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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3185
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos2
Name: nitric oxide synthase 2
Acc ID: CHEBI:38725
Term: mevinphos
Definition: An organophosphate insecticide that has formula C7H13O6P.
Chemical ID: MESH:D008799
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos2increases activityEXP 6480464CTDMevinphos results in increased activity of NOS2 protein

PMID:15617736
Nos2increases expressionEXP 6480464CTDMevinphos results in increased expression of NOS2 Mevinphos results in increased expression of NOS2 mRNA Mevinphos results in increased expression of NOS2 protein

PMID:15111025 PMID:17150954 PMID:17395621 PMID:21390240 PMID:24462917 PMID:25449601 PMID:28601397
Nos2multiple interactionsEXP 6480464CTD2-4-morpholinyl-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] HSPD1 protein affects the reaction [Mevinphos results in increased expression of NOS2 protein] methoctramine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 mRNA] PTEN protein inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] triciribine inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] Tropicamide inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] Wortmannin inhibits the reaction [Mevinphos results in increased expression of NOS2 protein]

PMID:17150954 PMID:17395621 PMID:24462917 PMID:28601397
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