GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nos2 | affects response to substance | ISO | Nos2 (Mus musculus) | 6480464 | CTD | NOS2 protein affects the susceptibility to Morphine | PMID:19751225 | Nos2 | increases expression | ISO | Nos2 (Mus musculus) | 6480464 | CTD | Morphine results in increased expression of NOS2 mRNA; Morphine results in increased expression of NOS2 protein | PMID:11590188 PMID:15220775 PMID:24756886 PMID:37394652 | Nos2 | multiple interactions | ISO | Nos2 (Mus musculus) | 6480464 | CTD | corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]; dorsomorphin inhibits the reaction [Resveratrol inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; Minocycline inhibits the reaction [Morphine results in increased expression of NOS2 protein]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of 6-Ketoprostaglandin F1 alpha]; NOS2 protein promotes the reaction [[Morphine results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; Resveratrol inhibits the reaction [Morphine results in increased expression of NOS2 protein]; TLR2 protein inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]]; Tunicamycin inhibits the reaction [corilagin inhibits the reaction [Morphine results in increased expression of NOS2 protein]] | PMID:16325209 PMID:24756886 PMID:37394652 | | ||||||||||||||||||||||
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