Nos2 (nitric oxide synthase 2) - Rat Genome Database

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Gene: Nos2 (nitric oxide synthase 2) Rattus norvegicus
Symbol: Nos2
Name: nitric oxide synthase 2
RGD ID: 3185
Description: Enables several functions, including Hsp90 protein binding activity; beta-catenin binding activity; and enzyme binding activity. Involved in several processes, including cellular response to cytokine stimulus; response to bacterium; and response to hexose. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and peroxisome. Used to study several diseases, including Alzheimer's disease; diabetic angiopathy; pleurisy; renal hypertension; and toxic shock syndrome. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); inflammatory bowel disease (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); hypertension (multiple); malaria; pulmonary tuberculosis; and type 2 diabetes mellitus. Orthologous to human NOS2 (nitric oxide synthase 2); PARTICIPATES IN endothelin signaling pathway; hypoxia inducible factor pathway; interleukin-12 signaling pathway; INTERACTS WITH (+)-pilocarpine; (+)-sesamin; (+)-Tetrandrine.
Type: protein-coding
Previously known as: inducible nitric oxide synthase; inducible NO synthase; inducible NOS; iNos; LOC497963; Nitric oxide synthase 2 inducible; Nitric oxide synthase 2 inducible macrophage; nitric oxide synthase 2, inducible; nitric oxide synthase 2, inducible, macrophage; nitric oxide synthase, inducible; nitric oxide synthase, inducible-like; NOS type II; Nos2a; peptidyl-cysteine S-nitrosylase NOS2; similar to Nitric oxide synthase, inducible (NOS type II) (Inducible NO synthase) (Inducible NOS) (iNOS)
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Nos2-ps1  
Is Marker For: Strains:   SS.LEW-(Nos2-D10M11Mit119)/Ayd   SS.MNS-(D10Mco10-Aldoc)/Jr   SS.MNS-(Aldoc-D10Mco1)/Jr  
QTLs:   Bp12   Bp76   Bp133  
Candidate Gene For: Bp12 Bp71 Bp136 Bp168 Eau9
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81064,313,335 - 64,349,221 (+)NCBIGRCr8
mRatBN7.21063,815,308 - 63,851,208 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1063,815,308 - 63,851,210 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1068,445,568 - 68,481,178 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01067,950,910 - 67,986,520 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01063,419,659 - 63,455,435 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01066,188,290 - 66,221,621 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1066,189,786 - 66,313,190 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01065,423,626 - 65,456,957 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41065,036,884 - 65,072,453 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11065,050,519 - 65,086,394 (+)NCBI
Celera1062,790,940 - 62,826,625 (+)NCBICelera
Cytogenetic Map10q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)