Sphk1 Mouse (+)-dihydromyricetin decreases expression ISO SPHK1 (Homo sapiens) 6480464 ampelopsin results in decreased expression of SPHK1 protein CTD PMID:22251058 Sphk1 Mouse (+)-dihydromyricetin decreases activity ISO SPHK1 (Homo sapiens) 6480464 ampelopsin results in decreased activity of SPHK1 protein CTD PMID:22251058 Sphk1 Mouse 1,2-dimethylhydrazine increases expression ISO Sphk1 (Rattus norvegicus) 6480464 1 and 2-Dimethylhydrazine results in increased expression of SPHK1 mRNA CTD PMID:27840820 Sphk1 Mouse 1,2-dimethylhydrazine increases expression EXP 6480464 1 and 2-Dimethylhydrazine results in increased expression of SPHK1 mRNA CTD PMID:22206623 Sphk1 Mouse 1,2-dimethylhydrazine multiple interactions EXP 6480464 [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of SPHK1 mRNA CTD PMID:22206623 Sphk1 Mouse 17alpha-ethynylestradiol increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Ethinyl Estradiol results in increased expression of SPHK1 mRNA CTD PMID:17351261 Sphk1 Mouse 17beta-estradiol affects expression ISO SPHK1 (Homo sapiens) 6480464 Estradiol affects the expression of SPHK1 mRNA CTD PMID:22574217 Sphk1 Mouse 17beta-estradiol increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Estradiol results in increased expression of SPHK1 mRNA CTD PMID:32145629 Sphk1 Mouse 17beta-estradiol multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of SPHK1 mRNA CTD PMID:30165855 Sphk1 Mouse 17beta-estradiol increases expression ISO SPHK1 (Homo sapiens) 6480464 Estradiol results in increased expression of SPHK1 mRNA CTD PMID:29654831 and PMID:31614463 Sphk1 Mouse 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 2 more ... CTD PMID:27318803 Sphk1 Mouse 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of SPHK1 mRNA CTD PMID:19933214 Sphk1 Mouse 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO Sphk1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin affects the expression of SPHK1 mRNA CTD PMID:34747641 Sphk1 Mouse 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of SPHK1 mRNA CTD PMID:21570461 Sphk1 Mouse 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Tetrachlorodibenzodioxin results in increased expression of SPHK1 mRNA CTD PMID:16960034 and PMID:21964420 Sphk1 Mouse 2-palmitoylglycerol increases expression ISO SPHK1 (Homo sapiens) 6480464 2-palmitoylglycerol results in increased expression of SPHK1 mRNA CTD PMID:37199045 Sphk1 Mouse 3-isobutyl-1-methyl-7H-xanthine multiple interactions EXP 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SPHK1 mRNA CTD PMID:16054899 Sphk1 Mouse 4-(ethoxymethylene)-2-phenyloxazol-5-one increases activity ISO Sphk1 (Rattus norvegicus) 6480464 Oxazolone results in increased activity of SPHK1 protein CTD PMID:24055189 Sphk1 Mouse 4-(ethoxymethylene)-2-phenyloxazol-5-one multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 resveratrol inhibits the reaction [Oxazolone results in increased activity of SPHK1 protein] CTD PMID:24055189 Sphk1 Mouse 4-hydroxy-17beta-estradiol increases expression ISO SPHK1 (Homo sapiens) 6480464 4-hydroxyestradiol results in increased expression of SPHK1 mRNA CTD PMID:29654831 Sphk1 Mouse 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of SPHK1 mRNA CTD PMID:28973697 Sphk1 Mouse 4-nitrophenol increases expression EXP 6480464 4-nitrophenol results in increased expression of SPHK1 mRNA CTD PMID:34673133 Sphk1 Mouse 5-aza-2'-deoxycytidine increases expression ISO SPHK1 (Homo sapiens) 6480464 Decitabine results in increased expression of SPHK1 mRNA CTD PMID:19194470 Sphk1 Mouse 6-propyl-2-thiouracil affects expression ISO Sphk1 (Rattus norvegicus) 6480464 Propylthiouracil affects the expression of SPHK1 mRNA CTD PMID:24780913 Sphk1 Mouse acrylamide increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Acrylamide results in increased expression of SPHK1 mRNA CTD PMID:28959563 Sphk1 Mouse afimoxifene decreases response to substance ISO SPHK1 (Homo sapiens) 6480464 SPHK1 results in decreased susceptibility to afimoxifene CTD PMID:21233418 Sphk1 Mouse aflatoxin B1 increases expression ISO SPHK1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of SPHK1 mRNA CTD PMID:22100608 and PMID:27153756 Sphk1 Mouse albendazole multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [Ivermectin co-treated with Albendazole] results in decreased expression of SPHK1 mRNA CTD PMID:16861626 Sphk1 Mouse aldehydo-D-glucose multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] more ... CTD PMID:21998146 Sphk1 Mouse aldehydo-D-glucose increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Glucose results in increased expression of SPHK1 mRNA CTD PMID:21998146 Sphk1 Mouse all-trans-retinoic acid decreases expression ISO Sphk1 (Rattus norvegicus) 6480464 Tretinoin results in decreased expression of SPHK1 mRNA CTD PMID:20488242 Sphk1 Mouse all-trans-retinoic acid decreases expression ISO SPHK1 (Homo sapiens) 6480464 Tretinoin results in decreased expression of SPHK1 mRNA CTD PMID:23830798 Sphk1 Mouse ammonium chloride affects expression ISO Sphk1 (Rattus norvegicus) 6480464 Ammonium Chloride affects the expression of SPHK1 mRNA CTD PMID:16483693 Sphk1 Mouse apigenin multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] CTD PMID:25557508 Sphk1 Mouse aristolochic acid A increases expression ISO SPHK1 (Homo sapiens) 6480464 aristolochic acid I results in increased expression of SPHK1 mRNA CTD PMID:33212167 Sphk1 Mouse arsane affects methylation ISO SPHK1 (Homo sapiens) 6480464 Arsenic affects the methylation of SPHK1 gene CTD PMID:25304211 Sphk1 Mouse arsane multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of SPHK1 mRNA CTD PMID:32525701 Sphk1 Mouse arsenic atom multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of SPHK1 mRNA CTD PMID:32525701 Sphk1 Mouse arsenic atom affects methylation ISO SPHK1 (Homo sapiens) 6480464 Arsenic affects the methylation of SPHK1 gene CTD PMID:25304211 Sphk1 Mouse arsenite(3-) increases expression ISO SPHK1 (Homo sapiens) 6480464 arsenite metabolite results in increased expression of SPHK1 mRNA CTD PMID:33129825 Sphk1 Mouse benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of SPHK1 mRNA CTD PMID:21569818 and PMID:22228805 Sphk1 Mouse benzo[a]pyrene increases expression ISO SPHK1 (Homo sapiens) 6480464 Benzo(a)pyrene metabolite results in increased expression of SPHK1 mRNA and Benzo(a)pyrene results in increased expression of SPHK1 mRNA CTD PMID:26314263 more ... Sphk1 Mouse benzo[a]pyrene diol epoxide I affects expression ISO SPHK1 (Homo sapiens) 6480464 7 more ... CTD PMID:20382639 Sphk1 Mouse bisphenol A decreases expression ISO Sphk1 (Rattus norvegicus) 6480464 bisphenol A results in decreased expression of SPHK1 mRNA CTD PMID:25181051 more ... Sphk1 Mouse bisphenol A increases expression ISO Sphk1 (Rattus norvegicus) 6480464 bisphenol A results in increased expression of SPHK1 mRNA CTD PMID:32145629 Sphk1 Mouse bisphenol A decreases expression ISO SPHK1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of SPHK1 mRNA CTD PMID:29275510 Sphk1 Mouse bortezomib decreases expression ISO SPHK1 (Homo sapiens) 6480464 Bortezomib results in decreased expression of SPHK1 protein CTD PMID:21195056 Sphk1 Mouse butan-1-ol multiple interactions ISO SPHK1 (Homo sapiens) 6480464 1-Butanol inhibits the reaction [C5 protein results in increased activity of SPHK1 protein] and [[Gasoline co-treated with 1-Butanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SPHK1 mRNA CTD PMID:19284563 and PMID:29432896 Sphk1 Mouse C60 fullerene increases expression ISO Sphk1 (Rattus norvegicus) 6480464 fullerene C60 results in increased expression of SPHK1 mRNA CTD PMID:19167457 Sphk1 Mouse cadmium atom increases expression ISO SPHK1 (Homo sapiens) 6480464 Cadmium results in increased expression of SPHK1 mRNA CTD PMID:21120746 and PMID:24376830 Sphk1 Mouse cadmium dichloride increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Cadmium Chloride results in increased expression of SPHK1 mRNA CTD PMID:33453195 Sphk1 Mouse cadmium dichloride increases expression EXP 6480464 Cadmium Chloride results in increased expression of SPHK1 mRNA CTD PMID:34666113 Sphk1 Mouse cadmium dichloride increases expression ISO SPHK1 (Homo sapiens) 6480464 Cadmium Chloride results in increased expression of SPHK1 mRNA CTD PMID:38568856 Sphk1 Mouse calcium atom multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium and resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19284563 and PMID:19346296 Sphk1 Mouse calcium atom multiple interactions EXP 6480464 [C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium and resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19346296 Sphk1 Mouse calcium(0) multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium and resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19284563 and PMID:19346296 Sphk1 Mouse calcium(0) multiple interactions EXP 6480464 [C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium and Resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19346296 Sphk1 Mouse cannabidiol multiple interactions EXP 6480464 Cannabidiol inhibits the reaction [MOG protein modified form results in increased expression of SPHK1 mRNA] CTD PMID:27256343 Sphk1 Mouse carbon nanotube increases expression ISO SPHK1 (Homo sapiens) 6480464 Nanotubes and Carbon results in increased expression of SPHK1 mRNA CTD PMID:25511174 Sphk1 Mouse carbon nanotube affects expression EXP 6480464 Nanotubes more ... CTD PMID:23845593 and PMID:25554681 Sphk1 Mouse cefaloridine increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Cephaloridine results in increased expression of SPHK1 mRNA CTD PMID:18500788 Sphk1 Mouse chlorpyrifos decreases methylation ISO Sphk1 (Rattus norvegicus) 6480464 Chlorpyrifos results in decreased methylation of SPHK1 gene CTD PMID:32905263 Sphk1 Mouse choline multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPHK1 mRNA CTD PMID:20938992 Sphk1 Mouse cisplatin decreases expression ISO Sphk1 (Rattus norvegicus) 6480464 Cisplatin results in decreased expression of SPHK1 mRNA CTD PMID:22023808 Sphk1 Mouse cisplatin multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of SPHK1 mRNA CTD PMID:27392435 Sphk1 Mouse cisplatin decreases expression ISO SPHK1 (Homo sapiens) 6480464 Cisplatin results in decreased expression of SPHK1 mRNA CTD PMID:27392435 Sphk1 Mouse cobalt dichloride decreases expression ISO SPHK1 (Homo sapiens) 6480464 cobaltous chloride results in decreased expression of SPHK1 mRNA CTD PMID:19320972 and PMID:26314263 Sphk1 Mouse copper(II) chloride increases expression ISO SPHK1 (Homo sapiens) 6480464 cupric chloride results in increased expression of SPHK1 mRNA CTD PMID:38568856 Sphk1 Mouse copper(II) sulfate decreases expression ISO SPHK1 (Homo sapiens) 6480464 Copper Sulfate results in decreased expression of SPHK1 mRNA CTD PMID:19549813 Sphk1 Mouse crocidolite asbestos increases expression ISO SPHK1 (Homo sapiens) 6480464 Asbestos and Crocidolite results in increased expression of SPHK1 mRNA CTD PMID:18687144 Sphk1 Mouse crocidolite asbestos affects expression ISO SPHK1 (Homo sapiens) 6480464 Asbestos and Crocidolite affects the expression of SPHK1 mRNA CTD PMID:25757056 Sphk1 Mouse cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of SPHK1 mRNA CTD PMID:19770486 Sphk1 Mouse cyclosporin A decreases expression ISO SPHK1 (Homo sapiens) 6480464 Cyclosporine results in decreased expression of SPHK1 mRNA CTD PMID:25562108 and PMID:27989131 Sphk1 Mouse D-glucose multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] more ... CTD PMID:21998146 Sphk1 Mouse D-glucose increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Glucose results in increased expression of SPHK1 mRNA CTD PMID:21998146 Sphk1 Mouse dexamethasone multiple interactions EXP 6480464 [Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of SPHK1 mRNA CTD PMID:16054899 Sphk1 Mouse dexamethasone increases expression EXP 6480464 Dexamethasone results in increased expression of SPHK1 mRNA CTD PMID:22733784 Sphk1 Mouse dextran sulfate multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SPHK1 protein] CTD PMID:30811821 Sphk1 Mouse dextran sulfate multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of SPHK1 mRNA CTD PMID:29950665 Sphk1 Mouse dextran sulfate increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Dextran Sulfate results in increased expression of SPHK1 protein CTD PMID:30811821 Sphk1 Mouse diazinon increases methylation ISO SPHK1 (Homo sapiens) 6480464 Diazinon results in increased methylation of SPHK1 gene CTD PMID:22964155 Sphk1 Mouse Dibutyl phosphate affects expression ISO SPHK1 (Homo sapiens) 6480464 di-n-butylphosphoric acid affects the expression of SPHK1 mRNA CTD PMID:37042841 Sphk1 Mouse dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of SPHK1 mRNA CTD PMID:17361019 and PMID:21266533 Sphk1 Mouse dioxygen multiple interactions EXP 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of SPHK1 mRNA CTD PMID:30529165 Sphk1 Mouse divanadium pentaoxide affects expression EXP 6480464 vanadium pentoxide affects the expression of SPHK1 mRNA CTD PMID:26210822 Sphk1 Mouse dorsomorphin multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 Sphk1 Mouse doxorubicin increases expression ISO SPHK1 (Homo sapiens) 6480464 Doxorubicin results in increased expression of SPHK1 mRNA CTD PMID:29803840 Sphk1 Mouse doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of SPHK1 mRNA CTD PMID:36227756 Sphk1 Mouse ethanol multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [[Gasoline co-treated with Ethanol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SPHK1 mRNA CTD PMID:29432896 Sphk1 Mouse folic acid multiple interactions EXP 6480464 [1 more ... CTD PMID:20938992 and PMID:22206623 Sphk1 Mouse fumonisin B1 multiple interactions EXP 6480464 fumonisin B1 inhibits the reaction [Particulate Matter results in increased expression of SPHK1 mRNA] and fumonisin B1 inhibits the reaction [Vehicle Emissions results in increased expression of SPHK1 mRNA] CTD PMID:27376354 Sphk1 Mouse furan increases expression ISO Sphk1 (Rattus norvegicus) 6480464 furan results in increased expression of SPHK1 mRNA CTD PMID:27387713 Sphk1 Mouse gentamycin decreases expression ISO Sphk1 (Rattus norvegicus) 6480464 Gentamicins results in decreased expression of SPHK1 mRNA CTD PMID:33387578 Sphk1 Mouse glucose multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] more ... CTD PMID:21998146 Sphk1 Mouse glucose increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Glucose results in increased expression of SPHK1 mRNA CTD PMID:21998146 Sphk1 Mouse hesperidin multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Hesperidin inhibits the reaction [Dextran Sulfate results in increased expression of SPHK1 protein] CTD PMID:30811821 Sphk1 Mouse irinotecan affects expression ISO Sphk1 (Rattus norvegicus) 6480464 Irinotecan affects the expression of SPHK1 mRNA CTD PMID:20097248 Sphk1 Mouse isobutanol multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [[Gasoline co-treated with isobutyl alcohol] results in increased abundance of [Particulate Matter co-treated with Polycyclic Aromatic Hydrocarbons]] which results in increased expression of SPHK1 mRNA CTD PMID:29432896 Sphk1 Mouse isoprenaline increases expression EXP 6480464 Isoproterenol results in increased expression of SPHK1 mRNA CTD PMID:20003209 Sphk1 Mouse ivermectin multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [Ivermectin co-treated with Albendazole] results in decreased expression of SPHK1 mRNA CTD PMID:16861626 Sphk1 Mouse kaempferol multiple interactions EXP 6480464 kaempferol inhibits the reaction [Lipopolysaccharides affects the expression of SPHK1 protein] and kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] CTD PMID:36243145 Sphk1 Mouse kaempferol multiple interactions ISO SPHK1 (Homo sapiens) 6480464 kaempferol inhibits the reaction [Lipopolysaccharides results in decreased expression of SPHK1 protein] CTD PMID:36243145 Sphk1 Mouse ketoconazole increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Ketoconazole results in increased expression of SPHK1 mRNA CTD PMID:25787151 Sphk1 Mouse L-methionine multiple interactions EXP 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SPHK1 mRNA CTD PMID:20938992 Sphk1 Mouse lead diacetate increases expression ISO SPHK1 (Homo sapiens) 6480464 lead acetate results in increased expression of SPHK1 mRNA CTD PMID:38568856 Sphk1 Mouse Licochalcone B increases expression ISO SPHK1 (Homo sapiens) 6480464 licochalcone B results in increased expression of SPHK1 mRNA CTD PMID:33647349 Sphk1 Mouse lipopolysaccharide multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] and Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SPHK1 mRNA] CTD PMID:16415329 and PMID:25557508 Sphk1 Mouse lipopolysaccharide multiple interactions ISO SPHK1 (Homo sapiens) 6480464 kaempferol inhibits the reaction [Lipopolysaccharides results in decreased expression of SPHK1 protein] CTD PMID:36243145 Sphk1 Mouse lipopolysaccharide decreases expression ISO SPHK1 (Homo sapiens) 6480464 Lipopolysaccharides results in decreased expression of SPHK1 protein CTD PMID:36243145 Sphk1 Mouse lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of SPHK1 mRNA and Lipopolysaccharides results in increased expression of SPHK1 protein CTD PMID:36243145 and PMID:38218310 Sphk1 Mouse lipopolysaccharide affects expression EXP 6480464 Lipopolysaccharides affects the expression of SPHK1 protein CTD PMID:36243145 Sphk1 Mouse lipopolysaccharide multiple interactions EXP 6480464 kaempferol inhibits the reaction [Lipopolysaccharides affects the expression of SPHK1 protein] and kaempferol inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] CTD PMID:36243145 Sphk1 Mouse lipopolysaccharide increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Lipopolysaccharides results in increased expression of SPHK1 mRNA and Lipopolysaccharides results in increased expression of SPHK1 protein CTD PMID:16415329 and PMID:25557508 Sphk1 Mouse menadione affects expression ISO SPHK1 (Homo sapiens) 6480464 Vitamin K 3 affects the expression of SPHK1 mRNA CTD PMID:20044591 Sphk1 Mouse methotrexate decreases expression ISO SPHK1 (Homo sapiens) 6480464 Methotrexate results in decreased expression of SPHK1 mRNA CTD PMID:17400583 Sphk1 Mouse methylmercury(1+) decreases expression ISO SPHK1 (Homo sapiens) 6480464 methylmercury II results in decreased expression of SPHK1 mRNA CTD PMID:26314263 Sphk1 Mouse methylparaben increases expression ISO SPHK1 (Homo sapiens) 6480464 methylparaben results in increased expression of SPHK1 mRNA CTD PMID:38568856 Sphk1 Mouse mifepristone multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Mifepristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA] CTD PMID:17164439 Sphk1 Mouse N,N-dimethylsphingosine decreases activity ISO SPHK1 (Homo sapiens) 6480464 N and N-dimethylsphingosine results in decreased activity of SPHK1 protein CTD PMID:17065523 and PMID:19284563 Sphk1 Mouse N,N-dimethylsphingosine decreases expression ISO SPHK1 (Homo sapiens) 6480464 N and N-dimethylsphingosine results in decreased expression of SPHK1 protein CTD PMID:21195056 Sphk1 Mouse N,N-dimethylsphingosine multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 N and N-dimethylsphingosine inhibits the reaction [Glucose results in increased activity of SPHK1 protein] CTD PMID:21998146 Sphk1 Mouse N-acetyl-L-cysteine multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Acetylcysteine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] CTD PMID:21998146 Sphk1 Mouse N-methyl-4-phenylpyridinium decreases expression ISO SPHK1 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 mRNA and 1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 protein CTD PMID:24399507 and PMID:33414358 Sphk1 Mouse N-methyl-4-phenylpyridinium multiple interactions ISO SPHK1 (Homo sapiens) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased activity of SPHK1 protein more ... CTD PMID:24399507 and PMID:33414358 Sphk1 Mouse N-methyl-N-nitrosourea increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Methylnitrosourea results in increased expression of SPHK1 mRNA CTD PMID:17412507 Sphk1 Mouse N-nitrosodiethylamine multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SPHK1 mRNA CTD PMID:20360939 Sphk1 Mouse N-Nitrosopyrrolidine increases expression ISO SPHK1 (Homo sapiens) 6480464 N-Nitrosopyrrolidine results in increased expression of SPHK1 mRNA CTD PMID:32234424 Sphk1 Mouse N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SPHK1 mRNA] CTD PMID:16415329 Sphk1 Mouse NAD zwitterion decreases activity ISO SPHK1 (Homo sapiens) 6480464 NAD results in decreased activity of SPHK1 protein CTD PMID:20518072 Sphk1 Mouse NAD(+) decreases activity ISO SPHK1 (Homo sapiens) 6480464 NAD results in decreased activity of SPHK1 protein CTD PMID:20518072 Sphk1 Mouse naphthalene increases expression EXP 6480464 naphthalene results in increased expression of SPHK1 mRNA CTD PMID:18978301 Sphk1 Mouse nickel atom increases expression EXP 6480464 Nickel results in increased expression of SPHK1 mRNA CTD PMID:12540486 Sphk1 Mouse nickel sulfate multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased expression of SPHK1 mRNA CTD PMID:18832182 Sphk1 Mouse nickel sulfate increases expression ISO SPHK1 (Homo sapiens) 6480464 nickel sulfate results in increased expression of SPHK1 mRNA CTD PMID:18832182 Sphk1 Mouse ochratoxin A decreases expression ISO SPHK1 (Homo sapiens) 6480464 ochratoxin A metabolite results in decreased expression of SPHK1 mRNA and ochratoxin A results in decreased expression of SPHK1 mRNA CTD PMID:26314263 Sphk1 Mouse onapristone multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 onapristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA] CTD PMID:17164439 Sphk1 Mouse onapristone decreases expression ISO Sphk1 (Rattus norvegicus) 6480464 onapristone results in decreased expression of SPHK1 mRNA CTD PMID:17164439 Sphk1 Mouse ouabain decreases expression ISO SPHK1 (Homo sapiens) 6480464 Ouabain results in decreased expression of SPHK1 mRNA CTD PMID:28795476 Sphk1 Mouse oxaliplatin multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of SPHK1 mRNA CTD PMID:25729387 Sphk1 Mouse oxaliplatin decreases expression ISO Sphk1 (Rattus norvegicus) 6480464 oxaliplatin results in decreased expression of SPHK1 mRNA CTD PMID:25729387 Sphk1 Mouse ozone increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Ozone results in increased expression of SPHK1 mRNA CTD PMID:28623178 Sphk1 Mouse ozone multiple interactions EXP 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which affects the expression of SPHK1 mRNA and [Air Pollutants results in increased abundance of Ozone] which affects the expression of SPHK1 mRNA CTD PMID:34911549 Sphk1 Mouse p-chloromercuribenzoic acid increases expression ISO SPHK1 (Homo sapiens) 6480464 p-Chloromercuribenzoic Acid results in increased expression of SPHK1 mRNA CTD PMID:26272509 Sphk1 Mouse panobinostat multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 Sphk1 Mouse panobinostat increases expression ISO SPHK1 (Homo sapiens) 6480464 panobinostat results in increased expression of SPHK1 mRNA CTD PMID:26272509 Sphk1 Mouse paracetamol affects expression EXP 6480464 Acetaminophen affects the expression of SPHK1 mRNA CTD PMID:17562736 Sphk1 Mouse paracetamol decreases expression ISO Sphk1 (Rattus norvegicus) 6480464 Acetaminophen results in decreased expression of SPHK1 mRNA CTD PMID:33387578 Sphk1 Mouse paracetamol increases expression ISO SPHK1 (Homo sapiens) 6480464 Acetaminophen results in increased expression of SPHK1 mRNA CTD PMID:29067470 Sphk1 Mouse paracetamol decreases expression ISO SPHK1 (Homo sapiens) 6480464 Acetaminophen results in decreased expression of SPHK1 mRNA CTD PMID:22230336 Sphk1 Mouse paraquat increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Paraquat results in increased expression of SPHK1 mRNA CTD PMID:32680482 Sphk1 Mouse perfluorooctanoic acid decreases expression ISO SPHK1 (Homo sapiens) 6480464 perfluorooctanoic acid results in decreased expression of SPHK1 mRNA CTD PMID:36326898 Sphk1 Mouse phenethyl caffeate multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 [Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in decreased expression of SPHK1 mRNA CTD PMID:20360939 Sphk1 Mouse phenobarbital affects expression ISO SPHK1 (Homo sapiens) 6480464 Phenobarbital affects the expression of SPHK1 mRNA CTD PMID:19159669 Sphk1 Mouse phenylmercury acetate increases expression ISO SPHK1 (Homo sapiens) 6480464 Phenylmercuric Acetate results in increased expression of SPHK1 mRNA CTD PMID:26272509 Sphk1 Mouse phenylmercury acetate multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 Sphk1 Mouse phosgene affects expression EXP 6480464 Phosgene affects the expression of SPHK1 mRNA CTD PMID:16300373 Sphk1 Mouse pirinixic acid multiple interactions EXP 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of SPHK1 mRNA CTD PMID:19710929 Sphk1 Mouse pirinixic acid increases expression EXP 6480464 pirinixic acid results in increased expression of SPHK1 mRNA CTD PMID:16985257 Sphk1 Mouse potassium dichromate decreases expression EXP 6480464 Potassium Dichromate results in decreased expression of SPHK1 mRNA CTD PMID:23608068 Sphk1 Mouse progesterone multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Mifepristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA] and onapristone inhibits the reaction [Progesterone results in increased expression of SPHK1 mRNA] CTD PMID:17164439 Sphk1 Mouse progesterone increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Progesterone results in increased expression of SPHK1 mRNA CTD PMID:17164439 Sphk1 Mouse prothioconazole decreases expression ISO SPHK1 (Homo sapiens) 6480464 prothioconazole results in decreased expression of SPHK1 mRNA CTD PMID:35048155 Sphk1 Mouse pyridoxamine multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Pyridoxamine inhibits the reaction [Glucose results in increased expression of and results in increased activity of SPHK1 protein] CTD PMID:21998146 Sphk1 Mouse ranitidine multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SPHK1 mRNA] CTD PMID:16415329 Sphk1 Mouse resveratrol increases expression ISO SPHK1 (Homo sapiens) 6480464 resveratrol results in increased expression of SPHK1 mRNA CTD PMID:16624241 Sphk1 Mouse resveratrol multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 resveratrol inhibits the reaction [Oxazolone results in increased activity of SPHK1 protein] CTD PMID:24055189 Sphk1 Mouse resveratrol multiple interactions EXP 6480464 resveratrol inhibits the reaction [[C5 protein results in increased activity of and results in increased localization of SPHK1 protein] which results in increased abundance of Calcium] CTD PMID:19346296 Sphk1 Mouse resveratrol multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate more ... CTD PMID:19284563 more ... Sphk1 Mouse resveratrol decreases expression ISO SPHK1 (Homo sapiens) 6480464 resveratrol metabolite results in decreased expression of SPHK1 protein more ... CTD PMID:20401667 more ... Sphk1 Mouse resveratrol decreases activity ISO SPHK1 (Homo sapiens) 6480464 resveratrol metabolite results in decreased activity of SPHK1 protein and resveratrol results in decreased activity of SPHK1 protein CTD PMID:22251058 Sphk1 Mouse SB 431542 multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 Sphk1 Mouse serpentine asbestos increases expression ISO SPHK1 (Homo sapiens) 6480464 Asbestos and Serpentine results in increased expression of SPHK1 mRNA CTD PMID:29523930 Sphk1 Mouse silicon dioxide increases expression ISO SPHK1 (Homo sapiens) 6480464 Silicon Dioxide results in increased expression of SPHK1 mRNA CTD PMID:22300531 and PMID:25351596 Sphk1 Mouse sodium arsenate multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [sodium arsenate results in increased abundance of Arsenic] which results in increased expression of SPHK1 mRNA CTD PMID:32525701 Sphk1 Mouse sodium arsenite increases expression ISO SPHK1 (Homo sapiens) 6480464 sodium arsenite results in increased expression of SPHK1 mRNA CTD PMID:22714537 more ... Sphk1 Mouse sodium fluoride increases expression EXP 6480464 Sodium Fluoride results in increased expression of SPHK1 mRNA CTD PMID:27862939 Sphk1 Mouse Soman increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Soman results in increased expression of SPHK1 mRNA CTD PMID:19281266 Sphk1 Mouse sphingosine 1-phosphate increases chemical synthesis ISO SPHK1 (Homo sapiens) 6480464 SPHK1 protein results in increased chemical synthesis of sphingosine 1-phosphate CTD PMID:22251058 Sphk1 Mouse sphingosine 1-phosphate multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate more ... CTD PMID:24399507 and PMID:26045781 Sphk1 Mouse streptozocin increases expression EXP 6480464 Streptozocin results in increased expression of SPHK1 CTD PMID:19657322 Sphk1 Mouse streptozocin increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Streptozocin results in increased expression of SPHK1 mRNA and Streptozocin results in increased expression of SPHK1 protein CTD PMID:21998146 Sphk1 Mouse T-2 toxin increases expression ISO SPHK1 (Homo sapiens) 6480464 T-2 Toxin results in increased expression of SPHK1 mRNA CTD PMID:34581912 Sphk1 Mouse tamoxifen increases expression ISO SPHK1 (Homo sapiens) 6480464 Tamoxifen results in increased expression of SPHK1 mRNA CTD PMID:15604281 Sphk1 Mouse tert-butyl hydroperoxide increases expression ISO SPHK1 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased expression of SPHK1 mRNA CTD PMID:15336504 Sphk1 Mouse tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of SPHK1 mRNA CTD PMID:17341687 Sphk1 Mouse tetrachloromethane increases expression ISO Sphk1 (Rattus norvegicus) 6480464 Carbon Tetrachloride results in increased expression of SPHK1 mRNA CTD PMID:31150632 Sphk1 Mouse thiram increases expression ISO SPHK1 (Homo sapiens) 6480464 Thiram results in increased expression of SPHK1 mRNA CTD PMID:38568856 Sphk1 Mouse titanium dioxide decreases expression EXP 6480464 titanium dioxide results in decreased expression of SPHK1 mRNA CTD PMID:23557971 Sphk1 Mouse titanium dioxide increases methylation EXP 6480464 titanium dioxide results in increased methylation of SPHK1 promoter CTD PMID:35295148 Sphk1 Mouse titanium dioxide decreases methylation EXP 6480464 titanium dioxide results in decreased methylation of SPHK1 promoter CTD PMID:35295148 Sphk1 Mouse titanium dioxide multiple interactions EXP 6480464 [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of SPHK1 mRNA CTD PMID:29950665 Sphk1 Mouse titanium dioxide increases expression EXP 6480464 titanium dioxide results in increased expression of SPHK1 mRNA CTD PMID:27760801 Sphk1 Mouse topotecan decreases expression ISO Sphk1 (Rattus norvegicus) 6480464 Topotecan results in decreased expression of SPHK1 mRNA CTD PMID:25729387 Sphk1 Mouse topotecan multiple interactions ISO Sphk1 (Rattus norvegicus) 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of SPHK1 mRNA CTD PMID:25729387 Sphk1 Mouse tributylstannane decreases expression ISO SPHK1 (Homo sapiens) 6480464 tributyltin results in decreased expression of SPHK1 mRNA CTD PMID:26314263 Sphk1 Mouse trichostatin A increases expression ISO SPHK1 (Homo sapiens) 6480464 trichostatin A results in increased expression of SPHK1 mRNA CTD PMID:24935251 and PMID:26272509 Sphk1 Mouse trichostatin A multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 Sphk1 Mouse triclosan decreases expression ISO SPHK1 (Homo sapiens) 6480464 Triclosan results in decreased expression of SPHK1 mRNA CTD PMID:30510588 Sphk1 Mouse triptonide affects expression EXP 6480464 triptonide affects the expression of SPHK1 mRNA CTD PMID:33045310 Sphk1 Mouse valproic acid increases methylation ISO SPHK1 (Homo sapiens) 6480464 Valproic Acid results in increased methylation of SPHK1 gene CTD PMID:29154799 Sphk1 Mouse valproic acid multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 Sphk1 Mouse valproic acid increases expression ISO SPHK1 (Homo sapiens) 6480464 Valproic Acid results in increased expression of SPHK1 mRNA CTD PMID:23179753 more ... Sphk1 Mouse vinclozolin increases expression ISO Sphk1 (Rattus norvegicus) 6480464 vinclozolin results in increased expression of SPHK1 mRNA CTD PMID:22570695 Sphk1 Mouse vorinostat multiple interactions ISO SPHK1 (Homo sapiens) 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SPHK1 mRNA CTD PMID:27188386 Sphk1 Mouse vorinostat increases expression ISO SPHK1 (Homo sapiens) 6480464 vorinostat results in increased expression of SPHK1 mRNA CTD PMID:26272509
