Mpo (myeloperoxidase) - Rat Genome Database

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Gene: Mpo (myeloperoxidase) Rattus norvegicus
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Symbol: Mpo
Name: myeloperoxidase
RGD ID: 1592081
Description: Enables peroxidase activity. Involved in several processes, including response to food; response to gold nanoparticle; and response to lipopolysaccharide. Located in extracellular space. Used to study acute kidney failure. Biomarker of chronic obstructive pulmonary disease; cystitis; and renovascular hypertension. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; cystic fibrosis; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MPO (myeloperoxidase); PARTICIPATES IN etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; interleukin-23 signaling pathway; INTERACTS WITH (+)-taxifolin; (20S)-ginsenoside Rg3; (R)-carnitine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Mpo_mapped; myeloperoxidase (mapped)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Mpoem1Mcwi
Genetic Models: SD-Mpoem1Mcwi
Candidate Gene For: Bp308
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81073,092,124 - 73,102,057 (+)NCBIGRCr8
mRatBN7.21072,594,883 - 72,608,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1072,594,661 - 72,604,819 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1077,205,622 - 77,215,277 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01076,710,570 - 76,720,225 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01072,175,076 - 72,184,731 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01075,087,892 - 75,098,260 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1075,087,892 - 75,098,260 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01075,004,128 - 75,014,496 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41076,085,872 - 76,097,012 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1071,507,771 - 71,517,382 (+)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (IDA,ISO)
Acute Lung Injury  (ISO)
alcoholic liver cirrhosis  (ISO)
Alzheimer's disease  (ISO)
Alzheimer's disease 1  (ISO)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
bacterial pneumonia  (ISO)
brain disease  (ISO)
Brain Hypoxia-Ischemia  (IEP)
Brain Injuries  (ISO)
brain ischemia  (ISO)
Burns  (IEP,ISO)
cardiovascular system disease  (ISO)
Chronic Bronchitis  (IEP)
chronic obstructive pulmonary disease  (IEP,ISO)
colitis  (ISO)
Contrast-Induced Nephropathy  (IDA)
cystic fibrosis  (ISO)
cystitis  (IEP)
Drug Eruptions  (ISO)
end stage renal disease  (ISO)
Enteritis  (IEP)
Experimental Arthritis  (ISO)
Experimental Colitis  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
extrahepatic cholestasis  (ISO)
glomerulonephritis  (ISO)
Hemorrhagic Shock  (ISO)
hepatocellular carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hypoxia  (ISO)
Inflammation  (ISO)
intellectual disability  (ISO)
interstitial lung disease  (ISO)
Joubert syndrome 1  (ISO)
keratosis  (ISO)
Kidney Calculi  (ISO)
kidney disease  (ISO)
Kidney Reperfusion Injury  (IEP,ISO)
liver cirrhosis  (ISO)
lung cancer  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lupus nephritis  (ISO)
major depressive disorder  (ISO)
Myeloperoxidase Deficiency  (ISO)
Myocardial Ischemia  (ISO)
Occupational Diseases  (ISO)
pancreatic cancer  (ISO)
pancreatitis  (ISO)
pleurisy  (ISO)
pre-malignant neoplasm  (ISO)
Prostatic Neoplasms  (ISO)
renovascular hypertension  (IEP)
Reperfusion Injury  (IEP,ISO)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (IEP)
status asthmaticus  (ISO)
Systemic Candidiasis  (ISO)
traumatic brain injury  (ISO)
trichuriasis  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
urticaria  (ISO)
vasculitis  (ISO)
Viral Bronchiolitis  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-isoborneol  (ISO)
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (EXP)
(4Z,7Z,10Z,13Z,15E,19Z)-17-hydroxydocosahexaenoic acid  (ISO)
(R)-camphor  (ISO)
(R)-carnitine  (EXP)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-colchicine  (EXP)
(S)-nicotine  (EXP)
(Z)-ligustilide  (ISO)
1,2-dimethylhydrazine  (ISO)
1,2-phenylenediamine  (ISO)
1,4-benzoquinone  (ISO)
1,7-dimethylxanthine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (EXP,ISO)
1-chloro-2,4,6-trinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
12-methyltetradecanoic acid  (ISO)
16,16-dimethylprostaglandin E2  (EXP)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
2''-galloylhyperin  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-dichloroaniline  (ISO)
2,4-dimethylaniline  (ISO)
2,6-dihydroxybenzoic acid  (ISO)
2,6-dimethylaniline  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-arachidonoylglycerol  (ISO)
2-bromohexadecanoic acid  (ISO)
2-naphthylamine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-dichloroaniline  (ISO)
3,4-dihydroxybenzoic acid  (EXP,ISO)
3,4-dimethylaniline  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-acetyldeoxynivalenol  (ISO)
3-Amino-1-methyl-5H-pyrido[4,3-b]indole  (ISO)
3-aminobenzamide  (ISO)
3-Chloroaniline  (ISO)
3-methyladenine  (EXP)
3-phenylprop-2-enal  (EXP,ISO)
4'-epidoxorubicin  (EXP)
4'-hydroxydiclofenac  (ISO)
4,4'-methylene-bis-(2-chloroaniline)  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP,ISO)
4-amino-TEMPO  (ISO)
4-aminobenzohydrazide  (ISO)
4-carboxy-TEMPO  (ISO)
4-chloroaniline  (ISO)
4-fluoroaniline  (ISO)
4-hydroxy-TEMPO  (ISO)
4-methyl-3-[[1-oxo-2-(propylamino)propyl]amino]-2-thiophenecarboxylic acid methyl ester  (ISO)
4-nitroaniline  (ISO)
4-phenylbutyric acid  (ISO)
5,5-dimethyl-1-pyrroline N-oxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP)
5-hydroxydiclofenac  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (EXP,ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
abacavir  (ISO)
acetaldehyde  (ISO)
acetic acid  (EXP,ISO)
acetic acid [2-[[(5-nitro-2-thiazolyl)amino]-oxomethyl]phenyl] ester  (ISO)
acetohydrazide  (ISO)
acetylsalicylic acid  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
albuterol  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (EXP,ISO)
Alkannin  (ISO)
all-trans-retinoic acid  (ISO)
allicin  (EXP)
allopurinol  (EXP)
alloxan  (EXP)
alpha-amanitin  (ISO)
Alpinetin  (ISO)
aluminium atom  (ISO)
aluminium oxide  (ISO)
aluminium(0)  (ISO)
ambroxol  (EXP)
amifostine  (ISO)
aminoglutethimide  (ISO)
aminoguanidine  (EXP)
amiodarone  (EXP)
ammonia  (ISO)
ammonium chloride  (EXP)
amodiaquine  (ISO)
amphetamine  (EXP)
ampicillin  (EXP)
andrographolide  (EXP)
aniline  (ISO)
anthocyanin  (EXP)
apocynin  (EXP,ISO)
arachidonic acid  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (EXP)
asbestos  (ISO)
asperuloside  (ISO)
astragaloside IV  (EXP)
atorvastatin calcium  (EXP)
baicalein  (ISO)
balsalazide  (ISO)
benzene  (ISO)
benzidine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzohydrazide  (ISO)
benzoic acid  (ISO)
Benzoyl peroxide  (ISO)
beraprost  (ISO)
berberine  (ISO)
Bergenin  (EXP)
beta-carotene  (EXP)
beta-D-glucosamine  (EXP)
biochanin A  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol F  (EXP)
bivalirudin  (ISO)
bleomycin A2  (EXP,ISO)
Boldine  (ISO)
budesonide  (EXP)
buta-1,3-diene  (ISO)
cadaverine  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
Calcimycin  (EXP,ISO)
calciol  (ISO)
camphor  (ISO)
candesartan  (EXP)
cannabidiol  (ISO)
capsaicin  (EXP)
capsazepine  (EXP,ISO)
carbendazim  (EXP)
CARBENOXOLONE  (ISO)
carbon nanotube  (EXP,ISO)
carboplatin  (EXP)
Cardamonin  (ISO)
carnosic acid  (ISO)
carnosine  (ISO)
Carnosol  (EXP)
carrageenan  (EXP)
carvacrol  (ISO)
carvedilol  (EXP,ISO)
celastrol  (EXP,ISO)
celecoxib  (EXP)
ceric oxide  (EXP,ISO)
cerium trichloride  (ISO)
ceruletide  (ISO)
CGP 52608  (ISO)
chalcones  (EXP)
chelerythrine  (ISO)
Chloralose  (ISO)
chlorogenic acid  (ISO)
chlorphenamine  (EXP)
chlorpyrifos  (EXP,ISO)
chondroitin sulfate  (EXP)
chrysin  (EXP)
ciprofloxacin  (EXP)
cirsilineol  (ISO)
cis-caffeic acid  (EXP,ISO)
cisplatin  (EXP,ISO)
clopidogrel  (ISO)
clozapine  (ISO)
cocaine  (EXP)
coenzyme Q10  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
cordycepin  (EXP)
corynoline  (ISO)
coumarins  (ISO)
crocidolite asbestos  (EXP,ISO)
crocin-1  (EXP)
cumene hydroperoxide  (ISO)
curcumin  (EXP,ISO)
cyanides  (ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
cysteamine  (EXP)
D-glucose  (EXP,ISO)
D-penicillamine  (ISO)
dapagliflozin  (EXP)
deoxynivalenol  (ISO)
desmethylnaproxen  (ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (ISO)
dextran  (ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
Dibromoacetonitrile  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
Dihydrotanshinone I  (ISO)
dimethyl sulfoxide  (ISO)
Diosbulbin B  (ISO)
diosmin  (EXP)
dioxygen  (EXP)
diphenyl diselenide  (EXP)
diquat  (EXP)
disodium selenite  (EXP)
docebenone  (ISO)
domperidone  (ISO)
donepezil hydrochloride  (EXP,ISO)
doxorubicin  (EXP)
edaravone  (EXP)
efavirenz  (EXP)
emodin  (EXP)
enalapril  (EXP)
erdosteine  (EXP)
eriodictyol  (ISO)
ethambutol  (EXP)
ethanol  (EXP,ISO)
ethylenediamine  (ISO)
etoposide  (ISO)
eugenol  (EXP)
EUK-134  (EXP)
Evodiamine  (ISO)
famotidine  (EXP,ISO)
Fargesin  (ISO)
fasudil  (ISO)
fenoterol  (ISO)
ferroheme b  (EXP)
ferulic acid  (ISO)
fisetin  (EXP)
flucloxacillin  (ISO)
fluconazole  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
Forsythiaside  (ISO)
fosaprepitant  (ISO)
Fraxinellone  (ISO)
fucoidan  (EXP,ISO)
fulvestrant  (EXP)
furan  (EXP)
gadolinium trichloride  (EXP)
galanthamine  (EXP)
gallic acid  (EXP,ISO)
gallocatechin  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gemcitabine  (ISO)
genistein  (EXP)
gentamycin  (EXP)
geraniol  (EXP,ISO)
gingerol  (EXP,ISO)
Ginkgolide C  (EXP)
ginsenoside Re  (ISO)
gliclazide  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glutathione disulfide  (ISO)
glyburide  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
gossypin  (EXP)
GR 113808  (ISO)
granisetron  (ISO)
halothane  (EXP)
heme b  (EXP)
hemin  (EXP)
heparin  (ISO)
hesperetin  (EXP,ISO)
hesperidin  (EXP)
hexane-1,6-diamine  (ISO)
hispidulin  (ISO)
hyaluronic acid  (EXP)
hydrazine  (ISO)
hydrogen chloride  (EXP,ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxamic acid  (EXP)
hydroxysafflor yellow A  (ISO)
hypochlorous acid  (ISO)
ibuprofen  (EXP)
imidacloprid  (EXP)
imiquimod  (ISO)
IMP  (EXP)
indole-3-butyric acid  (EXP)
indometacin  (EXP,ISO)
irinotecan  (ISO)
iron atom  (EXP)
iron dextran  (EXP)
iron(0)  (EXP)
isatin  (EXP)
isoflurane  (EXP)
isoniazide  (ISO)
isoorientin  (EXP)
isoprenaline  (EXP)
isovitexin  (ISO)
ketoprofen  (EXP)
ketorolac  (EXP)
Kukoamine B  (ISO)
kynurenic acid  (ISO)
L-arginine  (EXP)
L-ascorbic acid  (EXP,ISO)
L-cysteine  (ISO)
L-leucine  (ISO)
L-threonine  (ISO)
Lafutidine  (EXP)
lamivudine  (EXP)
lansoprazole  (EXP)
lanthanum trichloride  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (EXP,ISO)
lipoxin A4  (ISO)
liquiritigenin  (EXP)
liquiritin  (EXP)
lisinopril dihydrate  (ISO)
lovastatin  (EXP)
loxoprofen  (EXP)
lupeol  (EXP,ISO)
luteolin  (EXP)
malathion  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP,ISO)
mangiferin  (ISO)
mechlorethamine  (ISO)
melatonin  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
mesalamine  (EXP,ISO)
Mesna  (ISO)
metacetamol  (ISO)
metformin  (ISO)
methimazole  (EXP)
methotrexate  (EXP)
methylene blue  (EXP)
metoclopramide  (ISO)
mirabegron  (EXP)
mirtazapine  (EXP)
MitoTEMPO  (ISO)
MK 571  (ISO)
ML-7  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP,ISO)
monotropein  (ISO)
montelukast  (EXP)
Morphiceptin  (ISO)
N'-acetylisoniazid  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N,N-dimethylformamide  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-[3-(aminomethyl)benzyl]acetamidine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
n-propyl gallate  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naproxen  (ISO)
naringin  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nicorandil  (EXP)
nicotine  (EXP)
nimesulide  (EXP,ISO)
nitric oxide  (EXP,ISO)
nitroflurbiprofen  (EXP)
nitrogen dioxide  (ISO)
nitroglycerin  (EXP)
nitrososulfamethoxazole  (ISO)
notoginsenoside R1  (EXP,ISO)
NSC 23766  (ISO)
o-anisidine  (ISO)
o-toluidine  (ISO)
obeticholic acid  (ISO)
octadecanoic acid  (ISO)
olaparib  (ISO)
olmesartan  (EXP)
Olmesartan medoxomil  (EXP)
omeprazole  (EXP,ISO)
omethoate  (EXP)
Ono-AE1-329  (EXP)
oxaliplatin  (ISO)
p-toluidine  (ISO)
paclitaxel  (EXP)
pantoprazole  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentetrazol  (EXP)
pentobarbital  (EXP)
Pentoxifylline  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phenol  (ISO)
phenol red  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (EXP)
platycodin D  (EXP)
PNU-282987  (ISO)
polymyxin B2  (ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (EXP)
potassium chloride  (ISO)
potassium cyanide  (ISO)
prednisolone  (EXP,ISO)
probenecid  (ISO)
procainamide  (ISO)
procyanidin B2  (EXP)
progesterone  (ISO)
prostaglandin E2  (EXP)
putrescine  (ISO)
pyridaben  (ISO)
Pyridostigmine bromide  (EXP)
pyrrolidine dithiocarbamate  (ISO)
pyrvinium  (EXP)
quercetin  (EXP,ISO)
quetiapine fumarate  (ISO)
raloxifene  (EXP)
ranitidine  (EXP)
Rebamipide  (EXP,ISO)
resolvin D1  (ISO)
resolvin D2  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
riboflavin  (EXP)
rifampicin  (EXP)
rifaximin  (ISO)
rolipram  (EXP,ISO)
rosmarinic acid  (EXP)
rotenone  (EXP,ISO)
ruthenium red  (ISO)
rutin  (EXP)
ruxolitinib  (ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
salicylic acid  (ISO)
saxagliptin  (EXP)
SB 203580  (EXP,ISO)
scalaradial  (ISO)
senecionine  (ISO)
serotonin  (ISO)
serpentine asbestos  (ISO)
sevoflurane  (EXP)
sildenafil citrate  (EXP)
silibinin  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP)
Sinomenine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium azide  (EXP,ISO)
sodium chloride  (ISO)
sodium cyanide  (ISO)
sodium fluoride  (EXP)
sodium hypochlorite  (ISO)
sodium nitrate  (EXP)
sodium thiosulfate pentahydrate  (EXP)
spermine  (ISO)
spironolactone  (EXP)
stattic  (ISO)
streptozocin  (EXP,ISO)
sulfamethoxazole  (ISO)
sulfasalazine  (EXP,ISO)
sulfur dioxide  (EXP)
superoxide  (ISO)
synephrine  (ISO)
syringic acid  (ISO)
syringin  (ISO)
T-2 toxin  (ISO)
tacrolimus hydrate  (EXP)
taurine  (EXP,ISO)
taurocholic acid  (EXP)
telmisartan  (EXP,ISO)
TEMPO  (ISO)
tenofovir disoproxil fumarate  (EXP)
terbufos  (ISO)
terbutaline  (ISO)
tetrachloromethane  (EXP,ISO)
tetracyclines  (ISO)
tetramethylpyrazine  (ISO)
thalidomide  (ISO)
theophylline  (EXP,ISO)
thiabendazole  (ISO)
thiazolidines  (EXP)
thioacetamide  (EXP,ISO)
thiophenes  (ISO)
thymoquinone  (EXP)
tianeptine  (EXP)
tiquizium bromide  (EXP)
titanium dioxide  (ISO)
trans-caffeic acid  (EXP,ISO)
tributylstannane  (EXP)
trichloroacetic acid  (ISO)
trichostatin A  (ISO)
trimethylenediamine  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tropisetron  (EXP,ISO)
tungsten  (ISO)
umbelliferone  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
usnic acid  (EXP)
valproic acid  (EXP,ISO)
verapamil  (EXP)
vinclozolin  (EXP)
Vinpocetine  (ISO)
vitamin E  (EXP)
warfarin  (EXP)
WIN 55212-2  (ISO)
withaferin A  (EXP)
wortmannin  (EXP,ISO)
zafirlukast  (EXP)
zearalenone  (EXP,ISO)
zileuton  (EXP,ISO)
zinc atom  (EXP)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
azurophil granule  (IEA,ISO)
extracellular space  (IBA,IDA,IEA,ISO)
nucleoplasm  (IEA,ISO)
secretory granule  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Levels of IL-8 and myeloperoxidase in the lungs of pneumonia patients. Abul H, etal., Mol Cell Biochem. 2001 Jan;217(1-2):107-12.
2. Susceptibility to arsenic-induced hyperkeratosis and oxidative stress genes myeloperoxidase and catalase. Ahsan H, etal., Cancer Lett. 2003 Nov 10;201(1):57-65.
3. Bronchoalveolar matrix metalloproteinase 9 relates to restrictive lung function impairment in systemic sclerosis. Andersen GN, etal., Respir Med. 2007 Oct;101(10):2199-206. Epub 2007 Jul 20.
4. Critical role of myeloperoxidase and nicotinamide adenine dinucleotide phosphate-oxidase in high-burden systemic infection of mice with Candida albicans. Aratani Y, etal., J Infect Dis. 2002 Jun 15;185(12):1833-7. doi: 10.1086/340635. Epub 2002 May 16.
5. Effect of sodium bicarbonate in an experimental model of radiocontrast nephropathy. Barlak A, etal., Ren Fail. 2010;32(8):992-9.
6. Association of the G-463A myeloperoxidase gene polymorphism with renal disease in African Americans with systemic lupus erythematosus. Bouali H, etal., J Rheumatol. 2007 Oct;34(10):2028-34. Epub 2007 Sep 15.
7. Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice. Brovkovych V, etal., Am J Physiol Lung Cell Mol Physiol. 2008 Jul;295(1):L96-103. Epub 2008 Apr 18.
8. Lycopene inhibits caspase-3 activity and reduces oxidative organ damage in a rat model of thermal injury. Cevik O, etal., Burns. 2012 Sep;38(6):861-71. doi: 10.1016/j.burns.2012.01.006. Epub 2012 Feb 20.
9. THE ROLE OF CALCITONIN RECEPTOR-LIKE RECEPTOR IN COLONIC MOTILITY AND INFLAMMATION. Clifton MS, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Mar 15;.
10. Inhibition of myeloperoxidase release from rat polymorphonuclear leukocytes by a series of azachalcone derivatives. Edwards ML, etal., J Med Chem. 1994 Dec 9;37(25):4357-62.
11. 15-epi-lipoxin A4 inhibits myeloperoxidase signaling and enhances resolution of acute lung injury. El Kebir D, etal., Am J Respir Crit Care Med. 2009 Aug 15;180(4):311-9. Epub 2009 May 29.
12. Melatonin improves cardiovascular function and ameliorates renal, cardiac and cerebral damage in rats with renovascular hypertension. Ersahin M, etal., J Pineal Res. 2009 Aug;47(1):97-106. Epub 2009 Jun 22.
13. Montelukast inhibits caspase-3 activity and ameliorates oxidative damage in the spinal cord and urinary bladder of rats with spinal cord injury. Ersahin M, etal., Prostaglandins Other Lipid Mediat. 2012 Sep 15. pii: S1098-8823(12)00119-0. doi: 10.1016/j.prostaglandins.2012.09.002.
14. Serum ECP and MPO are increased during exacerbations of chronic bronchitis with airway obstruction. Fiorini G, etal., Biomed Pharmacother. 2000 Jun;54(5):274-8.
15. Myeloperoxidase and adenosine-deaminase levels in the pleural fluid leakage induced by carrageenan in the mouse model of pleurisy. Frode TS and Medeiros YS, Mediators Inflamm. 2001 Aug;10(4):223-7.
16. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
17. Dexmedetomidine attenuates remote lung injury induced by renal ischemia-reperfusion in mice. Gu J, etal., Acta Anaesthesiol Scand. 2011 Nov;55(10):1272-8. doi: 10.1111/j.1399-6576.2011.02526.x. Epub 2011 Sep 26.
18. The oxidation induced by anti-MPO antibodies triggers fibrosis in microscopic polyangiitis. Guilpain P, etal., Eur Respir J. 2010 Nov 11.
19. Serum levels of eosinophilic cationic protein (ECP), myeloperoxidase (MPO), lipid peroxidation products, interleukin (IL)-5 and interferon (IFN)-gamma in children with bronchial asthma at acute asthma attack and remission. Kalayci O, etal., Turk J Pediatr. 2000 Jan-Mar;42(1):9-16.
20. Association of a myeloperoxidase promoter polymorphism with multiple sclerosis. Kantarci OH, etal., J Neuroimmunol 2000 Jun 26;105(2):189-94.
21. Halofuginone has a beneficial effect on gentamicin-induced acute nephrotoxicity in rats. Karakoyun B, etal., Drug Chem Toxicol. 2009;32(4):312-8.
22. [MPO-positive cells and extracellular MPO in the glomeruli of MPO-ANCA-associated glomerulonephritis]. Kawashima S, etal., Nihon Jinzo Gakkai Shi. 2009;51(1):56-67.
23. [Changes in nitric oxide, prostaglandins and myeloperoxidase activity in acrolein-induced cystitis in rats]. Linares-Fernandez B and Alfieri AB, Invest Clin. 2009 Mar;50(1):23-33.
24. [A study on tumor necrosis factor alpha, macrophage inflammatory protein-2 and myeloperoxidase in blood, broncho-alveolar fluid and lung tissues of rat chronic bronchitis model]. Ma N, etal., Zhonghua Nei Ke Za Zhi. 1999 Aug;38(8):523-6.
25. Myeloperoxidase is critically involved in the induction of organ damage after renal ischemia reperfusion. Matthijsen RA, etal., Am J Pathol. 2007 Dec;171(6):1743-52. Epub 2007 Nov 30.
26. Diazoxide attenuates indomethacin-induced small intestinal damage in the rat. Menozzi A, etal., Eur J Pharmacol. 2011 Jan 10;650(1):378-83. Epub 2010 Oct 13.
27. Analysis of differential gene expression in rat tibia after an osteogenic stimulus in vivo: mechanical loading regulates osteopontin and myeloperoxidase. Miles RR, etal., J Cell Biochem. 1998 Mar 1;68(3):355-65.
28. Novel dry powder formulation of ovalbumin for development of COPD-like animal model: Physicochemical characterization and biomarker profiling in rats. Misaka S, etal., Eur J Pharm Sci. 2009 Jun 28;37(3-4):469-76. Epub 2009 Apr 10.
29. Myeloperoxidase and superoxide dismutase 2 polymorphisms comodulate the risk of hepatocellular carcinoma and death in alcoholic cirrhosis. Nahon P, etal., Hepatology. 2009 Nov;50(5):1484-93. doi: 10.1002/hep.23187.
30. A variant in myeloperoxidase promoter hastens the emergence of hepatocellular carcinoma in patients with HCV-related cirrhosis. Nahon P, etal., J Hepatol. 2012 Feb;56(2):426-32. doi: 10.1016/j.jhep.2011.08.010. Epub 2011 Sep 8.
31. Protein nitration in rat lungs during hyperoxia exposure: a possible role of myeloperoxidase. Narasaraju TA, etal., Am J Physiol Lung Cell Mol Physiol 2003 Nov;285(5):L1037-45. Epub 2003 Aug 15.
32. Endogenous myeloperoxidase promotes neutrophil-mediated renal injury, but attenuates T cell immunity inducing crescentic glomerulonephritis. Odobasic D, etal., J Am Soc Nephrol. 2007 Mar;18(3):760-70. Epub 2007 Jan 31.
33. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
34. A functional variant of the myeloperoxidase gene is associated with cardiovascular disease in end-stage renal disease patients. Pecoits-Filho R, etal., Kidney Int Suppl. 2003 May;(84):S172-6.
35. Effects of gold nanoparticles on endotoxin-induced uveitis in rats. Pereira DV, etal., Invest Ophthalmol Vis Sci. 2012 Dec 7;53(13):8036-41. doi: 10.1167/iovs.12-10743.
36. Polymorphisms in the myeloperoxidase gene locus are associated with acute kidney injury-related outcomes. Perianayagam MC, etal., Kidney Int. 2012 Oct;82(8):909-19. doi: 10.1038/ki.2012.235. Epub 2012 Jun 27.
37. Neuroinflammation after neonatal hypoxia-ischemia is associated with alterations in the purinergic system: adenosine deaminase 1 isoenzyme is the most predominant after insult. Pimentel VC, etal., Mol Cell Biochem. 2015 May;403(1-2):169-77. doi: 10.1007/s11010-015-2347-9. Epub 2015 Feb 27.
38. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
39. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
40. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
41. Genetic variation of myeloperoxidase gene contributes to atopic asthma susceptibility: a preliminary association study in Russian population. Polonikov AV, etal., J Asthma. 2009 Jun;46(5):523-8.
42. Myeloperoxidase promoter polymorphism -463G is associated with more severe clinical expression of cystic fibrosis pulmonary disease. Reynolds WF, etal., Mediators Inflamm. 2006;2006(2):36735.
43. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
44. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
45. Diagnostic efficacy of myeloperoxidase for the detection of acute coronary syndromes. Sawicki M, etal., Eur J Clin Invest. 2011 Jan 12. doi: 10.1111/j.1365-2362.2010.02457.x.
46. Opposing effects of emphysema, hay fever, and select genetic variants on lung cancer risk. Schabath MB, etal., Am J Epidemiol. 2005 Mar 1;161(5):412-22.
47. Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy. Sigurs N, etal., Acta Paediatr. 1994 Nov;83(11):1151-5.
48. Ischemia-reperfusion injury-induced pulmonary mitochondrial damage. Sommer SP, etal., J Heart Lung Transplant. 2011 Apr 4.
49. Aging effect on myeloperoxidase in rat kidney and its modulation by calorie restriction. Son TG, etal., Free Radic Res. 2005 Mar;39(3):283-9.
50. Protective effect of infliximab on ischemia/reperfusion-induced damage in rat kidney. Tasdemir C, etal., Ren Fail. 2012;34(9):1144-9. doi: 10.3109/0886022X.2012.717490. Epub 2012 Sep 6.
51. Multiple risk markers for atherogenesis associated with chronic inflammation are detectable in patients with renal stones. Tsao KC, etal., J Clin Lab Anal. 2007;21(6):426-31.
52. The effect of experimental diabetes on the circadian pattern of adenosine deaminase and myeloperoxidase activities in rat liver. Uluoglu C, etal., Gen Physiol Biophys. 2008 Mar;27(1):25-31.
53. Evaluation of thiol-based antioxidant therapeutics in cystic fibrosis sputum: Focus on myeloperoxidase. Vasu VT, etal., Free Radic Res. 2011 Feb;45(2):165-76. Epub 2010 Oct 18.
54. Prognostic value of plasma myeloperoxidase in ESRD patients. Wang AY, etal., Am J Kidney Dis. 2010 Nov;56(5):937-46. Epub 2010 Jul 16.
55. Galantamine anti-colitic effect: Role of alpha-7 nicotinic acetylcholine receptor in modulating Jak/STAT3, NF-κB/HMGB1/RAGE and p-AKT/Bcl-2 pathways. Wazea SA, etal., Sci Rep. 2018 Mar 23;8(1):5110. doi: 10.1038/s41598-018-23359-6.
56. Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinoma. Wheatley-Price P, etal., Cancer. 2008 Mar 1;112(5):1037-42.
57. Clinical features of patients with anti-neutrophil cytoplasmic autoantibodies targeting native myeloperoxidase antigen. Yamanishi Y, etal., Mod Rheumatol. 2012 Oct 21.
Additional References at PubMed
PMID:2981589   PMID:10085024   PMID:10772654   PMID:11792727   PMID:11907569   PMID:11980719   PMID:12089442   PMID:14613914   PMID:14651853   PMID:15159534   PMID:15878909   PMID:16502470  
PMID:17072967   PMID:17950080   PMID:18283562   PMID:18617697   PMID:19056867   PMID:19301098   PMID:19330621   PMID:20228064   PMID:21327394   PMID:21630459   PMID:21704008   PMID:23376485  
PMID:23533145   PMID:23691142   PMID:24035742   PMID:25404055   PMID:25645918   PMID:26474698   PMID:28131839   PMID:28466093   PMID:29270751   PMID:32762560   PMID:37981258  


Genomics

Comparative Map Data
Mpo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81073,092,124 - 73,102,057 (+)NCBIGRCr8
mRatBN7.21072,594,883 - 72,608,862 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1072,594,661 - 72,604,819 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1077,205,622 - 77,215,277 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01076,710,570 - 76,720,225 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01072,175,076 - 72,184,731 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01075,087,892 - 75,098,260 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1075,087,892 - 75,098,260 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01075,004,128 - 75,014,496 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41076,085,872 - 76,097,012 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1071,507,771 - 71,517,382 (+)NCBICelera
Cytogenetic Map10q26NCBI
MPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381758,269,855 - 58,280,935 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1758,269,855 - 58,280,935 (-)EnsemblGRCh38hg38GRCh38
GRCh371756,347,216 - 56,358,296 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361753,702,216 - 53,713,295 (-)NCBINCBI36Build 36hg18NCBI36
Build 341753,702,215 - 53,713,295NCBI
Celera1752,808,995 - 52,820,066 (-)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1751,708,013 - 51,718,966 (-)NCBIHuRef
CHM1_11756,412,238 - 56,423,315 (-)NCBICHM1_1
T2T-CHM13v2.01759,137,736 - 59,148,814 (-)NCBIT2T-CHM13v2.0
Mpo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391187,684,610 - 87,695,238 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1187,684,407 - 87,695,239 (+)EnsemblGRCm39 Ensembl
GRCm381187,793,784 - 87,804,412 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1187,793,581 - 87,804,413 (+)EnsemblGRCm38mm10GRCm38
MGSCv371187,607,286 - 87,617,914 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361187,609,776 - 87,620,592 (+)NCBIMGSCv36mm8
Celera1197,389,547 - 97,400,150 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1152.22NCBI
Mpo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554514,743,744 - 4,753,358 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554514,743,744 - 4,753,358 (+)NCBIChiLan1.0ChiLan1.0
MPO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21974,441,104 - 74,453,615 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11779,252,255 - 79,263,874 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01752,333,882 - 52,357,838 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11757,189,654 - 57,212,111 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1757,201,073 - 57,212,111 (-)Ensemblpanpan1.1panPan2
MPO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1932,927,483 - 32,938,007 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl932,927,483 - 32,937,820 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha932,164,643 - 32,175,070 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0933,734,267 - 33,744,696 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl933,734,273 - 33,744,637 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1932,520,407 - 32,530,846 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0932,803,860 - 32,814,324 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0932,897,366 - 32,907,792 (-)NCBIUU_Cfam_GSD_1.0
Mpo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560232,254,998 - 32,265,476 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364904,809,631 - 4,819,070 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364904,809,773 - 4,819,070 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1234,556,408 - 34,567,904 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11234,557,031 - 34,570,091 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21236,245,391 - 36,256,372 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MPO
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11635,120,194 - 35,130,851 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1635,120,581 - 35,130,671 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660775,935,107 - 5,946,375 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mpo
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624871121,026 - 131,323 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624871121,026 - 131,433 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mpo
44 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:228
Count of miRNA genes:171
Interacting mature miRNAs:187
Transcripts:ENSRNOT00000065910, ENSRNOT00000066474
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106694181373452992Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
12903245Cm110Cardiac mass QTL 1100.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)107111521772606468Rat
12903246Cm111Cardiac mass QTL 1110.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)107111521772606468Rat
12903247Cm112Cardiac mass QTL 1120.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107111521772606468Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
12902615Bw185Body weight QTL 1850.01body mass (VT:0001259)body weight (CMO:0000012)107111521772606468Rat
12903248Am14Aortic mass QTL 140.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)107111521772606468Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
12903249Kidm68Kidney mass QTL 680.02kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)107111521772606468Rat
1579918Bp279Blood pressure QTL 2790.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107111521772606468Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106750210873579767Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat

Markers in Region
D10Chm35  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21072,597,457 - 72,597,695 (+)MAPPERmRatBN7.2
Rnor_6.01075,090,892 - 75,091,129NCBIRnor6.0
Rnor_5.01075,011,259 - 75,011,496UniSTSRnor5.0
RGSC_v3.41076,088,872 - 76,089,109UniSTSRGSC3.4
Celera1071,510,771 - 71,511,006UniSTS
Cytogenetic Map10q26UniSTS
RH144619  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81073,101,517 - 73,102,055 (+)Marker Load Pipeline
mRatBN7.21072,604,279 - 72,604,817 (+)MAPPERmRatBN7.2
Rnor_6.01075,097,721 - 75,098,258NCBIRnor6.0
Rnor_5.01075,004,130 - 75,004,667UniSTSRnor5.0
RGSC_v3.41076,096,473 - 76,097,010UniSTSRGSC3.4
Celera1071,516,843 - 71,517,380UniSTS
Cytogenetic Map10q26UniSTS


Genetic Models
This gene Mpo is modified in the following models/strains:
SD-Mpoem1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
8 11 35 63 80 77 48 25 48 6 188 83 43 41 57 29

Sequence


Ensembl Acc Id: ENSRNOT00000065910   ⟹   ENSRNOP00000062232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1072,594,661 - 72,604,819 (+)Ensembl
Rnor_6.0 Ensembl1075,087,892 - 75,098,260 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000066474   ⟹   ENSRNOP00000059901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1075,089,928 - 75,097,933 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000081951   ⟹   ENSRNOP00000071759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1072,594,661 - 72,604,819 (+)Ensembl
Rnor_6.0 Ensembl1075,088,422 - 75,098,258 (+)Ensembl
RefSeq Acc Id: NM_001401812   ⟹   NP_001388741
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81073,092,402 - 73,102,057 (+)NCBI
mRatBN7.21072,595,164 - 72,604,819 (+)NCBI
RefSeq Acc Id: XM_006247095   ⟹   XP_006247157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81073,092,128 - 73,102,057 (+)NCBI
mRatBN7.21072,594,883 - 72,604,819 (+)NCBI
Rnor_6.01075,088,113 - 75,098,260 (+)NCBI
Rnor_5.01075,004,128 - 75,014,496 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247096   ⟹   XP_006247158
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81073,092,124 - 73,102,057 (+)NCBI
mRatBN7.21072,594,883 - 72,604,694 (+)NCBI
Rnor_6.01075,088,112 - 75,098,161 (+)NCBI
Rnor_5.01075,004,128 - 75,014,496 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063269097   ⟹   XP_063125167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81073,092,275 - 73,102,057 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001388741 (Get FASTA)   NCBI Sequence Viewer  
  XP_006247157 (Get FASTA)   NCBI Sequence Viewer  
  XP_006247158 (Get FASTA)   NCBI Sequence Viewer  
  XP_063125167 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM05612 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000062232.2
  ENSRNOP00000071759
  ENSRNOP00000071759.2
RefSeq Acc Id: XP_006247157   ⟸   XM_006247095
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K1A2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247158   ⟸   XM_006247096
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K1A2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062232   ⟸   ENSRNOT00000065910
Ensembl Acc Id: ENSRNOP00000059901   ⟸   ENSRNOT00000066474
Ensembl Acc Id: ENSRNOP00000071759   ⟸   ENSRNOT00000081951
RefSeq Acc Id: NP_001388741   ⟸   NM_001401812
- Peptide Label: precursor
- UniProtKB: A0A0G2K1A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063125167   ⟸   XM_063269097
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K1A2 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K1A2-F1-model_v2 AlphaFold A0A0G2K1A2 1-718 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1592081 AgrOrtholog
BioCyc Gene G2FUF-23741 BioCyc
Ensembl Genes ENSRNOG00000008310 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065910.4 UniProtKB/TrEMBL
  ENSRNOT00000081951 ENTREZGENE
  ENSRNOT00000081951.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.640.10 UniProtKB/TrEMBL
InterPro Haem_peroxidase UniProtKB/TrEMBL
  Haem_peroxidase_animal_sg UniProtKB/TrEMBL
  Haem_peroxidase_sf UniProtKB/TrEMBL
NCBI Gene 303413 ENTREZGENE
PANTHER OXIDASE/PEROXIDASE UniProtKB/TrEMBL
  PTHR11475:SF108 UniProtKB/TrEMBL
Pfam An_peroxidase UniProtKB/TrEMBL
PharmGKB MPO RGD
PhenoGen Mpo PhenoGen
PRINTS ANPEROXIDASE UniProtKB/TrEMBL
PROSITE PEROXIDASE_3 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008310 RatGTEx
Superfamily-SCOP Peroxidase_super UniProtKB/TrEMBL
UniProt A0A0G2K1A2 ENTREZGENE, UniProtKB/TrEMBL
  A6HHV7_RAT UniProtKB/TrEMBL
  D3ZGE2_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-04-13   myeloperoxidase  Mpo  myeloperoxidase (mapped)  Name updated 737654 APPROVED
2007-04-11 Mpo  myeloperoxidase (mapped)  Mpo_mapped  myeloperoxidase (mapped)  Data merged from RGD:3108 737654 APPROVED
2006-11-20 Mpo  myeloperoxidase (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Mpo_mapped  myeloperoxidase (mapped)      Symbol and Name updated 1556543 APPROVED
2002-06-10 Mpo  Myeloperoxidase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may contribute to hyperoxia-mediated lung injury via nitration of proteins, resulting in reactive nitrogen species 1302251
gene_expression expressed in lung tissue 1302251
gene_function mediates protein nitration during hypoxia 1302251