Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   


RGD ID: 620048
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sphk1
Name: sphingosine kinase 1
Acc ID: CHEBI:78759
Term: N,N-dimethylsphingosine
Definition: A sphingoid that is sphingosine in which the two amino hydrogens are replaced by amino groups.
Chemical ID: MESH:C061800
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sphk1multiple interactionsEXP 6480464CTDN N-dimethylsphingosine inhibits the reaction [Glucose results in increased activity of SPHK1 protein]

Sphk1decreases activityISORGD:13464046480464CTDN N-dimethylsphingosine results in decreased activity of SPHK1 protein

PMID:17065523 PMID:19284563
Sphk1decreases expressionISORGD:13464046480464CTDN N-dimethylsphingosine results in decreased expression of SPHK1 protein

Go Back to source page   Continue to Ontology report