Hcrt (hypocretin neuropeptide precursor) - Rat Genome Database

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Gene: Hcrt (hypocretin neuropeptide precursor) Rattus norvegicus
Analyze
Symbol: Hcrt
Name: hypocretin neuropeptide precursor
RGD ID: 2786
Description: Enables neuropeptide hormone activity; type 1 orexin receptor binding activity; and type 2 orexin receptor binding activity. Involved in several processes, including excitatory postsynaptic potential; regulation of metal ion transport; and regulation of transmission of nerve impulse. Located in secretory granule. Is active in neuronal dense core vesicle lumen. Biomarker of hyperglycemia; obesity; and sleeping sickness. Human ortholog(s) of this gene implicated in heroin dependence and narcolepsy. Orthologous to human HCRT (hypocretin neuropeptide precursor); PARTICIPATES IN orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; orexin/hypocretin signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypocretin; hypocretin (orexin) neuropeptide; hypocretin (orexin) neuropeptide precursor; orexin; orexin-A; prepro-orexin; preprohypocretin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,190,289 - 86,191,524 (-)NCBIGRCr8
mRatBN7.21085,689,979 - 85,691,214 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,689,465 - 85,691,210 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,726,483 - 90,727,718 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,205,335 - 90,206,570 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,598,213 - 85,599,448 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,669,216 - 88,670,430 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,669,214 - 88,670,430 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,463,386 - 88,464,600 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,699,633 - 89,700,847 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,714,002 - 89,715,214 (-)NCBI
Celera1084,405,435 - 84,406,649 (-)NCBICelera
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Circulating orexin changes during withdrawal are associated with nicotine craving and risk for smoking relapse. al'Absi M, etal., Addict Biol. 2019 Jul;24(4):743-753. doi: 10.1111/adb.12643. Epub 2018 Aug 16.
2. Adolescent alcohol exposure increases orexin-A/hypocretin-1 in the anterior hypothalamus. Amodeo LR, etal., Alcohol. 2020 Nov;88:65-72. doi: 10.1016/j.alcohol.2020.06.003. Epub 2020 Jun 30.
3. Orexin-A (hypocretin-1) impairs Morris water maze performance and CA1-Schaffer collateral long-term potentiation in rats. Aou S, etal., Neuroscience 2003;119(4):1221-8.
4. CSF hypocretin-1 (orexin-A) levels in childhood narcolepsy and neurologic disorders. Arii J, etal., Neurology. 2004 Dec 28;63(12):2440-2.
5. Pattern of orexin expression and direct biological actions of orexin-a in rat testis. Barreiro ML, etal., Endocrinology. 2005 Dec;146(12):5164-75. Epub 2005 Sep 1.
6. Orexin A expression and promoter methylation in patients with alcohol dependence comparing acute and protracted withdrawal. Bayerlein K, etal., Alcohol. 2011 Sep;45(6):541-7. doi: 10.1016/j.alcohol.2011.02.306. Epub 2011 May 28.
7. Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat. Beuckmann CT, etal., J Neurosci 2004 May 5;24(18):4469-77.
8. Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior. Boutrel B, etal., Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19168-73. Epub 2005 Dec 15.
9. Decreased plasma levels of orexin-A in sleep apnea. Busquets X, etal., Respiration. 2004 Nov-Dec;71(6):575-9.
10. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity. de Lecea L, etal., Proc Natl Acad Sci U S A 1998 Jan 6;95(1):322-7.
11. Stimulation of cortical acetylcholine release by orexin A. Fadel J, etal., Neuroscience 2005;130(2):541-7.
12. Orexin expression and function: glucocorticoid manipulation, stress, and feeding studies. Ford GK, etal., Endocrinology. 2005 Sep;146(9):3724-31. Epub 2005 Jun 16.
13. Hypothalamic levels of NPY, MCH, and prepro-orexin mRNA during pregnancy and lactation in the rat: role of prolactin. Garcia MC, etal., FASEB J 2003 Aug;17(11):1392-400.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Orexin neurons project to diverse sympathetic outflow systems. Geerling JC, etal., Neuroscience 2003;122(2):541-50.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Gastrointestinal-projecting neurones in the dorsal motor nucleus of the vagus exhibit direct and viscerotopically organized sensitivity to orexin. Grabauskas G and Moises HC, J Physiol 2003 May 15;549(Pt 1):37-56. Epub 2003 Apr 4.
18. Effects of orexin (hypocretin) on GIRK channels. Hoang QV, etal., J Neurophysiol 2003 Aug;90(2):693-702. Epub 2003 Apr 17.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Clozapine blocks sympathetic and thermogenic reactions induced by orexin A in rat. Monda M, etal., Physiol Res. 2004;53(5):507-13.
21. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
22. Hypocretin deficiency in Prader-Willi syndrome. Nevsimalova S, etal., Eur J Neurol. 2005 Jan;12(1):70-2.
23. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
24. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
25. Alterations of orexinergic and melanin-concentrating hormone neurons in experimental sleeping sickness. Palomba M, etal., Neuroscience. 2015 Apr 2;290:185-95. doi: 10.1016/j.neuroscience.2014.12.066. Epub 2015 Jan 13.
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Orexin A expression and promoter methylation in patients with cannabis dependence in comparison to nicotine-dependent cigarette smokers and nonsmokers. Rotter A, etal., Neuropsychobiology. 2012;66(2):126-33. doi: 10.1159/000339457. Epub 2012 Jul 27.
30. The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Sakurai T Nat Rev Neurosci. 2007 Mar;8(3):171-81. Epub 2007 Feb 14.
31. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Sakurai T, etal., Cell 1998 Feb 20;92(4):573-85.
32. Orexin receptor-1 mediates brown fat developmental differentiation. Sellayah D and Sikder D, Adipocyte. 2012 Jan 1;1(1):58-63. doi: 10.4161/adip.18965.
33. Hypocretin/orexin deficiency decreases cocaine abuse liability. Steiner N, etal., Neuropharmacology. 2018 May 1;133:395-403. doi: 10.1016/j.neuropharm.2018.02.010. Epub 2018 Feb 15.
34. Orexin-A immunoreactivity and prepro-orexin mRNA expression in hyperphagic rats induced by hypothalamic lesions and lactation. Sun G, etal., J Neuroendocrinol 2003 Jan;15(1):51-60.
35. Galanin-like peptide is target for regulation by orexin in the rat hypothalamus. Takenoya F, etal., Neurosci Lett 2003 Apr 17;340(3):209-12.
36. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
37. Orexin A in the nucleus accumbens stimulates feeding and locomotor activity. Thorpe AJ and Kotz CM, Brain Res. 2005 Jul 19;1050(1-2):156-62.
38. The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor. Wieland HA, etal., Eur J Biochem 2002 Feb;269(4):1128-35.
39. Peptides that regulate food intake: orexin gene expression is increased during states of hypertriglyceridemia. Wortley KE, etal., Am J Physiol Regul Integr Comp Physiol 2003 Jun;284(6):R1454-65. Epub 2003 Jan 30.
40. Postsynaptic excitation of prefrontal cortical pyramidal neurons by hypocretin-1/orexin A through the inhibition of potassium currents. Xia J, etal., J Neurosci Res. 2005 Dec 1;82(5):729-36.
41. Mechanisms of orexin A-evoked changes of intracellular calcium in primary cultured cortical neurons. Xia JX, etal., Neuroreport. 2005 May 12;16(7):783-6.
42. Orexin-A augments voltage-gated Ca2+ currents and synergistically increases growth hormone (GH) secretion with GH-releasing hormone in primary cultured ovine somatotropes. Xu R, etal., Endocrinology 2002 Dec;143(12):4609-19.
43. Expressions of the prepro-orexin and orexin type 2 receptor genes in obese rat. Yamamoto Y, etal., Peptides 2002 Sep;23(9):1689-96.
44. Dual regulatory effects of orexins on sympathetic nerve activity innervating brown adipose tissue in rats. Yasuda T, etal., Endocrinology. 2005 Jun;146(6):2744-8. Epub 2005 Mar 3.
45. Differences in orexin-A level in the functional brain network of HUD patients undergoing harm reduction therapy. You WR, etal., Medicine (Baltimore). 2022 Aug 19;101(33):e30093. doi: 10.1097/MD.0000000000030093.
46. Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. Zhu Y, etal., J Pharmacol Sci. 2003 Jul;92(3):259-66.
Additional References at PubMed
PMID:11283317   PMID:11340621   PMID:11748295   PMID:12126748   PMID:12147238   PMID:12409836   PMID:12535955   PMID:12611968   PMID:12736179   PMID:12948846   PMID:14499949   PMID:14749141  
PMID:14764632   PMID:15044362   PMID:15070772   PMID:15132733   PMID:15464197   PMID:15562511   PMID:15613374   PMID:15652654   PMID:15742403   PMID:15797953   PMID:15836821   PMID:15893599  
PMID:15924864   PMID:15976062   PMID:15978010   PMID:16045506   PMID:16054597   PMID:16100511   PMID:16110284   PMID:16153616   PMID:16157481   PMID:16168969   PMID:16271404   PMID:16388333  
PMID:16678283   PMID:16721031   PMID:16763079   PMID:16815564   PMID:16930690   PMID:17292491   PMID:17360905   PMID:17559101   PMID:17585016   PMID:17590434   PMID:17599478   PMID:17618058  
PMID:17626888   PMID:17638707   PMID:17924541   PMID:17928158   PMID:17928449   PMID:18187260   PMID:18577407   PMID:18591911   PMID:18614159   PMID:18783368   PMID:18973582   PMID:19028455  
PMID:19033203   PMID:19101033   PMID:19118115   PMID:19188611   PMID:19207823   PMID:19328827   PMID:19537922   PMID:19592616   PMID:19633949   PMID:19656173   PMID:19781813   PMID:19923781  
PMID:19945404   PMID:19952396   PMID:20141042   PMID:20141044   PMID:20149847   PMID:20177882   PMID:20307611   PMID:20331576   PMID:20528981   PMID:20541554   PMID:20542473   PMID:20600243  
PMID:20619297   PMID:20705949   PMID:20719929   PMID:20816937   PMID:20882064   PMID:21036204   PMID:21054340   PMID:21055430   PMID:21084614   PMID:21134420   PMID:21179559   PMID:21308795  
PMID:21347440   PMID:21547533   PMID:21575675   PMID:21589937   PMID:21605873   PMID:21739363   PMID:21741630   PMID:21871662   PMID:21884758   PMID:21971160   PMID:22213437   PMID:22300983  
PMID:22390944   PMID:22423101   PMID:22433299   PMID:22590628   PMID:22617634   PMID:22626650   PMID:22668854   PMID:22725682   PMID:22796468   PMID:22922124   PMID:22982721   PMID:23147417  
PMID:23264212   PMID:23404834   PMID:23558307   PMID:23664126   PMID:23861376   PMID:23922819   PMID:24068427   PMID:24262606   PMID:24277819   PMID:24304576   PMID:24333629   PMID:24634353  
PMID:24637063   PMID:24676683   PMID:24807827   PMID:24821311   PMID:24846570   PMID:24978951   PMID:25114294   PMID:25446223   PMID:25678147   PMID:25757577   PMID:26059340   PMID:26096126  
PMID:26254164   PMID:26287582   PMID:26415770   PMID:26787120   PMID:26843654   PMID:26907996   PMID:26919916   PMID:26919917   PMID:26943473   PMID:27080329   PMID:27137956   PMID:27385732  
PMID:27524625   PMID:27559138   PMID:27837432   PMID:28093335   PMID:28213131   PMID:28971565   PMID:29246398   PMID:29431649   PMID:29803804   PMID:29928888   PMID:30219208   PMID:30700376  
PMID:30721716   PMID:32694504   PMID:32798290   PMID:33048914   PMID:33170427   PMID:33212156   PMID:33352624   PMID:34358627   PMID:34500018   PMID:34533886   PMID:35013906   PMID:36656978  
PMID:37344019   PMID:38338864   PMID:39056112   PMID:39119889  


Genomics

Comparative Map Data
Hcrt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,190,289 - 86,191,524 (-)NCBIGRCr8
mRatBN7.21085,689,979 - 85,691,214 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,689,465 - 85,691,210 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,726,483 - 90,727,718 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,205,335 - 90,206,570 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,598,213 - 85,599,448 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,669,216 - 88,670,430 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,669,214 - 88,670,430 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,463,386 - 88,464,600 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,699,633 - 89,700,847 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,714,002 - 89,715,214 (-)NCBI
Celera1084,405,435 - 84,406,649 (-)NCBICelera
Cytogenetic Map10q31NCBI
HCRT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,184,060 - 42,185,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,184,060 - 42,185,452 (-)EnsemblGRCh38hg38GRCh38
GRCh371740,336,078 - 40,337,470 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,589,604 - 37,590,996 (-)NCBINCBI36Build 36hg18NCBI36
Build 341737,589,603 - 37,590,996NCBI
Celera1736,990,305 - 36,991,697 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,101,194 - 36,102,586 (-)NCBIHuRef
CHM1_11740,571,806 - 40,573,198 (-)NCBICHM1_1
T2T-CHM13v2.01743,040,552 - 43,041,944 (-)NCBIT2T-CHM13v2.0
Hcrt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,652,519 - 100,653,757 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,651,895 - 100,653,757 (-)EnsemblGRCm39 Ensembl
GRCm3811100,761,693 - 100,762,931 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,761,069 - 100,762,931 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711100,623,007 - 100,624,245 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,577,783 - 100,579,021 (-)NCBIMGSCv36mm8
Celera11111,378,254 - 111,379,492 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.6NCBI
Hcrt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,235,819 - 16,237,457 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,235,819 - 16,237,457 (-)NCBIChiLan1.0ChiLan1.0
HCRT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,798,659 - 22,800,095 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,688,821 - 24,691,491 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01715,130,581 - 15,132,024 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,353,203 - 15,354,594 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,353,203 - 15,354,594 (+)Ensemblpanpan1.1panPan2
HCRT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,729,616 - 20,732,074 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,730,779 - 20,732,028 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,191,816 - 20,193,065 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,448,985 - 21,450,877 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,449,587 - 21,450,836 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,234,894 - 20,236,143 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,501,999 - 20,503,248 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,605,051 - 20,606,300 (+)NCBIUU_Cfam_GSD_1.0
Hcrt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560220,066,733 - 20,068,144 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,006,997 - 17,008,369 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,007,001 - 17,008,363 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HCRT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,588,027 - 20,589,988 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,588,597 - 20,589,991 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,877,771 - 20,880,147 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HCRT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11664,083,199 - 64,085,393 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1664,084,070 - 64,085,292 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,898,734 - 34,900,062 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hcrt
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,744,648 - 1,746,633 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,744,782 - 1,747,360 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hcrt
2 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:37
Count of miRNA genes:35
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000025547
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104133325886333258Rat
1302404Cia27Collagen induced arthritis QTL 272.60.0045joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)1076452683107211142Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107437208494965338Rat
1300107Rf18Renal function QTL 183.41urine output (VT:0003620)timed urine volume (CMO:0000260)107877551698279596Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104502965095600334Rat
2317754Glom25Glomerulus QTL 253.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)1082685200107211142Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104444169989441699Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1053797385107211142Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
10450495Bp383Blood pressure QTL 3830.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)107624608594965338Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2292617Ept18Estrogen-induced pituitary tumorigenesis QTL 183.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
2293646Bss25Bone structure and strength QTL 2510.960.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1069738412107211142Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062057807107057807Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14232313287323132Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2300172Bmd57Bone mineral density QTL 579.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1069738412107211142Rat
70193Mcs7Mammary carcinoma susceptibility QTL 72.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1072224939107211142Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062057807107057807Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106674365598003205Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104444169989441699Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104232313287323132Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106134527698211570Rat
2293663Bss33Bone structure and strength QTL 339.340.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1069738412107211142Rat
1359017Hrtrt21Heart rate QTL 212.4heart pumping trait (VT:2000009)heart rate (CMO:0000002)105177294096772940Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1064890616107211142Rat
2312672Insul15Insulin level QTL 150.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1057134272102134272Rat
6893357Bw102Body weight QTL 1020.50.36body mass (VT:0001259)body weight (CMO:0000012)1080515287101325465Rat
2303589Bw87Body weight QTL 872body mass (VT:0001259)body weight (CMO:0000012)1081285008107211142Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1066978955107211142Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
2306793Ean5Experimental allergic neuritis QTL 54.7nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)107255241693995749Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)108402232193995963Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1051770177107211142Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)1066978955107211142Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068420376107211142Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)107889965587307728Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
70364Bp72Blood pressure QTL 72arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105112110096121100Rat
10450498Bp384Blood pressure QTL 3840.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1067750049107211142Rat
4889492Pancm2Pancreatic morphology QTL 23.2pancreatic beta cell morphology trait (VT:0005217)ratio of insulin-positive cell area to total area of splenic region of pancreas (CMO:0001814)1076748906107211142Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070199100107211142Rat
2293698Bss43Bone structure and strength QTL 435.330.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1059209888104209888Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)105177461295600334Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105480929299809292Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)106134527699703528Rat
631535Cm51Cardiac mass QTL 513heart mass (VT:0007028)calculated heart weight (CMO:0000073)105178628291669536Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040035094102359817Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040035094104060283Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104444169989441699Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)106134527699703528Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104736947092369470Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
12880055Am11Aortic mass QTL 110.004aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)108400727295933025Rat
2292438Bp311Blood pressure QTL 311arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1076246085107211142Rat
2312662Slep8Serum leptin concentration QTL 80.05blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1057134272102134272Rat
2301398Kidm38Kidney mass QTL 380.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)108400727295933025Rat
1600367Mcs15Mammary carcinoma susceptibility QTL 154.5mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1085565469103884409Rat
631537Oia4Oil induced arthritis QTL 4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)107563188787055282Rat
1358188Ept9Estrogen-induced pituitary tumorigenesis QTL 93.9pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)107345313696120911Rat
1642980Bp300Blood pressure QTL 300arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068383129107211142Rat
2312668Scl65Serum cholesterol level QTL 650.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1057134272102134272Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
RH139482  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,690,001 - 85,690,218 (+)MAPPERmRatBN7.2
Rnor_6.01088,669,226 - 88,669,442NCBIRnor6.0
Rnor_5.01088,463,396 - 88,463,612UniSTSRnor5.0
RGSC_v3.41089,699,643 - 89,699,859UniSTSRGSC3.4
Celera1084,405,445 - 84,405,661UniSTS
RH 3.4 Map10860.3UniSTS
Cytogenetic Map10q32.1UniSTS
PMC18213P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,690,304 - 85,691,205 (+)MAPPERmRatBN7.2
Rnor_6.01088,669,529 - 88,670,429NCBIRnor6.0
Rnor_5.01088,463,699 - 88,464,599UniSTSRnor5.0
RGSC_v3.41089,699,946 - 89,700,846UniSTSRGSC3.4
Celera1084,405,748 - 84,406,648UniSTS
Cytogenetic Map10q32.1UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
hemolymphoid system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
2 1 1 54 8 5 1 1 8 5 50 22 5

Sequence


Ensembl Acc Id: ENSRNOT00000025547   ⟹   ENSRNOP00000025547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,689,984 - 85,691,210 (-)Ensembl
Rnor_6.0 Ensembl1088,669,214 - 88,670,430 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095773   ⟹   ENSRNOP00000081572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,689,465 - 85,691,210 (-)Ensembl
RefSeq Acc Id: NM_013179   ⟹   NP_037311
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,190,289 - 86,191,524 (-)NCBI
mRatBN7.21085,689,979 - 85,691,214 (-)NCBI
Rnor_6.01088,669,216 - 88,670,430 (-)NCBI
Rnor_5.01088,463,386 - 88,464,600 (-)NCBI
RGSC_v3.41089,699,633 - 89,700,847 (-)RGD
Celera1084,405,435 - 84,406,649 (-)RGD
Sequence:
RefSeq Acc Id: NP_037311   ⟸   NM_013179
- Peptide Label: precursor
- UniProtKB: O55232 (UniProtKB/Swiss-Prot),   A6HJ60 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025547   ⟸   ENSRNOT00000025547
Ensembl Acc Id: ENSRNOP00000081572   ⟸   ENSRNOT00000095773

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55232-F1-model_v2 AlphaFold O55232 1-130 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2786 AgrOrtholog
BIND 128267
  130459
BioCyc Gene G2FUF-23214 BioCyc
Ensembl Genes ENSRNOG00000018892 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055033322 UniProtKB/Swiss-Prot
  ENSRNOG00060028629 UniProtKB/Swiss-Prot
  ENSRNOG00065028475 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025547.4 UniProtKB/Swiss-Prot
  ENSRNOT00000095773.1 UniProtKB/TrEMBL
  ENSRNOT00055057605 UniProtKB/Swiss-Prot
  ENSRNOT00060049791 UniProtKB/Swiss-Prot
  ENSRNOT00065049071 UniProtKB/Swiss-Prot
InterPro Orexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25723 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25723 ENTREZGENE
PANTHER OREXIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15173 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Orexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hcrt PhenoGen
PIRSF Orexin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS OREXINPP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018892 RatGTEx
  ENSRNOG00055033322 RatGTEx
  ENSRNOG00060028629 RatGTEx
  ENSRNOG00065028475 RatGTEx
TIGR TC220330
UniProt A0A8I5ZSA6_RAT UniProtKB/TrEMBL
  A6HJ59_RAT UniProtKB/TrEMBL
  A6HJ60 ENTREZGENE, UniProtKB/TrEMBL
  O55232 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-02-25 Hcrt  hypocretin neuropeptide precursor  Hcrt  hypocretin  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-18 Hcrt  tryptase alpha/beta 1  HcRt  hypocretin  Symbol updated to follow RGNC guidelines 1299863 APPROVED
2003-04-09 HcRt  hypocretin  Hcrt  Hypocretin (orexin) neuropeptide precursor  Name updated 629478 APPROVED
2002-06-10 Hcrt  Hypocretin (orexin) neuropeptide precursor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to granular vesicles at synapses 1298943
gene_expression mRNA expressed in brain 628422
gene_expression expression is restricted to neuronal cell bodies of the dorsal and lateral hypothalamic areas 1298943
gene_function a neuropeptide 628422
gene_process involved in regulating secretion of hormones like ACTH,LH, corticosterone, prolactin,insulin and thyroid stimulating hormone 628422
gene_process involved in regulating GHRH-stimulated GH secretion 628422
gene_process may act as neurotransmitters in CNS 1298943
gene_process involved in regulating feeding behavior 728644