Prkar1a (protein kinase cAMP-dependent type I regulatory subunit alpha) - Rat Genome Database

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Gene: Prkar1a (protein kinase cAMP-dependent type I regulatory subunit alpha) Rattus norvegicus
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Symbol: Prkar1a
Name: protein kinase cAMP-dependent type I regulatory subunit alpha
RGD ID: 3391
Description: Enables cAMP binding activity and cAMP-dependent protein kinase regulator activity. Involved in female meiotic nuclear division; negative regulation of meiotic nuclear division; and regulation of protein kinase activity. Located in cytoplasm. Part of cAMP-dependent protein kinase complex. Human ortholog(s) of this gene implicated in Carney complex; acrodysostosis; and primary pigmented nodular adrenocortical disease. Orthologous to human PRKAR1A (protein kinase cAMP-dependent type I regulatory subunit alpha); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: cAMP-dependent protein kinase type I-alpha regulatory subunit; Protein kinase cAMP dependent regulatory type 1; protein kinase cAMP-dependent type 1 regulatory subunit alpha; protein kinase, cAMP dependent regulatory, type I, alpha; Protein kinase, cAMP dependent, regulatory, type 1; protein kinase, cAMP-dependent, regulatory subunit type I alpha; protein kinase, cAMP-dependent, regulatory, type I, alpha; RIIA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Prkar1a-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
NCBI Annotation Information: Note: On NCBI's build 4.2, GeneID 25725 (Prkar1a) was annotated incorrectly on chromosome X of the reference assembly but annotated correctly on chromosome 10 of the alternate Celera assembly. The chromosome X location appears to be a Prkar1a pseudogene now represented by GeneID 100510791 and the Reference Sequence NG_027837. [17 Jun 2014]
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21094,621,042 - 94,639,534 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1094,620,039 - 94,639,041 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1099,678,564 - 99,695,215 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01099,141,642 - 99,158,293 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01094,551,627 - 94,568,234 (+)NCBIRnor_WKY
Rnor_6.01097,940,705 - 97,959,199 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1097,940,705 - 97,957,336 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01097,655,261 - 97,671,804 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410148,642,200 - 148,642,454 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11099,121,411 - 99,121,777 (+)NCBI
Celera1093,279,500 - 93,296,131 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-nitropyrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
3',5'-cyclic AMP  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
8-Br-cAMP  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
carbon nanotube  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
D-gluconic acid  (EXP)
deguelin  (ISO)
deoxycholic acid  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (EXP,ISO)
fenpyroximate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
lead diacetate  (ISO)
methapyrilene  (EXP)
methylparaben  (ISO)
Mitotane  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
phenobarbital  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
procymidone  (EXP)
propiconazole  (ISO)
quinoline  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP)
tetrahydropalmatine  (ISO)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
apoptotic cell death pathway  (IEA)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
insulin signaling pathway  (IEA)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
protein kinase A (PKA) signaling pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Association of dystrobrevin and regulatory subunit of protein kinase A: a new role for dystrobrevin as a scaffold for signaling proteins. Ceccarini M, etal., J Mol Biol. 2007 Aug 31;371(5):1174-87. doi: 10.1016/j.jmb.2007.06.019. Epub 2007 Jun 14.
2. Differential effects of haloperidol and clozapine on cAMP binding, protein kinase A (PKA) activity, and mRNA and protein expression of selective regulatory and catalytic subunit isoforms of PKA in rat brain. Dwivedi Y, etal., J Pharmacol Exp Ther. 2002 Apr;301(1):197-209.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Mutations of the PRKAR1A gene in Cushing's syndrome due to sporadic primary pigmented nodular adrenocortical disease. Groussin L, etal., J Clin Endocrinol Metab. 2002 Sep;87(9):4324-9.
6. Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. Kirschner LS, etal., Nat Genet. 2000 Sep;26(1):89-92.
7. Expression and modification of PKA and AKAPs during meiosis in rat oocytes. Kovo M, etal., Mol Cell Endocrinol 2002 Jun 28;192(1-2):105-13.
8. An active protein kinase A (PKA) is involved in meiotic arrest of rat growing oocytes. Kovo M, etal., Reproduction. 2006 Jul;132(1):33-43.
9. Molecular cloning and cDNA structure of the regulatory subunit of type I cAMP-dependent protein kinase from rat brain. Kuno T, etal., Biochem Biophys Res Commun 1987 Jul 31;146(2):878-83.
10. cAMP-Dependent PKA negatively regulates polyadenylation of c-mos mRNA in rat oocytes. Lazar S, etal., Mol Endocrinol 2002 Feb;16(2):331-41.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Clustered distribution of cAMP-dependent protein kinase regulatory isoform RI alpha during the development of the rat brain. Mucignat-Caretta C and Caretta A, J Comp Neurol. 2002 Sep 30;451(4):324-33.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
17. GOA pipeline RGD automated data pipeline
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
21. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
22. Myomegalin is a novel A-kinase anchoring protein involved in the phosphorylation of cardiac myosin binding protein C. Uys GM, etal., BMC Cell Biol. 2011 May 10;12:18. doi: 10.1186/1471-2121-12-18.
23. The conformationally dynamic C helix of the RIalpha subunit of protein kinase A mediates isoform-specific domain reorganization upon C subunit binding. Vigil D, etal., J Biol Chem. 2005 Oct 21;280(42):35521-7. Epub 2005 Aug 17.
Additional References at PubMed
PMID:7775586   PMID:8794865   PMID:12004056   PMID:12475942   PMID:12815184   PMID:15299028   PMID:15381255   PMID:17895835   PMID:17911601   PMID:18316483   PMID:19946888   PMID:20581396  
PMID:21423175   PMID:21502359   PMID:21812984   PMID:22674394   PMID:24307699   PMID:24413018   PMID:24501172   PMID:25097019   PMID:25587115   PMID:30026308   PMID:30053369  


Genomics

Comparative Map Data
Prkar1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21094,621,042 - 94,639,534 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1094,620,039 - 94,639,041 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1099,678,564 - 99,695,215 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01099,141,642 - 99,158,293 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01094,551,627 - 94,568,234 (+)NCBIRnor_WKY
Rnor_6.01097,940,705 - 97,959,199 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1097,940,705 - 97,957,336 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01097,655,261 - 97,671,804 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410148,642,200 - 148,642,454 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11099,121,411 - 99,121,777 (+)NCBI
Celera1093,279,500 - 93,296,131 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
PRKAR1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381768,413,623 - 68,551,316 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1768,511,780 - 68,551,319 (+)EnsemblGRCh38hg38GRCh38
GRCh371766,409,764 - 66,547,457 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361764,019,705 - 64,040,506 (+)NCBINCBI36Build 36hg18NCBI36
Build 341764,020,137 - 64,040,503NCBI
Celera1763,079,899 - 63,100,701 (+)NCBICelera
Cytogenetic Map17q24.2NCBI
HuRef1761,893,655 - 61,933,191 (+)NCBIHuRef
CHM1_11766,572,677 - 66,612,184 (+)NCBICHM1_1
T2T-CHM13v2.01769,290,146 - 69,428,169 (+)NCBIT2T-CHM13v2.0
Prkar1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911109,539,849 - 109,560,489 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11109,540,231 - 109,560,482 (+)EnsemblGRCm39 Ensembl
GRCm3811109,649,023 - 109,669,663 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11109,649,405 - 109,669,656 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711109,512,263 - 109,530,962 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611109,467,039 - 109,485,738 (+)NCBIMGSCv36mm8
Celera11121,389,458 - 121,408,159 (+)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1172.33NCBI
Prkar1a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554784,241,283 - 4,263,087 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554784,241,283 - 4,262,119 (-)NCBIChiLan1.0ChiLan1.0
PRKAR1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11767,838,484 - 67,859,610 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1767,838,484 - 67,877,943 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01762,448,718 - 62,488,493 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PRKAR1A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1915,180,940 - 15,203,035 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl915,181,393 - 15,200,683 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha916,073,435 - 16,095,493 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0916,843,167 - 16,864,963 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl916,843,199 - 16,864,958 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1915,788,124 - 15,809,877 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0911,723,365 - 11,745,163 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0911,723,316 - 11,745,376 (-)NCBIUU_Cfam_GSD_1.0
Prkar1a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560211,330,929 - 11,348,727 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365417,845,876 - 7,863,677 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKAR1A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1211,662,347 - 11,681,373 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11211,662,344 - 11,681,490 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21212,130,798 - 12,147,739 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap12p14NCBI
PRKAR1A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11653,021,666 - 53,042,594 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1653,023,963 - 53,042,493 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607723,949,350 - 23,970,349 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkar1a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248703,552,745 - 3,574,880 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248703,552,608 - 3,575,461 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Prkar1a
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:176
Count of miRNA genes:122
Interacting mature miRNAs:133
Transcripts:ENSRNOT00000071153
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631538Oia5Oil induced arthritis QTL 5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087055121107211142Rat
2313856Bp342Blood pressure QTL 3424.40.0001life span trait (VT:0005372)age at time of death (CMO:0001193)108730761796121100Rat
61363Oia3Oil induced arthritis QTL 30.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1087307617107211142Rat
634320Niddm49Non-insulin dependent diabetes mellitus QTL 494.41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1088539139107211142Rat
12880395Cm109Cardiac mass QTL 1090.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1090404397107211142Rat
12880396Am13Aortic mass QTL 130.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1090404397107211142Rat
12880398Kidm67Kidney mass QTL 670.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1090404397107211142Rat
12880384Cm107Cardiac mass QTL 1070.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)90404397107211142Rat
12880385Cm108Cardiac mass QTL 1080.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)90404397107211142Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
1300137Bp186Blood pressure QTL 1863.57arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1090627439107057807Rat
724530Bp149Blood pressure QTL 1490.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090627439107211142Rat
1558652Bw57Body weight QTL 574.20.0008body mass (VT:0001259)body weight (CMO:0000012)1090910316107211142Rat
61436Cia5Collagen induced arthritis QTL 54.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1091228102104060283Rat
70168Eae12Experimental allergic encephalomyelitis QTL 120.0009nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)1092238497101012337Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat

Markers in Region
RH131422  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21094,620,396 - 94,620,556 (+)MAPPERmRatBN7.2
Rnor_6.01097,940,061 - 97,940,220NCBIRnor6.0
Rnor_5.01097,654,617 - 97,654,776UniSTSRnor5.0
Celera1093,278,856 - 93,279,015UniSTS
Cytogenetic Map10q32.1UniSTS
RH94506  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21094,637,555 - 94,637,650 (+)MAPPERmRatBN7.2
mRatBN7.2X141,340,349 - 141,340,444 (-)MAPPERmRatBN7.2
mRatBN7.2X141,340,349 - 141,340,444 (+)MAPPERmRatBN7.2
mRatBN7.21094,637,555 - 94,637,650 (-)MAPPERmRatBN7.2
Rnor_6.01097,957,221 - 97,957,315NCBIRnor6.0
Rnor_6.0X146,072,848 - 146,072,942NCBIRnor6.0
Rnor_5.0X146,083,937 - 146,084,031UniSTSRnor5.0
Rnor_5.01097,671,689 - 97,671,783UniSTSRnor5.0
RGSC_v3.4X148,642,221 - 148,642,315UniSTSRGSC3.4
RGSC_v3.41099,107,292 - 99,107,386UniSTSRGSC3.4
Celera1093,296,016 - 93,296,110UniSTS
CeleraX137,322,754 - 137,322,848UniSTS
Cytogenetic Map10q32.1UniSTS
Cytogenetic MapXq36UniSTS
BM386718  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21094,629,142 - 94,629,292 (+)MAPPERmRatBN7.2
Rnor_6.01097,948,808 - 97,948,957NCBIRnor6.0
Rnor_5.01097,663,276 - 97,663,425UniSTSRnor5.0
Celera1093,287,603 - 93,287,752UniSTS
RH 3.4 Map101071.29UniSTS
Cytogenetic Map10q32.1UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000071153   ⟹   ENSRNOP00000067771
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1094,621,469 - 94,639,036 (+)Ensembl
Rnor_6.0 Ensembl1097,940,705 - 97,957,336 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000094613   ⟹   ENSRNOP00000095855
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1094,621,440 - 94,639,036 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000095989   ⟹   ENSRNOP00000080176
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1094,628,962 - 94,639,041 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119272   ⟹   ENSRNOP00000088358
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1094,620,039 - 94,639,041 (+)Ensembl
RefSeq Acc Id: NM_013181   ⟹   NP_037313
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21094,621,042 - 94,637,671 (+)NCBI
Rnor_6.01097,940,705 - 97,957,336 (+)NCBI
Rnor_5.01097,655,261 - 97,671,804 (+)NCBI
RGSC_v3.410148,642,200 - 148,642,454 (-)RGD
Celera1093,279,500 - 93,296,131 (+)RGD
Sequence:
RefSeq Acc Id: XM_008768311   ⟹   XP_008766533
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21094,621,406 - 94,639,534 (+)NCBI
Rnor_6.01097,941,074 - 97,959,199 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039085298   ⟹   XP_038941226
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21094,622,044 - 94,639,534 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_037313   ⟸   NM_013181
- UniProtKB: P09456 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008766533   ⟸   XM_008768311
- Peptide Label: isoform X1
- UniProtKB: P09456 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067771   ⟸   ENSRNOT00000071153
RefSeq Acc Id: XP_038941226   ⟸   XM_039085298
- Peptide Label: isoform X1
- UniProtKB: P09456 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000088358   ⟸   ENSRNOT00000119272
RefSeq Acc Id: ENSRNOP00000095855   ⟸   ENSRNOT00000094613
RefSeq Acc Id: ENSRNOP00000080176   ⟸   ENSRNOT00000095989
Protein Domains
Cyclic nucleotide-binding

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P09456-F1-model_v2 AlphaFold P09456 1-381 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697862
Promoter ID:EPDNEW_R8386
Type:initiation region
Name:Prkar1a_1
Description:protein kinase cAMP-dependent type 1 regulatory subunit alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01097,940,720 - 97,940,780EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3391 AgrOrtholog
BioCyc Gene G2FUF-22827 BioCyc
Ensembl Genes ENSRNOG00000049876 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000067771.2 UniProtKB/TrEMBL
  ENSRNOP00000080176.1 UniProtKB/TrEMBL
  ENSRNOP00000088358.1 UniProtKB/TrEMBL
  ENSRNOP00000095855.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000071153.2 UniProtKB/TrEMBL
  ENSRNOT00000094613.1 UniProtKB/TrEMBL
  ENSRNOT00000095989.1 UniProtKB/TrEMBL
  ENSRNOT00000119272.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro cAMP_dep_PK_reg_su UniProtKB/TrEMBL
  cAMP_dep_PK_reg_su_I/II_a/b UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25725 UniProtKB/Swiss-Prot
NCBI Gene 25725 ENTREZGENE
Pfam cNMP_binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIIa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Prkar1a PhenoGen
PIRSF PK_regulatory UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART cNMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RIIa UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC216814
UniProt A0A8I5ZQ48_RAT UniProtKB/TrEMBL
  A0A8I6A621_RAT UniProtKB/TrEMBL
  A0A8I6AKN7_RAT UniProtKB/TrEMBL
  A0A8L2QZB9_RAT UniProtKB/TrEMBL
  KAP0_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-03 Prkar1a  protein kinase cAMP-dependent type I regulatory subunit alpha  Prkar1a  protein kinase cAMP-dependent type 1 regulatory subunit alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-03 Prkar1a  protein kinase cAMP-dependent type 1 regulatory subunit alpha  Prkar1a  protein kinase, cAMP-dependent, regulatory subunit type I alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-30 Prkar1a  protein kinase, cAMP-dependent, regulatory subunit type I alpha  Prkar1a  protein kinase, cAMP-dependent, regulatory, type I, alpha  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Prkar1a  Protein kinase, cAMP dependent, regulatory, type 1      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function binds and inactivates the catalytic subunit of the PKA enzyme; targets different PKA isoenzymes to various subcellular loci and specific substrates 633705
gene_physical_interaction interacts with A-kinase anchoring proteins (AKAPs) 633705