Gene: Kcnj2 (potassium voltage-gated channel subfamily J member 2) Rattus norvegicus
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Symbol: Kcnj2
Name: potassium voltage-gated channel subfamily J member 2
Description: ENCODES a protein that exhibits identical protein binding (ortholog); inward rectifier potassium channel activity (ortholog); phosphatidylinositol-4,5-bisphosphate binding (ortholog); INVOLVED IN cellular response to mechanical stimulus; positive regulation of potassium ion transmembrane transport; regulation of cardiac muscle cell contraction; PARTICIPATES IN neuron-to-neuron signaling pathway via the chemical synapse; acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; ASSOCIATED WITH myocardial infarction; Andersen-Tawil syndrome (ortholog); Arsenic Poisoning (ortholog); FOUND IN dendrite; dendritic spine; Golgi apparatus; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; ammonium chloride; barium chloride
AGR Description: Predicted to have identical protein binding activity, phosphatidylinositol-4,5-bisphosphate binding activity, and transmembrane transporter activity; involved in cellular response to mechanical stimulus, positive regulation of potassium ion transmembrane transport, and regulation of cardiac muscle cell contraction; localizes to several cellular components, including the T-tubule, cytoplasm, and dendritic spine; used to study myocardial infarction; orthologous to human KCNJ2 (potassium voltage-gated channel subfamily J member 2).
Merged Description: Predicted to have identical protein binding activity, phosphatidylinositol-4,5-bisphosphate binding activity, and transmembrane transporter activity; involved in cellular response to mechanical stimulus, positive regulation of potassium ion transmembrane transport, and regulation of cardiac muscle cell contraction; localizes to several cellular components, including the T-tubule, cytoplasm, and dendritic spine; used to study myocardial infarction; orthologous to human KCNJ2 (potassium voltage-gated channel subfamily J member 2); PARTICIPATES IN neuron-to-neuron signaling pathway via the chemical synapse; acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; ammonium chloride; barium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: inward rectifier K(+) channel Kir2.1; inward rectifier potassium channel 2; IRK-1; Kir2.1; potassium channel, inwardly rectifying subfamily J member 2; potassium channel, inwardly rectifying subfamily J, member 2; potassium inwardly-rectifying channel, subfamily J, member 2; RBL-IRK1
Orthologs:
Allele / Splice: Kcnj2em2Mcwi   Kcnj2em4Mcwi  
Genetic Models: SS-Kcnj2em4Mcwi SS-Kcnj2em2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01099,429,337 - 99,442,520 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01099,125,234 - 99,134,077 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.410100,574,985 - 100,576,268 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.110100,589,354 - 100,590,638 (+)NCBI
Celera1094,712,069 - 94,713,352 (+)NCBICelera
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Kcnj2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 61968
Created: 2001-04-11
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.