DOC2B (double C2 domain beta) - Rat Genome Database

Name: DOC2B
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| FTP Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: DOC2B (double C2 domain beta) Pan paniscus

Analyze

Symbol:

DOC2B

Name:

double C2 domain beta

RGD ID:

11895420

Description:

ENCODES a protein that exhibits calcium ion binding (ortholog); calcium-dependent phospholipid binding (ortholog); syntaxin binding (ortholog); INVOLVED IN calcium ion-regulated exocytosis of neurotransmitter (ortholog); exocytosis (ortholog); positive regulation of calcium ion-dependent exocytosis (ortholog); FOUND IN cytoplasm (ortholog); plasma membrane (ortholog); presynapse (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

double C2-like domain-containing protein beta

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DOC2B (double C2 domain beta)	NCBI	Ortholog
Mus musculus (house mouse):	Doc2b (double C2, beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Doc2b (double C2 domain beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Doc2b (double C2 domain beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DOC2B (double C2 domain beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Doc2b (double C2 domain beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DOC2B (double C2 domain beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	DOC2B (double C2 domain beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Doc2b (double C2 domain beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	17	80,050 - 123,659 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	17	19,854 - 58,336 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

calcium ion-regulated exocytosis of neurotransmitter (ISO)

exocytosis (ISO)

positive regulation of calcium ion-dependent exocytosis (ISO)

positive regulation of insulin secretion (ISO)

positive regulation of vesicle fusion (ISO)

protein localization (ISO)

spontaneous neurotransmitter secretion (ISO)

Cellular Component

cytoplasm (ISO)

plasma membrane (ISO)

presynapse (ISO)

SNARE complex (ISO)

synapse (ISO)

Molecular Function

calcium ion binding (ISO)

calcium-dependent phospholipid binding (ISO)

protein binding (ISO)

syntaxin binding (ISO)

References

Genomics

Comparative Map Data

DOC2B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	17	80,050 - 123,659 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	17	19,854 - 58,336 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

DOC2B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	17	142,789 - 181,650 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	17	142,789 - 181,650 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	17	6,009 - 31,421 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	5,810 - 31,270 (-)	NCBI	NCBI36		hg18	NCBI36
Celera	17	96,907 - 129,072 (-)	NCBI
Cytogenetic Map	17	p13.3	NCBI
HuRef	17	15,749 - 39,198 (-)	NCBI		HuRef
CHM1_1	17	16,004 - 40,168 (-)	NCBI		CHM1_1

Doc2b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	75,659,096 - 75,686,886 (-)	NCBI	GRCm39		mm39
GRCm38	11	75,768,270 - 75,796,060 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	75,768,966 - 75,796,049 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	75,582,592 - 75,609,559 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	11	75,585,285 - 75,612,252 (-)	NCBI			mm8
Celera	11	83,278,304 - 83,305,458 (-)	NCBI		Celera
Cytogenetic Map	11	B5	NCBI

Doc2b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	10	63,921,255 - 63,952,944 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	63,928,064 - 63,952,726 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	64,053,913 - 64,078,844 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	63,115,782 - 63,140,805 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	10	63,129,404 - 63,154,428 (-)	NCBI
Celera	10	59,653,415 - 59,678,192 (-)	NCBI		Celera
Cytogenetic Map	10	q24	NCBI

Doc2b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955481	1,842,815 - 1,860,374 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955481	1,839,894 - 1,859,733 (-)	NCBI	ChiLan1.0	ChiLan1.0

DOC2B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	9	45,450,302 - 45,485,247 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	9	45,450,270 - 45,488,638 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Doc2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936538	7,461,030 - 7,486,648 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DOC2B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	47,529,566 - 47,562,373 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	47,529,383 - 47,558,236 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

DOC2B
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1 Ensembl	16	19,294 - 49,309 (-)	Ensembl
ChlSab1.1	16	17,890 - 51,080 (-)	NCBI

Doc2b
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624786	4,029,384 - 4,060,676 (+)	NCBI

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003846023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034941188	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034941189	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	SSBP01000581	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

XM_003846023 ⟹ XP_003846071

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1	17	80,050 - 111,813 (-)	NCBI
Mhudiblu_PPA_v0	17	23,443 - 57,322 (-)	NCBI

Sequence:

show sequence

GAGGTCGCAGTCCAGTGAGGAATCGGTTTGCGCGGGGTGGGGATGGCATGTGAGAACCCCCTCC
TAGCTCAGCTGTGGCTCCAGACTTGTCACTGAGACCTGGAAAACCAGCGTCAAACCCCAGCCCT
TCCCGGGATGTGGCCCTTCTCCAGGGCTGGTGCTGCCCCTCCCCTGCGCAGCAGGGATGTCTGC
GCCTGGCTTGGGCACTCACCAGGGCCTGTGGGCTGCGGGCCTGGAGTTTCCCAAGCATCAAATG
TGCCACCGGAAGCTGAAGCCGCCCTGGGCACGCTGGACTTCAGCCTGCTGTATGACCAGGAGAA
CAACGCCCTCCACTGCACCATCACCAAGGCCAAGGGCCTGAAGCCAATGGACCACAATGGGCTG
GCAGACCCCTACGTCAAGCTGCACCTGCTGCCAGGAGCCAGTAAGGCAAATAAGCTCAGAACAA
AAACTCTCCGTAACACTCTGAACCCCACATGGAACGAGACCCTCACTTACTACGGGATCACAGA
TGAAGACATGATCCGCAAGACCCTGCGGATCTCTGTGTGTGACGAGGACAAATTCCGGCACAAT
GAGTTCATCGGGGAGACACGTGTGCCCCTGAAGAAGCTGAAACCCAACCACACCAAGACCTTCA
GCATCTGCCTGGAGAAGCAGCTGCCGGTGGACAAGACCGAAGACAAGTCCCTGGAGGAGCGGGG
CCGCATCCTCATCTCCCTCAAGTACAGCTCGCAGAAGCAGGGCCTGCTGGTAGGCATCGTGCGG
TGCGCCCACCTGGCCGCCATGGACGCCAATGGCTACTCGGACCCCTACGTGAAAACATACCTGA
GGCCAGATGTGGACAAGAAATCCAAACATAAGACAGCGGTGAAGAAAAAAACCCTGAACCCGGA
GTTTAATGAGGAGTTCTGTTACGAGATCAAGCATGGGGACCTGGCCAAGAAGTCCCTGGAGGTC
ACCGTTTGGGATTACGACATTGGAAAATCCAACGATTTCATTGGTGGTGTGGTTCTGGGCATCC
ACGCCAAGGGGGAGCGCCTGAAGCACTGGTTTGACTGCCTGAAGAACAAGGACAAGCGCATCGA
GCGCTGGCACACGCTCACCAGCGAGCTCCCAGGGGCGTGCTCAGCGACTGACGCCCACCCGCCA
CTGCTACCCCTGCCGCCACCTGCGCCCAGCACGGCCGGCCCCGGGCTTCCCCAGCAGCCACCAA
GGCCTGTGGCCCCCACACTGGGGGAGATCCAGAACCCCTGCTTGGACACAGAGCCACTGCAGTC
CCCGTCGGAGGACGTGGAGGGCTCAGCCACTCTGGGACGGGGAGGGCAAGGAGCTGGGGTGGGG
GGCTCTCAGCCCTCTGGGGCCCAAGAGGCGGTGGTGGAAAGAGACCTCAGCACCTGCCCAGGGG
AAGGGGACACGCCCATCTGGGAGCAAAGACCCTTCTAGAGGCCAGCCCTGGCTGAGAGGACAGG
AGTGTGGGGGCGCCTTGGCGGACAGTGGGAACAGAGGAGGGAGGTGGTGAGCAGACAGACAGGT
GGAGGATGGGACCTTGAAGACTGGCTGCTCCAGCCCAAGAAAGCCTGACTGCATCCCTCATCTC
TTCGCTGCTGGACAGATGGAAGAAGCGGGGCCTGCCGGCCGAAAGTC

hide sequence

RefSeq Acc Id:

XM_034941188 ⟹ XP_034797079

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
Mhudiblu_PPA_v0	17	19,854 - 58,336 (-)	NCBI

RefSeq Acc Id:

XM_034941189 ⟹ XP_034797080

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
Mhudiblu_PPA_v0	17	23,443 - 58,233 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003846071	(Get FASTA)	NCBI Sequence Viewer
	XP_034797079	(Get FASTA)	NCBI Sequence Viewer
	XP_034797080	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_003846071 ⟸ XM_003846023

- Peptide Label:

isoform X3

- Sequence:

show sequence

MWPFSRAGAAPPLRSRDVCAWLGHSPGPVGCGPGVSQASNVPPEAEAALGTLDFSLLYDQENNA
LHCTITKAKGLKPMDHNGLADPYVKLHLLPGASKANKLRTKTLRNTLNPTWNETLTYYGITDED
MIRKTLRISVCDEDKFRHNEFIGETRVPLKKLKPNHTKTFSICLEKQLPVDKTEDKSLEERGRI
LISLKYSSQKQGLLVGIVRCAHLAAMDANGYSDPYVKTYLRPDVDKKSKHKTAVKKKTLNPEFN
EEFCYEIKHGDLAKKSLEVTVWDYDIGKSNDFIGGVVLGIHAKGERLKHWFDCLKNKDKRIERW
HTLTSELPGACSATDAHPPLLPLPPPAPSTAGPGLPQQPPRPVAPTLGEIQNPCLDTEPLQSPS
EDVEGSATLGRGGQGAGVGGSQPSGAQEAVVERDLSTCPGEGDTPIWEQRPF

hide sequence

RefSeq Acc Id:	XP_034797079 ⟸ XM_034941188
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_034797080 ⟸ XM_034941189
- Peptide Label:	isoform X2

Additional Information

External Database Links

Database	Acc Id	Source(s)
NCBI Gene	DOC2B	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)