Jup (junction plakoglobin) - Rat Genome Database

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Gene: Jup (junction plakoglobin) Rattus norvegicus
Analyze
Symbol: Jup
Name: junction plakoglobin
RGD ID: 620412
Description: Enables protein tyrosine kinase binding activity. Predicted to be involved in several processes, including cellular response to indole-3-methanol; regulation of DNA-templated transcription; and regulation of heart contraction. Predicted to act upstream of or within cell adhesion; desmosome assembly; and skin development. Located in several cellular components, including apicolateral plasma membrane; fascia adherens; and lateral plasma membrane. Colocalizes with actin cytoskeleton. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human JUP (junction plakoglobin); PARTICIPATES IN E-cadherin signaling pathway; N-cadherin signaling pathway; acute myeloid leukemia pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: gamma-catenin (plakoglobin)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21085,300,438 - 85,327,378 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,300,440 - 85,327,057 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,340,290 - 90,366,730 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01089,818,505 - 89,845,011 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01085,208,718 - 85,235,336 (-)NCBIRnor_WKY
Rnor_6.01088,280,517 - 88,307,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,279,632 - 88,307,412 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,073,764 - 88,100,700 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,307,938 - 89,335,254 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,322,309 - 89,349,624 (-)NCBI
Celera1084,018,429 - 84,045,045 (-)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
buspirone  (EXP)
butan-1-ol  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
dexamethasone  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
doxorubicin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
genistein  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
indirubin  (EXP)
indometacin  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
nefazodone  (EXP)
nickel subsulfide  (ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitrobenzenes  (EXP)
ozone  (EXP)
paracetamol  (EXP)
phosgene  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-allylcysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulforaphane  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
trichloroethene  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The human plakoglobin gene localizes on chromosome 17q21 and is subjected to loss of heterozygosity in breast and ovarian cancers. Aberle H, etal., Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6384-8.
2. Identification and prognostic significance of an epithelial-mesenchymal transition expression profile in human bladder tumors. Baumgart E, etal., Clin Cancer Res. 2007 Mar 15;13(6):1685-94.
3. Methylation of the gamma-catenin gene is associated with poor prognosis of renal cell carcinoma. Breault JE, etal., Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):557-64.
4. Expression of plakoglobin in renal cell carcinoma. Buchner A, etal., Anticancer Res. 1998 Nov-Dec;18(6A):4231-5.
5. Expression of adhesion proteins E-cadherin, alpha-catenin, beta-catenin and gamma-catenin is different in T1 and T2 breast tumours. Bukholm IR, etal., Pathology. 2006 Oct;38(5):403-7.
6. Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study. Chen YM, etal., Biol Reprod. 2003 Aug;69(2):656-72. Epub 2003 Apr 16.
7. TCDD-dependent downregulation of gamma-catenin in rat liver epithelial cells (WB-F344). Dietrich C, etal., Int J Cancer 2003 Feb 10;103(4):435-9.
8. Plakophilin-2 loss promotes TGF-beta1/p38 MAPK-dependent fibrotic gene expression in cardiomyocytes. Dubash AD, etal., J Cell Biol. 2016 Feb 15;212(4):425-38. doi: 10.1083/jcb.201507018. Epub 2016 Feb 8.
9. The area composita of adhering junctions connecting heart muscle cells of vertebrates. I. Molecular definition in intercalated disks of cardiomyocytes by immunoelectron microscopy of desmosomal proteins. Franke WW, etal., Eur J Cell Biol. 2006 Feb;85(2):69-82. Epub 2006 Jan 9.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations. Gehmlich K, etal., Cardiovasc Res. 2011 Apr 1;90(1):77-87. doi: 10.1093/cvr/cvq353. Epub 2010 Nov 9.
12. Retention of the expression of E-cadherin and catenins is associated with shorter survival in grade III ductal carcinoma of the breast. Gillett CE, etal., J Pathol. 2001 Apr;193(4):433-41.
13. Cell-cell contact changes the dynamics of lamellar activity in nontransformed epitheliocytes but not in their ras-transformed descendants. Gloushankova NA, etal., Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):879-83.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. N-cadherin in adult rat cardiomyocytes in culture. II. Spatio-temporal appearance of proteins involved in cell-cell contact and communication. Formation of two distinct N-cadherin/catenin complexes. Hertig CM, etal., J Cell Sci. 1996 Jan;109 ( Pt 1):11-20.
16. Heterogeneity of ATP-sensitive K+ channels in cardiac myocytes: enrichment at the intercalated disk. Hong M, etal., J Biol Chem. 2012 Nov 30;287(49):41258-67. doi: 10.1074/jbc.M112.412122. Epub 2012 Oct 12.
17. Elevated expression of E-cadherin and alpha-, beta-, and gamma-catenins in metastatic lesions compared with primary epithelial ovarian carcinomas. Imai T, etal., Hum Pathol. 2004 Dec;35(12):1469-76.
18. Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease). McKoy G, etal., Lancet. 2000 Jun 17;355(9221):2119-24.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Abnormalities of E- and P-cadherin and catenin (beta-, gamma-catenin, and p120ctn) expression in endometrial cancer and endometrial atypical hyperplasia. Moreno-Bueno G, etal., J Pathol. 2003 Apr;199(4):471-8.
21. E-cadherin and alpha-, beta- and gamma-catenin expression in prostate cancers: correlation with tumour invasion. Morita N, etal., Br J Cancer. 1999 Apr;79(11-12):1879-83.
22. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
23. Remodeling of the cardiac sodium channel, connexin43, and plakoglobin at the intercalated disk in patients with arrhythmogenic cardiomyopathy. Noorman M, etal., Heart Rhythm. 2013 Mar;10(3):412-9. doi: 10.1016/j.hrthm.2012.11.018. Epub 2012 Nov 23.
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. Junctional plaque proteins shift to the apical surface of uterine epithelial cells during early pregnancy in the rat. Orchard MD, etal., Acta Histochem. 1999 Apr;101(2):147-56.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Robinson cytologic grading in invasive ductal carcinoma of the breast: correlation with E-cadherin and alpha-, beta- and gamma-catenin expression and regional lymph node metastasis. Robles-Frias A, etal., Acta Cytol. 2006 Mar-Apr;50(2):151-7.
32. [Expresion of E-cadherin and catenins in urothelial carcinomas] San Miguel Fraile P, etal., Actas Urol Esp. 2007 Apr;31(4):355-60.
33. Alterations of beta- and gamma-catenin in N-butyl-N-(-4-hydroxybutyl)nitrosamine-induced murine bladder cancer. Shiina H, etal., Cancer Res. 2001 Oct 1;61(19):7101-9.
34. Functional Loss of the gamma-catenin gene through epigenetic and genetic pathways in human prostate cancer. Shiina H, etal., Cancer Res. 2005 Mar 15;65(6):2130-8.
35. New insights into testicular germ cell tumorigenesis from gene expression profiling. Skotheim RI, etal., Cancer Res. 2002 Apr 15;62(8):2359-64.
36. Candidate genes for testicular cancer evaluated by in situ protein expression analyses on tissue microarrays. Skotheim RI, etal., Neoplasia. 2003 Sep-Oct;5(5):397-404.
37. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:1639850   PMID:2726765   PMID:7650039   PMID:7890674   PMID:7983064   PMID:8582267   PMID:8663237   PMID:8821035   PMID:8853988   PMID:8954745   PMID:9049256   PMID:9847250  
PMID:9864371   PMID:10403777   PMID:10460003   PMID:10662781   PMID:10825188   PMID:10868478   PMID:12847106   PMID:14579029   PMID:14661054   PMID:14673151   PMID:15489334   PMID:15775979  
PMID:16510873   PMID:16917092   PMID:17559062   PMID:17924338   PMID:18261826   PMID:18496566   PMID:18816447   PMID:18937352   PMID:19056867   PMID:19805073   PMID:20859650   PMID:21296051  
PMID:21423176   PMID:21880664   PMID:22781308   PMID:22889254   PMID:23136403   PMID:23376485   PMID:23381804   PMID:23747726   PMID:23979707   PMID:25468996   PMID:28115160   PMID:32357304  


Genomics

Comparative Map Data
Jup
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21085,300,438 - 85,327,378 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,300,440 - 85,327,057 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,340,290 - 90,366,730 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01089,818,505 - 89,845,011 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01085,208,718 - 85,235,336 (-)NCBIRnor_WKY
Rnor_6.01088,280,517 - 88,307,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,279,632 - 88,307,412 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,073,764 - 88,100,700 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,307,938 - 89,335,254 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,322,309 - 89,349,624 (-)NCBI
Celera1084,018,429 - 84,045,045 (-)NCBICelera
Cytogenetic Map10q31NCBI
JUP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381741,754,609 - 41,786,711 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1741,754,604 - 41,786,931 (-)EnsemblGRCh38hg38GRCh38
GRCh371739,910,861 - 39,942,963 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,164,390 - 37,196,475 (-)NCBINCBI36Build 36hg18NCBI36
Build 341737,164,389 - 37,196,475NCBI
Celera1736,562,207 - 36,594,276 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1735,672,969 - 35,704,921 (-)NCBIHuRef
CHM1_11740,146,477 - 40,178,584 (-)NCBICHM1_1
T2T-CHM13v2.01742,611,153 - 42,643,244 (-)NCBIT2T-CHM13v2.0
Jup
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,259,682 - 100,288,639 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,259,784 - 100,288,589 (-)EnsemblGRCm39 Ensembl
GRCm3811100,368,856 - 100,397,839 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,368,958 - 100,397,763 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711100,231,933 - 100,259,053 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,186,709 - 100,213,829 (-)NCBIMGSCv36mm8
Celera11110,988,014 - 111,016,158 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.47NCBI
Jup
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545115,989,180 - 16,004,155 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545115,993,055 - 16,004,152 (-)NCBIChiLan1.0ChiLan1.0
JUP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11715,747,163 - 15,777,479 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,747,163 - 15,777,479 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01715,527,115 - 15,559,251 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
JUP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1921,028,773 - 21,053,071 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl921,028,828 - 21,053,071 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,490,821 - 20,515,048 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,749,530 - 21,774,004 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,749,494 - 21,776,711 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,535,712 - 20,559,942 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,801,655 - 20,825,888 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,905,422 - 20,929,851 (+)NCBIUU_Cfam_GSD_1.0
Jup
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,380,553 - 20,403,963 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649016,668,575 - 16,694,615 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493649016,671,176 - 16,694,552 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JUP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,901,396 - 20,931,210 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,902,395 - 20,931,208 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21221,145,385 - 21,184,606 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JUP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,470,974 - 64,503,085 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1664,470,959 - 64,503,322 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607735,301,719 - 35,334,347 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Jup
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,954,290 - 1,975,018 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,954,733 - 1,972,080 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Jup
150 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:314
Count of miRNA genes:160
Interacting mature miRNAs:191
Transcripts:ENSRNOT00000040845
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat

Markers in Region
RH128545  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,300,546 - 85,300,704 (+)MAPPERmRatBN7.2
Rnor_6.01088,280,626 - 88,280,783NCBIRnor6.0
Rnor_5.01088,073,873 - 88,074,030UniSTSRnor5.0
RGSC_v3.41089,308,047 - 89,308,204UniSTSRGSC3.4
Celera1084,018,538 - 84,018,695UniSTS
RH 3.4 Map10860.39UniSTS
Cytogenetic Map10q32.1UniSTS
Jup  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,302,010 - 85,302,158 (+)MAPPERmRatBN7.2
Rnor_6.01088,282,090 - 88,282,237NCBIRnor6.0
Rnor_5.01088,075,337 - 88,075,484UniSTSRnor5.0
RGSC_v3.41089,309,511 - 89,309,658UniSTSRGSC3.4
Celera1084,020,002 - 84,020,149UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 49 33 19 33 5 8 73 35 41 11 5
Low 8 8 8 3 3 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000040845   ⟹   ENSRNOP00000043950
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,300,440 - 85,327,057 (-)Ensembl
Rnor_6.0 Ensembl1088,280,519 - 88,307,132 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089933   ⟹   ENSRNOP00000070840
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,300,440 - 85,327,057 (-)Ensembl
Rnor_6.0 Ensembl1088,279,632 - 88,307,412 (-)Ensembl
RefSeq Acc Id: NM_031047   ⟹   NP_112309
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,300,438 - 85,327,057 (-)NCBI
Rnor_6.01088,280,517 - 88,307,132 (-)NCBI
Rnor_5.01088,073,764 - 88,100,700 (-)NCBI
RGSC_v3.41089,307,938 - 89,335,254 (-)RGD
Celera1084,018,429 - 84,045,045 (-)RGD
Sequence:
RefSeq Acc Id: XM_006247429   ⟹   XP_006247491
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,300,438 - 85,327,378 (-)NCBI
Rnor_6.01088,280,517 - 88,307,428 (-)NCBI
Rnor_5.01088,073,764 - 88,100,700 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247430   ⟹   XP_006247492
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21085,300,438 - 85,327,372 (-)NCBI
Rnor_6.01088,281,081 - 88,307,437 (-)NCBI
Rnor_5.01088,073,764 - 88,100,700 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_112309   ⟸   NM_031047
- UniProtKB: Q6P0K8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006247491   ⟸   XM_006247429
- Peptide Label: isoform X1
- UniProtKB: Q6P0K8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006247492   ⟸   XM_006247430
- Peptide Label: isoform X1
- UniProtKB: Q6P0K8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070840   ⟸   ENSRNOT00000089933
RefSeq Acc Id: ENSRNOP00000043950   ⟸   ENSRNOT00000040845

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P0K8-F1-model_v2 AlphaFold Q6P0K8 1-745 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697719
Promoter ID:EPDNEW_R8241
Type:initiation region
Name:Jup_1
Description:junction plakoglobin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01088,307,439 - 88,307,499EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620412 AgrOrtholog
BioCyc Gene G2FUF-23240 BioCyc
Ensembl Genes ENSRNOG00000015380 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000043950 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000070840.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000040845 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000089933.2 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599724 IMAGE-MGC_LOAD
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Armadillo UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Beta-catenin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Plakoglobin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81679 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72417 IMAGE-MGC_LOAD
NCBI Gene 81679 ENTREZGENE
PANTHER PTHR45976 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR45976:SF3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Arm UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB JUP RGD
PhenoGen Jup PhenoGen
PRINTS BCATNINFAMLY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ARM_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART ARM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2R4T1_RAT UniProtKB/TrEMBL
  PLAK_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Jup  junction plakoglobin      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Jup  unction plakoglobin      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_drugs TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin)(1 nM)when given to WB-F344 cells, localizes the protein in the cytoplasm and downregulates its activity 633036
gene_process mRNA involved in transcriptional downregulation or destabilization of proteins during tumorigenesis 633036