Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | aniridia | | ISO | RGD:736174 | 8554872 | ClinVar Annotator: match by term: Congenital aniridia | ClinVar | | genetic disease | | ISO | RGD:736174 | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | Neurodevelopmental Disorders | | ISO | RGD:736174 | 8554872 | ClinVar Annotator: match by term: Neurodevelopmental disorder | ClinVar | | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Imported Disease Annotations - CTD
Gene-Chemical Interaction Annotations Click to see Annotation Detail View
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References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. | Ashpole NM, etal., J Biol Chem. 2012 Jun 8;287(24):19856-69. doi: 10.1074/jbc.M111.322537. Epub 2012 Apr 18. |
| 2. | Calcium/calmodulin-dependent protein kinase IIdelta 2 and gamma isoforms regulate potassium currents of rat brain capillary endothelial cells under hypoxic conditions. | Balla Z, etal., J Biol Chem 2002 Jun 14;277(24):21306-14. |
| 3. | MicroRNA-145 suppresses ROS-induced Ca2+ overload of cardiomyocytes by targeting CaMKIIdelta. | Cha MJ, etal., Biochem Biophys Res Commun. 2013 Jun 14;435(4):720-6. doi: 10.1016/j.bbrc.2013.05.050. Epub 2013 May 20. |
| 4. | Rad GTPase deficiency leads to cardiac hypertrophy. | Chang L, etal., Circulation. 2007 Dec 18;116(25):2976-83. Epub 2007 Dec 3. |
| 5. | CaMKII regulation in information processing and storage. | Coultrap SJ and Bayer KU, Trends Neurosci. 2012 Oct;35(10):607-18. doi: 10.1016/j.tins.2012.05.003. Epub 2012 Jun 19. |
| 6. | Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. | De Felice FG, etal., Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1971-6. doi: 10.1073/pnas.0809158106. Epub 2009 Feb 2. |
| 7. | Mapping of a quantitative trait locus for blood pressure on rat chromosome 2. | Deng AY, etal., J Clin Invest 1994 Jul;94(1):431-6 |
| 8. | Mapping of rat chromosome 2 markers generated from chromosome-sorted DNA. | Deng AY, etal., Mamm Genome 1997 Oct;8(10):731-5. |
| 9. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
| 10. | MEF2 is regulated by CaMKIIdelta2 and a HDAC4-HDAC5 heterodimer in vascular smooth muscle cells. | Ginnan R, etal., Biochem J. 2012 May 15;444(1):105-14. doi: 10.1042/BJ20120152. |
| 11. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
| 12. | Differential regulated interactions of calcium/calmodulin-dependent protein kinase II with isoforms of voltage-gated calcium channel beta subunits. | Grueter CE, etal., Biochemistry. 2008 Feb 12;47(6):1760-7. Epub 2008 Jan 19. |
| 13. | Crucial role for Ca2(+)/calmodulin-dependent protein kinase-II in regulating diastolic stress of normal and failing hearts via titin phosphorylation. | Hamdani N, etal., Circ Res. 2013 Feb 15;112(4):664-74. doi: 10.1161/CIRCRESAHA.111.300105. Epub 2013 Jan 2. |
| 14. | Calcium/calmodulin-dependent protein kinase II-delta isoform regulation of vascular smooth muscle cell proliferation. | House SJ, etal., Am J Physiol Cell Physiol. 2007 Jun;292(6):C2276-87. Epub 2007 Jan 31. |
| 15. | iNOS regulation by calcium/calmodulin-dependent protein kinase II in vascular smooth muscle. | Jones RJ, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2634-42. Epub 2007 Feb 9. |
| 16. | The deltaA isoform of calmodulin kinase II mediates pathological cardiac hypertrophy by interfering with the HDAC4-MEF2 signaling pathway. | Li C, etal., Biochem Biophys Res Commun. 2011 May 27;409(1):125-30. Epub 2011 May 3. |
| 17. | Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. | Maier LS, etal., Circ Res. 2003 May 2;92(8):904-11. Epub 2003 Apr 3. |
| 18. | Novel and uncommon isoforms of the calcium sensing enzyme calcium/calmodulin dependent protein kinase II in heart tissue. | Mayer P, etal., Basic Res Cardiol 1995 Sep-Oct;90(5):372-9. |
| 19. | CaM kinase II delta2-dependent regulation of vascular smooth muscle cell polarization and migration. | Mercure MZ, etal., Am J Physiol Cell Physiol. 2008 Jun;294(6):C1465-75. Epub 2008 Apr 2. |
| 20. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
| 21. | The S18 ribosomal protein is a putative substrate for Ca2+/calmodulin-activated protein kinase II. | Mishra-Gorur K, etal., J Biol Chem 2002 Sep 13;277(37):33537-40. Epub 2002 Jul 26. |
| 22. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
| 23. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
| 24. | PID Annotation Import Pipeline | Pipeline to import Pathway Interaction Database annotations from NCI into RGD |
| 25. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
| 26. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
| 27. | Polymorphisms in CACNA1E and Camk2d are associated with seizure susceptibility of Sprague-Dawley rats. | Rijkers K, etal., Epilepsy Res. 2010 Sep;91(1):28-34. Epub 2010 Jul 16. |
| 28. | New therapeutic targets in cardiology: arrhythmias and Ca2+/calmodulin-dependent kinase II (CaMKII). | Rokita AG and Anderson ME, Circulation. 2012 Oct 23;126(17):2125-39. doi: 10.1161/CIRCULATIONAHA.112.124990. |
| 29. | Identification of novel isoforms of the delta subunit of Ca2+/calmodulin-dependent protein kinase II. Differential expression in rat brain and aorta. | Schworer CM, etal., J Biol Chem 1993 Jul 5;268(19):14443-9. |
| 30. | Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. | Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34 |
| 31. | Nuclear localization of the delta subunit of Ca2+/calmodulin-dependent protein kinase II in rat cerebellar granule cells. | Takeuchi Y, etal., J Neurochem. 1999 Feb;72(2):815-25. |
| 32. | Tissue-specific expression of four types of rat calmodulin-dependent protein kinase II mRNAs. | Tobimatsu T and Fujisawa H, J Biol Chem 1989 Oct 25;264(30):17907-12. |
| 33. | The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. | Zhang T, etal., Circ Res. 2003 May 2;92(8):912-9. Epub 2003 Apr 3. |
Additional References at PubMed
| PMID:8130281 | PMID:8224201 | PMID:10753652 | PMID:11264466 | PMID:12147342 | PMID:12477932 | PMID:12619878 | PMID:12660151 | PMID:14761894 | PMID:15489334 | PMID:15631885 | PMID:15652482 |
| PMID:17179159 | PMID:17234969 | PMID:17873280 | PMID:18096823 | PMID:18721804 | PMID:19422373 | PMID:19602725 | PMID:19883656 | PMID:19910575 | PMID:19946888 | PMID:20124353 | PMID:20442409 |
| PMID:20668654 | PMID:20877009 | PMID:21486818 | PMID:21575598 | PMID:21677263 | PMID:21998325 | PMID:22048920 | PMID:22553113 | PMID:22871113 | PMID:23238742 | PMID:23360843 | PMID:23585120 |
| PMID:24003228 | PMID:24106266 | PMID:24347176 | PMID:25416956 | PMID:25539453 | PMID:25820554 | PMID:25931508 | PMID:26067684 | PMID:27199283 | PMID:27940402 | PMID:29476059 | PMID:30462989 |
| PMID:31051256 | PMID:31515488 | PMID:31584202 | PMID:32971072 | PMID:33281190 | PMID:34814703 | PMID:35138512 |
Genomics
Comparative Map Data
| Camk2d (Rattus norvegicus - Norway rat) |
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| CAMK2D (Homo sapiens - human) |
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| Camk2d (Mus musculus - house mouse) |
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| Camk2d (Chinchilla lanigera - long-tailed chinchilla) |
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| CAMK2D (Pan paniscus - bonobo/pygmy chimpanzee) |
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| CAMK2D (Canis lupus familiaris - dog) |
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| Camk2d (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| CAMK2D (Sus scrofa - pig) |
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| CAMK2D (Chlorocebus sabaeus - green monkey) |
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Variants
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Variants in Camk2d
1390 total Variants 
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