Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Nos1 (nitric oxide synthase 1) Rattus norvegicus
Symbol: Nos1
Name: nitric oxide synthase 1
RGD ID: 3184
Description: Exhibits several functions, including ATPase binding activity; nucleotide binding activity; and transition metal ion binding activity. Involved in several processes, including negative regulation of blood circulation; regulation of cation transmembrane transport; and regulation of neuron death. Localizes to several cellular components, including azurophil granule; postsynaptic specialization; and sarcolemma. Predicted to colocalize with caveola. Used to study several diseases, including brain ischemia (multiple); end stage renal disease; impotence; mental depression; and portal hypertension. Biomarker of several diseases, including brain disease (multiple); cardiomyopathy (multiple); hypertension (multiple); kidney failure (multiple); and retinal disease (multiple). Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; cystic fibrosis; and hypertrophic pyloric stenosis. Orthologous to human NOS1 (nitric oxide synthase 1); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; INTERACTS WITH (+)-pilocarpine; (S)-colchicine; 1,2-dimethylhydrazine.
Type: protein-coding
Also known as: bNOS; constitutive NOS; N-NOS; NC-NOS; neuronal NOS; nitric oxidase synthase; nitric oxide synthase 1 (neuronal); nitric oxide synthase 1, neuronal; nitric oxide synthase, brain; nNOS; NOS type I; peptidyl-cysteine S-nitrosylase NOS1
Homo sapiens (human) : NOS1 (nitric oxide synthase 1)  HGNC  Alliance
Mus musculus (house mouse) : Nos1 (nitric oxide synthase 1, neuronal)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nos1 (nitric oxide synthase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NOS1 (nitric oxide synthase 1)
Canis lupus familiaris (dog) : NOS1 (nitric oxide synthase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nos1 (nitric oxide synthase 1)
Sus scrofa (pig) : NOS1 (nitric oxide synthase 1)
Heterocephalus glaber (naked mole-rat) : Nos1 (nitric oxide synthase 1)
more info ...
Allele / Splice: Nos1m1Mcwi  
Genetic Models: BN-Nos1m1Mcwi
Is Marker For: Strains:   SD  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01244,214,949 - 44,405,530 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1244,213,943 - 44,520,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01246,049,288 - 46,209,569 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41239,812,500 - 39,869,484 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11239,675,108 - 39,732,872 (-)NCBI
Celera1240,283,655 - 40,368,674 (-)NCBICelera
Cytogenetic Map12q16NCBI
RH 3.4 Map12717.0RGD
RH 3.4 Map12718.8RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Related Rat Strains
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Nos1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3184
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.