Nos2 (nitric oxide synthase 2) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Nos2 (nitric oxide synthase 2) Rattus norvegicus
Analyze
Symbol: Nos2
Name: nitric oxide synthase 2
RGD ID: 3185
Description: Enables several functions, including Hsp90 protein binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in several processes, including cellular response to cytokine stimulus; response to bacterium; and response to hexose. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and peroxisome. Used to study several diseases, including Alzheimer's disease; diabetic angiopathy; pleurisy; renal hypertension; and toxic shock syndrome. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); inflammatory bowel disease (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); hypertension (multiple); malaria; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human NOS2 (nitric oxide synthase 2); PARTICIPATES IN endothelin signaling pathway; hypoxia inducible factor pathway; interleukin-12 signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-sesamin; (+)-Tetrandrine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: inducible nitric oxide synthase; inducible NO synthase; inducible NOS; iNos; LOC497963; Nitric oxide synthase 2 inducible; Nitric oxide synthase 2 inducible macrophage; nitric oxide synthase 2, inducible; nitric oxide synthase 2, inducible, macrophage; nitric oxide synthase, inducible; nitric oxide synthase, inducible-like; NOS type II; Nos2a; peptidyl-cysteine S-nitrosylase NOS2; similar to Nitric oxide synthase, inducible (NOS type II) (Inducible NO synthase) (Inducible NOS) (iNOS)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Nos2-ps1  
Is Marker For: Strains:   SS.LEW-(Nos2-D10M11Mit119)/Ayd   SS.MNS-(D10Mco10-Aldoc)/Jr   SS.MNS-(Aldoc-D10Mco1)/Jr  
QTLs:   Bp12   Bp76   Bp133  
Candidate Gene For: Bp12 Bp71 Bp136 Bp168 Eau9
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21063,815,308 - 63,851,208 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,815,308 - 63,851,210 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1068,445,568 - 68,481,178 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01067,950,910 - 67,986,520 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01063,419,659 - 63,455,435 (+)NCBIRnor_WKY
Rnor_6.01066,188,290 - 66,221,621 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1066,189,786 - 66,313,190 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01065,423,626 - 65,456,957 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41065,036,884 - 65,072,453 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11065,050,519 - 65,086,394 (+)NCBI
Celera1062,790,940 - 62,826,625 (+)NCBICelera
Cytogenetic Map10q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model