Sphk1 (sphingosine kinase 1) - Rat Genome Database

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Pathways
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Gene: Sphk1 (sphingosine kinase 1) Ictidomys tridecemlineatus
Analyze
Symbol: Sphk1
Name: sphingosine kinase 1
RGD ID: 12632111
Description: ENCODES a protein that exhibits D-erythro-sphingosine kinase activity (ortholog); INVOLVED IN blood vessel development (ortholog); brain development (ortholog); cell population proliferation (ortholog); PARTICIPATES IN platelet-derived growth factor signaling pathway; sphingosine 1-phosphate signaling pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Fibrosis (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); presynapse (ortholog); synaptic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sphingosine kinase 1, transcript variant X1; sphingosine kinase 1, transcript variant X2; sphingosine kinase 1, transcript variant X3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056024,922,623 - 4,928,472 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365941,486,111 - 1,489,188 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365941,482,830 - 1,489,337 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel development  (IEA,ISO)
brain development  (IEA,ISO)
calcium-mediated signaling  (IEA)
cell population proliferation  (IEA,ISO)
cellular response to growth factor stimulus  (IEA,ISO)
cellular response to hydrogen peroxide  (IEA,ISO)
cellular response to starvation  (ISO)
cellular response to vascular endothelial growth factor stimulus  (IEA)
cyclooxygenase pathway  (ISO)
DNA biosynthetic process  (IEA,ISO)
female pregnancy  (ISO)
inflammatory response  (IEA,ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of ceramide biosynthetic process  (IEA)
positive regulation of angiogenesis  (IEA)
positive regulation of cell growth  (IEA)
positive regulation of cell migration  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of fibroblast proliferation  (IEA,ISO)
positive regulation of interleukin-17 production  (ISO)
positive regulation of mitotic cell cycle  (IEA)
positive regulation of mitotic nuclear division  (IEA,ISO)
positive regulation of neuron projection development  (ISO)
positive regulation of neurotransmitter secretion  (ISO)
positive regulation of non-canonical NF-kappaB signal transduction  (IEA)
positive regulation of p38MAPK cascade  (IEA)
positive regulation of peptidyl-threonine phosphorylation  (IEA)
positive regulation of protein phosphorylation  (ISO)
positive regulation of protein ubiquitination  (IEA)
positive regulation of smooth muscle contraction  (IEA)
regulation of endocytosis  (IEA)
regulation of endosomal vesicle fusion  (IEA)
regulation of interleukin-1 beta production  (IEA,ISO)
regulation of microglial cell activation  (IEA)
regulation of neuroinflammatory response  (IEA)
regulation of phagocytosis  (IEA)
regulation of tumor necrosis factor-mediated signaling pathway  (IEA)
response to amine  (ISO)
response to ATP  (ISO)
response to interleukin-1  (ISO)
response to magnesium ion  (ISO)
response to organic cyclic compound  (ISO)
response to progesterone  (ISO)
response to tumor necrosis factor  (IEA)
sphingolipid mediated signaling pathway  (IEA,ISO)
sphingosine biosynthetic process  (IEA)
sphingosine metabolic process  (IEA)
sphingosine-1-phosphate receptor signaling pathway  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Sphk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244056024,922,623 - 4,928,472 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365941,486,111 - 1,489,188 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365941,482,830 - 1,489,337 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPHK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381776,383,204 - 76,387,855 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1776,376,584 - 76,387,860 (+)EnsemblGRCh38hg38GRCh38
GRCh371774,379,285 - 74,383,936 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361771,892,297 - 71,895,536 (+)NCBINCBI36Build 36hg18NCBI36
Build 341771,892,325 - 71,895,530NCBI
Celera1770,973,067 - 70,976,318 (+)NCBICelera
Cytogenetic Map17q25.1NCBI
HuRef1769,809,173 - 69,812,424 (+)NCBIHuRef
CHM1_11774,445,769 - 74,449,020 (+)NCBICHM1_1
T2T-CHM13v2.01777,279,777 - 77,284,428 (+)NCBIT2T-CHM13v2.0
Sphk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911116,421,662 - 116,427,502 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11116,421,751 - 116,427,501 (+)EnsemblGRCm39 Ensembl
GRCm3811116,530,836 - 116,536,675 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,530,925 - 116,536,674 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl11116,530,925 - 116,536,675 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711116,393,225 - 116,397,989 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611116,349,437 - 116,352,760 (+)NCBIMGSCv36mm8
Celera11128,300,450 - 128,305,214 (+)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1181.42NCBI
Sphk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr810102,257,413 - 102,263,086 (+)NCBIGRCr8
mRatBN7.210101,758,567 - 101,764,240 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl10101,758,711 - 101,764,240 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10106,815,189 - 106,820,851 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.010106,278,279 - 106,283,941 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.010101,679,445 - 101,685,112 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.010105,498,728 - 105,504,401 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl10105,498,728 - 105,504,393 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.010105,162,314 - 105,167,987 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410106,641,509 - 106,645,579 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.110106,656,012 - 106,660,081 (+)NCBI
Celera10100,330,875 - 100,336,542 (+)NCBICelera
Cytogenetic Map10q32.1-q32.2NCBI
Sphk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555065,902,345 - 5,904,988 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555065,902,079 - 5,906,639 (-)NCBIChiLan1.0ChiLan1.0
SPHK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21992,424,277 - 92,430,882 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11797,251,477 - 97,256,099 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01770,331,370 - 70,336,043 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11775,875,530 - 75,886,481 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1775,883,329 - 75,886,481 (+)Ensemblpanpan1.1panPan2
SPHK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.194,311,698 - 4,314,773 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl94,311,683 - 4,314,483 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha94,992,955 - 4,996,576 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.094,984,498 - 4,988,116 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl94,984,483 - 4,987,049 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.195,012,727 - 5,016,344 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.095,132,520 - 5,136,143 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.095,213,806 - 5,217,418 (-)NCBIUU_Cfam_GSD_1.0
SPHK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl125,114,947 - 5,120,083 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1125,114,946 - 5,122,580 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2125,018,690 - 5,023,812 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SPHK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11645,290,147 - 45,295,175 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1645,290,421 - 45,293,128 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607716,031,997 - 16,036,965 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sphk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248016,253,219 - 6,257,128 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSSTOT00000019990   ⟹   ENSSTOP00000021636
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049365941,486,111 - 1,489,188 (+)Ensembl
RefSeq Acc Id: XM_005332597   ⟹   XP_005332654
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244056024,922,623 - 4,926,675 (-)NCBI
SpeTri2.0NW_0049365941,485,183 - 1,489,337 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013361643   ⟹   XP_013217097
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244056024,922,623 - 4,926,835 (-)NCBI
SpeTri2.0NW_0049365941,485,167 - 1,489,337 (+)NCBI
Sequence:
RefSeq Acc Id: XM_021731247   ⟹   XP_021586922
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244056024,922,623 - 4,928,472 (-)NCBI
SpeTri2.0NW_0049365941,482,830 - 1,489,337 (+)NCBI
Sequence:
RefSeq Acc Id: XM_040268419   ⟹   XP_040124353
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_0244056024,922,623 - 4,925,330 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_013217097   ⟸   XM_013361643
- Peptide Label: isoform X4
- UniProtKB: I3NB89 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005332654   ⟸   XM_005332597
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_021586922   ⟸   XM_021731247
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_040124353   ⟸   XM_040268419
- Peptide Label: isoform X2
RefSeq Acc Id: ENSSTOP00000021636   ⟸   ENSSTOT00000019990
Protein Domains
DAGKc


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000021818 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000019990.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.200.40 UniProtKB/TrEMBL
InterPro ATP-NAD_kinase_N UniProtKB/TrEMBL
  Diacylglycerol_kinase_cat_dom UniProtKB/TrEMBL
  NAD/diacylglycerol_kinase_sf UniProtKB/TrEMBL
NCBI Gene Sphk1 ENTREZGENE
PANTHER SPHINGOSINE KINASE UniProtKB/TrEMBL
  SPHINGOSINE KINASE 1 UniProtKB/TrEMBL
Pfam DAGK_cat UniProtKB/TrEMBL
PROSITE DAGK UniProtKB/TrEMBL
SMART DAGKc UniProtKB/TrEMBL
Superfamily-SCOP SSF111331 UniProtKB/TrEMBL
UniProt I3NB89 ENTREZGENE, UniProtKB/TrEMBL