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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3184
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos1
Name: nitric oxide synthase 1
Acc ID: CHEBI:149489
Term: 5,5-dimethyl-1-pyrroline N-oxide
Definition: A member of the class of 1-pyrroline nitrones (1-pyrroline N-oxides) resulting from the formal N-oxidation of 5,5-dimethyl-1-pyrroline. Used as a spin trap for the study of radicals formed by enzymatic acetaldehyde oxidation.
Chemical ID: MESH:C017245
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos1multiple interactionsISORGD:6195516480464CTD[NOS1 co-treated with sodium sulfite co-treated with 5, 5-dimethyl-1-pyrroline-1-oxide] results in increased oxidation of ALB protein

PMID:20348042
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.