Nog (noggin) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Nog (noggin) Rattus norvegicus
Analyze
Symbol: Nog
Name: noggin
RGD ID: 3183
Description: Predicted to enable cytokine binding activity and protein homodimerization activity. Involved in several processes, including hippocampus development; learning or memory; and regulation of gliogenesis. Located in axon and extracellular space. Part of protein-containing complex. Biomarker of acute kidney tubular necrosis and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Huntington's disease; bone disease (multiple); cleft lip; and hyperopia. Orthologous to human NOG (noggin); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH (20S)-ginsenoside Rg3; 17beta-estradiol; amitriptyline.
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21074,128,712 - 74,130,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1074,128,712 - 74,130,339 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1078,757,906 - 78,759,533 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01078,262,852 - 78,264,479 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01073,730,695 - 73,732,322 (-)NCBIRnor_WKY
Rnor_6.01076,811,759 - 76,813,386 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1076,811,759 - 76,813,386 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01076,677,612 - 76,679,239 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41077,689,244 - 77,690,871 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11077,703,801 - 77,704,728 (-)NCBI
Celera1073,029,127 - 73,030,754 (-)NCBICelera
Cytogenetic Map10q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(20S)-ginsenoside Rg3  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3',5'-cyclic AMP  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
acetic acid  (ISO)
acrylamide  (ISO)
all-trans-retinoic acid  (ISO)
amitriptyline  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromochloroacetic acid  (ISO)
butanal  (ISO)
chloroprene  (EXP)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
dexamethasone  (EXP)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
dorsomorphin  (ISO)
entinostat  (ISO)
folic acid  (ISO)
furan  (EXP)
glycerol 2-phosphate  (EXP)
icariin  (ISO)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
N-nitrosodiethylamine  (EXP)
neomycin  (ISO)
nickel atom  (ISO)
octreotide  (ISO)
p-chloromercuribenzoic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pasireotide  (ISO)
pentane-2,3-dione  (EXP)
phenethyl caffeate  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
Salidroside  (ISO)
SB 431542  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sotorasib  (ISO)
sulforaphane  (ISO)
testosterone  (ISO)
thimerosal  (ISO)
trametinib  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (ISO)
atrial cardiac muscle tissue morphogenesis  (IEA,ISO)
axial mesoderm development  (IEA,ISO)
axon guidance  (ISO)
BMP signaling pathway  (ISO)
BMP signaling pathway involved in heart development  (IEA,ISO)
brain development  (ISO)
cartilage development  (IEA,ISO)
cell differentiation in hindbrain  (IEA,ISO)
cell population proliferation  (ISO)
cellular response to BMP stimulus  (IEP,ISO)
cellular response to hypoxia  (IEP)
central nervous system development  (ISO)
cranial skeletal system development  (IEA,ISO)
dorsal/ventral pattern formation  (IBA,IEA,ISO)
embryonic digit morphogenesis  (IEA,ISO)
embryonic skeletal joint morphogenesis  (IEA,ISO)
embryonic skeletal system development  (ISO)
endocardial cushion morphogenesis  (IEA,ISO)
endoderm development  (ISO)
endoderm formation  (IEA,ISO)
epithelial cell proliferation  (IEA,ISO)
epithelial to mesenchymal transition  (IEA,ISO,ISS)
exploration behavior  (IEA,ISO)
face morphogenesis  (IEA,ISO)
fibroblast growth factor receptor signaling pathway  (ISO)
fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation  (IEA,ISO)
forebrain development  (IEP,ISO)
heart trabecula morphogenesis  (IEA,ISO)
hippocampus development  (IEP)
in utero embryonic development  (IEA,ISO)
limb development  (ISO)
long-term synaptic potentiation  (IEA,ISO)
lung morphogenesis  (IEA,ISO)
membranous septum morphogenesis  (IEA,ISO)
memory  (IMP)
mesenchymal cell differentiation  (IMP,ISO)
mesoderm formation  (IEA,ISO)
middle ear morphogenesis  (IEA,ISO)
motor neuron axon guidance  (IEA,ISO)
negative regulation of apoptotic signaling pathway  (IEA,ISO)
negative regulation of astrocyte differentiation  (IEA,IMP,ISO,ISS)
negative regulation of BMP signaling pathway  (IBA,IEA,ISO,ISS)
negative regulation of canonical Wnt signaling pathway  (IEA,ISO)
negative regulation of cardiac muscle cell proliferation  (IEA,ISO,ISS)
negative regulation of cartilage development  (IEA,ISO)
negative regulation of cell migration  (IEA,ISO)
negative regulation of cytokine activity  (IEA,ISO)
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of osteoblast differentiation  (IEA,ISO)
negative regulation of pathway-restricted SMAD protein phosphorylation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
neural plate morphogenesis  (IEA,ISO)
neural tube closure  (IEA,ISO)
neural tube development  (ISO)
notochord morphogenesis  (IEA,ISO)
ossification  (IEP)
osteoblast differentiation  (IBA,IEA,ISO,ISS)
outflow tract morphogenesis  (IEA,ISO)
pattern specification process  (ISO)
pharyngeal arch artery morphogenesis  (IEA,ISO)
pituitary gland development  (IEA,ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (IEA,ISO,ISS)
positive regulation of cell population proliferation  (IMP)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of glomerulus development  (IEA,ISO,ISS)
positive regulation of oligodendrocyte progenitor proliferation  (IMP)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
presynaptic modulation of chemical synaptic transmission  (IEA,ISO)
prostatic bud formation  (IEA,ISO)
regulation of BMP signaling pathway  (ISO)
regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation  (IEA,ISO)
regulation of neuronal synaptic plasticity  (IEA,ISO)
short-term synaptic potentiation  (IEA,ISO)
skeletal system development  (ISO)
smoothened signaling pathway  (IEA,ISO)
somatic stem cell population maintenance  (IEA,ISO)
somite development  (IEA,ISO)
specification of segmental identity, mandibular segment  (ISO)
spinal cord development  (IEA,ISO)
stem cell differentiation  (IEA,ISO)
ureteric bud development  (ISO)
ureteric bud formation  (IEA,ISO)
urogenital system development  (ISO)
ventricular compact myocardium morphogenesis  (IEA,ISO)
ventricular septum morphogenesis  (ISO)
visual learning  (IEA,IMP,ISO)
wound healing  (IEA,IEP,ISO,ISS)

Cellular Component
axon  (IDA)
extracellular space  (IBA,IDA,IEA,ISO)
presynapse  (IEA)
protein-containing complex  (IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Noggin and Wnt3a enable BMP4-dependent differentiation of telencephalic stem cells into GluR-agonist responsive neurons. Andersson T, etal., Mol Cell Neurosci. 2011 May;47(1):10-8. doi: 10.1016/j.mcn.2011.01.006. Epub 2011 Jan 14.
2. Activation of vascular bone morphogenetic protein signaling in diabetes mellitus. Bostrom KI, etal., Circ Res. 2011 Feb 18;108(4):446-57. doi: 10.1161/CIRCRESAHA.110.236596. Epub 2010 Dec 30.
3. Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease. Cho SR, etal., J Clin Invest. 2007 Oct;117(10):2889-902.
4. Stapes ankylosis in a family with a novel NOG mutation: otologic features of the facioaudiosymphalangism syndrome. Declau F, etal., Otol Neurotol. 2005 Sep;26(5):934-40.
5. Expression of the BMP-2, -4 and -7 and their antagonists gremlin, chordin, noggin and follistatin during ectopic osteogenesis. Dudaric L, etal., Coll Antropol. 2013 Dec;37(4):1291-8.
6. A combined in situ hybridization and RT-PCR method to detect spatial and temporal patterns of Noggin gene expression in embryonic and postnatal rat hippocampus. Fan X, etal., Brain Res Brain Res Protoc. 2004 Jun;13(2):99-105.
7. Spatial and temporal patterns of expression of Noggin and BMP4 in embryonic and postnatal rat hippocampus. Fan X, etal., Brain Res Dev Brain Res 2003 Dec 19;146(1-2):51-8.
8. Effect of antisense oligonucleotide of noggin on spatial learning and memory of rats. Fan XT, etal., Acta Pharmacol Sin. 2003 May;24(5):394-7.
9. Antisense Noggin oligodeoxynucleotide administration decreases cell proliferation in the dentate gyrus of adult rats. Fan XT, etal., Neurosci Lett. 2004 Aug 5;366(1):107-11.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
12. Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. Gong Y, etal., Nat Genet. 1999 Mar;21(3):302-4.
13. Polymorphisms of the noggin gene and mandibular micrognathia: a first approximation. Gutiérrez SJ, etal., Acta Odontol Latinoam. 2010;23(1):13-9.
14. Spinally upregulated noggin suppresses axonal and dendritic plasticity following dorsal rhizotomy. Hampton DW, etal., Exp Neurol. 2007 Mar;204(1):366-79. Epub 2006 Dec 22.
15. Noggin heterozygous mice: an animal model for congenital conductive hearing loss in humans. Hwang CH and Wu DK, Hum Mol Genet. 2008 Mar 15;17(6):844-53. Epub 2007 Dec 20.
16. Novel NOG mutation in Japanese patients with stapes ankylosis with broad thumbs and toes. Ishino T, etal., Eur J Med Genet. 2015 Sep;58(9):427-32. doi: 10.1016/j.ejmg.2015.06.005. Epub 2015 Jul 26.
17. A role for Noggin in the development of oligodendrocyte precursor cells. Kondo T and Raff MC, Dev Biol 2004 Mar 1;267(1):242-51.
18. A new subtype of brachydactyly type B caused by point mutations in the bone morphogenetic protein antagonist NOGGIN. Lehmann K, etal., Am J Hum Genet. 2007 Aug;81(2):388-96. Epub 2007 Jun 8.
19. Identification of functional variants for cleft lip with or without cleft palate in or near PAX7, FGFR2, and NOG by targeted sequencing of GWAS loci. Leslie EJ, etal., Am J Hum Genet. 2015 Mar 5;96(3):397-411. doi: 10.1016/j.ajhg.2015.01.004. Epub 2015 Feb 19.
20. Aberrant Bmp signaling and notochord delamination in the pathogenesis of esophageal atresia. Li Y, etal., Dev Dyn. 2007 Mar;236(3):746-54.
21. Identification of a novel NOG mutation in a Chinese family with proximal symphalangism. Liu F, etal., Clin Chim Acta. 2014 Feb 15;429:129-33. doi: 10.1016/j.cca.2013.12.004. Epub 2013 Dec 8.
22. BMP inhibition enhances axonal growth and functional recovery after spinal cord injury. Matsuura I, etal., J Neurochem. 2008 May;105(4):1471-9. doi: 10.1111/j.1471-4159.2008.05251.x. Epub 2008 Jan 24.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Noggin expression in the adult rat brain. Mikawa S and Sato K, Neuroscience. 2011 Jun 16;184:38-53. doi: 10.1016/j.neuroscience.2011.03.036. Epub 2011 Apr 9.
25. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
26. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
27. Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk. Paez-Pereda M, etal., Proc Natl Acad Sci U S A 2003 Feb 4;100(3):1034-9.
28. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
29. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
30. Early Characterization of Blast-related Heterotopic Ossification in a Rat Model. Qureshi AT, etal., Clin Orthop Relat Res. 2015 Sep;473(9):2831-9. doi: 10.1007/s11999-015-4240-y.
31. GOA pipeline RGD automated data pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
34. Comprehensive gene review and curation RGD comprehensive gene curation
35. Medical treatment of craniosynostosis: recombinant Noggin inhibits coronal suture closure in the rat craniosynostosis model. Shen K, etal., Orthod Craniofac Res. 2009 Aug;12(3):254-62. doi: 10.1111/j.1601-6343.2009.01460.x.
36. Association between NOGGIN and SPRY2 polymorphisms and nonsyndromic cleft lip with or without cleft palate. Song T, etal., Am J Med Genet A. 2015 Jan;167A(1):137-41. doi: 10.1002/ajmg.a.36802. Epub 2014 Oct 22.
37. Mutations of the NOG gene in individuals with proximal symphalangism and multiple synostosis syndrome. Takahashi T, etal., Clin Genet. 2001 Dec;60(6):447-51.
38. Noggin and BMP4 co-modulate adult hippocampal neurogenesis in the APP(swe)/PS1(DeltaE9) transgenic mouse model of Alzheimer's disease. Tang J, etal., Biochem Biophys Res Commun. 2009 Jul 31;385(3):341-5. doi: 10.1016/j.bbrc.2009.05.067. Epub 2009 May 20.
39. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
40. Reduced production of noggin by immune cells of patients with relapsing-remitting multiple sclerosis. Urshansky N, etal., J Neuroimmunol. 2011 Mar;232(1-2):171-8. doi: 10.1016/j.jneuroim.2010.10.007. Epub 2010 Nov 26.
41. Identification of mammalian noggin and its expression in the adult nervous system. Valenzuela DM, etal., J Neurosci 1995 Sep;15(9):6077-84.
42. Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins. Villanueva S, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Apr;290(4):R861-70. Epub 2005 Nov 10.
43. Noggin and sclerostin bone morphogenetic protein antagonists form a mutually inhibitory complex. Winkler DG, etal., J Biol Chem. 2004 Aug 27;279(35):36293-8. Epub 2004 Jun 14.
44. Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing mice. Wu XB, etal., J Clin Invest. 2003 Sep;112(6):924-34.
45. Noggin inhibits hypoxia-induced proliferation by targeting store-operated calcium entry and transient receptor potential cation channels. Yang K, etal., Am J Physiol Cell Physiol. 2015 Jun 1;308(11):C869-78. doi: 10.1152/ajpcell.00349.2014. Epub 2015 Mar 4.
46. Functional analysis of alleged NOGGIN mutation G92E disproves its pathogenic relevance. Zimmer J, etal., PLoS One. 2012;7(4):e35062. doi: 10.1371/journal.pone.0035062. Epub 2012 Apr 18.
Additional References at PubMed
PMID:8582276   PMID:8752214   PMID:8889548   PMID:9585504   PMID:10684250   PMID:10688202   PMID:10780858   PMID:11562478   PMID:11784076   PMID:12141440   PMID:12397106   PMID:12435358  
PMID:15110716   PMID:15252029   PMID:15539560   PMID:15975920   PMID:16712836   PMID:16828469   PMID:16916379   PMID:17218603   PMID:17359964   PMID:17360443   PMID:17400546   PMID:17522159  
PMID:17889703   PMID:18028109   PMID:18028901   PMID:18462699   PMID:19850029   PMID:19852960   PMID:20501701   PMID:20675382   PMID:21624478   PMID:24835669   PMID:27546891  


Genomics

Comparative Map Data
Nog
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21074,128,712 - 74,130,339 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1074,128,712 - 74,130,339 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1078,757,906 - 78,759,533 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01078,262,852 - 78,264,479 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01073,730,695 - 73,732,322 (-)NCBIRnor_WKY
Rnor_6.01076,811,759 - 76,813,386 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1076,811,759 - 76,813,386 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01076,677,612 - 76,679,239 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41077,689,244 - 77,690,871 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11077,703,801 - 77,704,728 (-)NCBI
Celera1073,029,127 - 73,030,754 (-)NCBICelera
Cytogenetic Map10q26NCBI
NOG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381756,593,699 - 56,595,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1756,593,699 - 56,595,611 (+)EnsemblGRCh38hg38GRCh38
GRCh371754,671,060 - 54,672,972 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361752,026,274 - 52,027,546 (+)NCBINCBI36Build 36hg18NCBI36
Build 341752,026,273 - 52,027,542NCBI
Celera1751,132,757 - 51,134,648 (+)NCBICelera
Cytogenetic Map17q22NCBI
HuRef1750,031,838 - 50,033,727 (+)NCBIHuRef
CHM1_11754,735,932 - 54,737,820 (+)NCBICHM1_1
T2T-CHM13v2.01757,469,821 - 57,471,732 (+)NCBIT2T-CHM13v2.0
Nog
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391189,191,464 - 89,193,385 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1189,191,464 - 89,193,158 (-)EnsemblGRCm39 Ensembl
GRCm381189,300,638 - 89,302,559 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1189,300,638 - 89,302,332 (-)EnsemblGRCm38mm10GRCm38
MGSCv371189,161,952 - 89,163,873 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361189,117,412 - 89,118,110 (-)NCBIMGSCv36mm8
Celera1198,919,523 - 98,921,373 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1154.34NCBI
Nog
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554516,193,042 - 6,193,740 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554516,192,368 - 6,193,766 (-)NCBIChiLan1.0ChiLan1.0
NOG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11755,532,208 - 55,533,782 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1755,532,394 - 55,533,092 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01750,669,186 - 50,671,081 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NOG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1931,453,604 - 31,456,060 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha930,695,378 - 30,696,228 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0932,262,855 - 32,263,712 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl932,262,940 - 32,263,663 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1931,048,413 - 31,049,269 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0931,332,204 - 31,333,060 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0931,415,982 - 31,416,833 (+)NCBIUU_Cfam_GSD_1.0
Nog
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560230,811,040 - 30,812,486 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364906,262,785 - 6,263,483 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364906,262,651 - 6,264,069 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1232,891,321 - 32,892,206 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11232,891,321 - 32,892,206 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NOG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11636,816,783 - 36,818,693 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1636,817,476 - 36,818,174 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660777,642,384 - 7,644,356 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nog
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462479511,696,353 - 11,697,051 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462479511,696,102 - 11,697,367 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:73
Count of miRNA genes:62
Interacting mature miRNAs:67
Transcripts:ENSRNOT00000032388
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
2317042Aia20Adjuvant induced arthritis QTL 203.38joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)103756507982565079Rat
2317043Aia7Adjuvant induced arthritis QTL 73.82joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)103756507982565079Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104194452678307017Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)14232313287323132Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)104287676679813922Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)cortical volumetric bone mineral density (CMO:0001730)104944455181709989Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104944455181709989Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)104944455181709989Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1051770177107211142Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)106134527681714865Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106134541382564856Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106592723382565079Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
2289982Bp303Blood pressure QTL 303arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)107345299275632053Rat
724555Bp150Blood pressure QTL 1500.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107345299278210622Rat
12880053Cm104Cardiac mass QTL 1040.009heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)107345299283463334Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat

Markers in Region
RH66786  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21074,129,406 - 74,129,564 (+)MAPPERmRatBN7.2
Rnor_6.01076,812,454 - 76,812,611NCBIRnor6.0
Rnor_5.01076,678,307 - 76,678,464UniSTSRnor5.0
RGSC_v3.41077,689,939 - 77,690,096UniSTSRGSC3.4
Celera1073,029,822 - 73,029,979UniSTS
Cytogenetic Map10q26UniSTS
Nog  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21074,129,651 - 74,130,012 (+)MAPPERmRatBN7.2
Rnor_6.01076,812,699 - 76,813,059NCBIRnor6.0
Rnor_5.01076,678,552 - 76,678,912UniSTSRnor5.0
RGSC_v3.41077,690,184 - 77,690,544UniSTSRGSC3.4
Celera1073,030,067 - 73,030,427UniSTS
Cytogenetic Map10q26UniSTS
PMC316831P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21074,129,880 - 74,130,092 (+)MAPPERmRatBN7.2
Rnor_6.01076,812,928 - 76,813,139NCBIRnor6.0
Rnor_5.01076,678,781 - 76,678,992UniSTSRnor5.0
RGSC_v3.41077,690,413 - 77,690,624UniSTSRGSC3.4
Celera1073,030,296 - 73,030,507UniSTS
Cytogenetic Map10q26UniSTS
UniSTS:265422  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21074,129,394 - 74,129,916 (+)MAPPERmRatBN7.2
Rnor_6.01076,812,442 - 76,812,963NCBIRnor6.0
Rnor_5.01076,678,295 - 76,678,816UniSTSRnor5.0
RGSC_v3.41077,689,927 - 77,690,448UniSTSRGSC3.4
Celera1073,029,810 - 73,030,331UniSTS
Cytogenetic Map10q26UniSTS
UniSTS:489090  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21074,129,391 - 74,130,090 (+)MAPPERmRatBN7.2
Rnor_6.01076,812,439 - 76,813,137NCBIRnor6.0
Rnor_5.01076,678,292 - 76,678,990UniSTSRnor5.0
RGSC_v3.41077,689,924 - 77,690,622UniSTSRGSC3.4
Celera1073,029,807 - 73,030,505UniSTS
Cytogenetic Map10q26UniSTS
UniSTS:495034  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21074,129,343 - 74,130,155 (+)MAPPERmRatBN7.2
Rnor_6.01076,812,391 - 76,813,202NCBIRnor6.0
Rnor_5.01076,678,244 - 76,679,055UniSTSRnor5.0
RGSC_v3.41077,689,876 - 77,690,687UniSTSRGSC3.4
Celera1073,029,759 - 73,030,570UniSTS
Cytogenetic Map10q26UniSTS
NOG_2549  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21074,129,044 - 74,129,735 (+)MAPPERmRatBN7.2
Rnor_6.01076,812,092 - 76,812,782NCBIRnor6.0
Rnor_5.01076,677,945 - 76,678,635UniSTSRnor5.0
RGSC_v3.41077,689,577 - 77,690,267UniSTSRGSC3.4
Celera1073,029,460 - 73,030,150UniSTS
Cytogenetic Map10q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 20 2
Low 3 12 6 6 1 6 8 11 54 19 27 11 8
Below cutoff 15 30 19 13 19 15 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000032388   ⟹   ENSRNOP00000030212
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1074,128,712 - 74,130,339 (-)Ensembl
Rnor_6.0 Ensembl1076,811,759 - 76,813,386 (-)Ensembl
RefSeq Acc Id: NM_012990   ⟹   NP_037122
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21074,128,712 - 74,130,339 (-)NCBI
Rnor_6.01076,811,759 - 76,813,386 (-)NCBI
Rnor_5.01076,677,612 - 76,679,239 (-)NCBI
RGSC_v3.41077,689,244 - 77,690,871 (-)RGD
Celera1073,029,127 - 73,030,754 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_037122 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA83260 (Get FASTA)   NCBI Sequence Viewer  
  EDM05657 (Get FASTA)   NCBI Sequence Viewer  
  Q62809 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_037122   ⟸   NM_012990
- Peptide Label: precursor
- UniProtKB: G3V8X8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000030212   ⟸   ENSRNOT00000032388

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62809-F1-model_v2 AlphaFold Q62809 1-144 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3183 AgrOrtholog
BioCyc Gene G2FUF-23688 BioCyc
Ensembl Genes ENSRNOG00000023683 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000030212 ENTREZGENE
  ENSRNOP00000030212.3 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000032388 ENTREZGENE
  ENSRNOT00000032388.5 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Noggin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25495 UniProtKB/TrEMBL
NCBI Gene 25495 ENTREZGENE
PANTHER PTHR10494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nog PhenoGen
PIRSF Noggin UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC206935
UniProt G3V8X8 ENTREZGENE, UniProtKB/TrEMBL
  NOGG_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Nog  Noggin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the tufted cells of the olfactory bulb, the piriform cortex of the brain, and the Purkinje cells of the cerebellum 729002