(+)-dihydromyricetin decreases expression ISO SPHK1 (Homo sapiens) 6480464 ampelopsin results in decreased expression of SPHK1 protein CTD PMID:22251058 (+)-dihydromyricetin decreases activity ISO SPHK1 (Homo sapiens) 6480464 ampelopsin results in decreased activity of SPHK1 protein CTD PMID:22251058 1,2-dimethylhydrazine increases expression ISO Sphk1 (Rattus norvegicus) 6480464 1 and 2-Dimethylhydrazine results in increased expression of SPHK1 mRNA CTD PMID:27840820 1,2-dimethylhydrazine increases expression EXP 6480464 1 and 2-Dimethylhydrazine results in increased expression of SPHK1 mRNA CTD PMID:22206623 1,2-dimethylhydrazine multiple interactions EXP 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SPHK1 mRNA CTD PMID:22206623 17alpha-ethynylestradiol increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Ethinyl Estradiol results in increased expression of SPHK1 mRNA CTD PMID:17351261 17beta-estradiol affects expression ISO SPHK1 (Homo sapiens) 6480464 Estradiol affects the expression of SPHK1 mRNA CTD PMID:22574217 17beta-estradiol increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Estradiol results in increased expression of SPHK1 mRNA CTD PMID:32145629 17beta-estradiol multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of SPHK1 mRNA CTD PMID:30165855 17beta-estradiol increases expression ISO SPHK1 (Homo sapiens) 6480464 Estradiol results in increased expression of SPHK1 mRNA CTD PMID:29654831 and PMID:31614463 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 2 more ... CTD PMID:27318803 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SPHK1 mRNA CTD PMID:19933214 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Sphk1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin affects the expression of SPHK1 mRNA CTD PMID:34747641 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of SPHK1 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in increased expression of SPHK1 mRNA CTD PMID:16960034 and PMID:21964420 2-palmitoylglycerol increases expression ISO SPHK1 (Homo sapiens) 6480464 2-palmitoylglycerol results in increased expression of SPHK1 mRNA CTD PMID:37199045 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SPHK1 mRNA CTD PMID:16054899 4-(ethoxymethylene)-2-phenyloxazol-5-one increases activity ISO Sphk1 (Rattus norvegicus) 6480464 Oxazolone results in increased activity of SPHK1 protein CTD PMID:24055189 4-(ethoxymethylene)-2-phenyloxazol-5-one multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 resveratrol inhibits the reaction [Oxazolone results in increased activity of SPHK1 protein] CTD PMID:24055189 4-hydroxy-17beta-estradiol increases expression ISO SPHK1 (Homo sapiens) 6480464 4-hydroxyestradiol results in increased expression of SPHK1 mRNA CTD PMID:29654831 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of SPHK1 mRNA CTD PMID:28973697 4-nitrophenol increases expression EXP 6480464 4-nitrophenol results in increased expression of SPHK1 mRNA CTD PMID:34673133 5-aza-2'-deoxycytidine increases expression ISO SPHK1 (Homo sapiens) 6480464 Decitabine results in increased expression of SPHK1 mRNA CTD PMID:19194470 6-propyl-2-thiouracil affects expression ISO Sphk1 (Rattus norvegicus) 6480464 Propylthiouracil affects the expression of SPHK1 mRNA CTD PMID:24780913 acrylamide increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Acrylamide results in increased expression of SPHK1 mRNA CTD PMID:28959563 afimoxifene decreases response to substance ISO SPHK1 (Homo sapiens) 6480464 SPHK1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 aflatoxin B1 increases expression ISO SPHK1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of SPHK1 mRNA CTD PMID:22100608 and PMID:27153756 albendazole multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [Ivermectin co-treated with Albendazole] results in decreased expression of SPHK1 mRNA CTD PMID:16861626 aldehydo-D-glucose multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] more ... CTD PMID:21998146 aldehydo-D-glucose increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Glucose results in increased expression of SPHK1 mRNA CTD PMID:21998146 all-trans-retinoic acid decreases expression ISO Sphk1 (Rattus norvegicus) 6480464 Tretinoin results in decreased expression of SPHK1 mRNA CTD PMID:20488242 all-trans-retinoic acid decreases expression ISO SPHK1 (Homo sapiens) 6480464 Tretinoin results in decreased expression of SPHK1 mRNA CTD PMID:23830798 ammonium chloride affects expression ISO Sphk1 (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of SPHK1 mRNA CTD PMID:16483693 apigenin multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] CTD PMID:25557508 aristolochic acid A increases expression ISO SPHK1 (Homo sapiens) 6480464 aristolochic acid I results in increased expression of SPHK1 mRNA CTD PMID:33212167 arsane affects methylation ISO SPHK1 (Homo sapiens) 6480464 Arsenic affects the methylation of SPHK1 gene CTD PMID:25304211 arsane multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of SPHK1 mRNA CTD PMID:32525701 arsenic atom multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of SPHK1 mRNA CTD PMID:32525701 arsenic atom affects methylation ISO SPHK1 (Homo sapiens) 6480464 Arsenic affects the methylation of SPHK1 gene CTD PMID:25304211 arsenite(3-) increases expression ISO SPHK1 (Homo sapiens) 6480464 arsenite metabolite results in increased expression of SPHK1 mRNA CTD PMID:33129825 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of SPHK1 mRNA CTD PMID:21569818 and PMID:22228805 benzo[a]pyrene increases expression ISO SPHK1 (Homo sapiens) 6480464 Benzo(a)pyrene metabolite results in increased expression of SPHK1 mRNA and Benzo(a)pyrene results in increased expression of SPHK1 mRNA CTD PMID:26314263 more ... benzo[a]pyrene diol epoxide I affects expression ISO SPHK1 (Homo sapiens) 6480464 7 more ... CTD PMID:20382639 bisphenol A decreases expression ISO Sphk1 (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of SPHK1 mRNA CTD PMID:25181051 more ... bisphenol A increases expression ISO Sphk1 (Rattus norvegicus) 6480464 bisphenol A results in increased expression of SPHK1 mRNA CTD PMID:32145629 bisphenol A decreases expression ISO SPHK1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of SPHK1 mRNA CTD PMID:29275510 bortezomib decreases expression ISO SPHK1 (Homo sapiens) 6480464 Bortezomib results in decreased expression of SPHK1 protein CTD PMID:21195056 butan-1-ol multiple interactions ISO SPHK1 (Homo sapiens) 6480464 1-Butanol inhibits the reaction [C5 protein results in increased activity of SPHK1 protein] and [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SPHK1 mRNA CTD PMID:19284563 and PMID:29432896 C60 fullerene increases expression ISO Sphk1 (Rattus norvegicus) 6480464 fullerene C60 results in increased expression of SPHK1 mRNA CTD PMID:19167457 cadmium atom increases expression ISO SPHK1 (Homo sapiens) 6480464 Cadmium results in increased expression of SPHK1 mRNA CTD PMID:21120746 and PMID:24376830 cadmium dichloride increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Cadmium Chloride results in increased expression of SPHK1 mRNA CTD PMID:33453195 cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of SPHK1 mRNA CTD PMID:34666113 calcium atom multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium and resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19284563 and PMID:19346296 calcium atom multiple interactions EXP 6480464 [C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium and resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19346296 calcium(0) multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium and resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19284563 and PMID:19346296 calcium(0) multiple interactions EXP 6480464 [C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium and Resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19346296 cannabidiol multiple interactions EXP 6480464 Cannabidiol inhibits the reaction [MOG protein modified form results in increased expression of SPHK1 mRNA] CTD PMID:27256343 carbon nanotube increases expression ISO SPHK1 (Homo sapiens) 6480464 Nanotubes and Carbon results in increased expression of SPHK1 mRNA CTD PMID:25511174 carbon nanotube affects expression EXP 6480464 Nanotubes more ... CTD PMID:23845593 and PMID:25554681 cefaloridine increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Cephaloridine results in increased expression of SPHK1 mRNA CTD PMID:18500788 chlorpyrifos decreases methylation ISO Sphk1 (Rattus norvegicus) 6480464 Chlorpyrifos results in decreased methylation of SPHK1 gene CTD PMID:32905263 choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPHK1 mRNA CTD PMID:20938992 cisplatin decreases expression ISO Sphk1 (Rattus norvegicus) 6480464 Cisplatin results in decreased expression of SPHK1 mRNA CTD PMID:22023808 cisplatin multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of SPHK1 mRNA CTD PMID:27392435 cisplatin decreases expression ISO SPHK1 (Homo sapiens) 6480464 Cisplatin results in decreased expression of SPHK1 mRNA CTD PMID:27392435 cobalt dichloride decreases expression ISO SPHK1 (Homo sapiens) 6480464 cobaltous chloride results in decreased expression of SPHK1 mRNA CTD PMID:19320972 and PMID:26314263 copper(II) sulfate decreases expression ISO SPHK1 (Homo sapiens) 6480464 Copper Sulfate results in decreased expression of SPHK1 mRNA CTD PMID:19549813 crocidolite asbestos increases expression ISO SPHK1 (Homo sapiens) 6480464 Asbestos and Crocidolite results in increased expression of SPHK1 mRNA CTD PMID:18687144 crocidolite asbestos affects expression ISO SPHK1 (Homo sapiens) 6480464 Asbestos and Crocidolite affects the expression of SPHK1 mRNA CTD PMID:25757056 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of SPHK1 mRNA CTD PMID:19770486 cyclosporin A decreases expression ISO SPHK1 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of SPHK1 mRNA CTD PMID:25562108 and PMID:27989131 D-glucose multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] more ... CTD PMID:21998146 D-glucose increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Glucose results in increased expression of SPHK1 mRNA CTD PMID:21998146 dexamethasone multiple interactions EXP 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SPHK1 mRNA CTD PMID:16054899 dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of SPHK1 mRNA CTD PMID:22733784 dextran sulfate multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SPHK1 protein] CTD PMID:30811821 dextran sulfate multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of SPHK1 mRNA CTD PMID:29950665 dextran sulfate increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Dextran Sulfate results in increased expression of SPHK1 protein CTD PMID:30811821 diazinon increases methylation ISO SPHK1 (Homo sapiens) 6480464 Diazinon results in increased methylation of SPHK1 gene CTD PMID:22964155 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of SPHK1 mRNA CTD PMID:17361019 and PMID:21266533 dioxygen multiple interactions EXP 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of SPHK1 mRNA CTD PMID:30529165 divanadium pentaoxide affects expression EXP 6480464 vanadium pentoxide affects the expression of SPHK1 mRNA CTD PMID:26210822 dorsomorphin multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin increases expression ISO SPHK1 (Homo sapiens) 6480464 Doxorubicin results in increased expression of SPHK1 mRNA CTD PMID:29803840 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of SPHK1 mRNA CTD PMID:36227756 ethanol multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SPHK1 mRNA CTD PMID:29432896 folic acid multiple interactions EXP 6480464 [1 more ... CTD PMID:20938992 and PMID:22206623 fumonisin B1 multiple interactions EXP 6480464 fumonisin B1 inhibits the reaction [Particulate Matter results in increased expression of SPHK1 mRNA] and fumonisin B1 inhibits the reaction [Vehicle Emissions results in increased expression of SPHK1 mRNA] CTD PMID:27376354 furan increases expression ISO Sphk1 (Rattus norvegicus) 6480464 furan results in increased expression of SPHK1 mRNA CTD PMID:27387713 gentamycin decreases expression ISO Sphk1 (Rattus norvegicus) 6480464 Gentamicins results in decreased expression of SPHK1 mRNA CTD PMID:33387578 glucose multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] more ... CTD PMID:21998146 glucose increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Glucose results in increased expression of SPHK1 mRNA CTD PMID:21998146 hesperidin multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SPHK1 protein] CTD PMID:30811821 irinotecan affects expression ISO Sphk1 (Rattus norvegicus) 6480464 Irinotecan affects the expression of SPHK1 mRNA CTD PMID:20097248 isobutanol multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SPHK1 mRNA CTD PMID:29432896 isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of SPHK1 mRNA CTD PMID:20003209 ivermectin multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [Ivermectin co-treated with Albendazole] results in decreased expression of SPHK1 mRNA CTD PMID:16861626 kaempferol multiple interactions EXP 6480464 kaempferol inhibits the reaction [Lipopolysaccharides affects the expression of SPHK1 protein] and kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] CTD PMID:36243145 kaempferol multiple interactions ISO SPHK1 (Homo sapiens) 6480464 kaempferol inhibits the reaction [Lipopolysaccharides results in decreased expression of SPHK1 protein] CTD PMID:36243145 ketoconazole increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Ketoconazole results in increased expression of SPHK1 mRNA CTD PMID:25787151 L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPHK1 mRNA CTD PMID:20938992 Licochalcone B increases expression ISO SPHK1 (Homo sapiens) 6480464 licochalcone B results in increased expression of SPHK1 mRNA CTD PMID:33647349 lipopolysaccharide multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] and Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SPHK1 mRNA] CTD PMID:16415329 and PMID:25557508 lipopolysaccharide multiple interactions ISO SPHK1 (Homo sapiens) 6480464 kaempferol inhibits the reaction [Lipopolysaccharides results in decreased expression of SPHK1 protein] CTD PMID:36243145 lipopolysaccharide decreases expression ISO SPHK1 (Homo sapiens) 6480464 Lipopolysaccharides results in decreased expression of SPHK1 protein CTD PMID:36243145 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of SPHK1 protein CTD PMID:36243145 lipopolysaccharide affects expression EXP 6480464 Lipopolysaccharides affects the expression of SPHK1 protein CTD PMID:36243145 lipopolysaccharide multiple interactions EXP 6480464 kaempferol inhibits the reaction [Lipopolysaccharides affects the expression of SPHK1 protein] and kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] CTD PMID:36243145 lipopolysaccharide increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Lipopolysaccharides results in increased expression of SPHK1 mRNA and Lipopolysaccharides results in increased expression of SPHK1 protein CTD PMID:16415329 and PMID:25557508 menadione affects expression ISO SPHK1 (Homo sapiens) 6480464 Vitamin K 3 affects the expression of SPHK1 mRNA CTD PMID:20044591 methotrexate decreases expression ISO SPHK1 (Homo sapiens) 6480464 Methotrexate results in decreased expression of SPHK1 mRNA CTD PMID:17400583 methylmercury(1+) decreases expression ISO SPHK1 (Homo sapiens) 6480464 methylmercury II results in decreased expression of SPHK1 mRNA CTD PMID:26314263 mifepristone multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Mifepristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA] CTD PMID:17164439 N,N-dimethylsphingosine decreases activity ISO SPHK1 (Homo sapiens) 6480464 N and N-dimethylsphingosine results in decreased activity of SPHK1 protein CTD PMID:17065523 and PMID:19284563 N,N-dimethylsphingosine decreases expression ISO SPHK1 (Homo sapiens) 6480464 N and N-dimethylsphingosine results in decreased expression of SPHK1 protein CTD PMID:21195056 N,N-dimethylsphingosine multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 N and N-dimethylsphingosine inhibits the reaction [Glucose results in increased activity of SPHK1 protein] CTD PMID:21998146 N-acetyl-L-cysteine multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] CTD PMID:21998146 N-methyl-4-phenylpyridinium decreases expression ISO SPHK1 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 mRNA and 1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 protein CTD PMID:24399507 and PMID:33414358 N-methyl-4-phenylpyridinium multiple interactions ISO SPHK1 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased activity of SPHK1 protein more ... CTD PMID:24399507 and PMID:33414358 N-methyl-N-nitrosourea increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Methylnitrosourea results in increased expression of SPHK1 mRNA CTD PMID:17412507 N-nitrosodiethylamine multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SPHK1 mRNA CTD PMID:20360939 N-Nitrosopyrrolidine increases expression ISO SPHK1 (Homo sapiens) 6480464 N-Nitrosopyrrolidine results in increased expression of SPHK1 mRNA CTD PMID:32234424 N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SPHK1 mRNA] CTD PMID:16415329 NAD zwitterion decreases activity ISO SPHK1 (Homo sapiens) 6480464 NAD results in decreased activity of SPHK1 protein CTD PMID:20518072 NAD(+) decreases activity ISO SPHK1 (Homo sapiens) 6480464 NAD results in decreased activity of SPHK1 protein CTD PMID:20518072 naphthalene increases expression EXP 6480464 naphthalene results in increased expression of SPHK1 mRNA CTD PMID:18978301 nickel atom increases expression EXP 6480464 Nickel results in increased expression of SPHK1 mRNA CTD PMID:12540486 nickel sulfate multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of SPHK1 mRNA CTD PMID:18832182 nickel sulfate increases expression ISO SPHK1 (Homo sapiens) 6480464 nickel sulfate results in increased expression of SPHK1 mRNA CTD PMID:18832182 ochratoxin A decreases expression ISO SPHK1 (Homo sapiens) 6480464 ochratoxin A metabolite results in decreased expression of SPHK1 mRNA and ochratoxin A results in decreased expression of SPHK1 mRNA CTD PMID:26314263 onapristone multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 onapristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA] CTD PMID:17164439 onapristone decreases expression ISO Sphk1 (Rattus norvegicus) 6480464 onapristone results in decreased expression of SPHK1 mRNA CTD PMID:17164439 ouabain decreases expression ISO SPHK1 (Homo sapiens) 6480464 Ouabain results in decreased expression of SPHK1 mRNA CTD PMID:28795476 oxaliplatin multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of SPHK1 mRNA CTD PMID:25729387 oxaliplatin decreases expression ISO Sphk1 (Rattus norvegicus) 6480464 oxaliplatin results in decreased expression of SPHK1 mRNA CTD PMID:25729387 ozone increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Ozone results in increased expression of SPHK1 mRNA CTD PMID:28623178 ozone multiple interactions EXP 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which affects the expression of SPHK1 mRNA and [Air Pollutants results in increased abundance of Ozone] which affects the expression of SPHK1 mRNA CTD PMID:34911549 p-chloromercuribenzoic acid increases expression ISO SPHK1 (Homo sapiens) 6480464 p-Chloromercuribenzoic Acid results in increased expression of SPHK1 mRNA CTD PMID:26272509 panobinostat multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 panobinostat increases expression ISO SPHK1 (Homo sapiens) 6480464 panobinostat results in increased expression of SPHK1 mRNA CTD PMID:26272509 paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of SPHK1 mRNA CTD PMID:17562736 paracetamol decreases expression ISO Sphk1 (Rattus norvegicus) 6480464 Acetaminophen results in decreased expression of SPHK1 mRNA CTD PMID:33387578 paracetamol increases expression ISO SPHK1 (Homo sapiens) 6480464 Acetaminophen results in increased expression of SPHK1 mRNA CTD PMID:29067470 paracetamol decreases expression ISO SPHK1 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of SPHK1 mRNA CTD PMID:22230336 paraquat increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Paraquat results in increased expression of SPHK1 mRNA CTD PMID:32680482 perfluorooctanoic acid decreases expression ISO SPHK1 (Homo sapiens) 6480464 perfluorooctanoic acid results in decreased expression of SPHK1 mRNA CTD PMID:36326898 phenethyl caffeate multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SPHK1 mRNA CTD PMID:20360939 phenobarbital affects expression ISO SPHK1 (Homo sapiens) 6480464 Phenobarbital affects the expression of SPHK1 mRNA CTD PMID:19159669 phenylmercury acetate increases expression ISO SPHK1 (Homo sapiens) 6480464 Phenylmercuric Acetate results in increased expression of SPHK1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 phosgene affects expression EXP 6480464 Phosgene affects the expression of SPHK1 mRNA CTD PMID:16300373 pirinixic acid multiple interactions EXP 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SPHK1 mRNA CTD PMID:19710929 pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of SPHK1 mRNA CTD PMID:16985257 potassium dichromate decreases expression EXP 6480464 Potassium Dichromate results in decreased expression of SPHK1 mRNA CTD PMID:23608068 progesterone multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Mifepristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA] and onapristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA] CTD PMID:17164439 progesterone increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Progesterone results in increased expression of SPHK1 mRNA CTD PMID:17164439 prothioconazole decreases expression ISO SPHK1 (Homo sapiens) 6480464 prothioconazole results in decreased expression of SPHK1 mRNA CTD PMID:35048155 pyridoxamine multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Pyridoxamine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] CTD PMID:21998146 ranitidine multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SPHK1 mRNA] CTD PMID:16415329 resveratrol increases expression ISO SPHK1 (Homo sapiens) 6480464 resveratrol results in increased expression of SPHK1 mRNA CTD PMID:16624241 resveratrol multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 resveratrol inhibits the reaction [Oxazolone results in increased activity of SPHK1 protein] CTD PMID:24055189 resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19346296 resveratrol multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate more ... CTD PMID:19284563 more ... resveratrol decreases expression ISO SPHK1 (Homo sapiens) 6480464 resveratrol metabolite results in decreased expression of SPHK1 protein more ... CTD PMID:20401667 more ... resveratrol decreases activity ISO SPHK1 (Homo sapiens) 6480464 resveratrol metabolite results in decreased activity of SPHK1 protein and resveratrol results in decreased activity of SPHK1 protein CTD PMID:22251058 SB 431542 multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 serpentine asbestos increases expression ISO SPHK1 (Homo sapiens) 6480464 Asbestos and Serpentine results in increased expression of SPHK1 mRNA CTD PMID:29523930 silicon dioxide increases expression ISO SPHK1 (Homo sapiens) 6480464 Silicon Dioxide results in increased expression of SPHK1 mRNA CTD PMID:22300531 and PMID:25351596 sodium arsenate multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of SPHK1 mRNA CTD PMID:32525701 sodium arsenite increases expression ISO SPHK1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of SPHK1 mRNA CTD PMID:22714537 and PMID:34032870 sodium fluoride increases expression EXP 6480464 Sodium Fluoride results in increased expression of SPHK1 mRNA CTD PMID:27862939 Soman increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Soman results in increased expression of SPHK1 mRNA CTD PMID:19281266 sphingosine 1-phosphate increases chemical synthesis ISO SPHK1 (Homo sapiens) 6480464 SPHK1 protein results in increased chemical synthesis of sphingosine 1-phosphate CTD PMID:22251058 sphingosine 1-phosphate multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate more ... CTD PMID:24399507 and PMID:26045781 streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of SPHK1 CTD PMID:19657322 streptozocin increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Streptozocin results in increased expression of SPHK1 mRNA and Streptozocin results in increased expression of SPHK1 protein CTD PMID:21998146 T-2 toxin increases expression ISO SPHK1 (Homo sapiens) 6480464 T-2 Toxin results in increased expression of SPHK1 mRNA CTD PMID:34581912 tamoxifen increases expression ISO SPHK1 (Homo sapiens) 6480464 Tamoxifen results in increased expression of SPHK1 mRNA CTD PMID:15604281 tert-butyl hydroperoxide increases expression ISO SPHK1 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased expression of SPHK1 mRNA CTD PMID:15336504 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of SPHK1 mRNA CTD PMID:17341687 tetrachloromethane increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Carbon Tetrachloride results in increased expression of SPHK1 mRNA CTD PMID:31150632 titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of SPHK1 mRNA CTD PMID:23557971 titanium dioxide multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of SPHK1 mRNA CTD PMID:29950665 titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of SPHK1 mRNA CTD PMID:27760801 topotecan decreases expression ISO Sphk1 (Rattus norvegicus) 6480464 Topotecan results in decreased expression of SPHK1 mRNA CTD PMID:25729387 topotecan multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of SPHK1 mRNA CTD PMID:25729387 tributylstannane decreases expression ISO SPHK1 (Homo sapiens) 6480464 tributyltin results in decreased expression of SPHK1 mRNA CTD PMID:26314263 trichostatin A increases expression ISO SPHK1 (Homo sapiens) 6480464 trichostatin A results in increased expression of SPHK1 mRNA CTD PMID:24935251 and PMID:26272509 trichostatin A multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 triclosan decreases expression ISO SPHK1 (Homo sapiens) 6480464 Triclosan results in decreased expression of SPHK1 mRNA CTD PMID:30510588 triptonide affects expression EXP 6480464 triptonide affects the expression of SPHK1 mRNA CTD PMID:33045310 valproic acid increases methylation ISO SPHK1 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of SPHK1 gene CTD PMID:29154799 valproic acid multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 valproic acid increases expression ISO SPHK1 (Homo sapiens) 6480464 Valproic Acid results in increased expression of SPHK1 mRNA CTD PMID:23179753 more ... vinclozolin increases expression ISO Sphk1 (Rattus norvegicus) 6480464 vinclozolin results in increased expression of SPHK1 mRNA CTD PMID:22570695 vorinostat multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 vorinostat increases expression ISO SPHK1 (Homo sapiens) 6480464 vorinostat results in increased expression of SPHK1 mRNA CTD PMID:26272509
