SPHK1 (sphingosine kinase 1) - Rat Genome Database

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Gene: SPHK1 (sphingosine kinase 1) Chlorocebus sabaeus
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Symbol: SPHK1
Name: sphingosine kinase 1
RGD ID: 18583198
Description: ENCODES a protein that exhibits D-erythro-sphingosine kinase activity (ortholog); INVOLVED IN blood vessel development (ortholog); brain development (ortholog); cell population proliferation (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Fibrosis (ortholog); high grade glioma (ortholog); FOUND IN axon (ortholog); presynapse (ortholog); synaptic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChlSab1.1 - Green Monkey 1.1 Assembly
Position:
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11645,290,147 - 45,295,175 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1645,290,421 - 45,293,128 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607716,031,997 - 16,036,965 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel development  (IEA,ISO)
brain development  (IEA,ISO)
calcium-mediated signaling  (IEA)
cell population proliferation  (IEA,ISO)
cellular response to growth factor stimulus  (IEA,ISO)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to starvation  (ISO)
cellular response to vascular endothelial growth factor stimulus  (IEA)
cyclooxygenase pathway  (ISO)
DNA biosynthetic process  (IEA,ISO)
female pregnancy  (ISO)
inflammatory response  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of ceramide biosynthetic process  (IEA)
phosphorylation  (ISO)
positive regulation of angiogenesis  (IEA)
positive regulation of cell growth  (IEA)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of interleukin-17 production  (ISO)
positive regulation of mitotic cell cycle  (IEA)
positive regulation of mitotic nuclear division  (IEA,ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of neurotransmitter secretion  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA)
positive regulation of p38MAPK cascade  (IEA)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein ubiquitination  (IEA)
positive regulation of smooth muscle contraction  (IEA)
protein acetylation  (ISO)
regulation of endocytosis  (IEA)
regulation of endosomal vesicle fusion  (IEA)
regulation of interleukin-1 beta production  (IEA,ISO)
regulation of microglial cell activation  (IEA)
regulation of neuroinflammatory response  (IEA)
regulation of phagocytosis  (IEA)
regulation of tumor necrosis factor-mediated signaling pathway  (IEA)
response to amine  (ISO)
response to ATP  (ISO)
response to interleukin-1  (ISO)
response to magnesium ion  (ISO)
response to organic cyclic compound  (ISO)
response to progesterone  (ISO)
response to tumor necrosis factor  (IEA)
sphingolipid mediated signaling pathway  (IEA,ISO)
sphingosine biosynthetic process  (IEA)
sphingosine metabolic process  (IEA)
sphingosine-1-phosphate receptor signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
SPHK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11645,290,147 - 45,295,175 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1645,290,421 - 45,293,128 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607716,031,997 - 16,036,965 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
SPHK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381776,383,204 - 76,387,855 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1776,376,584 - 76,387,860 (+)EnsemblGRCh38hg38GRCh38
GRCh371774,379,285 - 74,383,936 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361771,892,297 - 71,895,536 (+)NCBINCBI36Build 36hg18NCBI36
Build 341771,892,325 - 71,895,530NCBI
Celera1770,973,067 - 70,976,318 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1769,809,173 - 69,812,424 (+)NCBIHuRef
CHM1_11774,445,769 - 74,449,020 (+)NCBICHM1_1
T2T-CHM13v2.01777,279,777 - 77,284,428 (+)NCBIT2T-CHM13v2.0
Sphk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911116,421,662 - 116,427,502 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11116,421,751 - 116,427,501 (+)EnsemblGRCm39 Ensembl
GRCm3811116,530,836 - 116,536,675 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,530,925 - 116,536,674 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,530,925 - 116,536,675 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711116,393,225 - 116,397,989 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611116,349,437 - 116,352,760 (+)NCBIMGSCv36mm8
Celera11128,300,450 - 128,305,214 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1181.42NCBI
Sphk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810102,257,413 - 102,263,086 (+)NCBIGRCr8
mRatBN7.210101,758,567 - 101,764,240 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,758,711 - 101,764,240 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10106,815,189 - 106,820,851 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010106,278,279 - 106,283,941 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,679,445 - 101,685,112 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010105,498,728 - 105,504,401 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,498,728 - 105,504,393 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010105,162,314 - 105,167,987 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,641,509 - 106,645,579 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,656,012 - 106,660,081 (+)NCBI
Celera10100,330,875 - 100,336,542 (+)NCBICelera
Cytogenetic Map10q32.1-q32.2NCBI
Sphk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555065,902,345 - 5,904,988 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555065,902,079 - 5,906,639 (-)NCBIChiLan1.0ChiLan1.0
SPHK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21992,424,277 - 92,430,882 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11797,251,477 - 97,256,099 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01770,331,370 - 70,336,043 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11775,875,530 - 75,886,481 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1775,883,329 - 75,886,481 (+)Ensemblpanpan1.1panPan2
SPHK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,311,698 - 4,314,773 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,311,683 - 4,314,483 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha94,992,955 - 4,996,576 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.094,984,498 - 4,988,116 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl94,984,483 - 4,987,049 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.195,012,727 - 5,016,344 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,132,520 - 5,136,143 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,213,806 - 5,217,418 (-)NCBIUU_Cfam_GSD_1.0
Sphk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056024,922,623 - 4,928,472 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365941,486,111 - 1,489,188 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365941,482,830 - 1,489,337 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPHK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,114,947 - 5,120,083 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,114,946 - 5,122,580 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2125,018,690 - 5,023,812 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sphk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248016,253,219 - 6,257,128 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression

ectoderm
endocrine system
hemolymphoid system
mesenchyme
mesoderm
nervous system
reproductive system
76 36 20 36 36 60 20

Sequence


Ensembl Acc Id: ENSCSAT00000003070   ⟹   ENSCSAP00000001361
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.1 Ensembl1645,290,421 - 45,293,128 (-)Ensembl
RefSeq Acc Id: XM_008011632   ⟹   XP_008009823
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11645,290,147 - 45,293,434 (-)NCBI
Vero_WHO_p1.0NW_02366607716,031,997 - 16,035,802 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008011633   ⟹   XP_008009824
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11645,290,147 - 45,293,434 (-)NCBI
Vero_WHO_p1.0NW_02366607716,031,997 - 16,035,802 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008011634   ⟹   XP_008009825
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
ChlSab1.11645,290,147 - 45,295,175 (-)NCBI
Vero_WHO_p1.0NW_02366607716,031,997 - 16,036,965 (-)NCBI
Sequence:
RefSeq Acc Id: XM_037993132   ⟹   XP_037849060
Type: CODING
Position:
Green Monkey AssemblyChrPosition (strand)Source
Vero_WHO_p1.0NW_02366607716,031,997 - 16,036,965 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008009823 (Get FASTA)   NCBI Sequence Viewer  
  XP_008009824 (Get FASTA)   NCBI Sequence Viewer  
  XP_008009825 (Get FASTA)   NCBI Sequence Viewer  
  XP_037849060 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCSAP00000001361
  ENSCSAP00000001361.1
RefSeq Acc Id: XP_008009825   ⟸   XM_008011634
- Peptide Label: isoform X2
RefSeq Acc Id: XP_008009824   ⟸   XM_008011633
- Peptide Label: isoform X2
RefSeq Acc Id: XP_008009823   ⟸   XM_008011632
- Peptide Label: isoform X1
- UniProtKB: A0A0D9QYC2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCSAP00000001361   ⟸   ENSCSAT00000003070
RefSeq Acc Id: XP_037849060   ⟸   XM_037993132
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCSAG00000005041 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCSAT00000003070.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.40 UniProtKB/TrEMBL
InterPro ATP-NAD_kinase_N UniProtKB/TrEMBL
  Diacylglycerol_kinase_cat_dom UniProtKB/TrEMBL
  Lipid_Phosphate_FormReg UniProtKB/TrEMBL
  NAD/diacylglycerol_kinase_sf UniProtKB/TrEMBL
NCBI Gene SPHK1 ENTREZGENE
PANTHER SPHINGOSINE KINASE UniProtKB/TrEMBL
  SPHINGOSINE KINASE 1 UniProtKB/TrEMBL
Pfam DAGK_cat UniProtKB/TrEMBL
PROSITE DAGK UniProtKB/TrEMBL
SMART DAGKc UniProtKB/TrEMBL
Superfamily-SCOP SSF111331 UniProtKB/TrEMBL
UniProt A0A0D9QYC2 ENTREZGENE, UniProtKB/TrEMBL