Ccl5 (C-C motif chemokine ligand 5) - Rat Genome Database

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Gene: Ccl5 (C-C motif chemokine ligand 5) Rattus norvegicus
Symbol: Ccl5
Name: C-C motif chemokine ligand 5
RGD ID: 69069
Description: Enables chemokine activity and heparin binding activity. Involved in several processes, including cellular response to organonitrogen compound; lymphocyte migration; and positive regulation of leukocyte chemotaxis. Located in extracellular space. Used to study Chagas disease; bronchiolitis obliterans; kidney disease; non-alcoholic fatty liver disease; and orchitis. Biomarker of several diseases, including alcoholic hepatitis; artery disease (multiple); cardiac arrest; lung disease (multiple); and uveitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; liver disease (multiple); pulmonary tuberculosis; and severe acute respiratory syndrome. Orthologous to human CCL5 (C-C motif chemokine ligand 5); PARTICIPATES IN syndecan signaling pathway; Chagas disease pathway; chemokine mediated signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C-C motif chemokine 5; chemokine (C-C motif) ligand 5; RANTES; regulated upon activation normal T-cell expressed and secreted; Scya5; SIS-delta; small inducible cytokine A5; small inducible cytokine A5 (RANTES); small-inducible cytokine A5; T-cell-specific protein RANTES
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Eau3 Bp299 Eau9
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21068,322,826 - 68,327,365 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1068,322,829 - 68,327,377 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1072,942,820 - 72,947,359 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01072,448,203 - 72,452,742 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01067,912,255 - 67,916,794 (-)NCBIRnor_WKY
Rnor_6.01070,739,764 - 70,744,303 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,739,800 - 70,744,315 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01070,373,353 - 70,377,892 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,605,791 - 71,610,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11071,620,206 - 71,624,712 (-)NCBI
Celera1067,264,203 - 67,268,742 (-)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute Liver Failure  (ISO)
alcoholic hepatitis  (IEP,ISO)
allergic conjunctivitis  (IEP)
allergic contact dermatitis  (ISO)
Alzheimer's disease  (ISO)
Animal Toxoplasmosis  (IEP)
anti-basement membrane glomerulonephritis  (IEP)
arteriosclerosis  (IEP,ISO)
asthma  (IEP,ISO)
atopic dermatitis  (ISO)
autoimmune hepatitis  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (IEP,IMP)
bronchopneumonia  (ISO)
cardiac arrest  (IEP)
Chagas disease  (IMP)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
chronic inflammatory demyelinating polyradiculoneuropathy  (ISO)
chronic obstructive pulmonary disease  (ISO)
Cytomegalovirus Infections  (ISO)
diabetes mellitus  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
end stage renal disease  (IEP)
endometriosis  (IEP)
Endotoxemia  (IEP)
exercise-induced bronchoconstriction  (ISO)
Experimental Arthritis  (IEP,IMP)
Experimental Autoimmune Encephalomyelitis  (IEP,ISO)
Experimental Liver Cirrhosis  (ISO)
Experimental Seizures  (IEP)
extrinsic allergic alveolitis  (ISO)
fatty liver disease  (ISO)
Fever  (IDA)
genetic disease  (ISO)
genital herpes  (ISO)
glomerulonephritis  (ISO)
glucose intolerance  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Hermansky-Pudlak syndrome  (ISO)
Herpesviridae Infections  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Human Influenza  (ISO)
Hyperalgesia  (IDA,IEP)
Hyperoxaluria  (IEP,ISO)
hypertension  (ISO)
Hypoventilation  (ISO)
Immediate Hypersensitivity  (IEP)
Inflammation  (IEP,ISO)
interstitial lung disease  (ISO)
invasive ductal carcinoma  (ISO)
kidney disease  (IMP)
liver cirrhosis  (ISO)
Liver Metastasis  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (IEP)
malignant mesothelioma  (ISO)
Metabolic Syndrome  (IEP)
multiple sclerosis  (ISO)
Mycoplasma pneumoniae pneumonia  (ISO)
myocardial infarction  (IEP)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
non-alcoholic fatty liver  (ISO)
non-alcoholic fatty liver disease  (IEP,IMP)
non-alcoholic steatohepatitis  (ISO)
obesity  (IEP)
obstructive sleep apnea  (ISO)
orchitis  (IDA)
Ovarian Neoplasms  (ISO)
Pain  (IMP)
pancreatic cancer  (ISO)
pancreatitis  (IEP,ISO)
Paramyxoviridae Infections  (ISO)
peptic esophagitis  (IEP)
pleurisy  (ISO)
Pneumococcal Pneumonia  (ISO)
posterior uveitis  (IEP)
pre-eclampsia  (IEP)
primary biliary cholangitis  (ISO)
Pseudomonas Infections  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (ISO)
pulmonary sarcoidosis  (ISO)
pulmonary tuberculosis  (ISO)
Reperfusion Injury  (IEP,ISO)
Respiration Disorders  (ISO)
respiratory syncytial virus infectious disease  (ISO)
sciatic neuropathy  (IEP)
scrapie  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Sepsis  (IEP)
severe acute respiratory syndrome  (ISO)
Spinal Cord Injuries  (ISO)
Spontaneous Abortions  (ISO)
stomach cancer  (ISO)
Tissue Adhesions  (IMP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
uveitis  (IEP)
Viral Bronchiolitis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(-)-alpha-phellandrene  (ISO)
(-)-anisomycin  (ISO)
(-)-demecolcine  (ISO)
(4-oxo-3-\{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl\}-3,4-dihydrophthalazin-1-yl)acetic acid  (ISO)
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1,4-benzoquinone  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-naphthylamine  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitroquinoline N-oxide  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
7-ketocholesterol  (ISO)
8-Br-cAMP  (ISO)
8-chloro-2'-deoxyguanosine  (ISO)
9,10-anthraquinone  (ISO)
9-hydroxycanthin-6-one  (ISO)
acetamide  (EXP)
acrolein  (ISO)
adenine  (ISO)
albuterol  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (ISO)
alexidine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
aluminium hydroxide  (ISO)
ammonium chloride  (EXP)
amorolfine  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antimycin A  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
arecoline  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
asbestos  (ISO)
atropine  (ISO)
Bardoxolone methyl  (ISO)
beclomethasone  (ISO)
benazepril  (EXP)
benzalkonium chloride  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzethonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-Funaltrexamine  (ISO)
beta-naphthoflavone  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
budesonide  (ISO)
butanal  (ISO)
butenafine  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
Calcimycin  (EXP,ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
carrageenan  (EXP,ISO)
catechol  (ISO)
celecoxib  (ISO)
cephaeline  (ISO)
cerium trichloride  (ISO)
chenodeoxycholic acid  (ISO)
chlorohydrocarbon  (EXP)
chloroprene  (ISO)
chloroquine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
ciglitazone  (ISO)
cisplatin  (EXP,ISO)
clopidogrel  (ISO)
cobalt atom  (ISO)
codeine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
crocidolite asbestos  (ISO)
cycloheximide  (ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cytidine  (ISO)
D-glucose  (ISO)
D-penicillamine  (EXP)
dantrolene  (EXP)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dequalinium  (ISO)
desipramine  (ISO)
dexamethasone  (EXP,ISO)
dichlorine  (ISO)
dichloromethane  (EXP)
Didecyldimethylammonium  (ISO)
diethylstilbestrol  (ISO)
diflorasone  (ISO)
digitoxigenin  (ISO)
digoxin  (ISO)
dimethyl sulfoxide  (ISO)
dimethyl-(phenylmethyl)-[2-[2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy]ethyl]ammonium  (ISO)
dinitrogen  (ISO)
dioxygen  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
emetine  (ISO)
endosulfan  (ISO)
enilconazole  (ISO)
Erionite  (ISO)
ethambutol  (EXP)
ethanol  (ISO)
ethionamide  (EXP)
ethyl acetate  (ISO)
Ethyl icosapentate  (ISO)
ethylbenzene  (EXP)
ethylene glycol  (EXP)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
fenofibrate  (ISO)
Fexofenadine hydrochloride  (ISO)
flavonoids  (EXP)
flunisolide  (ISO)
fluoxetine  (ISO)
flutamide  (EXP)
fluticasone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
formoterol fumarate  (ISO)
fragrance  (ISO)
fucoidan  (ISO)
fulvestrant  (ISO)
fumonisin B1  (ISO)
gemfibrozil  (EXP)
gentamycin  (EXP)
glucose  (ISO)
glutathione  (ISO)
glycine betaine  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
graphene oxide  (ISO)
GW 1929  (ISO)
helenalin  (ISO)
heparan sulfate  (ISO)
hesperetin  (ISO)
hexadecanoic acid  (ISO)
homocysteine  (ISO)
hyaluronic acid  (ISO)
hydrazines  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxytyrosol  (ISO)
indometacin  (EXP)
ionomycin  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
isotretinoin  (EXP,ISO)
itraconazole  (ISO)
kaempferol  (ISO)
ketamine  (ISO)
ketoconazole  (ISO)
lanatoside C  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lead(II) chloride  (ISO)
leukotriene B4  (EXP)
lipopolysaccharide  (EXP,ISO)
losartan  (EXP)
Luliconazole  (ISO)
LY294002  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
maraviroc  (ISO)
masoprocol  (EXP)
mechlorethamine  (EXP)
meclocycline  (ISO)
melatonin  (ISO)
menadione  (EXP)
mercaptopurine  (EXP)
mercury dichloride  (EXP)
metam  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methionine sulfoximine  (ISO)
methotrexate  (ISO)
Methylbenzethonium chloride  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
microcystin-LR  (EXP)
minocycline  (ISO)
monocrotaline  (EXP)
monodansylcadaverine  (ISO)
morphine  (ISO)
mycophenolic acid  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
naloxone  (ISO)
naringin  (ISO)
neocuproine  (ISO)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nitric oxide  (ISO)
nitrogen dioxide  (ISO)
o-anisidine  (ISO)
ochratoxin A  (EXP)
oxaliplatin  (EXP)
oxytetracycline  (ISO)
ozone  (ISO)
palmatine  (ISO)
paracetamol  (EXP,ISO)
parthenolide  (ISO)
PCB138  (EXP)
PD123319  (EXP)
pentachlorophenol  (ISO)
pentanal  (ISO)
Pentoxifylline  (EXP)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
pevonedistat  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phytoestrogen  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
polymyxin B2  (ISO)
prazosin  (ISO)
procyanidin B3  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
propidium  (ISO)
Proscillaridin  (ISO)
prostaglandin E2  (ISO)
purine-6-thiol  (EXP)
pyocyanine  (ISO)
pyrrolidine dithiocarbamate  (ISO)
quartz  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rifampicin  (EXP)
rofecoxib  (ISO)
rutin  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitrosoglutathione  (ISO)
salubrinal  (ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sodium chloride  (EXP)
sodium cholate  (ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
Sodium oleate  (ISO)
Soman  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tacrine  (EXP)
tacrolimus hydrate  (ISO)
tamibarotene  (ISO)
taurocholic acid  (ISO)
telmisartan  (ISO)
temozolomide  (ISO)
terameprocol  (ISO)
terbinafine  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (EXP,ISO)
Tetramethylthiourea  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (EXP,ISO)
topotecan  (EXP)
trametinib  (ISO)
tremolite asbestos  (ISO)
triadimefon  (EXP)
triamcinolone acetonide  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (ISO)
vanadyl sulfate  (ISO)
verteporfin  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin E  (ISO)
wortmannin  (ISO)
WR-1065  (ISO)
zinc atom  (ISO)
zinc oxide  (EXP)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of phospholipase D activity  (ISO)
calcium ion transport  (ISO)
cell chemotaxis  (IEA)
cell-cell signaling  (ISO)
cellular response to alkyl hydroperoxide  (IEP)
cellular response to amino acid stimulus  (IEP)
cellular response to cytokine stimulus  (IEP)
cellular response to ethanol  (IEP)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to high density lipoprotein particle stimulus  (IEP)
cellular response to interleukin-1  (IBA,ISO)
cellular response to lipid  (IEP)
cellular response to lipopolysaccharide  (IEP)
cellular response to morphine  (IEP)
cellular response to organic cyclic compound  (ISO)
cellular response to transforming growth factor beta stimulus  (IEP)
cellular response to tumor necrosis factor  (IBA,IEP,ISO)
cellular response to type II interferon  (IBA,ISO)
cellular response to vitamin K  (IEP)
chemokine-mediated signaling pathway  (IBA,ISO,ISS)
chronic inflammatory response  (IEP)
dibenzo-p-dioxin metabolic process  (IEP)
eosinophil chemotaxis  (ISO)
epithelial cell proliferation  (ISO)
exocytosis  (ISO)
G protein-coupled receptor signaling pathway  (IBA,ISO,ISS)
immune response  (IEA)
inflammatory response  (IBA,ISO)
intracellular calcium ion homeostasis  (ISO)
leukocyte cell-cell adhesion  (ISO)
lipopolysaccharide-mediated signaling pathway  (ISO)
lymphocyte chemotaxis  (IBA,IDA)
MAPK cascade  (ISO)
monocyte chemotaxis  (IBA)
negative regulation of cellular process  (IMP)
negative regulation of chemokine-mediated signaling pathway  (IEA)
negative regulation of G protein-coupled receptor signaling pathway  (ISO)
negative regulation of macrophage apoptotic process  (ISO)
negative regulation of T cell apoptotic process  (ISO)
negative regulation of viral genome replication  (ISO)
neutrophil activation  (ISO)
neutrophil chemotaxis  (IBA)
positive chemotaxis  (IEA)
positive regulation of angiogenesis  (IMP)
positive regulation of calcium ion transport  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of cell-cell adhesion mediated by integrin  (ISO)
positive regulation of cellular biosynthetic process  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IBA)
positive regulation of fever generation  (IDA)
positive regulation of gene expression  (IDA,IMP)
positive regulation of GTPase activity  (IBA)
positive regulation of homotypic cell-cell adhesion  (ISO)
positive regulation of macrophage chemotaxis  (ISO)
positive regulation of mast cell chemotaxis  (IDA)
positive regulation of monocyte chemotaxis  (ISO)
positive regulation of natural killer cell chemotaxis  (ISO)
positive regulation of neuron differentiation  (IMP)
positive regulation of osteoclast differentiation  (IDA)
positive regulation of phosphatidylinositol 3-kinase signaling  (IDA,ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of T cell apoptotic process  (ISO)
positive regulation of T cell chemotaxis  (IBA,IDA,ISO)
positive regulation of T cell migration  (ISO)
positive regulation of T cell proliferation  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
protein kinase B signaling  (ISO)
pseudopodium assembly  (IDA)
regulation of insulin secretion  (ISO,ISS)
regulation of programmed cell death  (IMP)
regulation of T cell activation  (ISO)
response to activity  (IEP)
response to alcohol  (IEP)
response to bacterium  (IEP)
response to cholesterol  (IEP)
response to cytokine  (IEP,ISO)
response to estrogen  (IEP)
response to glucocorticoid  (IEP)
response to insulin  (IEP)
response to lipopolysaccharide  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to salt stress  (IEP)
response to toxic substance  (ISO)
response to tumor necrosis factor  (ISO)
response to type II interferon  (IDA)
response to xenobiotic stimulus  (IEP)
T-helper 1 cell diapedesis  (IDA)

Cellular Component


References - curated
# Reference Title Reference Citation
1. The preventive effect of Met-RANTES on postoperative intraperitoneal adhesion formation in the rat model. Akyildiz H, etal., Surgery. 2008 Sep;144(3):404-9. Epub 2008 Jul 10.
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53. Qingfei Xiaoyan Wan, a traditional Chinese medicine formula, ameliorates Pseudomonas aeruginosa-induced acute lung inflammation by regulation of PI3K/AKT and Ras/MAPK pathways. Hou Y, etal., Acta Pharm Sin B. 2016 May;6(3):212-21. doi: 10.1016/j.apsb.2016.03.002. Epub 2016 Mar 22.
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55. A CCL5 Haplotype Is Associated with Low Seropositivity Rate of HCV Infection in People Who Inject Drugs. Huik K, etal., PLoS One. 2016 Jun 15;11(6):e0156850. doi: 10.1371/journal.pone.0156850. eCollection 2016.
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79. Serum inflammatory markers in diabetic retinopathy. Meleth AD, etal., Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4295-301.
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148. Cytokine and chemokine expression in a rat endometriosis is similar to that in human endometriosis. Umezawa M, etal., Cytokine. 2008 Aug;43(2):105-9. Epub 2008 Jul 1.
149. Antagonism of RANTES receptors reduces atherosclerotic plaque formation in mice. Veillard NR, etal., Circ Res. 2004 Feb 6;94(2):253-61. Epub 2003 Dec 1.
150. Upregulation of macrophage migration inhibitory factor (MIF) and CD74, receptor for MIF, in rat bladder during persistent cyclophosphamide-induced inflammation. Vera PL, etal., Exp Biol Med (Maywood). 2008 May;233(5):620-6. Epub 2008 Mar 28.
151. Persistence of lung inflammation and lung cytokines with high-resolution CT abnormalities during recovery from SARS. Wang CH, etal., Respir Res. 2005 May 11;6:42. doi: 10.1186/1465-9921-6-42.
152. Inhibiting glycogen synthase kinase-3 reduces endotoxaemic acute renal failure by down-regulating inflammation and renal cell apoptosis. Wang Y, etal., Br J Pharmacol. 2009 Jul;157(6):1004-13. Epub 2009 Jun 5.
153. Triptolide inhibits CC chemokines expressed in rat adjuvant-induced arthritis. Wang Y, etal., Int Immunopharmacol. 2006 Dec 5;6(12):1825-32. Epub 2006 Aug 31.
154. Dynamic changes in clinical features and cytokine/chemokine responses in SARS patients treated with interferon alfacon-1 plus corticosteroids. Ward SE, etal., Antivir Ther. 2005;10(2):263-75.
155. Haplotype-tagging RANTES gene variants influence response to antiviral therapy in chronic hepatitis C. Wasmuth HE, etal., Hepatology. 2004 Aug;40(2):327-34. doi: 10.1002/hep.20322.
156. [Changes of RANTES levels in livers of patients with chronic hepatitis B: the clinical significance and the possible mechanisms]. Wei XQ, etal., Zhonghua Gan Zang Bing Za Zhi. 2007 Aug;15(8):585-8.
157. Altered levels of CC chemokines during pulmonary CMV predict BOS and mortality post-lung transplantation. Weigt SS, etal., Am J Transplant. 2008 Jul;8(7):1512-22.
158. Opposite action of peroxisome proliferator-activated receptor-gamma in regulating renal inflammation: functional switch by its ligand. Wen X, etal., J Biol Chem. 2010 Sep 24;285(39):29981-8. Epub 2010 Jul 27.
159. Concentration of chemokines in peripheral blood in first trimester of diabetic pregnancy. Wender-Ozegowska E, etal., Acta Obstet Gynecol Scand. 2008;87(1):14-9.
160. RANTES is required for ischaemia-induced angiogenesis, which may hamper RANTES-targeted anti-atherosclerotic therapy. Westerweel PE, etal., Thromb Haemost. 2008 Apr;99(4):794-5.
161. Chemokine decoy receptor d6 plays a negative role in human breast cancer. Wu FY, etal., Mol Cancer Res. 2008 Aug;6(8):1276-88.
162. DNA vaccination with naked DNA encoding MCP-1 and RANTES protects against renal injury in adriamycin nephropathy. Wu H, etal., Kidney Int. 2005 Jun;67(6):2178-86.
163. [Effect of epimedium herb on RANTES and monocyte chemotactic protein-3 expression in lung tissue of asthmatic rats] Xie JY, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2008 Mar;28(3):238-41.
164. Role of the extracellular signal-regulated kinase 1/2 signaling pathway in regulating the secretion of bronchial smooth muscle cells in a rat model of chronic asthma. Xie M, etal., Chin Med J (Engl). 2008 Jan 5;121(1):73-7.
165. Genetic variants in chemokine CC subfamily genes influence hepatitis C virus viral clearance. Yao Y, etal., J Hum Genet. 2018 Jul;63(7):831-839. doi: 10.1038/s10038-018-0452-9. Epub 2018 Apr 27.
166. Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. Yeligar SM, etal., J Immunol. 2009 Nov 1;183(9):5964-76. Epub 2009 Oct 14.
167. Sinomenine, an antirheumatic alkaloid, ameliorates clinical signs of disease in the Lewis rat model of acute experimental autoimmune encephalolmyelitis. Zeng Y, etal., Biol Pharm Bull. 2007 Aug;30(8):1438-44.
168. [Study on the association between RANTES-403G/A as well as -28C/G gene polymorphism and their susceptibility to the hepatitis B virus infections in Dong and Han ethnicities in Guizhou, China]. Zhang C, etal., Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Dec;33(12):1279-82.
169. Oxidized high-density lipoprotein enhances inflammatory activity in rat mesangial cells. Zhang M, etal., Diabetes Metab Res Rev. 2010 Sep;26(6):455-63.
170. RANTES gene polymorphisms and asthma risk: A meta-analysis. Zhang YG, etal., Arch Med Res. 2010 Jan;41(1):50-8.
171. [Association of RANTES gene promoter -28C/G polymorphism with respiratory syncytial virus bronchiolitis]. Zhao DY, etal., Zhonghua Er Ke Za Zhi. 2008 Feb;46(2):89-93.
172. Genetic variants of RANTES are associated with serum RANTES level and protection for type 1 diabetes. Zhernakova A, etal., Genes Immun. 2006 Oct;7(7):544-9. Epub 2006 Jul 20.
173. RANTES in exhaled breath condensate of allergic asthma patients with exercise-induced bronchoconstriction. Zietkowski Z, etal., Respiration. 2010;80(6):463-71. Epub 2009 Dec 7.
174. [Detection of ICAM-1 and RANTES in infants with bronchiolitis]. Zou LP and Zhang SL, Zhongguo Dang Dai Er Ke Za Zhi. 2010 Mar;12(3):181-3.
Additional References at PubMed
PMID:1375672   PMID:1699135   PMID:7517217   PMID:7544376   PMID:7545673   PMID:8558019   PMID:8631850   PMID:8699119   PMID:9139699   PMID:9407497   PMID:9417081   PMID:9469451  
PMID:10488085   PMID:10490959   PMID:10660125   PMID:10734056   PMID:10841574   PMID:10910894   PMID:12477932   PMID:12899200   PMID:15001559   PMID:15504940   PMID:15530372   PMID:15557190  
PMID:15718270   PMID:16778803   PMID:16830364   PMID:17001303   PMID:17218081   PMID:18337562   PMID:18832695   PMID:19779041   PMID:20132097   PMID:21147091   PMID:21148126   PMID:21167894  
PMID:21297082   PMID:21827949   PMID:22292067   PMID:22450806   PMID:22752444   PMID:22960654   PMID:23460747   PMID:23480650   PMID:23498802   PMID:23620790   PMID:23696660   PMID:23979485  
PMID:24656930   PMID:25635831   PMID:28146100   PMID:28381538   PMID:31032369   PMID:36483459  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21068,322,826 - 68,327,365 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1068,322,829 - 68,327,377 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1072,942,820 - 72,947,359 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01072,448,203 - 72,452,742 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01067,912,255 - 67,916,794 (-)NCBIRnor_WKY
Rnor_6.01070,739,764 - 70,744,303 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1070,739,800 - 70,744,315 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01070,373,353 - 70,377,892 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,605,791 - 71,610,330 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11071,620,206 - 71,624,712 (-)NCBI
Celera1067,264,203 - 67,268,742 (-)NCBICelera
Cytogenetic Map10q26NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381735,871,491 - 35,880,360 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1735,871,491 - 35,880,793 (-)EnsemblGRCh38hg38GRCh38
GRCh371734,198,495 - 34,207,364 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361731,222,608 - 31,231,490 (-)NCBINCBI36Build 36hg18NCBI36
Celera1731,108,052 - 31,116,934 (-)NCBICelera
Cytogenetic Map17q12NCBI
HuRef1730,383,508 - 30,392,390 (-)NCBIHuRef
CHM1_11734,263,060 - 34,271,942 (-)NCBICHM1_1
T2T-CHM13v2.01736,819,399 - 36,828,268 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391183,416,604 - 83,421,344 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,416,604 - 83,421,344 (-)EnsemblGRCm39 Ensembl
GRCm381183,525,778 - 83,530,518 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,525,778 - 83,530,518 (-)EnsemblGRCm38mm10GRCm38
MGSCv371183,339,280 - 83,344,020 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361183,341,974 - 83,346,692 (-)NCBIMGSCv36mm8
Celera1193,127,305 - 93,132,049 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1150.66NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495548110,293,399 - 10,301,143 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495548110,293,758 - 10,301,118 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11730,476,222 - 30,484,892 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01720,915,198 - 20,923,530 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11721,210,798 - 21,219,172 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1721,210,798 - 21,219,172 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1937,817,409 - 37,823,852 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl937,817,305 - 37,823,852 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha937,039,892 - 37,046,335 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0938,627,353 - 38,633,796 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl938,627,249 - 38,633,796 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1937,410,157 - 37,416,605 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0937,695,725 - 37,702,162 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0937,783,127 - 37,789,578 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440560236,815,103 - 36,821,857 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936490253,279 - 259,947 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1239,648,598 - 39,659,118 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11239,652,731 - 39,659,121 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21241,218,074 - 41,228,604 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11629,351,214 - 29,361,317 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666075615,422 - 624,588 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248753,334,078 - 3,341,614 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248753,334,136 - 3,342,085 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ccl5
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:33
Count of miRNA genes:32
Interacting mature miRNAs:32
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106694181373452992Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106750210873579767Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642290Bp299Blood pressure QTL 299arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106823013469282520Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,328,123 - 68,328,363 (+)MAPPERmRatBN7.2
Rnor_6.01070,745,062 - 70,745,301NCBIRnor6.0
Rnor_5.01070,378,651 - 70,378,890UniSTSRnor5.0
RGSC_v3.41071,611,089 - 71,611,328UniSTSRGSC3.4
Celera1067,269,501 - 67,269,740UniSTS
Cytogenetic Map10q26UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,322,907 - 68,323,098 (+)MAPPERmRatBN7.2
Rnor_6.01070,739,846 - 70,740,036NCBIRnor6.0
Rnor_5.01070,373,435 - 70,373,625UniSTSRnor5.0
RGSC_v3.41071,605,873 - 71,606,063UniSTSRGSC3.4
Celera1067,264,285 - 67,264,475UniSTS
Cytogenetic Map10q26UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 9 11 6 14 6 1 7 10
Low 2 18 32 21 5 21 6 7 24 28 23 1 6
Below cutoff 4 8 8 8 2 4 27 7 2


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014865   ⟹   ENSRNOP00000014865
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1068,322,829 - 68,327,377 (-)Ensembl
Rnor_6.0 Ensembl1070,739,800 - 70,744,315 (-)Ensembl
RefSeq Acc Id: NM_031116   ⟹   NP_112378
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
mRatBN7.21068,322,826 - 68,327,365 (-)NCBI
Rnor_6.01070,739,764 - 70,744,303 (-)NCBI
Rnor_5.01070,373,353 - 70,377,892 (-)NCBI
RGSC_v3.41071,605,791 - 71,610,330 (-)RGD
Celera1067,264,203 - 67,268,742 (-)RGD
Reference Sequences
RefSeq Acc Id: NP_112378   ⟸   NM_031116
- Peptide Label: precursor
- UniProtKB: Q6PED1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014865   ⟸   ENSRNOT00000014865
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50231-F1-model_v2 AlphaFold P50231 1-92 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697533
Promoter ID:EPDNEW_R8058
Type:single initiation site
Description:C-C motif chemokine ligand 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01070,744,318 - 70,744,378EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69069 AgrOrtholog
BioCyc Gene G2FUF-23874 BioCyc
Ensembl Genes ENSRNOG00000010906 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000014865.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014865.7 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_CC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81780 UniProtKB/TrEMBL
  PTHR12015 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ccl5 PhenoGen
SMART SCY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218419
UniProt CCL5_RAT UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-08 Ccl5  C-C motif chemokine ligand 5  Ccl5  chemokine (C-C motif) ligand 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Ccl5  chemokine (C-C motif) ligand 5  Scya5  small inducible cytokine A5  Symbol and Name updated 629477 APPROVED
2002-06-10 Scya5  small inducible cytokine A5      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression increases during renal allografts 61510
gene_expression increases during renal allografts 68880
gene_expression mRNA expression in testicular somatic cells increases in response to Sendai virus infection 704384