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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620048
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sphk1
Name: sphingosine kinase 1
Acc ID: CHEBI:37550
Term: sphingosine 1-phosphate
Definition: A phosphosphingolipid that consists of sphingosine having a phospho group attached at position 1
Chemical ID: MESH:C060506
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sphk1increases chemical synthesisISORGD:13464046480464CTDSPHK1 protein results in increased chemical synthesis of sphingosine 1-phosphate

PMID:22251058
Sphk1multiple interactionsISORGD:13464046480464CTD[resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 mRNA] sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 protein]

PMID:24399507 PMID:26045781
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