Abcc3 (ATP binding cassette subfamily C member 3) - Rat Genome Database

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Gene: Abcc3 (ATP binding cassette subfamily C member 3) Rattus norvegicus
Analyze
Symbol: Abcc3
Name: ATP binding cassette subfamily C member 3
RGD ID: 71101
Description: Exhibits ABC-type bile acid transporter activity. Involved in several processes, including anion transport; response to estradiol; and response to lipopolysaccharide. Localizes to basolateral plasma membrane. Biomarker of several diseases, including bilirubin metabolic disorder (multiple); fatty liver disease (multiple); hepatocellular carcinoma; hyperprolactinemia; and kidney disease (multiple). Orthologous to human ABCC3 (ATP binding cassette subfamily C member 3); PARTICIPATES IN doxorubicin pharmacokinetics pathway; etoposide pharmacodynamics pathway; etoposide pharmacokinetics pathway; INTERACTS WITH (S)-colchicine; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: ATP-binding cassette sub-family C member 3; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; ATP-binding cassette, subfamily C (CFTR/MRP), member 3; canalicular multispecific organic anion transporter 2; MLP-2; Mlp2; MRP-like protein 2; Mrp3; multidrug resistance protein 3; multidrug resistance-associated protein 3; organic anion transporter
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21079,296,681 - 79,342,749 (-)NCBI
Rnor_6.0 Ensembl1082,047,863 - 82,117,109 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01082,047,308 - 82,116,928 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01081,896,621 - 81,938,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01081,879,487 - 81,880,151 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41082,986,552 - 83,030,799 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1078,085,499 - 78,131,465 (-)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(-)-anisomycin  (ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
(S)-colchicine  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-phenylenediamine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-estradiol 17-glucosiduronic acid  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-amino-4,6-dinitrotoluene  (EXP)
2-nitrofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP)
3-phenylprop-2-enal  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5(6)-carboxy-2',7'-dichlorofluorescein  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acetaminophen O-beta-D-glucosiduronic acid  (EXP,ISO)
acrolein  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (ISO)
alfacalcidol  (ISO)
all-trans-retinoic acid  (ISO)
allyl alcohol  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-pinene  (ISO)
amikacin  (EXP)
amiodarone  (EXP,ISO)
ampicillin  (ISO)
angelicin  (EXP)
antirheumatic drug  (ISO)
aristolochic acid  (EXP)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (ISO)
ATP  (ISO)
azathioprine  (EXP)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosentan  (EXP,ISO)
bromobenzene  (EXP)
buserelin  (ISO)
butan-1-ol  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcein am  (ISO)
calcipotriol  (ISO)
calcitriol  (ISO)
captan  (ISO)
carbamazepine  (EXP)
carbon nanotube  (ISO)
cefalotin  (ISO)
chenodeoxycholic acid  (EXP,ISO)
chloroacetaldehyde  (ISO)
chloroform  (EXP)
chloroprene  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (ISO)
cholate  (ISO)
cholic acid  (ISO)
choline  (EXP,ISO)
chrysin  (ISO)
ciprofibrate  (ISO)
ciprofloxacin  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clotrimazole  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
coniferyl aldehyde  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumarin  (EXP)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cyproconazole  (EXP,ISO)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dichloroacetic acid  (ISO)
diethylstilbestrol  (ISO)
Diglycolic acid  (EXP,ISO)
dimethylarsinic acid  (EXP)
diosgenin  (EXP)
disodium selenite  (ISO)
doxorubicin  (ISO)
doxycycline  (EXP)
emodin  (EXP,ISO)
endosulfan  (EXP)
enilconazole  (ISO)
epoxiconazole  (EXP,ISO)
erythromycin estolate  (EXP)
ethanol  (EXP,ISO)
ethoxyquin  (ISO)
etoposide  (ISO)
felbamate  (EXP)
fenofibrate  (EXP)
Fexofenadine hydrochloride  (ISO)
fipronil  (EXP,ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (EXP)
furosemide  (ISO)
gamma-hexachlorocyclohexane  (EXP)
geneticin  (ISO)
genistein  (ISO)
ginsenoside Rg1  (ISO)
glutathione  (ISO)
glyburide  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
GW 4064  (ISO)
Hexachloro-1,3-butadiene  (EXP)
hexachlorobenzene  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
imipenem hydrate  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoniazide  (EXP)
isoprenaline  (EXP,ISO)
L-methionine  (EXP,ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leukotriene C4  (ISO)
lipopolysaccharide  (EXP,ISO)
lithocholic acid  (ISO)
macitentan  (ISO)
menadione  (ISO)
metformin  (EXP)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
methoxsalen  (EXP,ISO)
methylarsonic acid  (EXP)
methyltestosterone  (ISO)
metronidazole  (ISO)
metyrapone  (ISO)
mifepristone  (ISO)
MK 571  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzoylglycine  (ISO)
N-hydroxy-PhIP  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-Vinyl-2-pyrrolidone  (EXP)
naloxone  (EXP)
nefazodone  (EXP,ISO)
neomycin  (ISO)
nickel sulfate  (ISO)
nifedipine  (ISO)
nimesulide  (EXP)
nocodazole  (ISO)
obeticholic acid  (EXP)
okadaic acid  (ISO)
oltipraz  (EXP,ISO)
omeprazole  (EXP)
orphenadrine  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
p-toluidine  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
parthenolide  (ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perhexiline  (EXP)
phenethyl caffeate  (EXP)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (EXP)
PhIP  (ISO)
physcion  (EXP)
piperonyl butoxide  (EXP,ISO)
Pirarubicin  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pravastatin  (EXP)
prednisone  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
probenecid  (ISO)
prochloraz  (EXP,ISO)
progesterone  (ISO)
propanal  (ISO)
propane-1,2-diol  (ISO)
propiconazole  (EXP,ISO)
psoralen  (EXP)
pyrazinecarboxamide  (EXP)
pyrrolidines  (EXP)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
rifampicin  (ISO)
rosuvastatin calcium  (EXP)
rotenone  (EXP)
SB 203580  (ISO)
senecionine  (EXP,ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sorafenib  (ISO)
spironolactone  (EXP,ISO)
stilbene oxide  (EXP)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
tamoxifen  (EXP,ISO)
tauro-beta-muricholic acid  (EXP)
taurochenodeoxycholic acid  (EXP)
taurocholic acid  (EXP,ISO)
tauroursodeoxycholic acid  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetraphene  (ISO)
thiacloprid  (ISO)
thioacetamide  (EXP)
thiophanate-methyl  (ISO)
ticlopidine  (EXP)
titanium dioxide  (ISO)
Tolvaptan  (ISO)
triadimefon  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimethylarsine oxide  (EXP)
triphenyl phosphate  (EXP)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
verapamil  (ISO)
vincristine  (ISO)
yohimbine  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (EXP,ISO)
ziram  (ISO)

References

References - curated
1. Akita H, etal., Pharm Res. 2002 Jan;19(1):34-41.
2. Aleksandrova MI, etal., Bull Exp Biol Med. 2013 Feb;154(4):508-11.
3. Bartholomae S, etal., Pediatr Blood Cancer. 2016 Feb;63(2):242-7. doi: 10.1002/pbc.25785. Epub 2015 Oct 29.
4. Bodo A, etal., J Biol Chem 2003 Jun 27;278(26):23529-37.
5. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. GOA data from the GO Consortium
7. Hagenbuch B, etal., News Physiol Sci 2002 Dec;17:231-4.
8. Hardwick RN, etal., Drug Metab Dispos. 2012 Mar;40(3):450-60. doi: 10.1124/dmd.111.041095. Epub 2011 Nov 23.
9. Hasegawa Y, etal., J Pharm Pharmacol. 2010 Mar;62(3):310-4. doi: 10.1211/jpp.62.03.0004.
10. Hirohashi T, etal., J Biol Chem. 2000 Jan 28;275(4):2905-10. doi: 10.1074/jbc.275.4.2905.
11. Hirohashi T, etal., Mol Pharmacol 1998 Jun;53(6):1068-75.
12. Kobayashi K, etal., Pharmacogenet Genomics. 2008 Sep;18(9):823-33. doi: 10.1097/FPC.0b013e328306e9ae.
13. Konig J, etal., Hepatology 1999 Apr;29(4):1156-63.
14. Konig J, etal., Int J Cancer. 2005 Jun 20;115(3):359-67.
15. Kuroda M, etal., J Gastroenterol Hepatol. 2004 Feb;19(2):146-53.
16. Li T, etal., Am J Physiol Gastrointest Liver Physiol 2003 Sep;285(3):G602-10.
17. Lickteig AJ, etal., Drug Metab Dispos. 2007 Oct;35(10):1970-8. Epub 2007 Jul 19.
18. Lu H and Klaassen C, Drug Metab Dispos. 2008 Jan;36(1):16-23. Epub 2007 Sep 12.
19. McGill MR and Jaeschke H, Pharm Res. 2013 Sep;30(9):2174-87. doi: 10.1007/s11095-013-1007-6. Epub 2013 Mar 6.
20. Merrell MD, etal., J Biochem Mol Toxicol. 2008;22(2):128-35.
21. MGD Curation, June 12, 2002
22. MGD data from the GO Consortium
23. Muguruma M, etal., Arch Toxicol. 2008 Jul 22.
24. Naud J, etal., J Pharmacol Exp Ther. 2007 Mar;320(3):978-85. Epub 2006 Nov 29.
25. NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. Nishiya T, etal., Toxicol Sci. 2006 Jun;91(2):651-9. Epub 2006 Mar 16.
27. Okumura H, etal., Biochem Pharmacol. 2007 Aug 1;74(3):488-95. Epub 2007 May 3.
28. Ortiz DF, etal., Am J Physiol. 1999 Jun;276(6 Pt 1):G1493-500.
29. Petrovic V, etal., Drug Metab Dispos. 2008 Sep;36(9):1944-50. Epub 2008 May 27.
30. Pipeline to import KEGG annotations from KEGG into RGD
31. Pipeline to import SMPDB annotations from SMPDB into RGD
32. RGD automated data pipeline
33. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
34. RGD automated import pipeline for gene-chemical interactions
35. Rost D, etal., Am J Physiol Gastrointest Liver Physiol 2002 Apr;282(4):G720-6.
36. Ruiz ML, etal., Drug Metab Dispos. 2006 Jun;34(6):1030-4. Epub 2006 Mar 22.
37. Thorn CF, etal., Pharmacogenet Genomics. 2011 Jul;21(7):440-6. doi: 10.1097/FPC.0b013e32833ffb56.
38. Villanueva SS, etal., Drug Metab Dispos. 2008 Mar;36(3):475-80. Epub 2007 Dec 20.
39. Zuniga-Garcia V, etal., Dig Dis Sci. 2015 Aug;60(8):2373-83. doi: 10.1007/s10620-015-3633-9. Epub 2015 Apr 5.
Additional References at PubMed
PMID:11846400   PMID:12951053   PMID:14724430   PMID:14981926   PMID:16946557   PMID:19334674   PMID:22015764   PMID:23077105   PMID:25931508   PMID:26337276  


Genomics

Comparative Map Data
Abcc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21079,296,681 - 79,342,749 (-)NCBI
Rnor_6.0 Ensembl1082,047,863 - 82,117,109 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01082,047,308 - 82,116,928 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01081,896,621 - 81,938,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01081,879,487 - 81,880,151 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41082,986,552 - 83,030,799 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1078,085,499 - 78,131,465 (-)NCBICelera
Cytogenetic Map10q26NCBI
ABCC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1750,634,777 - 50,692,253 (+)EnsemblGRCh38hg38GRCh38
GRCh381750,634,881 - 50,692,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371748,712,242 - 48,769,614 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361746,067,227 - 46,124,062 (+)NCBINCBI36hg18NCBI36
Build 341746,067,226 - 46,124,061NCBI
Celera1745,173,593 - 45,230,401 (+)NCBI
Cytogenetic Map17q21.33NCBI
HuRef1744,080,218 - 44,136,477 (+)NCBIHuRef
CHM1_11748,776,209 - 48,833,053 (+)NCBICHM1_1
Abcc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391194,234,121 - 94,283,843 (-)NCBIGRCm39mm39
GRCm39 Ensembl1194,234,121 - 94,283,823 (-)Ensembl
GRCm381194,343,295 - 94,393,017 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1194,343,295 - 94,392,997 (-)EnsemblGRCm38mm10GRCm38
MGSCv371194,204,609 - 94,254,290 (-)NCBIGRCm37mm9NCBIm37
MGSCv361194,159,385 - 94,209,066 (-)NCBImm8
Celera11103,962,067 - 104,011,589 (-)NCBICelera
Cytogenetic Map11DNCBI
Abcc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545111,087,570 - 11,130,482 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545111,087,246 - 11,130,108 (-)NCBIChiLan1.0ChiLan1.0
ABCC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1926,551,953 - 26,596,330 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl926,551,268 - 26,595,646 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha925,944,553 - 25,988,893 (+)NCBI
ROS_Cfam_1.0927,346,054 - 27,390,624 (+)NCBI
UMICH_Zoey_3.1926,113,720 - 26,158,047 (+)NCBI
UNSW_CanFamBas_1.0926,372,406 - 26,416,803 (+)NCBI
UU_Cfam_GSD_1.0926,502,563 - 26,547,109 (+)NCBI
Abcc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560225,988,457 - 26,035,171 (+)NCBI
SpeTri2.0NW_00493649011,039,968 - 11,086,670 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABCC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1226,920,821 - 26,978,363 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11226,920,764 - 26,978,389 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21227,060,930 - 27,117,540 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11642,646,316 - 42,703,124 (-)NCBI
ChlSab1.1 Ensembl1642,646,812 - 42,702,852 (-)Ensembl
Vero_WHO_p1.0NW_02366607713,362,436 - 13,419,564 (-)NCBI
Abcc3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247956,516,384 - 6,558,332 (+)NCBI

Position Markers
RH136767  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21079,296,715 - 79,296,805 (+)MAPPER
Rnor_6.01082,047,331 - 82,047,420NCBIRnor6.0
Rnor_5.01081,879,510 - 81,879,599UniSTSRnor5.0
RGSC_v3.41082,986,575 - 82,986,664UniSTSRGSC3.4
Celera1078,085,522 - 78,085,611UniSTS
RH 3.4 Map10720.4UniSTS
Cytogenetic Map10q26UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10642907599492409Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109841807108540162Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101482789492423564Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014827894107857673Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014827894110992275Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)1020170031102897474Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102152390683549467Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)12152390690312401Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12152390690312401Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)12152390690312401Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)12152390690312401Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102152390690312401Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102290149793886300Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1023861015112626471Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1024483076107857673Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1024483076107857673Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1024483076107857673Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)1027237530101482600Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1027237530102427718Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103618592982675365Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103618592995845311Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)104051404485514044Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)104051404485514044Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1041260363106105607Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1041260363107857673Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1041260363107857673Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1043289657108540162Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104370495588704955Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104659302198939209Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104684834691848346Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104684834691848346Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104684834691848346Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105063833795638337Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)105128920384596393Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)105128920384596393Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)105128920384596393Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)105128920384596393Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)105128920384596393Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105310471898104718Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1053621375112626471Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1053621375112626471Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105362581598939209Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105363748594807701Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)1055224855100224855Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1055678976112626471Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)1055679084102427604Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1056698730101698730Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1060450007105450007Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1060875260105875260Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1060875260105875260Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1060875260105875260Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1062096293107096293Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106464817584601269Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)1064648175101691360Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1064648175102149713Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1064648175102149713Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106464831185513822Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1065590122110590122Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1065992275110992275Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1065992275110992275Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1067880046112626471Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1067988218110992091Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106830503785514044Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1069123603101482600Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1069385595112626471Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1069385595112626471Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1070166960112626471Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1070800069112626471Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1071692298112626471Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1073008136112626471Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1073008136112626471Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1073008136112626471Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1073467158112626471Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107504539197308358Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1075544754112626471Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1075544754112626471Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107598366286419171Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107598380599492217Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107598380599492217Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)107705574186962563Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107705574198282519Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107834302790042115Rat
2325836Bp346Blood pressure QTL 3460.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107897027986962563Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107897027998282519Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1078970279112626471Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1079927661112626471Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1080239190112626471Rat
724516Uae17Urinary albumin excretion QTL 173.6urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)108094611088200662Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)1081515116101758478Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)108164977590297007Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:220
Count of miRNA genes:133
Interacting mature miRNAs:143
Transcripts:ENSRNOT00000003977, ENSRNOT00000051497
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 5 5 5 5 4 17 11
Low 43 52 36 14 36 8 10 74 31 24 8
Below cutoff 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_080581 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017596972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039085088 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001840004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB010467 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF072816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY039030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210133 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000003977   ⟹   ENSRNOP00000003977
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1082,047,863 - 82,116,621 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000051497   ⟹   ENSRNOP00000041502
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1082,047,863 - 82,116,621 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079711   ⟹   ENSRNOP00000073075
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1082,074,211 - 82,117,109 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085451   ⟹   ENSRNOP00000069018
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1082,050,695 - 82,116,679 (-)Ensembl
RefSeq Acc Id: NM_080581   ⟹   NP_542148
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21079,296,693 - 79,342,595 (-)NCBI
Rnor_6.01082,047,308 - 82,116,669 (-)NCBI
Rnor_5.01081,879,487 - 81,880,151 (-)NCBI
Rnor_5.01081,896,621 - 81,938,192 (-)NCBI
RGSC_v3.41082,986,552 - 83,030,799 (-)RGD
Celera1078,085,499 - 78,131,465 (-)RGD
Sequence:
RefSeq Acc Id: XM_017596967   ⟹   XP_017452456
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01082,074,513 - 82,116,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596968   ⟹   XP_017452457
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21079,310,561 - 79,342,748 (-)NCBI
Rnor_6.01082,083,094 - 82,116,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596969   ⟹   XP_017452458
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21079,311,074 - 79,342,749 (-)NCBI
Rnor_6.01082,083,602 - 82,116,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596970   ⟹   XP_017452459
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21079,310,792 - 79,342,748 (-)NCBI
Rnor_6.01082,083,332 - 82,116,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596971   ⟹   XP_017452460
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21079,310,787 - 79,342,748 (-)NCBI
Rnor_6.01082,083,314 - 82,116,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017596972   ⟹   XP_017452461
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21079,311,077 - 79,342,748 (-)NCBI
Rnor_6.01082,083,586 - 82,116,928 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085087   ⟹   XP_038941015
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21079,296,681 - 79,323,774 (-)NCBI
RefSeq Acc Id: XM_039085088   ⟹   XP_038941016
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21079,296,681 - 79,316,607 (-)NCBI
RefSeq Acc Id: XR_001840004
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21079,306,149 - 79,342,748 (-)NCBI
Rnor_6.01082,078,648 - 82,116,928 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005489679
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21079,310,916 - 79,342,749 (-)NCBI
RefSeq Acc Id: XR_005489680
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21079,310,889 - 79,342,748 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_542148   ⟸   NM_080581
- Sequence:
RefSeq Acc Id: XP_017452456   ⟸   XM_017596967
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017452457   ⟸   XM_017596968
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017452460   ⟸   XM_017596971
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017452459   ⟸   XM_017596970
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017452461   ⟸   XM_017596972
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_017452458   ⟸   XM_017596969
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000073075   ⟸   ENSRNOT00000079711
RefSeq Acc Id: ENSRNOP00000069018   ⟸   ENSRNOT00000085451
RefSeq Acc Id: ENSRNOP00000041502   ⟸   ENSRNOT00000051497
RefSeq Acc Id: ENSRNOP00000003977   ⟸   ENSRNOT00000003977
RefSeq Acc Id: XP_038941015   ⟸   XM_039085087
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038941016   ⟸   XM_039085088
- Peptide Label: isoform X6
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697603
Promoter ID:EPDNEW_R8126
Type:initiation region
Name:Abcc3_1
Description:ATP binding cassette subfamily C member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01082,116,680 - 82,116,740EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71101 AgrOrtholog
Ensembl Genes ENSRNOG00000002948 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000003977 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000041502 UniProtKB/TrEMBL
  ENSRNOP00000069018 UniProtKB/TrEMBL
  ENSRNOP00000073075 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000003977 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000051497 UniProtKB/TrEMBL
  ENSRNOT00000079711 UniProtKB/TrEMBL
  ENSRNOT00000085451 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC1_TM_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_transporter_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Multidrug-R_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140668 UniProtKB/Swiss-Prot
NCBI Gene 140668 ENTREZGENE
Pfam ABC_membrane UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB ABCC3 RGD
PhenoGen Abcc3 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF90123 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs MRP_assoc_pro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JU97_RAT UniProtKB/TrEMBL
  A0A0G2K4K3_RAT UniProtKB/TrEMBL
  D3ZF64_RAT UniProtKB/TrEMBL
  F1LMJ7_RAT UniProtKB/TrEMBL
  MRP3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O88270 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Abcc3  ATP binding cassette subfamily C member 3  Abcc3  ATP-binding cassette, subfamily C (CFTR/MRP), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-11-16 Abcc3  ATP-binding cassette, subfamily C (CFTR/MRP), member 3  Abcc3  ATP-binding cassette, sub-family C (CFTR/MRP), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Abcc3  ATP-binding cassette, sub-family C (CFTR/MRP), member 3      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process may act as an inducible transporter in the biliary and intestinal excretion of organic anions 724707
gene_regulation upregulated in hepatocytes during liver regeneration after 90% but not after 70% partial hepatectomy 1304286