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Gene: Ccl5 (C-C motif chemokine ligand 5) Rattus norvegicus
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Symbol: Ccl5
Name: C-C motif chemokine ligand 5
Description: Exhibits chemokine activity and heparin binding activity. Involved in several processes, including cellular response to organonitrogen compound; lymphocyte migration; and positive regulation of leukocyte chemotaxis. Localizes to the extracellular space. Used to study Chagas disease; bronchiolitis obliterans; kidney disease; and orchitis. Biomarker of several diseases, including artery disease (multiple); cardiac arrest; end stage renal failure; lung disease (multiple); and uveitis (multiple). Human ortholog(s) of this gene implicated in asthma; hepatitis C; pancreatitis; pulmonary tuberculosis; and type 1 diabetes mellitus. Orthologous to human CCL5 (C-C motif chemokine ligand 5); PARTICIPATES IN syndecan signaling pathway; Chagas disease pathway; chemokine mediated signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C-C motif chemokine 5; chemokine (C-C motif) ligand 5; RANTES; regulated upon activation normal T-cell expressed and secreted; Scya5; SIS-delta; small inducible cytokine A5; small inducible cytokine A5 (RANTES); small-inducible cytokine A5; T-cell-specific protein RANTES
Orthologs:
Homo sapiens (human) : CCL5 (C-C motif chemokine ligand 5)  HGNC  Alliance
Mus musculus (house mouse) : Ccl5 (chemokine (C-C motif) ligand 5)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ccl5 (C-C motif chemokine ligand 5)
Pan paniscus (bonobo/pygmy chimpanzee) : CCL5 (C-C motif chemokine ligand 5)
Canis lupus familiaris (dog) : CCL5 (C-C motif chemokine ligand 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ccl5 (C-C motif chemokine ligand 5)
Sus scrofa (pig) : CCL5 (C-C motif chemokine ligand 5)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01070,739,764 - 70,744,303 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01070,373,353 - 70,377,892 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41071,605,791 - 71,610,330 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11071,620,206 - 71,624,712 (-)NCBI
Celera1067,264,203 - 67,268,742 (-)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Ccl5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69069
Created: 2001-11-08
Species: Rattus norvegicus
Last Modified: 2019-06-04
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.