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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3184
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos1
Name: nitric oxide synthase 1
Acc ID: CHEBI:180664
Term: 4-hydroxy-TEMPO
Definition: A member of the class of aminoxyls that is TEMPO carrying a hydroxy substituent at position 4. It is a radical scavenger which exhibits anti-inflammatory and analgesic properties.
Chemical ID: MESH:C001803
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos1increases phosphorylationEXP 6480464CTDtempol results in increased phosphorylation of NOS1 proteinPMID:20056918
Nos1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tempol results in increased phosphorylation of NOS1 protein]; tempol inhibits the reaction [lead acetate results in increased expression of NOS1 protein]; tempol inhibits the reaction [Phenol results in decreased expression of NOS1 mRNA]PMID:11454931 PMID:16785328 PMID:20056918
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