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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3184
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos1
Name: nitric oxide synthase 1
Acc ID: CHEBI:46053
Term: 2,4,6-trinitrotoluene
Definition: A trinitrotoluene having the nitro groups at positions 2, 4 and 6.
Chemical ID: MESH:D014303
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos1decreases activityEXP 6480464CTDTrinitrotoluene results in decreased activity of NOS1 proteinPMID:15223068
Nos1increases expressionEXP 6480464CTDTrinitrotoluene results in increased expression of NOS1 mRNAPMID:15223068
Nos1increases reductionEXP 6480464CTDNOS1 protein results in increased reduction of TrinitrotoluenePMID:15223068
Nos1multiple interactionsEXP 6480464CTD[NOS1 protein results in increased reduction of Trinitrotoluene] which results in decreased chemical synthesis of Nitric Oxide; [NOS1 protein results in increased susceptibility to Trinitrotoluene] which results in increased abundance of Hydrogen Peroxide; Calcium Chloride promotes the reaction [NOS1 protein results in increased reduction of Trinitrotoluene]PMID:15223068
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