] results in decreased expression of SPHK1 mRNA CTD PMID:16861626 Sphk1 Rat aldehydo-D-glucose multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] more ... CTD PMID:21998146 Sphk1 Rat aldehydo-D-glucose increases expression EXP 6480464 Glucose results in increased expression of SPHK1 mRNA CTD PMID:21998146 Sphk1 Rat all-trans-retinoic acid decreases expression EXP 6480464 Tretinoin results in decreased expression of SPHK1 mRNA CTD PMID:20488242 Sphk1 Rat all-trans-retinoic acid decreases expression ISO SPHK1 (Homo sapiens) 6480464 Tretinoin results in decreased expression of SPHK1 mRNA CTD PMID:23830798 Sphk1 Rat ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of SPHK1 mRNA CTD PMID:16483693 Sphk1 Rat apigenin multiple interactions EXP 6480464 Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] CTD PMID:25557508 Sphk1 Rat aristolochic acid A increases expression ISO SPHK1 (Homo sapiens) 6480464 aristolochic acid I results in increased expression of SPHK1 mRNA CTD PMID:33212167 Sphk1 Rat arsane multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of SPHK1 mRNA CTD PMID:32525701 Sphk1 Rat arsane affects methylation ISO SPHK1 (Homo sapiens) 6480464 Arsenic affects the methylation of SPHK1 gene CTD PMID:25304211 Sphk1 Rat arsenic atom multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of SPHK1 mRNA CTD PMID:32525701 Sphk1 Rat arsenic atom affects methylation ISO SPHK1 (Homo sapiens) 6480464 Arsenic affects the methylation of SPHK1 gene CTD PMID:25304211 Sphk1 Rat arsenite(3-) increases expression ISO SPHK1 (Homo sapiens) 6480464 arsenite metabolite results in increased expression of SPHK1 mRNA CTD PMID:33129825 Sphk1 Rat benzo[a]pyrene increases expression ISO Sphk1 (Mus musculus) 6480464 Benzo(a)pyrene results in increased expression of SPHK1 mRNA CTD PMID:21569818 and PMID:22228805 Sphk1 Rat benzo[a]pyrene increases expression ISO SPHK1 (Homo sapiens) 6480464 Benzo(a)pyrene metabolite results in increased expression of SPHK1 mRNA and Benzo(a)pyrene results in increased expression of SPHK1 mRNA CTD PMID:26314263 more ... Sphk1 Rat benzo[a]pyrene diol epoxide I affects expression ISO SPHK1 (Homo sapiens) 6480464 7 more ... CTD PMID:20382639 Sphk1 Rat bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of SPHK1 mRNA CTD PMID:25181051 more ... Sphk1 Rat bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of SPHK1 mRNA CTD PMID:32145629 Sphk1 Rat bisphenol A decreases expression ISO SPHK1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of SPHK1 mRNA CTD PMID:29275510 Sphk1 Rat bortezomib decreases expression ISO SPHK1 (Homo sapiens) 6480464 Bortezomib results in decreased expression of SPHK1 protein CTD PMID:21195056 Sphk1 Rat butan-1-ol multiple interactions ISO SPHK1 (Homo sapiens) 6480464 1-Butanol inhibits the reaction [C5 protein results in increased activity of SPHK1 protein] and [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SPHK1 mRNA CTD PMID:19284563 and PMID:29432896 Sphk1 Rat C60 fullerene increases expression EXP 6480464 fullerene C60 results in increased expression of SPHK1 mRNA CTD PMID:19167457 Sphk1 Rat cadmium atom increases expression ISO SPHK1 (Homo sapiens) 6480464 Cadmium results in increased expression of SPHK1 mRNA CTD PMID:21120746 and PMID:24376830 Sphk1 Rat cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of SPHK1 mRNA CTD PMID:33453195 Sphk1 Rat cadmium dichloride increases expression ISO Sphk1 (Mus musculus) 6480464 Cadmium Chloride results in increased expression of SPHK1 mRNA CTD PMID:34666113 Sphk1 Rat cadmium dichloride increases expression ISO SPHK1 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of SPHK1 mRNA CTD PMID:38568856 Sphk1 Rat calcium atom multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium and resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19284563 and PMID:19346296 Sphk1 Rat calcium atom multiple interactions ISO Sphk1 (Mus musculus) 6480464 [C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium and resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19346296 Sphk1 Rat calcium(0) multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium and resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19284563 and PMID:19346296 Sphk1 Rat calcium(0) multiple interactions ISO Sphk1 (Mus musculus) 6480464 [C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium and resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19346296 Sphk1 Rat cannabidiol multiple interactions ISO Sphk1 (Mus musculus) 6480464 Cannabidiol inhibits the reaction [MOG protein modified form results in increased expression of SPHK1 mRNA] CTD PMID:27256343 Sphk1 Rat carbon nanotube increases expression ISO SPHK1 (Homo sapiens) 6480464 Nanotubes and Carbon results in increased expression of SPHK1 mRNA CTD PMID:25511174 Sphk1 Rat carbon nanotube affects expression ISO Sphk1 (Mus musculus) 6480464 Nanotubes more ... CTD PMID:23845593 and PMID:25554681 Sphk1 Rat cefaloridine increases expression EXP 6480464 Cephaloridine results in increased expression of SPHK1 mRNA CTD PMID:18500788 Sphk1 Rat chlorpyrifos decreases methylation EXP 6480464 Chlorpyrifos results in decreased methylation of SPHK1 gene CTD PMID:32905263 Sphk1 Rat choline multiple interactions ISO Sphk1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPHK1 mRNA CTD PMID:20938992 Sphk1 Rat cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of SPHK1 mRNA CTD PMID:22023808 Sphk1 Rat cisplatin multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of SPHK1 mRNA CTD PMID:27392435 Sphk1 Rat cisplatin decreases expression ISO SPHK1 (Homo sapiens) 6480464 Cisplatin results in decreased expression of SPHK1 mRNA CTD PMID:27392435 Sphk1 Rat cobalt dichloride decreases expression ISO SPHK1 (Homo sapiens) 6480464 cobaltous chloride results in decreased expression of SPHK1 mRNA CTD PMID:19320972 and PMID:26314263 Sphk1 Rat copper(II) chloride increases expression ISO SPHK1 (Homo sapiens) 6480464 cupric chloride results in increased expression of SPHK1 mRNA CTD PMID:38568856 Sphk1 Rat copper(II) sulfate decreases expression ISO SPHK1 (Homo sapiens) 6480464 Copper Sulfate results in decreased expression of SPHK1 mRNA CTD PMID:19549813 Sphk1 Rat crocidolite asbestos increases expression ISO SPHK1 (Homo sapiens) 6480464 Asbestos and Crocidolite results in increased expression of SPHK1 mRNA CTD PMID:18687144 Sphk1 Rat crocidolite asbestos affects expression ISO SPHK1 (Homo sapiens) 6480464 Asbestos and Crocidolite affects the expression of SPHK1 mRNA CTD PMID:25757056 Sphk1 Rat cyclosporin A increases expression ISO Sphk1 (Mus musculus) 6480464 Cyclosporine results in increased expression of SPHK1 mRNA CTD PMID:19770486 Sphk1 Rat cyclosporin A decreases expression ISO SPHK1 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of SPHK1 mRNA CTD PMID:25562108 and PMID:27989131 Sphk1 Rat D-glucose multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] more ... CTD PMID:21998146 Sphk1 Rat D-glucose increases expression EXP 6480464 Glucose results in increased expression of SPHK1 mRNA CTD PMID:21998146 Sphk1 Rat dexamethasone multiple interactions ISO Sphk1 (Mus musculus) 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SPHK1 mRNA CTD PMID:16054899 Sphk1 Rat dexamethasone increases expression ISO Sphk1 (Mus musculus) 6480464 Dexamethasone results in increased expression of SPHK1 mRNA CTD PMID:22733784 Sphk1 Rat dextran sulfate increases expression EXP 6480464 Dextran Sulfate results in increased expression of SPHK1 protein CTD PMID:30811821 Sphk1 Rat dextran sulfate multiple interactions ISO Sphk1 (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of SPHK1 mRNA CTD PMID:29950665 Sphk1 Rat dextran sulfate multiple interactions EXP 6480464 Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SPHK1 protein] CTD PMID:30811821 Sphk1 Rat diazinon increases methylation ISO SPHK1 (Homo sapiens) 6480464 Diazinon results in increased methylation of SPHK1 gene CTD PMID:22964155 Sphk1 Rat Dibutyl phosphate affects expression ISO SPHK1 (Homo sapiens) 6480464 di-n-butylphosphoric acid affects the expression of SPHK1 mRNA CTD PMID:37042841 Sphk1 Rat dibutyl phthalate increases expression ISO Sphk1 (Mus musculus) 6480464 Dibutyl Phthalate results in increased expression of SPHK1 mRNA CTD PMID:17361019 and PMID:21266533 Sphk1 Rat dioxygen multiple interactions ISO Sphk1 (Mus musculus) 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of SPHK1 mRNA CTD PMID:30529165 Sphk1 Rat divanadium pentaoxide affects expression ISO Sphk1 (Mus musculus) 6480464 vanadium pentoxide affects the expression of SPHK1 mRNA CTD PMID:26210822 Sphk1 Rat dorsomorphin multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 Sphk1 Rat doxorubicin increases expression ISO SPHK1 (Homo sapiens) 6480464 Doxorubicin results in increased expression of SPHK1 mRNA CTD PMID:29803840 Sphk1 Rat doxorubicin increases expression ISO Sphk1 (Mus musculus) 6480464 Doxorubicin results in increased expression of SPHK1 mRNA CTD PMID:36227756 Sphk1 Rat ethanol multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SPHK1 mRNA CTD PMID:29432896 Sphk1 Rat folic acid multiple interactions ISO Sphk1 (Mus musculus) 6480464 [1 more ... CTD PMID:20938992 and PMID:22206623 Sphk1 Rat fumonisin B1 multiple interactions ISO Sphk1 (Mus musculus) 6480464 fumonisin B1 inhibits the reaction [Particulate Matter results in increased expression of SPHK1 mRNA] and fumonisin B1 inhibits the reaction [Vehicle Emissions results in increased expression of SPHK1 mRNA] CTD PMID:27376354 Sphk1 Rat furan increases expression EXP 6480464 furan results in increased expression of SPHK1 mRNA CTD PMID:27387713 Sphk1 Rat gentamycin decreases expression EXP 6480464 Gentamicins results in decreased expression of SPHK1 mRNA CTD PMID:33387578 Sphk1 Rat glucose multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] more ... CTD PMID:21998146 Sphk1 Rat glucose increases expression EXP 6480464 Glucose results in increased expression of SPHK1 mRNA CTD PMID:21998146 Sphk1 Rat hesperidin multiple interactions EXP 6480464 Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SPHK1 protein] CTD PMID:30811821 Sphk1 Rat irinotecan affects expression EXP 6480464 Irinotecan affects the expression of SPHK1 mRNA CTD PMID:20097248 Sphk1 Rat isobutanol multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SPHK1 mRNA CTD PMID:29432896 Sphk1 Rat isoprenaline increases expression ISO Sphk1 (Mus musculus) 6480464 Isoproterenol results in increased expression of SPHK1 mRNA CTD PMID:20003209 Sphk1 Rat ivermectin multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [Ivermectin co-treated with Albendazole] results in decreased expression of SPHK1 mRNA CTD PMID:16861626 Sphk1 Rat kaempferol multiple interactions ISO SPHK1 (Homo sapiens) 6480464 kaempferol inhibits the reaction [Lipopolysaccharides results in decreased expression of SPHK1 protein] CTD PMID:36243145 Sphk1 Rat kaempferol multiple interactions ISO Sphk1 (Mus musculus) 6480464 kaempferol inhibits the reaction [Lipopolysaccharides affects the expression of SPHK1 protein] and kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] CTD PMID:36243145 Sphk1 Rat ketoconazole increases expression EXP 6480464 Ketoconazole results in increased expression of SPHK1 mRNA CTD PMID:25787151 Sphk1 Rat L-methionine multiple interactions ISO Sphk1 (Mus musculus) 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPHK1 mRNA CTD PMID:20938992 Sphk1 Rat lead diacetate increases expression ISO SPHK1 (Homo sapiens) 6480464 lead acetate results in increased expression of SPHK1 mRNA CTD PMID:38568856 Sphk1 Rat Licochalcone B increases expression ISO SPHK1 (Homo sapiens) 6480464 licochalcone B results in increased expression of SPHK1 mRNA CTD PMID:33647349 Sphk1 Rat lipopolysaccharide multiple interactions EXP 6480464 Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] and Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SPHK1 mRNA] CTD PMID:16415329 and PMID:25557508 Sphk1 Rat lipopolysaccharide multiple interactions ISO Sphk1 (Mus musculus) 6480464 kaempferol inhibits the reaction [Lipopolysaccharides affects the expression of SPHK1 protein] and kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] CTD PMID:36243145 Sphk1 Rat lipopolysaccharide decreases expression ISO SPHK1 (Homo sapiens) 6480464 Lipopolysaccharides results in decreased expression of SPHK1 protein CTD PMID:36243145 Sphk1 Rat lipopolysaccharide increases expression ISO Sphk1 (Mus musculus) 6480464 Lipopolysaccharides results in increased expression of SPHK1 protein CTD PMID:36243145 Sphk1 Rat lipopolysaccharide multiple interactions ISO SPHK1 (Homo sapiens) 6480464 kaempferol inhibits the reaction [Lipopolysaccharides results in decreased expression of SPHK1 protein] CTD PMID:36243145 Sphk1 Rat lipopolysaccharide affects expression ISO Sphk1 (Mus musculus) 6480464 Lipopolysaccharides affects the expression of SPHK1 protein CTD PMID:36243145 Sphk1 Rat lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of SPHK1 mRNA and Lipopolysaccharides results in increased expression of SPHK1 protein CTD PMID:16415329 and PMID:25557508 Sphk1 Rat menadione affects expression ISO SPHK1 (Homo sapiens) 6480464 Vitamin K 3 affects the expression of SPHK1 mRNA CTD PMID:20044591 Sphk1 Rat methotrexate decreases expression ISO SPHK1 (Homo sapiens) 6480464 Methotrexate results in decreased expression of SPHK1 mRNA CTD PMID:17400583 Sphk1 Rat methylmercury(1+) decreases expression ISO SPHK1 (Homo sapiens) 6480464 methylmercury II results in decreased expression of SPHK1 mRNA CTD PMID:26314263 Sphk1 Rat methylparaben increases expression ISO SPHK1 (Homo sapiens) 6480464 methylparaben results in increased expression of SPHK1 mRNA CTD PMID:38568856 Sphk1 Rat mifepristone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA] CTD PMID:17164439 Sphk1 Rat N,N-dimethylsphingosine decreases activity ISO SPHK1 (Homo sapiens) 6480464 N and N-dimethylsphingosine results in decreased activity of SPHK1 protein CTD PMID:17065523 and PMID:19284563 Sphk1 Rat N,N-dimethylsphingosine decreases expression ISO SPHK1 (Homo sapiens) 6480464 N and N-dimethylsphingosine results in decreased expression of SPHK1 protein CTD PMID:21195056 Sphk1 Rat N,N-dimethylsphingosine multiple interactions EXP 6480464 N and N-dimethylsphingosine inhibits the reaction [Glucose results in increased activity of SPHK1 protein] CTD PMID:21998146 Sphk1 Rat N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] CTD PMID:21998146 Sphk1 Rat N-methyl-4-phenylpyridinium decreases expression ISO SPHK1 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 mRNA and 1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 protein CTD PMID:24399507 and PMID:33414358 Sphk1 Rat N-methyl-4-phenylpyridinium multiple interactions ISO SPHK1 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased activity of SPHK1 protein more ... CTD PMID:24399507 and PMID:33414358 Sphk1 Rat N-methyl-N-nitrosourea increases expression EXP 6480464 Methylnitrosourea results in increased expression of SPHK1 mRNA CTD PMID:17412507 Sphk1 Rat N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SPHK1 mRNA CTD PMID:20360939 Sphk1 Rat N-Nitrosopyrrolidine increases expression ISO SPHK1 (Homo sapiens) 6480464 N-Nitrosopyrrolidine results in increased expression of SPHK1 mRNA CTD PMID:32234424 Sphk1 Rat N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine multiple interactions EXP 6480464 Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SPHK1 mRNA] CTD PMID:16415329 Sphk1 Rat NAD zwitterion decreases activity ISO SPHK1 (Homo sapiens) 6480464 NAD results in decreased activity of SPHK1 protein CTD PMID:20518072 Sphk1 Rat NAD(+) decreases activity ISO SPHK1 (Homo sapiens) 6480464 NAD results in decreased activity of SPHK1 protein CTD PMID:20518072 Sphk1 Rat naphthalene increases expression ISO Sphk1 (Mus musculus) 6480464 naphthalene results in increased expression of SPHK1 mRNA CTD PMID:18978301 Sphk1 Rat nickel atom increases expression ISO Sphk1 (Mus musculus) 6480464 Nickel results in increased expression of SPHK1 mRNA CTD PMID:12540486 Sphk1 Rat nickel sulfate multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of SPHK1 mRNA CTD PMID:18832182 Sphk1 Rat nickel sulfate increases expression ISO SPHK1 (Homo sapiens) 6480464 nickel sulfate results in increased expression of SPHK1 mRNA CTD PMID:18832182 Sphk1 Rat ochratoxin A decreases expression ISO SPHK1 (Homo sapiens) 6480464 ochratoxin A metabolite results in decreased expression of SPHK1 mRNA and ochratoxin A results in decreased expression of SPHK1 mRNA CTD PMID:26314263 Sphk1 Rat onapristone multiple interactions EXP 6480464 onapristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA] CTD PMID:17164439 Sphk1 Rat onapristone decreases expression EXP 6480464 onapristone results in decreased expression of SPHK1 mRNA CTD PMID:17164439 Sphk1 Rat ouabain decreases expression ISO SPHK1 (Homo sapiens) 6480464 Ouabain results in decreased expression of SPHK1 mRNA CTD PMID:28795476 Sphk1 Rat oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of SPHK1 mRNA CTD PMID:25729387 Sphk1 Rat oxaliplatin decreases expression EXP 6480464 oxaliplatin results in decreased expression of SPHK1 mRNA CTD PMID:25729387 Sphk1 Rat ozone increases expression EXP 6480464 Ozone results in increased expression of SPHK1 mRNA CTD PMID:28623178 Sphk1 Rat ozone multiple interactions ISO Sphk1 (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which affects the expression of SPHK1 mRNA and [Air Pollutants results in increased abundance of Ozone] which affects the expression of SPHK1 mRNA CTD PMID:34911549 Sphk1 Rat p-chloromercuribenzoic acid increases expression ISO SPHK1 (Homo sapiens) 6480464 p-Chloromercuribenzoic Acid results in increased expression of SPHK1 mRNA CTD PMID:26272509 Sphk1 Rat panobinostat multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 Sphk1 Rat panobinostat increases expression ISO SPHK1 (Homo sapiens) 6480464 panobinostat results in increased expression of SPHK1 mRNA CTD PMID:26272509 Sphk1 Rat paracetamol affects expression ISO Sphk1 (Mus musculus) 6480464 Acetaminophen affects the expression of SPHK1 mRNA CTD PMID:17562736 Sphk1 Rat paracetamol decreases expression EXP 6480464 Acetaminophen results in decreased expression of SPHK1 mRNA CTD PMID:33387578 Sphk1 Rat paracetamol increases expression ISO SPHK1 (Homo sapiens) 6480464 Acetaminophen results in increased expression of SPHK1 mRNA CTD PMID:29067470 Sphk1 Rat paracetamol decreases expression ISO SPHK1 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of SPHK1 mRNA CTD PMID:22230336 Sphk1 Rat paraquat increases expression EXP 6480464 Paraquat results in increased expression of SPHK1 mRNA CTD PMID:32680482 Sphk1 Rat perfluorooctanoic acid decreases expression ISO SPHK1 (Homo sapiens) 6480464 perfluorooctanoic acid results in decreased expression of SPHK1 mRNA CTD PMID:36326898 Sphk1 Rat phenethyl caffeate multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SPHK1 mRNA CTD PMID:20360939 Sphk1 Rat phenobarbital affects expression ISO SPHK1 (Homo sapiens) 6480464 Phenobarbital affects the expression of SPHK1 mRNA CTD PMID:19159669 Sphk1 Rat phenylmercury acetate increases expression ISO SPHK1 (Homo sapiens) 6480464 Phenylmercuric Acetate results in increased expression of SPHK1 mRNA CTD PMID:26272509 Sphk1 Rat phenylmercury acetate multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 Sphk1 Rat phosgene affects expression ISO Sphk1 (Mus musculus) 6480464 Phosgene affects the expression of SPHK1 mRNA CTD PMID:16300373 Sphk1 Rat pirinixic acid multiple interactions ISO Sphk1 (Mus musculus) 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SPHK1 mRNA CTD PMID:19710929 Sphk1 Rat pirinixic acid increases expression ISO Sphk1 (Mus musculus) 6480464 pirinixic acid results in increased expression of SPHK1 mRNA CTD PMID:16985257 Sphk1 Rat potassium dichromate decreases expression ISO Sphk1 (Mus musculus) 6480464 Potassium Dichromate results in decreased expression of SPHK1 mRNA CTD PMID:23608068 Sphk1 Rat progesterone multiple interactions EXP 6480464 Mifepristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA] and onapristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA] CTD PMID:17164439 Sphk1 Rat progesterone increases expression EXP 6480464 Progesterone results in increased expression of SPHK1 mRNA CTD PMID:17164439 Sphk1 Rat prothioconazole decreases expression ISO SPHK1 (Homo sapiens) 6480464 prothioconazole results in decreased expression of SPHK1 mRNA CTD PMID:35048155 Sphk1 Rat pyridoxamine multiple interactions EXP 6480464 Pyridoxamine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] CTD PMID:21998146 Sphk1 Rat ranitidine multiple interactions EXP 6480464 Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SPHK1 mRNA] CTD PMID:16415329 Sphk1 Rat resveratrol increases expression ISO SPHK1 (Homo sapiens) 6480464 resveratrol results in increased expression of SPHK1 mRNA CTD PMID:16624241 Sphk1 Rat resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [Oxazolone results in increased activity of SPHK1 protein] CTD PMID:24055189 Sphk1 Rat resveratrol multiple interactions ISO Sphk1 (Mus musculus) 6480464 resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19346296 Sphk1 Rat resveratrol multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate more ... CTD PMID:19284563 more ... Sphk1 Rat resveratrol decreases expression ISO SPHK1 (Homo sapiens) 6480464 resveratrol metabolite results in decreased expression of SPHK1 protein more ... CTD PMID:20401667 more ... Sphk1 Rat resveratrol decreases activity ISO SPHK1 (Homo sapiens) 6480464 resveratrol metabolite results in decreased activity of SPHK1 protein and resveratrol results in decreased activity of SPHK1 protein CTD PMID:22251058 Sphk1 Rat SB 431542 multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 Sphk1 Rat serpentine asbestos increases expression ISO SPHK1 (Homo sapiens) 6480464 Asbestos and Serpentine results in increased expression of SPHK1 mRNA CTD PMID:29523930 Sphk1 Rat silicon dioxide increases expression ISO SPHK1 (Homo sapiens) 6480464 Silicon Dioxide results in increased expression of SPHK1 mRNA CTD PMID:22300531 and PMID:25351596 Sphk1 Rat sodium arsenate multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of SPHK1 mRNA CTD PMID:32525701 Sphk1 Rat sodium arsenite increases expression ISO SPHK1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of SPHK1 mRNA CTD PMID:22714537 more ... Sphk1 Rat sodium fluoride increases expression ISO Sphk1 (Mus musculus) 6480464 Sodium Fluoride results in increased expression of SPHK1 mRNA CTD PMID:27862939 Sphk1 Rat Soman increases expression EXP 6480464 Soman results in increased expression of SPHK1 mRNA CTD PMID:19281266 Sphk1 Rat sphingosine 1-phosphate increases chemical synthesis ISO SPHK1 (Homo sapiens) 6480464 SPHK1 protein results in increased chemical synthesis of sphingosine 1-phosphate CTD PMID:22251058 Sphk1 Rat sphingosine 1-phosphate multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate more ... CTD PMID:24399507 and PMID:26045781 Sphk1 Rat streptozocin increases expression ISO Sphk1 (Mus musculus) 6480464 Streptozocin results in increased expression of SPHK1 CTD PMID:19657322 Sphk1 Rat streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of SPHK1 mRNA and Streptozocin results in increased expression of SPHK1 protein CTD PMID:21998146 Sphk1 Rat T-2 toxin increases expression ISO SPHK1 (Homo sapiens) 6480464 T-2 Toxin results in increased expression of SPHK1 mRNA CTD PMID:34581912 Sphk1 Rat tamoxifen increases expression ISO SPHK1 (Homo sapiens) 6480464 Tamoxifen results in increased expression of SPHK1 mRNA CTD PMID:15604281 Sphk1 Rat tert-butyl hydroperoxide increases expression ISO SPHK1 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased expression of SPHK1 mRNA CTD PMID:15336504 Sphk1 Rat tetrachloromethane increases expression ISO Sphk1 (Mus musculus) 6480464 Carbon Tetrachloride results in increased expression of SPHK1 mRNA CTD PMID:17341687 Sphk1 Rat tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of SPHK1 mRNA CTD PMID:31150632 Sphk1 Rat thiram increases expression ISO SPHK1 (Homo sapiens) 6480464 Thiram results in increased expression of SPHK1 mRNA CTD PMID:38568856 Sphk1 Rat titanium dioxide decreases expression ISO Sphk1 (Mus musculus) 6480464 titanium dioxide results in decreased expression of SPHK1 mRNA CTD PMID:23557971 Sphk1 Rat titanium dioxide multiple interactions ISO Sphk1 (Mus musculus) 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of SPHK1 mRNA CTD PMID:29950665 Sphk1 Rat titanium dioxide increases expression ISO Sphk1 (Mus musculus) 6480464 titanium dioxide results in increased expression of SPHK1 mRNA CTD PMID:27760801 Sphk1 Rat topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of SPHK1 mRNA CTD PMID:25729387 Sphk1 Rat topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of SPHK1 mRNA CTD PMID:25729387 Sphk1 Rat tributylstannane decreases expression ISO SPHK1 (Homo sapiens) 6480464 tributyltin results in decreased expression of SPHK1 mRNA CTD PMID:26314263 Sphk1 Rat trichostatin A increases expression ISO SPHK1 (Homo sapiens) 6480464 trichostatin A results in increased expression of SPHK1 mRNA CTD PMID:24935251 and PMID:26272509 Sphk1 Rat trichostatin A multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 Sphk1 Rat triclosan decreases expression ISO SPHK1 (Homo sapiens) 6480464 Triclosan results in decreased expression of SPHK1 mRNA CTD PMID:30510588 Sphk1 Rat triptonide affects expression ISO Sphk1 (Mus musculus) 6480464 triptonide affects the expression of SPHK1 mRNA CTD PMID:33045310 Sphk1 Rat valproic acid increases methylation ISO SPHK1 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of SPHK1 gene CTD PMID:29154799 Sphk1 Rat valproic acid multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 Sphk1 Rat valproic acid increases expression ISO SPHK1 (Homo sapiens) 6480464 Valproic Acid results in increased expression of SPHK1 mRNA CTD PMID:23179753 more ... Sphk1 Rat vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of SPHK1 mRNA CTD PMID:22570695 Sphk1 Rat vorinostat multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 Sphk1 Rat vorinostat increases expression ISO SPHK1 (Homo sapiens) 6480464 vorinostat results in increased expression of SPHK1 mRNA CTD PMID:26272509