GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nos2 | affects expression | EXP | | 6480464 | CTD | Quercetin affects the expression of NOS2 protein | PMID:15476665 | Nos2 | decreases expression | EXP | | 6480464 | CTD | Quercetin results in decreased expression of NOS2 protein | PMID:18551111 | Nos2 | increases expression | EXP | | 6480464 | CTD | Quercetin results in increased expression of NOS2 protein | PMID:25411067 | Nos2 | multiple interactions | EXP | | 6480464 | CTD | [Quercetin co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [Ethanol results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [17-(dimethylaminoethylamino)-17-demethoxygeldanamycin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Quercetin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Quercetin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [[TNF protein co-treated with IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Cadmium results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [cypermethrin results in increased expression of NOS2 mRNA]; Quercetin inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [geldanamycin results in decreased expression of NOS2 mRNA]; Quercetin inhibits the reaction [Glucose results in increased expression of NOS2 mRNA]; Quercetin inhibits the reaction [Glucose results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Hydrochloric Acid results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [IL1B protein results in decreased expression of NOS2 mRNA]; Quercetin inhibits the reaction [IL1B protein results in decreased expression of NOS2 protein]; Quercetin inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Quercetin inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Monocrotaline results in increased expression of NOS2 mRNA]; Quercetin inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]; Quercetin inhibits the reaction [Streptozocin results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [tanespimycin results in decreased expression of NOS2 mRNA] | PMID:11835313 PMID:12741479 PMID:14700523 PMID:15930438 PMID:16177186 PMID:16226777 PMID:16647178 PMID:18090225 PMID:22221676 PMID:22257724 PMID:22685622 PMID:22713545 PMID:22919443 PMID:23138875 PMID:23770986 PMID:24122261 PMID:25411067 PMID:25460361 PMID:26690102 PMID:27224288 PMID:35876585 PMID:9581680 | Nos2 | decreases expression | ISO | Nos2 (Mus musculus) | 6480464 | CTD | Quercetin results in decreased expression of NOS2 mRNA | PMID:17135264 PMID:24465016 | Nos2 | decreases expression | ISO | NOS2 (Homo sapiens) | 6480464 | CTD | Quercetin results in decreased expression of NOS2 mRNA; Quercetin results in decreased expression of NOS2 protein | PMID:12144868 PMID:17184768 PMID:20596804 PMID:23645742 | Nos2 | multiple interactions | ISO | Nos2 (Mus musculus) | 6480464 | CTD | [3,5-dimethoxy-4'-hydroxystilbene co-treated with Quercetin] results in decreased expression of NOS2 mRNA; [Quercetin co-treated with Lipopolysaccharides] affects the expression of NOS2 mRNA; [Quercetin results in decreased expression of NOS2 mRNA] inhibits the reaction [Nitric Oxide results in increased expression of BCL2 mRNA]; dorsomorphin inhibits the reaction [Quercetin inhibits the reaction [[TNF protein co-treated with INS1 protein] results in increased expression of NOS2 protein]]; dorsomorphin inhibits the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; dorsomorphin inhibits the reaction [Quercetin results in decreased expression of NOS2 mRNA]; Hemin promotes the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; HMOX1 protein promotes the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; Lipopolysaccharides inhibits the reaction [Quercetin results in increased expression of NOS2]; Quercetin affects the reaction [LEP protein affects the expression of NOS2 mRNA]; Quercetin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Quercetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Quercetin analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [[[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; Quercetin inhibits the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of NOS2 mRNA]; Quercetin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 mRNA] which results in increased chemical synthesis of Nitric Oxide]; Quercetin inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NOS2 mRNA]; Quercetin inhibits the reaction [[TNF protein co-treated with INS1 protein] results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Calcium Chloride results in increased expression of NOS2 mRNA]; Quercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Dietary Fats results in increased expression of NOS2 mRNA]; Quercetin inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA]; Quercetin inhibits the reaction [IFNG protein results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Lipopolysaccharides promotes the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Quercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [nickel sulfate results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Streptozocin results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [Zymosan results in increased expression of NOS2 mRNA]; tin protoporphyrin IX inhibits the reaction [Quercetin inhibits the reaction [Lipopolysaccharides results in increased activity of NOS2 protein]]; TOLLIP protein affects the reaction [Quercetin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]] | PMID:10086329 PMID:11020457 PMID:11500931 PMID:11518563 PMID:12512693 PMID:12619901 PMID:12628514 PMID:14563492 PMID:15630180 PMID:15831208 PMID:15832817 PMID:16171798 PMID:17135264 PMID:17177504 PMID:17651994 PMID:18274639 PMID:18809656 PMID:19352036 PMID:20417174 PMID:20579867 PMID:21356098 PMID:22185406 PMID:22210036 PMID:22698256 PMID:22713545 PMID:23353651 PMID:23439570 PMID:23735482 PMID:24040572 PMID:24337353 PMID:24465016 PMID:25712622 PMID:25957741 PMID:26218279 PMID:26887929 PMID:27257013 | Nos2 | multiple interactions | ISO | NOS2 (Homo sapiens) | 6480464 | CTD | Quercetin inhibits the reaction [[IL1B protein co-treated with TNF protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Quercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NOS2 mRNA]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased expression of NOS2 mRNA] | PMID:18394220 PMID:20361964 PMID:25712622 | | ||||||||||||||||||||||
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