Nos1 (nitric oxide synthase 1) - Rat Genome Database

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Gene: Nos1 (nitric oxide synthase 1) Rattus norvegicus
Symbol: Nos1
Name: nitric oxide synthase 1
RGD ID: 3184
Description: Enables several functions, including ATPase binding activity; nucleotide binding activity; and transition metal ion binding activity. Involved in several processes, including behavioral response to cocaine; blood vessel diameter maintenance; and regulation of monoatomic cation transmembrane transport. Located in several cellular components, including azurophil granule; nuclear membrane; and sarcolemma. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Used to study several diseases, including acute necrotizing pancreatitis; brain ischemia (multiple); end stage renal disease; impotence; and portal hypertension. Biomarker of several diseases, including brain disease (multiple); cardiomyopathy (multiple); hypertension (multiple); kidney failure (multiple); and retinal disease (multiple). Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; and cystic fibrosis. Orthologous to human NOS1 (nitric oxide synthase 1); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; INTERACTS WITH (+)-pilocarpine; (S)-colchicine; 1,2-dimethylhydrazine.
Type: protein-coding
Previously known as: bNOS; constitutive NOS; N-NOS; NC-NOS; neuronal NOS; nitric oxidase synthase; nitric oxide synthase 1 (neuronal); nitric oxide synthase 1, neuronal; nitric oxide synthase, brain; nNOS; NOS type I; peptidyl-cysteine S-nitrosylase NOS1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Nos1m1Mcwi  
Genetic Models: BN-Nos1m1Mcwi
Is Marker For: Strains:   SD  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81244,276,011 - 44,456,371 (-)NCBIGRCr8
mRatBN7.21238,615,111 - 38,795,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1238,626,714 - 38,710,945 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1239,802,061 - 39,886,285 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01240,415,854 - 40,500,100 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01239,468,822 - 39,553,063 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01244,214,949 - 44,405,530 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1244,213,943 - 44,520,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01246,049,288 - 46,209,569 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41239,812,500 - 39,869,484 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11239,675,108 - 39,732,872 (-)NCBI
Celera1240,283,655 - 40,368,674 (-)NCBICelera
RH 3.4 Map12717.0RGD
RH 3.4 Map12718.8RGD
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
achalasia  (ISS)
acute kidney failure  (IEP)
acute necrotizing pancreatitis  (IDA)
alcoholic cardiomyopathy  (IEP)
Alzheimer's disease  (ISO)
amphetamine abuse  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
autism spectrum disorder  (ISO)
brain ischemia  (IEP,IMP)
Bronchial Hyperreactivity  (ISO)
Carbon Monoxide Poisoning  (IMP)
Cardiomegaly  (IEP)
cardiomyopathy  (IEP)
cerebellar disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
congestive heart failure  (IEP)
cystic fibrosis  (ISO)
Dehydration  (IEP)
depressive disorder  (IDA,ISO)
Diabetic Nephropathies  (IDA,IMP)
diabetic retinopathy  (IEP)
disease of mental health  (ISO)
Duchenne muscular dystrophy  (ISO)
End Stage Liver Disease  (ISO)
end stage renal disease  (IDA,IEP)
Experimental Diabetes Mellitus  (IDA)
Experimental Radiation Injuries  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (IEP)
Fetal Hypoxia  (IEP)
Fever  (ISO)
Heat Stroke  (IEP)
hepatic encephalopathy  (IEP,ISO)
Human Influenza  (ISO)
Hyperalgesia  (IEP,ISO)
hypertension  (IDA,IEP,IMP)
hypertrophic pyloric stenosis  (ISS)
Hypoxia  (ISO)
impotence  (IDA,IEP)
Infantile Hypertrophic Pyloric Stenosis 1  (ISO)
intestinal perforation  (ISO)
intracranial aneurysm  (ISO)
major depressive disorder  (IEP)
Memory Disorders  (IMP)
morphine dependence  (ISO)
motor neuron disease  (ISO)
nephrotic syndrome  (IEP)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
Nervous System Trauma  (ISO)
Neuralgia  (IDA)
Neurobehavioral Manifestations  (ISO)
obesity  (IEP)
Parkinson's disease  (ISO)
Parkinsonism  (IEP)
portal hypertension  (IDA)
Prehypertension  (IEP)
Prenatal Exposure Delayed Effects  (IEP)
renovascular hypertension  (IEP)
Reperfusion Injury  (IMP)
retinopathy of prematurity  (IEP)
Right Ventricular Hypertrophy  (IDA)
schizophrenia  (IMP,ISO)
Sepsis  (IMP)
Spinal Cord Injuries  (IEP,IMP)
status epilepticus  (ISO)
Stroke  (IMP)
temporal lobe epilepsy  (IEP)
transient cerebral ischemia  (IDA)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP)
urethral obstruction  (IEP)
Urination Disorders  (ISO)
Ventricular Remodeling  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(3,4-dihydroxyphenyl)acetic acid  (ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrotoluene  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-palmitoylglycerol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
4-hydroxy-TEMPO  (EXP)
5,5-dimethyl-1-pyrroline N-oxide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,8-diacetoxy-4-methylcoumarin  (ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
ADP-D-ribose  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alloxan  (ISO)
alpha-Zearalanol  (EXP)
aluminium sulfate (anhydrous)  (EXP)
aminoguanidine  (EXP)
ammonium chloride  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-carotene  (ISO)
betulinic acid  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
buspirone  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP)
calcium dichloride  (EXP)
calcium(0)  (EXP)
Candesartan cilexetil  (EXP)
cantharidin  (ISO)
capsaicin  (EXP,ISO)
CGP 52608  (ISO)
chaetocin  (EXP)
chlorpyrifos  (EXP,ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP)
cypermethrin  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (ISO)
Decursin  (ISO)
dexamethasone  (EXP,ISO)
Diallyl sulfide  (EXP)
dibutyl phthalate  (EXP)
dibutylstannane  (EXP)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
dimemorfan  (EXP)
diminazene diaceturate  (EXP)
dioxygen  (EXP)
disodium selenite  (ISO)
dizocilpine maleate  (ISO)
dobutamine  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
edaravone  (EXP)
endosulfan  (EXP)
enoxacin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (EXP)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
ethylparaben  (ISO)
fenbufen  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
fulvestrant  (ISO)
gentamycin  (ISO)
glucose  (ISO)
GW 4064  (ISO)
hexachlorobenzene  (ISO)
hexacosan-1-ol  (EXP)
homovanillic acid  (ISO)
hydralazine  (EXP)
hydrogen peroxide  (EXP,ISO)
ibuprofen  (ISO)
icariin  (EXP)
ifosfamide  (EXP)
indometacin  (ISO)
isoprenaline  (EXP)
kainic acid  (EXP)
KT 5720  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(II) chloride  (EXP,ISO)
leflunomide  (EXP)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium chloride  (EXP)
lithium hydride  (EXP)
loperamide  (ISO)
losartan  (EXP)
lycopene  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (ISO)
manganese(II) sulfate  (EXP)
mastoparan  (EXP)
Mazindol  (ISO)
melatonin  (EXP)
melittin  (EXP)
mephedrone  (EXP)
mercury dichloride  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methoctramine tetrahydrochloride  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP)
metoprolol  (EXP)
mevinphos  (EXP)
milrinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morin  (EXP)
morphine  (EXP,ISO)
mosapride citrate dihydrate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-D-aspartic acid  (ISO)
naloxone  (ISO)
Neferine  (EXP)
nickel atom  (ISO)
nitric oxide  (EXP,ISO)
nitroglycerin  (EXP)
nitroprusside  (ISO)
O-acetyl-L-carnitine  (EXP)
ouabain  (EXP)
oxidopamine  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
palytoxin  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenol  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
puerarin  (ISO)
quercetin  (EXP,ISO)
ramipril  (EXP)
reactive nitrogen species  (EXP)
reactive oxygen species  (EXP)
reserpine  (EXP)
resveratrol  (EXP,ISO)
rofecoxib  (ISO)
S-methyl-L-thiocitrulline  (EXP,ISO)
SB 431542  (ISO)
selenic acid  (ISO)
selenomethionine  (ISO)
serpentine asbestos  (ISO)
sildenafil citrate  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirtinol  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium chloride  (EXP)
sodium sulfite  (ISO)
streptozocin  (EXP,ISO)
sumatriptan  (EXP)
tacrine  (EXP)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thymoquinone  (EXP)
thyroxine  (EXP)
tributylstannane  (EXP)
triclosan  (ISO)
triphenylstannane  (EXP)
triptonide  (ISO)
Tropicamide  (EXP)
trovafloxacin  (ISO)
U-73122  (EXP)
udenafil  (EXP)
valproic acid  (EXP)
valsartan  (EXP)
vincristine  (ISO)
zileuton  (ISO)
zinc dichloride  (EXP)
zinc protoporphyrin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
arginine catabolic process  (IBA,IDA)
behavioral response to cocaine  (IMP)
calcium ion transport  (ISO)
cellular response to epinephrine stimulus  (IMP)
cellular response to growth factor stimulus  (ISO)
cellular response to mechanical stimulus  (IMP)
establishment of localization in cell  (ISO)
establishment of protein localization  (IDA)
female pregnancy  (IEP)
multicellular organismal response to stress  (IEA,ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of blood pressure  (IBA,IMP)
negative regulation of calcium ion transport  (ISO)
negative regulation of cell population proliferation  (IMP)
negative regulation of cytosolic calcium ion concentration  (IMP)
negative regulation of hepatic stellate cell contraction  (IDA)
negative regulation of insulin secretion  (IMP)
negative regulation of iron ion transmembrane transport  (IMP)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of potassium ion transport  (ISO)
negative regulation of serotonin uptake  (ISO)
negative regulation of vasoconstriction  (IMP)
nitric oxide biosynthetic process  (IBA,IDA,IEA,ISO)
nitric oxide mediated signal transduction  (IBA)
nitric oxide metabolic process  (IEP)
nitric oxide-cGMP-mediated signaling  (IMP)
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway  (IMP)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (ISO)
positive regulation of cellular process  (IMP)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of long-term synaptic potentiation  (IMP)
positive regulation of peptidyl-serine phosphorylation  (IEA,ISO)
positive regulation of sodium ion transmembrane transport  (IMP)
positive regulation of the force of heart contraction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
potassium ion transport  (ISO)
regulation of neurogenesis  (ISO)
regulation of postsynaptic membrane potential  (ISO)
regulation of sodium ion transport  (ISO)
response to activity  (IEP)
response to estrogen  (IDA)
response to ethanol  (IEP)
response to heat  (IEA,ISO)
response to hormone  (IBA)
response to hypoxia  (IEA,IEP,ISO)
response to lead ion  (IEP)
response to lipopolysaccharide  (IBA,IEP)
response to nicotine  (IEP)
response to nitric oxide  (IEP)
response to nutrient levels  (IEP)
response to organic cyclic compound  (IEP)
response to organonitrogen compound  (IEP)
response to peptide hormone  (IMP)
response to vitamin E  (IEP)
retrograde trans-synaptic signaling by nitric oxide  (ISO)
striated muscle contraction  (ISO)
synaptic signaling by nitric oxide  (ISO)
vasodilation  (IEA,IMP,ISO)
xenobiotic catabolic process  (ISO)


References - curated
# Reference Title Reference Citation
1. Altered Contractile Response due to Increased beta3-Adrenoceptor Stimulation in Diabetic Cardiomyopathy: The Role of Nitric Oxide Synthase 1-derived Nitric Oxide. Amour J, etal., Anesthesiology. 2007 Sep;107(3):452-460.
2. Complementary inhibition of cerebral aneurysm formation by eNOS and nNOS. Aoki T, etal., Lab Invest. 2011 Apr;91(4):619-26. Epub 2011 Feb 14.
3. Renoprotective effect of pioglitazone by the prevention of glomerular hyperfiltration through the possible restoration of altered macula densa signaling in rats with type 2 diabetic nephropathy. Asakura J, etal., Nephron Exp Nephrol. 2012;122(3-4):83-94. doi: 10.1159/000348661. Epub 2013 Mar 29.
4. Neuronal nitric oxide synthase protects the pancreatic beta cell from glucolipotoxicity-induced endoplasmic reticulum stress and apoptosis. Bachar E, etal., Diabetologia. 2010 Oct;53(10):2177-87. Epub 2010 Jul 2.
5. Nitric oxide synthases and protein oxidation in the quadriceps femoris of patients with chronic obstructive pulmonary disease. Barreiro E, etal., Am J Respir Cell Mol Biol. 2003 Dec;29(6):771-8. Epub 2003 Jun 19.
6. Nitrergic dendrites in the superficial layers of the rat superior colliculus: retinal afferents and alternatively spliced isoforms in normal and deafferented animals. Batista CM, etal., J Neurosci Res 2003 Feb 1;71(3):455-61.
7. Reduced neuronal nitric oxide synthase (NOS1) antigen in sacral motor neurones in motor neurone disease. Baxter RG, etal., Acta Neuropathol. 2002 Oct;104(4):391-7. Epub 2002 Jun 26.
8. Role of myocardial neuronal nitric oxide synthase-derived nitric oxide in beta-adrenergic hyporesponsiveness after myocardial infarction-induced heart failure in rat. Bendall JK, etal., Circulation. 2004 Oct 19;110(16):2368-75. Epub 2004 Oct 4.
9. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Bredt DS, etal., Nature. 1991 Jun 27;351(6329):714-8. doi: 10.1038/351714a0.
10. Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease. Brindicci C, etal., Am J Respir Crit Care Med. 2010 Jan 1;181(1):21-30. Epub 2009 Sep 24.
11. Synaptic localization of nitric oxide synthase and soluble guanylyl cyclase in the hippocampus. Burette A, etal., J Neurosci. 2002 Oct 15;22(20):8961-70.
12. Downregulation of nNOS and synthesis of PGs associated with endotoxin-induced delay in gastric emptying. Calatayud S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Dec;283(6):G1360-7.
13. Nitrous oxide discretely up-regulates nNOS and p53 in neonatal rat brain. Cattano D, etal., Minerva Anestesiol. 2010 Jun;76(6):420-4. Epub 2010 Apr 12.
14. Inhibition of neuronal nitric oxide synthase causes attenuation of cerebrovascular dysfunction in experimental heatstroke. Cheng BC, etal., Neuropharmacology. 2007 Feb;52(2):297-305. Epub 2006 Sep 6.
15. Calmodulin activates electron transfer through neuronal nitric-oxide synthase reductase domain by releasing an NADPH-dependent conformational lock. Craig DH, etal., J Biol Chem 2002 Sep 13;277(37):33987-94.
16. The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS. Cui W, etal., Br J Pharmacol. 2013 Mar;168(5):1201-14. doi: 10.1111/bph.12004.
17. Elevated expression of CAPON and neuronal nitric oxide synthase in the sciatic nerve of rats following constriction injury. Cui Z, etal., Vet J. 2011 Mar;187(3):374-80. Epub 2010 Mar 3.
18. Renal redox response to normal pregnancy in the rat. Cunningham MW Jr, etal., Am J Physiol Regul Integr Comp Physiol. 2013 Mar 15;304(6):R443-9. doi: 10.1152/ajpregu.00496.2012. Epub 2013 Jan 2.
19. Coupling of neuronal nitric oxide synthase to NMDA receptors via postsynaptic density-95 depends on estrogen and contributes to the central control of adult female reproduction. d'Anglemont de Tassigny X, etal., J Neurosci. 2007 Jun 6;27(23):6103-14.
20. Spinal cord transection significantly influences nNOS-IR in neuronal circuitry that underlies the tail-flick reflex activity. Davidova A, etal., Cell Mol Neurobiol. 2009 Sep;29(6-7):879-86. Epub 2009 Mar 17.
21. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
22. Cyclic stretch stimulates nitric oxide synthase-1-dependent peroxynitrite formation by neonatal rat pulmonary artery smooth muscle. Dick AS, etal., Free Radic Biol Med. 2013 Apr 22;61C:310-319. doi: 10.1016/j.freeradbiomed.2013.04.027.
23. [Effects of electroacupuncture on the expressions of neuroal nitric oxide synthase and astrocyte in dentate gyrus of rats with Parkinson's disease]. Ding YX, etal., Zhongguo Zhen Jiu. 2013 Jun;33(6):533-7.
24. Reduction of neuronal and inducible nitric oxide synthase gene expression in patients with cystic fibrosis. Dotsch J, etal., Eur Arch Otorhinolaryngol. 2002 Apr;259(4):222-6.
25. Plasma membrane calcium ATPase 4b inhibits nitric oxide generation through calcium-induced dynamic interaction with neuronal nitric oxide synthase. Duan W, etal., Protein Cell. 2013 Apr;4(4):286-98. doi: 10.1007/s13238-013-2116-z. Epub 2013 Apr 3.
26. Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON. Fang M, etal., Neuron 2000 Oct;28(1):183-93.
27. Human influenza viral infection in utero increases nNOS expression in hippocampi of neonatal mice. Fatemi SH, etal., Synapse. 1998 May;29(1):84-8.
28. Differential expression of nNOS mRNA and protein in the nucleus tractus solitarii of young and aged Wistar-Kyoto and spontaneously hypertensive rats. Ferrari MF and Fior-Chadi DR, J Hypertens. 2005 Sep;23(9):1683-90.
29. Hypothyroid phenotype is contributed by mitochondrial complex I inactivation due to translocated neuronal nitric-oxide synthase. Franco MC, etal., J Biol Chem. 2006 Feb 24;281(8):4779-86. Epub 2005 Dec 16.
30. Involvement of nNOS/NO/sGC/cGMP signaling pathway in cocaine sensitization and in the associated hippocampal alterations: does phosphodiesterase 5 inhibition help to drug vulnerability? Gabach LA, etal., Psychopharmacology (Berl). 2013 Sep;229(1):41-50. doi: 10.1007/s00213-013-3084-y. Epub 2013 Apr 12.
31. Association of a NOS1 promoter repeat with Alzheimer's disease. Galimberti D, etal., Neurobiol Aging. 2008 Sep;29(9):1359-65. doi: 10.1016/j.neurobiolaging.2007.03.003. Epub 2007 Apr 6.
32. Diabetes induces sex-dependent changes in neuronal nitric oxide synthase dimerization and function in the rat gastric antrum. Gangula PR, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Mar;292(3):G725-33.
33. Y-27632 improves the erectile dysfunction with ageing in SD rats through adjusting the imbalance between nNo and the Rho-kinase pathways. Gao BH, etal., Andrologia. 2007 Aug;39(4):146-50.
34. Variants of NOS1, NOS2, and NOS3 genes in asthmatics. Gao PS, etal., Biochem Biophys Res Commun. 2000 Jan 27;267(3):761-3.
35. Nitric oxide synthase and nitric oxide alterations in chronically stressed rats: a model for nitric oxide in major depressive disorder. Gao SF, etal., Psychoneuroendocrinology. 2014 Sep;47:136-40. doi: 10.1016/j.psyneuen.2014.05.009. Epub 2014 May 22.
36. Sustained gonadotropin-releasing hormone stimulation mobilizes the cAMP/PKA pathway to induce nitric oxide synthase type 1 expression in rat pituitary cells in vitro and in vivo at proestrus. Garrel G, etal., Biol Reprod. 2010 Jun;82(6):1170-9. Epub 2010 Feb 24.
37. Overexpression of neutrophil neuronal nitric oxide synthase in Parkinson's disease. Gatto EM, etal., Nitric Oxide. 2000 Oct;4(5):534-9.
38. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
39. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
40. Caveolin-3 and nitric oxide synthase I in healthy and diseased skeletal muscle. Gossrau R, Acta Histochem. 1998 Feb;100(1):99-112. doi: 10.1016/S0065-1281(98)80009-3.
41. A neuronal NO synthase (NOS1) gene polymorphism is associated with asthma. Grasemann H, etal., Biochem Biophys Res Commun. 2000 Jun 7;272(2):391-4.
42. Nasal nitric oxide levels in cystic fibrosis patients are associated with a neuronal NO synthase (NOS1) gene polymorphism. Grasemann H, etal., Nitric Oxide. 2002 Mar;6(2):236-41.
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PMID:19948738   PMID:20008826   PMID:20014403   PMID:20018145   PMID:20044475   PMID:20056918   PMID:20104578   PMID:20112741   PMID:20149028   PMID:20232214   PMID:20335319   PMID:20371700  
PMID:20397260   PMID:20492351   PMID:20667480   PMID:20684262   PMID:20707900   PMID:20718865   PMID:20731778   PMID:20736047   PMID:20862803   PMID:21125397   PMID:21155253   PMID:21158118  
PMID:21189546   PMID:21244098   PMID:21245950   PMID:21255634   PMID:21535296   PMID:21595896   PMID:21608012   PMID:21651902   PMID:21664432   PMID:21681338   PMID:21763759   PMID:21780165  
PMID:21813683   PMID:21831995   PMID:21840380   PMID:21847584   PMID:21960957   PMID:21968757   PMID:22128174   PMID:22198001   PMID:22316281   PMID:22370956   PMID:22391324   PMID:22445759  
PMID:22486744   PMID:22531298   PMID:22576624   PMID:22672990   PMID:22687613   PMID:22687614   PMID:22722929   PMID:22860427   PMID:22902770   PMID:22909987   PMID:22921486   PMID:22923618  
PMID:22992730   PMID:23012472   PMID:23022956   PMID:23059423   PMID:23109339   PMID:23155193   PMID:23216343   PMID:23285183   PMID:23324998   PMID:23406748   PMID:23406756   PMID:23419891  
PMID:23454199   PMID:23489187   PMID:23507581   PMID:23564306   PMID:23575992   PMID:23624088   PMID:23681475   PMID:23685166   PMID:23789902   PMID:23953569   PMID:24025168   PMID:24069609  
PMID:24186360   PMID:24329704   PMID:24477538   PMID:24495843   PMID:24499461   PMID:24512289   PMID:24562683   PMID:24680940   PMID:24707733   PMID:24731840   PMID:24740233   PMID:24908089  
PMID:24958506   PMID:24961237   PMID:25194041   PMID:25216050   PMID:25312245   PMID:25399920   PMID:25540233   PMID:25598224   PMID:25726374   PMID:25804308   PMID:25931508   PMID:25947172  
PMID:26035438   PMID:26084225   PMID:26115586   PMID:26352281   PMID:26400279   PMID:26438559   PMID:26491965   PMID:26585490   PMID:26607632   PMID:26797190   PMID:26945078   PMID:26995406  
PMID:27116881   PMID:27171264   PMID:27225184   PMID:27371683   PMID:27377302   PMID:27529477   PMID:27534879   PMID:27541371   PMID:27562066   PMID:27624386   PMID:27686338   PMID:27760279  
PMID:27761804   PMID:27903582   PMID:27960152   PMID:28087360   PMID:28089352   PMID:28126743   PMID:28232486   PMID:28430607   PMID:28720408   PMID:28921679   PMID:29016640   PMID:29074292  
PMID:29182640   PMID:29382335   PMID:29687838   PMID:29983399   PMID:30066461   PMID:30108200   PMID:30627906   PMID:30926606   PMID:31463706   PMID:31492421   PMID:31642335   PMID:31989159  
PMID:32070010   PMID:32573772   PMID:33181440   PMID:33296434   PMID:34203264   PMID:34536522   PMID:35055166   PMID:35563364   PMID:36964568   PMID:37442439   PMID:38100901  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81244,276,011 - 44,456,371 (-)NCBIGRCr8
mRatBN7.21238,615,111 - 38,795,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1238,626,714 - 38,710,945 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1239,802,061 - 39,886,285 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01240,415,854 - 40,500,100 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01239,468,822 - 39,553,063 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01244,214,949 - 44,405,530 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1244,213,943 - 44,520,341 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01246,049,288 - 46,209,569 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41239,812,500 - 39,869,484 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11239,675,108 - 39,732,872 (-)NCBI
Celera1240,283,655 - 40,368,674 (-)NCBICelera
RH 3.4 Map12717.0RGD
RH 3.4 Map12718.8RGD
Cytogenetic Map12q16NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3812117,208,142 - 117,361,626 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12117,208,142 - 117,452,170 (-)EnsemblGRCh38hg38GRCh38
GRCh3712117,645,947 - 117,799,431 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612116,135,362 - 116,283,965 (-)NCBINCBI36Build 36hg18NCBI36
Build 3412116,113,698 - 116,262,302NCBI
Celera12117,280,475 - 117,430,209 (-)NCBICelera
Cytogenetic Map12q24.22NCBI
HuRef12114,655,115 - 114,808,727 (-)NCBIHuRef
CHM1_112117,611,241 - 117,767,258 (-)NCBICHM1_1
T2T-CHM13v2.012117,189,186 - 117,342,679 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm395118,004,904 - 118,096,905 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5117,919,097 - 118,096,905 (+)EnsemblGRCm39 Ensembl
GRCm385117,866,839 - 117,958,840 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5117,781,032 - 117,958,840 (+)EnsemblGRCm38mm10GRCm38
MGSCv375118,317,128 - 118,403,822 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365118,128,149 - 118,214,843 (+)NCBIMGSCv36mm8
Celera5114,958,747 - 115,046,830 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map557.29NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495545513,797,545 - 13,972,566 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545513,797,557 - 13,978,402 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v210125,268,855 - 125,423,277 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112125,265,237 - 125,419,664 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012114,784,232 - 114,938,385 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112118,163,655 - 118,314,005 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12118,163,655 - 118,314,005 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12613,787,341 - 13,895,176 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2613,786,309 - 13,962,332 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2613,781,845 - 13,865,309 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02614,042,033 - 14,222,209 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2614,044,400 - 14,151,070 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12614,009,781 - 14,093,258 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02614,087,144 - 14,170,688 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02614,122,943 - 14,206,510 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118154,176,906 - 154,267,437 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365585,233,459 - 5,301,414 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365585,162,471 - 5,302,488 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1435,113,184 - 35,295,944 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11435,112,898 - 35,299,297 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21437,401,967 - 37,515,427 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.111112,642,374 - 112,673,882 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037132,411,769 - 132,561,385 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474716,003,969 - 16,113,165 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474715,940,614 - 16,118,051 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Nos1
1535 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:185
Count of miRNA genes:69
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000001493, ENSRNOT00000046205, ENSRNOT00000066810
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,714,540 - 38,714,782 (+)MAPPERmRatBN7.2
Rnor_6.01244,384,957 - 44,385,198NCBIRnor6.0
Rnor_5.01246,213,380 - 46,213,621UniSTSRnor5.0
RGSC_v3.41239,872,948 - 39,873,190RGDRGSC3.4
RGSC_v3.41239,872,949 - 39,873,190UniSTSRGSC3.4
RGSC_v3.11239,736,336 - 39,736,578RGD
Celera1240,372,169 - 40,372,410UniSTS
Cytogenetic Map12q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,614,425 - 38,614,544 (+)MAPPERmRatBN7.2
Rnor_6.01244,288,330 - 44,288,448NCBIRnor6.0
Rnor_5.01246,118,433 - 46,118,551UniSTSRnor5.0
RGSC_v3.41239,763,184 - 39,763,302UniSTSRGSC3.4
RGSC_v3.41239,763,183 - 39,763,302RGDRGSC3.4
RGSC_v3.11239,626,572 - 39,626,690RGD
Celera1240,272,878 - 40,272,996UniSTS
RH 3.4 Map12712.1UniSTS
RH 3.4 Map12712.1RGD
RH 2.0 Map12496.3RGD
SHRSP x BN Map1243.24RGD
Cytogenetic Map12q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,626,400 - 38,626,588 (+)MAPPERmRatBN7.2
Rnor_6.01244,215,433 - 44,215,620NCBIRnor6.0
Rnor_5.01246,048,975 - 46,049,162UniSTSRnor5.0
Celera1240,283,342 - 40,283,529UniSTS
Cytogenetic Map12q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,709,882 - 38,710,034 (+)MAPPERmRatBN7.2
Rnor_6.01244,380,328 - 44,380,479NCBIRnor6.0
Rnor_5.01246,208,507 - 46,208,658UniSTSRnor5.0
RGSC_v3.41239,868,422 - 39,868,573UniSTSRGSC3.4
Celera1240,367,612 - 40,367,763UniSTS
Cytogenetic Map12q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,572,383 - 38,572,587 (+)MAPPERmRatBN7.2
Rnor_6.01244,245,999 - 44,246,202NCBIRnor6.0
Rnor_5.01246,076,562 - 46,076,765UniSTSRnor5.0
RGSC_v3.41239,721,196 - 39,721,399UniSTSRGSC3.4
Celera1240,230,583 - 40,230,786UniSTS
RH 3.4 Map12722.4UniSTS
Cytogenetic Map12q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,571,133 - 38,571,347 (+)MAPPERmRatBN7.2
Rnor_6.01244,244,749 - 44,244,962NCBIRnor6.0
Rnor_5.01246,075,312 - 46,075,525UniSTSRnor5.0
RGSC_v3.41239,719,946 - 39,720,159UniSTSRGSC3.4
Celera1240,229,333 - 40,229,546UniSTS
RH 3.4 Map12707.9UniSTS
Cytogenetic Map12q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,571,931 - 38,572,117 (+)MAPPERmRatBN7.2
Rnor_6.01244,245,547 - 44,245,732NCBIRnor6.0
Rnor_5.01246,076,110 - 46,076,295UniSTSRnor5.0
RGSC_v3.41239,720,744 - 39,720,929UniSTSRGSC3.4
Celera1240,230,131 - 40,230,316UniSTS
RH 3.4 Map12707.9UniSTS
Cytogenetic Map12q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,563,599 - 38,563,825 (+)MAPPERmRatBN7.2
Rnor_6.01244,237,215 - 44,237,440NCBIRnor6.0
Rnor_5.01246,067,778 - 46,068,003UniSTSRnor5.0
RGSC_v3.41239,712,412 - 39,712,637UniSTSRGSC3.4
Celera1240,221,800 - 40,222,025UniSTS
Cytogenetic Map12q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,710,131 - 38,710,571 (+)MAPPERmRatBN7.2
Rnor_6.01244,380,577 - 44,381,016NCBIRnor6.0
Rnor_5.01246,208,756 - 46,209,195UniSTSRnor5.0
RGSC_v3.41239,868,671 - 39,869,110UniSTSRGSC3.4
Celera1240,367,861 - 40,368,300UniSTS
Cytogenetic Map12q16UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,592,125 - 38,592,591 (+)MAPPERmRatBN7.2
Rnor_6.01244,265,792 - 44,266,257NCBIRnor6.0
Rnor_5.01246,096,355 - 46,096,820UniSTSRnor5.0
RGSC_v3.41239,740,940 - 39,741,405UniSTSRGSC3.4
Celera1240,250,492 - 40,250,957UniSTS
Cytogenetic Map12q16UniSTS

Related Rat Strains
The following Strains have been annotated to Nos1

Genetic Models
This gene Nos1 is modified in the following models/strains:


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 2 42 2
Low 3 8 29 16 8 16 8 9 24 35 27 7 8
Below cutoff 35 25 25 11 25 8 12 4


Nucleotide Sequences
RefSeq Transcripts NM_052799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF008912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF008913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF128540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ001143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ001146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ001147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ005845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U67309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000001493   ⟹   ENSRNOP00000001493
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1238,626,714 - 38,710,945 (-)Ensembl
Rnor_6.0 Ensembl1244,215,847 - 44,381,289 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000066810   ⟹   ENSRNOP00000062735
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1238,626,714 - 38,710,945 (-)Ensembl
Rnor_6.0 Ensembl1244,213,943 - 44,520,341 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107669   ⟹   ENSRNOP00000077880
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1238,627,934 - 38,710,945 (-)Ensembl
RefSeq Acc Id: NM_052799   ⟹   NP_434686
Rat AssemblyChrPosition (strand)Source
GRCr81244,287,614 - 44,371,837 (-)NCBI
mRatBN7.21238,626,714 - 38,710,945 (-)NCBI
Rnor_6.01244,215,746 - 44,381,390 (-)NCBI
Rnor_5.01246,049,288 - 46,209,569 (-)NCBI
RGSC_v3.41239,812,500 - 39,869,484 (-)RGD
Celera1240,283,655 - 40,368,674 (-)RGD
RefSeq Acc Id: XM_039089059   ⟹   XP_038944987
Rat AssemblyChrPosition (strand)Source
GRCr81244,276,011 - 44,396,000 (-)NCBI
mRatBN7.21238,615,111 - 38,735,132 (-)NCBI
RefSeq Acc Id: XM_039089060   ⟹   XP_038944988
Rat AssemblyChrPosition (strand)Source
GRCr81244,276,011 - 44,456,371 (-)NCBI
mRatBN7.21238,615,111 - 38,795,492 (-)NCBI
RefSeq Acc Id: XM_063271041   ⟹   XP_063127111
Rat AssemblyChrPosition (strand)Source
GRCr81244,276,011 - 44,395,998 (-)NCBI
RefSeq Acc Id: XM_063271042   ⟹   XP_063127112
Rat AssemblyChrPosition (strand)Source
GRCr81244,282,462 - 44,395,997 (-)NCBI
RefSeq Acc Id: XM_063271043   ⟹   XP_063127113
Rat AssemblyChrPosition (strand)Source
GRCr81244,282,462 - 44,395,995 (-)NCBI
RefSeq Acc Id: NP_434686   ⟸   NM_052799
- UniProtKB: D3ZEW7 (UniProtKB/TrEMBL),   A0A8I5YCJ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001493   ⟸   ENSRNOT00000001493
RefSeq Acc Id: ENSRNOP00000062735   ⟸   ENSRNOT00000066810
RefSeq Acc Id: XP_038944988   ⟸   XM_039089060
- Peptide Label: isoform X1
- UniProtKB: A0A8I5YCJ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944987   ⟸   XM_039089059
- Peptide Label: isoform X1
- UniProtKB: A0A8I5YCJ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000077880   ⟸   ENSRNOT00000107669
RefSeq Acc Id: XP_063127111   ⟸   XM_063271041
- Peptide Label: isoform X2
- UniProtKB: P70594 (UniProtKB/Swiss-Prot),   P29476 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063127112   ⟸   XM_063271042
- Peptide Label: isoform X3
- UniProtKB: A0A8I5YCJ4 (UniProtKB/TrEMBL),   D3ZEW7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127113   ⟸   XM_063271043
- Peptide Label: isoform X4
- UniProtKB: P70594 (UniProtKB/Swiss-Prot),   P29476 (UniProtKB/Swiss-Prot),   F1LQL1 (UniProtKB/TrEMBL)
Protein Domains
FAD-binding FR-type   Flavodoxin-like   PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29476-F1-model_v2 AlphaFold P29476 1-1429 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3184 AgrOrtholog
BioCyc Gene G2FUF-19072 BioCyc
BioCyc Pathway PWY-4983 [nitric oxide biosynthesis II (mammals)] BioCyc
BioCyc Pathway Image PWY-4983 BioCyc
Ensembl Genes ENSRNOG00000001130 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001493.9 UniProtKB/TrEMBL
  ENSRNOT00000066810.4 UniProtKB/TrEMBL
  ENSRNOT00000107669.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.440.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Translation factors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CysJ-like_FAD-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-bd_FR_type UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavdoxin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavodoxin/NO_synth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavoprot_Pyr_Nucl_cyt_Rdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavoprotein-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FNR_nucleotide-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADPH_Cyt_P450_Rdtase_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_dom_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_dom_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_dom_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_euk UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS_N_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OxRdtase_FAD/NAD-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Riboflavin_synthase-like_b-brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24598 UniProtKB/Swiss-Prot
Pfam FAD_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Flavodoxin_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD_binding_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NO_synthase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nos1 PhenoGen
PIRSF NOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FPNCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NOS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001130 RatGTEx
SMART PDZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52218 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52343 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56512 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF63380 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary P70594 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-10 Nos1  nitric oxide synthase 1  Nos1  nitric oxide synthase 1, neuronal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Nos1  nitric oxide synthase 1, neuronal     nitric oxide synthase 1   Name updated 629478 APPROVED
2002-06-10 Nos1  nitric oxide synthase 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to mitochondrial membranes and postsynaptic densities 727494
gene_disease amyloid beta induced expression is observed in Alzheimers disease which could be a result of defective heme oxygenase 2 and carbon monoxide signaling 625673
gene_disease amyloid beta induced expression is observed in Alzheimers disease which could be a result of defective heme oxygenase 2 and carbon monoxide signaling 734540
gene_drugs mRNA level was higher in animals treated with N-(2-chloroethyl)-N-ethyl-2 bromobenzylamine (DSP4) 625673
gene_expression expressed in kidney 70545
gene_function produces nitric oxide from L-arginine and molecular oxygen 68897
gene_pathway necessary component of the signaling pathway along with light, glutamate and NMDA receptor, to reset the biological clock phase 734539
gene_pathway necessary component of the signaling pathway along with light, glutamate and NMDA receptor, to reset the biological clock phase 734540
gene_process mediator of erectile function and regulates skeletal muscle vasoconstriction, body fluid homeostasis, neuroendocrine physiology, and smooth muscle motility 68911
gene_regulation activity is inhibited by stearoylethanolamide (SEA) treatment of C6 glioma cells 625526
gene_regulation highest activity is measured at pH 6.7 in the hypothalamic suprachiasmatic nuclei 734539
gene_transcript can identify only one variable exon 1302827