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Gene: Prkar1a (protein kinase cAMP-dependent type I regulatory subunit alpha) Rattus norvegicus
Symbol: Prkar1a
Name: protein kinase cAMP-dependent type I regulatory subunit alpha
Description: Exhibits cAMP binding activity and cAMP-dependent protein kinase regulator activity. Involved in female meiotic nuclear division; negative regulation of meiotic nuclear division; and regulation of protein kinase activity. Localizes to cAMP-dependent protein kinase complex and cytoplasm. Predicted to colocalize with axoneme and immunological synapse. Human ortholog(s) of this gene implicated in Carney complex; acrodysostosis; and primary pigmented nodular adrenocortical disease. Orthologous to human PRKAR1A (protein kinase cAMP-dependent type I regulatory subunit alpha); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; amiodarone pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol 3-benzoate; 2,4,6-trinitrotoluene.
Type: protein-coding
Also known as: cAMP-dependent protein kinase type I-alpha regulatory subunit; Protein kinase cAMP dependent regulatory type 1; protein kinase cAMP-dependent type 1 regulatory subunit alpha; protein kinase, cAMP dependent regulatory, type I, alpha; Protein kinase, cAMP dependent, regulatory, type 1; protein kinase, cAMP-dependent, regulatory subunit type I alpha; protein kinase, cAMP-dependent, regulatory, type I, alpha; RIIA
Related Pseudogenes: Prkar1a-ps1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Note: On NCBI's build 4.2, GeneID 25725 (Prkar1a) was annotated incorrectly on chromosome X of the reference assembly but annotated correctly on chromosome 10 of the alternate Celera assembly. The chromosome X location appears to be a Prkar1a pseudogene now represented by GeneID 100510791 and the Reference Sequence NG_027837. [17 Jun 2014]
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01097,940,705 - 97,959,199 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1097,940,705 - 97,957,336 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01097,655,261 - 97,671,804 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410148,642,200 - 148,642,454 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11099,121,411 - 99,121,777 (+)NCBI
Celera1093,279,500 - 93,296,131 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Prkar1a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3391
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.