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Gene: Doc2b (double C2 domain beta) Rattus norvegicus

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Symbol:

Doc2b

Name:

double C2 domain beta

RGD ID:

620519

Description:

Enables calcium-dependent phospholipid binding activity. Involved in calcium ion-regulated exocytosis of neurotransmitter; calcium-dependent activation of synaptic vesicle fusion; and positive regulation of calcium ion-dependent exocytosis. Located in plasma membrane. Part of SNARE complex. Is active in glutamatergic synapse. Is extrinsic component of synaptic vesicle membrane. Orthologous to human DOC2B (double C2 domain beta); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 6-propyl-2-thiouracil; amitrole.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

doc2-beta; double C2, beta; double C2-like domain-containing protein beta; double C2-like domains, beta

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DOC2B (double C2 domain beta)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Doc2b (double C2, beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Doc2b (double C2 domain beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DOC2B (double C2 domain beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DOC2B (double C2 domain beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Doc2b (double C2 domain beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DOC2B (double C2 domain beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	DOC2B (double C2 domain beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Doc2b (double C2 domain beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	DOC2A (double C2 domain alpha)	HGNC	OrthoDB
Alliance orthologs ³
Homo sapiens (human):	DOC2B (double C2 domain beta)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Doc2b (double C2, beta)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	doc2b (double C2-like domains, beta)	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Rph	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	rbf-1	Alliance	DIOPT (Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	61,126,295 - 61,151,533 (-)	NCBI		GRCr8
mRatBN7.2	10	60,628,029 - 60,653,267 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	60,628,029 - 60,653,267 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	65,274,693 - 65,300,895 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	64,780,111 - 64,806,313 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	60,242,686 - 60,268,888 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	63,921,255 - 63,952,944 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	63,928,064 - 63,952,726 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	64,053,913 - 64,078,844 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	63,115,782 - 63,140,805 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	63,129,404 - 63,154,428 (-)	NCBI
Celera	10	59,653,415 - 59,678,192 (-)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,2',5,5'-tetrachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

actinomycin D (ISO)

amitrole (EXP)

ammonium chloride (EXP)

anthra[1,9-cd]pyrazol-6(2H)-one (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

buta-1,3-diene (ISO)

C60 fullerene (EXP)

carbon nanotube (ISO)

chloroprene (ISO)

choline (ISO)

clotrimazole (EXP)

Cuprizon (EXP)

dibutyl phthalate (ISO)

dioxygen (ISO)

folic acid (ISO)

genistein (ISO)

L-methionine (ISO)

lead(0) (ISO)

leflunomide (ISO)

lipopolysaccharide (ISO)

malathion (ISO)

methapyrilene (ISO)

methimazole (EXP)

N-methyl-4-phenylpyridinium (ISO)

Nutlin-3 (ISO)

ozone (ISO)

PCB138 (EXP)

pinostrobin (ISO)

pirinixic acid (ISO)

progesterone (ISO)

rotenone (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

sotorasib (ISO)

sulfadimethoxine (EXP)

testosterone (ISO)

titanium dioxide (ISO)

trametinib (ISO)

triclosan (ISO)

valproic acid (EXP)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium ion-regulated exocytosis of neurotransmitter (IDA,IEA,ISO)

calcium-dependent activation of synaptic vesicle fusion (IBA,IDA,IEA,IMP,ISO)

exocytosis (IEP)

neurotransmitter secretion (IEA)

positive regulation of calcium ion-dependent exocytosis (IBA,IDA)

positive regulation of insulin secretion (IEA,ISO,ISS)

positive regulation of vesicle fusion (IDA)

protein localization (IEA,ISO,ISS)

spontaneous neurotransmitter secretion (IEA,ISO)

Cellular Component

cytoplasm (IEA,ISO,ISS)

extrinsic component of synaptic vesicle membrane (IDA,IEP)

glutamatergic synapse (IDA,IMP)

membrane (IEA)

plasma membrane (IDA,IEA,ISO)

presynapse (IEA)

SNARE complex (IDA)

synapse (IBA)

Molecular Function

calcium ion binding (IEA,ISO)

calcium-dependent phospholipid binding (IDA)

metal ion binding (IEA)

protein binding (ISO)

syntaxin binding (IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	DOC2B acts as a calcium switch and enhances vesicle fusion.	Friedrich R, etal., J Neurosci. 2008 Jul 2;28(27):6794-806. doi: 10.1523/JNEUROSCI.0538-08.2008.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release.	Groffen AJ, etal., Science. 2010 Mar 26;327(5973):1614-8. doi: 10.1126/science.1183765. Epub 2010 Feb 11.
5.	Calcium-dependent phospholipid binding to the C2A domain of a ubiquitous form of double C2 protein (Doc2 beta).	Kojima T, etal., J Biochem (Tokyo) 1996 Sep;120(3):671-6.
6.	Different spatiotemporal expression of DOC2 genes in the developing rat brain argues for an additional, nonsynaptic role of DOC2B in early development.	Korteweg N, etal., Eur J Neurosci 2000 Jan;12(1):165-71.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
9.	GOA pipeline	RGD automated data pipeline
10.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
11.	DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion.	Verhage M, etal., Neuron 1997 Mar;18(3):453-61.
12.	Doc2 is a Ca2+ sensor required for asynchronous neurotransmitter release.	Yao J, etal., Cell. 2011 Oct 28;147(3):666-77. doi: 10.1016/j.cell.2011.09.046.

Additional References at PubMed

PMID:9804756	PMID:17548353	PMID:19033398	PMID:21521611	PMID:23427263	PMID:24356452	PMID:26195798	PMID:26395669

Genomics

Comparative Map Data

Doc2b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	61,126,295 - 61,151,533 (-)	NCBI		GRCr8
mRatBN7.2	10	60,628,029 - 60,653,267 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	60,628,029 - 60,653,267 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	65,274,693 - 65,300,895 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	64,780,111 - 64,806,313 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	60,242,686 - 60,268,888 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	63,921,255 - 63,952,944 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	63,928,064 - 63,952,726 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	64,053,913 - 64,078,844 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	63,115,782 - 63,140,805 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	63,129,404 - 63,154,428 (-)	NCBI
Celera	10	59,653,415 - 59,678,192 (-)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

DOC2B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	142,789 - 181,650 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	142,789 - 181,650 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	67 - 31,441 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	5,810 - 31,270 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	17	96,907 - 129,072 (-)	NCBI		Celera
Cytogenetic Map	17	p13.3	NCBI
HuRef	17	15,749 - 39,198 (-)	NCBI		HuRef
CHM1_1	17	16,004 - 40,168 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	17	48,059 - 84,879 (-)	NCBI		T2T-CHM13v2.0

Doc2b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	75,659,096 - 75,686,886 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	75,659,792 - 75,686,875 (-)	Ensembl		GRCm39 Ensembl
GRCm38	11	75,768,270 - 75,796,060 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	75,768,966 - 75,796,049 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	75,582,592 - 75,609,559 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	75,585,285 - 75,612,252 (-)	NCBI		MGSCv36	mm8
Celera	11	83,278,304 - 83,305,458 (-)	NCBI		Celera
Cytogenetic Map	11	B5	NCBI
cM Map	11	45.92	NCBI

Doc2b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955481	1,842,815 - 1,860,374 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955481	1,839,894 - 1,859,733 (-)	NCBI	ChiLan1.0	ChiLan1.0

DOC2B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	19	7,677,806 - 7,716,293 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	17	9,235,284 - 9,272,796 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	19,854 - 58,336 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	80,050 - 123,659 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

DOC2B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	45,450,270 - 45,488,638 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	45,450,302 - 45,485,247 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	44,600,738 - 44,639,091 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	46,269,076 - 46,307,688 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	9	45,047,177 - 45,085,473 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	45,340,905 - 45,379,302 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	45,419,613 - 45,457,959 (+)	NCBI		UU_Cfam_GSD_1.0

Doc2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	44,582,572 - 44,608,703 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936538	7,469,408 - 7,483,516 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936538	7,461,030 - 7,486,648 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DOC2B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	47,529,367 - 47,562,373 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	47,529,383 - 47,558,236 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

DOC2B
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	17,890 - 51,080 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	19,294 - 49,309 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	22,046,077 - 22,087,709 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Doc2b
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624786	4,029,390 - 4,060,196 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624786	4,029,384 - 4,060,676 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	52
Count of miRNA genes:	50
Interacting mature miRNAs:	51
Transcripts:	ENSRNOT00000008429
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61441	Btemp1	Thermal response to stress QTL 1	4		body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	10	35893451	64140567	Rat
1549846	Scl47	Serum cholesterol level QTL 47	3.6		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	10	51071897	96071897	Rat
1578779	Tcas10	Tongue tumor susceptibility QTL 10	3.12		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	10	31796281	76796281	Rat
1298069	Bp168	Blood pressure QTL 168	5.5		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	10	27023535	98502431	Rat
2293669	Bmd33	Bone mineral density QTL 33	4.5	0.0001	femur strength trait (VT:0010010)	femoral neck polar moment of inertia (CMO:0001670)	10	27443787	72443787	Rat
631552	Vetf2	Vascular elastic tissue fragility QTL 2	4.5	0.0002	aorta elastic tissue integrity trait (VT:0010556)	artery internal elastic lamina non-tumorous lesion count (CMO:0001913)	10	35509383	91417879	Rat
631554	Bp133	Blood pressure QTL 133		0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	1250554	64349221	Rat
631557	Bp136	Blood pressure QTL 136		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	56868440	76129113	Rat
61325	Aia5	Adjuvant induced arthritis QTL 5		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2293679	Bmd30	Bone mineral density QTL 30	3.5	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	27443787	72443787	Rat
1298078	Stresp5	Stress response QTL 5	2.99	0.00025	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	10	42546145	107713808	Rat
1549831	Bss6	Bone structure and strength QTL 6	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	10	58073360	103073360	Rat
2298544	Neuinf9	Neuroinflammation QTL 9	4.6		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	10	19939207	64939207	Rat
61332	Eau3	Experimental allergic uveoretinitis QTL 3		0.004	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	18035782	63035782	Rat
70164	Bw21	Body weight QTL 21	4.36	0.00005	body mass (VT:0001259)	body weight (CMO:0000012)	10	54296336	99451733	Rat
61463	Bp12	Blood pressure QTL 12	6.3	0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	41831278	86831278	Rat
1579919	Bp281	Blood pressure QTL 281		0.01	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	50464802	95464802	Rat
8694173	Bw149	Body weight QTL 149	4.38	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	10	44939359	89939359	Rat
2300218	Hpcl2	Hepatic cholesterol level QTL 2			liver cholesterol amount (VT:0010498)	liver cholesterol level (CMO:0001597)	10	45529164	96099749	Rat
70171	Cari1	Carrageenan-induced inflammation QTL 1	4.9	0.0005	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	10	54296227	107713808	Rat
1598852	Anxrr19	Anxiety related response QTL 19	5.07		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	10	18668419	63668419	Rat
1581497	Esta1	Estrogen-induced thymic atrophy QTL 1			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	10	21833758	61843633	Rat
10450493	Bp382	Blood pressure QTL 382		0.002	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	50860288	95860288	Rat
724527	Bp148	Blood pressure QTL 148		0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	28950353	73950353	Rat
1358897	Stresp6	Stress response QTL 6	4.17	0.022	blood norepinephrine amount (VT:0005663)	plasma norepinephrine level (CMO:0001010)	10	35893263	64653589	Rat
1331762	Rf40	Renal function QTL 40	3.873		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal vascular resistance (CMO:0001900)	10	29800910	64653589	Rat
2300171	Bmd58	Bone mineral density QTL 58	4.9	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	10	27443787	72443787	Rat
61354	Pia10	Pristane induced arthritis QTL 10		0.01	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2301967	Cm73	Cardiac mass QTL 73	4.55		heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	10	14991535	86964295	Rat
70188	BpQTLcluster1	Blood pressure QTL cluster 1	4.864		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	42823274	87823274	Rat
9589030	Epfw9	Epididymal fat weight QTL 9	19.24	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	10	44939359	89939359	Rat
2316949	Gluco60	Glucose level QTL 60	3.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	10	14991535	107556066	Rat
2293652	Bmd22	Bone mineral density QTL 22	4.9	0.0001	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	10	27443787	72443787	Rat
70198	BpQTLcluster9	Blood pressure QTL cluster 9	2.94		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	42823274	87823274	Rat
2306787	Ean3	Experimental allergic neuritis QTL 3	3.1		nervous system integrity trait (VT:0010566)	body weight loss (CMO:0001399)	10	54296227	67476781	Rat
724556	Pur2	Proteinuria QTL 2	5.5		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	10	22931373	91127454	Rat
8662860	Vetf10	Vascular elastic tissue fragility QTL 10			artery integrity trait (VT:0010639)	number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)	10	6660923	73950353	Rat
2306792	Ean4	Experimental allergic neuritis QTL 4	4		nervous system integrity trait (VT:0010566)	IFNG-secreting splenocyte count (CMO:0002122)	10	49495492	94495492	Rat
61387	Bp1	Blood pressure QTL 1	5.1		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	52269185	107713808	Rat
1354587	Kidm21	Kidney mass QTL 21	3.3		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	10	15533012	73695498	Rat
634329	Pia15	Pristane induced arthritis QTL 15	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	24662123	73695339	Rat
70224	Eae3	Experimental allergic encephalomyelitis QTL 3	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	10	27023535	61843633	Rat
2298480	Eau7	Experimental allergic uveoretinitis QTL 7		0.0049	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	10	35509383	80509383	Rat
1331791	Cm31	Cardiac mass QTL 31	3.84606		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	10	29800910	91417879	Rat
2298495	Eae23	Experimental allergic encephalomyelitis QTL 23	16.93		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis duration (CMO:0001424)	10	16175525	61175525	Rat
2313087	Bmd80	Bone mineral density QTL 80	3.2	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	10	20110614	65110614	Rat
631530	Tls3	T-lymphoma susceptibility QTL 3	0	0.0001	thymus integrity trait (VT:0010555)	percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)	10	27587226	96099902	Rat
2289985	Bp305	Blood pressure QTL 305			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	29076978	74076978	Rat
1354608	Cm33	Cardiac mass QTL 33	2.8		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	10	55307972	93608131	Rat
631532	Cm50	Cardiac mass QTL 50	6.6		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	10	18035782	63035782	Rat
8552805	Bw145	Body weight QTL 145	2.2		body mass (VT:0001259)	change in body weight to body weight ratio (CMO:0002216)	10	43608793	88608793	Rat
631267	Cia20	Collagen induced arthritis QTL 20	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	23948641	107713808	Rat
2293705	Bmd25	Bone mineral density QTL 25	7.1	0.0001	femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	10	27443787	72443787	Rat
631269	Cia22	Collagen induced arthritis QTL 22	8.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
1576308	Schws1	Schwannoma susceptibility QTL 1		0.0041	nervous system integrity trait (VT:0010566)	percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)	10	40535708	107713808	Rat
631268	Cia21	Collagen induced arthritis QTL 21	3.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	14991535	107713808	Rat
7207811	Bmd90	Bone mineral density QTL 90	5.2		femur size trait (VT:1000369)	femoral neck cross-sectional area (CMO:0001697)	10	49943710	94943710	Rat
1576311	Pia26	Pristane induced arthritis QTL 26			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	31129113	76129113	Rat
631270	Cia23	Collagen induced arthritis QTL 23	3.9		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	40535708	107713808	Rat
7411614	Foco18	Food consumption QTL 18		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	10	44939359	89939359	Rat
631547	Bp87	Blood pressure QTL 87	4.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	47869129	92869129	Rat
61427	Cia16	Collagen induced arthritis QTL 16	3.2		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	10	6864618	96620484	Rat
12880050	Am10	Aortic mass QTL 10		0.016	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	10	39503487	84503487	Rat
2292436	Bp310	Blood pressure QTL 310			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	10	50604677	95604677	Rat
6893342	Cm78	Cardiac mass QTL 78	0.1	0.88	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	10	35509383	88177745	Rat
2313055	Bw96	Body weight QTL 96	3.6	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	10	20110614	65110614	Rat
631542	Bp82	Blood pressure QTL 82	6.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	10	27023535	99451848	Rat

Markers in Region

BG375498

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	10	60,651,205 - 60,651,334 (+)	MAPPER	mRatBN7.2
Rnor_6.0	10	63,950,826 - 63,950,954	NCBI	Rnor6.0
Rnor_5.0	10	64,055,749 - 64,055,877	UniSTS	Rnor5.0
RGSC_v3.4	10	63,138,730 - 63,138,858	UniSTS	RGSC3.4
Celera	10	59,676,182 - 59,676,310	UniSTS
Cytogenetic Map	10	q24	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	47	113	89	88	57	25	57	6	214	95	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031142	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017597549	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473948	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U70778	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000090461 ⟹ ENSRNOP00000074543

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	60,628,029 - 60,653,267 (-)	Ensembl
Rnor_6.0 Ensembl	10	63,928,064 - 63,952,726 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108492 ⟹ ENSRNOP00000077032

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	60,628,029 - 60,653,267 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000118069 ⟹ ENSRNOP00000079044

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	10	60,628,029 - 60,653,267 (-)	Ensembl

RefSeq Acc Id:

NM_031142 ⟹ NP_112404

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	10	61,126,295 - 61,151,533 (-)	NCBI
mRatBN7.2	10	60,628,029 - 60,653,267 (-)	NCBI
Rnor_6.0	10	63,927,658 - 63,952,881 (-)	NCBI
Rnor_5.0	10	64,053,913 - 64,078,844 (+)	NCBI
RGSC_v3.4	10	63,115,782 - 63,140,805 (-)	RGD
Celera	10	59,653,415 - 59,678,192 (-)	RGD

Sequence:

show sequence

GCCGCCGCCGAGCAGGCAGCAGCCGCGTCAGGGCCGTCCGGGGGCCACACCGGCGATGCCCGCA
GCCCCCGCAGCGCCCCGCGGGACCCGCTGACTTACCCCCGGGCCGGGGTCATACCGGGCCGGGC
CGGGCCGCGAGCGGCGGCGCTGCCTGCATGACCCTCCGGAGGCGCGGGGAGAAGGCGACCATCA
GCATCCAAGAGCATATGGCCATCGACGTGTGTCCCGGGCCCATCCGGCCTATCAAGCAGATCTC
CGATTACTTCCCCCGCTTCCCGCGGGGCCTCCCCCCCACCGCCGCGCCCCGCGCCTCCGCGCCC
CCGGACGCCCCCGCGCGCTCGCCCGCAGCCACCGCCGGCCCCCGCAGCCCCTCCGACGGCGCCC
GCGACGACGACGAAGATGTGGACCAGCTCTTCGGAGCCTACGGTGCCAGCCCAGGCCCCAGCCC
CGGACCCAGCCCCGTGAGGCCGCCGGCCAAGCCCCCCGAGGACGAACCGGACGCCGACGGCTAC
GAGTCAGACGACTGCACCGCCCTGGGTACACTGGACTTCAGTCTGCTCTATGACCAGGAGAACA
ACGCACTGCACTGCACCATCAGCAAAGCCAAGGGCCTGAAGCCGATGGATCACAATGGACTGGC
TGATCCCTACGTCAAACTACACTTGCTGCCTGGAGCCAGCAAGGCAAATAAGCTCAGAACAAAA
ACCCTACGGAACACTCTGAACCCCTCCTGGAACGAGACCCTCACCTATTACGGGATCACGGATG
AGGACATGATCCGAAAGACCCTGAGGATCTCCGTGTGTGACGAGGACAAATTCCGCCACAACGA
GTTCATCGGAGAGACTCGAGTGCCCCTGAAGAAGCTGAAACCCAACCACACCAAGACATTCAGC
ATCTGCCTGGAGAAGCAGCTGCCGGTGGACAAGGCAGAGGACAAGTCCCTGGAGGAGCGTGGCC
GCATCCTCATCTCTCTCAAGTACAGCTCACAGAAGCAGGGCCTGCTGGTGGGCATCGTTCGCTG
CGCACACCTGGCGGCCATGGATGCTAACGGCTACTCAGACCCCTACGTGAAAACATATCTGAAA
CCAGATGTAGACAAGAAATCCAAGCATAAGACCGCAGTCAAGAAGAAAACACTAAACCCTGAAT
TCAATGAGGAGTTCTGTTACGAGATCAAGCATGGAGACCTAGCCAAAAAGACCCTGGAGGTCAC
TGTCTGGGACTATGATATTGGAAAATCCAATGATTTCATCGGTGGGGTGGTTCTGGGCATCAAT
GCCAAGGGTGAGCGCCTGAAGCACTGGTTTGACTGTCTGAAGAACAAGGACAAGAGGATTGAGC
GTTGGCACACGCTCACCAATGAGATCCCAGGGGCTGTACTCAGCGACTGACTGTCCCATCTGCT
GCCACCCACCCTTGCCACCCAGCCCACACAGGTCCAACCCTGGGCTTTCTCAGCTGCCACCAAG
GGCTGTGGCCCTCACAATGGGCAAGATCCAGGTTGTCTGCTCGGACATAGCCACTGCAGCCCCT
GCTAGGAGGCTAGGAGGCCAAGAGCACCCAGCCTCTCGCAGAGGGACAGGAAAACACAACATGA
AACCTGTTTCAGCTCCCCTGGCACCCCAAAGGGCCAGAGCTGGGAGAAATCCTCAGCCTCAGCT
CTGTCCAGTGGAAGGGCTATCTACAGTGAGGACCTATCAGAGGTGAGGGGTGGAACCCTGCTGC
AAGCACAGAAATGGGGGTACTCTGGCTACCTGGAGACCACAGAGGGAGGACTATGGGCAGGCAG
AGCCCAGG

hide sequence

Protein Sequences


Protein RefSeqs	NP_112404	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB47747	(Get FASTA)	NCBI Sequence Viewer
	EDM05243	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000074543.2
	ENSRNOP00000077032.1
	ENSRNOP00000079044.1
GenBank Protein	P70610	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_112404 ⟸ NM_031142

- UniProtKB:

P70610 (UniProtKB/Swiss-Prot), A0A8I5XVQ2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTLRRRGEKATISIQEHMAIDVCPGPIRPIKQISDYFPRFPRGLPPTAAPRASAPPDAPARSPA
ATAGPRSPSDGARDDDEDVDQLFGAYGASPGPSPGPSPVRPPAKPPEDEPDADGYESDDCTALG
TLDFSLLYDQENNALHCTISKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPS
WNETLTYYGITDEDMIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPV
DKAEDKSLEERGRILISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLKPDVDKKSKH
KTAVKKKTLNPEFNEEFCYEIKHGDLAKKTLEVTVWDYDIGKSNDFIGGVVLGINAKGERLKHW
FDCLKNKDKRIERWHTLTNEIPGAVLSD

hide sequence

Ensembl Acc Id:

ENSRNOP00000074543 ⟸ ENSRNOT00000090461

Ensembl Acc Id:

ENSRNOP00000079044 ⟸ ENSRNOT00000118069

Ensembl Acc Id:

ENSRNOP00000077032 ⟸ ENSRNOT00000108492

Protein Domains

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P70610-F1-model_v2	AlphaFold	P70610	1-412	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620519	AgrOrtholog
BioCyc Gene	G2FUF-24186	BioCyc
Ensembl Genes	ENSRNOG00000060054	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000090461.2	UniProtKB/TrEMBL
	ENSRNOT00000108492.1	UniProtKB/TrEMBL
	ENSRNOT00000118069.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.150	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	C2_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	C2_domain_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Doc2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Rabphilin/DOC2/Noc2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Rabphilin_Doc2_C2A	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Synaptotagmin	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:81820	UniProtKB/Swiss-Prot
NCBI Gene	81820	ENTREZGENE
PANTHER	DOUBLE C2-LIKE DOMAIN-CONTAINING PROTEIN BETA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR45729	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PF00168	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Doc2b	PhenoGen
PIRSF	Doc2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS	C2DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SYNAPTOTAGMN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	PS50004	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000060054	RatGTEx
SMART	SM00239	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF49562	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K8B5_RAT	UniProtKB/TrEMBL
	A0A8I5XVQ2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZM21_RAT	UniProtKB/TrEMBL
	A6HGT8_RAT	UniProtKB/TrEMBL
	DOC2B_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-03-29	Doc2b	double C2 domain beta	Doc2b	double C2-like domains, beta	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-17	Doc2b	double C2-like domains, beta	Doc2b	double C2, beta	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Doc2b	double C2, beta		Doc2b	Symbol and Name status set to approved	1299863	APPROVED
2002-08-07	Doc2b	Doc2b			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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