Alcrsp5 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL Registration

QTL: Alcrsp5 (Alcohol response QTL 5) Rattus norvegicus

Symbol: Alcrsp5
Name: Alcohol response QTL 5
RGD ID: 1641928
Previously known as: Loss of righting reflex; LORR
Trait: response to alcohol trait   (VT:0010489)    
Measurement Type: duration of loss of righting reflex   (CMO:0002289)    
LOD Score: Likelihood Ratio: 11.1
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81218,473,041 - 52,308,831RGD_MAPPER_PIPELINE
mRatBN7.21212,812,385 - 46,669,029RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01218,342,477 - 52,716,770RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01220,209,592 - 54,450,796RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41213,948,769 - 46,782,294RGD_MAPPER_PIPELINERGSC3.4
RGSC_v3.11213,812,157 - 46,649,226RGD
Cross Type: intercross
Strains Crossed: LAS1 HAS1 
JBrowse: View Region in Genome Browser (JBrowse)
Model




  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Alcrsp5Ratalcohol-induced mental disorder susceptibilityIDA 1334439 RGD 

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Alcrsp5Ratalcohol preference  IDA 1334439 RGD 
Alcrsp5Ratimpaired righting response  IDA 1334439 RGD 

Clinical Measurement
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Alcrsp5Ratduration of loss of righting reflex  IDA 1334439 RGD 

Experimental Condition
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Alcrsp5Ratethanol  IDA 13344393.5 g/kg and intraperitoneallyRGD 

Measurement Method
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Alcrsp5Ratin vivo visual assessment  IDA 1334439 RGD 

Rat Strain
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Alcrsp5RatHAS1  IEA 1334439 RGD 
Alcrsp5RatLAS1  IEA 1334439 RGD 

Vertebrate Trait
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Alcrsp5Ratresponse to alcohol trait  IDA 1334439 RGD 


#
Reference Title
Reference Citation
1. Quantitative trait Loci mapping for ethanol sensitivity and neurotensin receptor density in an F2 intercross derived from inbred high and low alcohol sensitivity selectively bred rat lines. Radcliffe RA, etal., Alcohol Clin Exp Res 2004 Dec;28(12):1796-804.


1 to 20 of 732 rows
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD ID
Symbol
Name
Chr
Start
Stop
Species
1560686Sdk1sidekick cell adhesion molecule 1121237807413363934Rat
41240022LOC120096102U6 spliceosomal RNA121303886713038969Rat
1584808Nip7-ps9nucleolar pre-rRNA processing protein NIP7, pseudogene 9121342089613421417Rat
41079527LOC120095893uncharacterized LOC120095893121343303013460245Rat
7598302LOC102547234uncharacterized LOC102547234121354778913607490Rat
2323211Card11caspase recruitment domain family, member 11121362114013758115Rat
71018Gna12G protein subunit alpha 12121380558013886255Rat
1311314Amz1archaelysin family metallopeptidase 1121388651813924275Rat
1565146Brat1BRCA1-associated ATM activator 1121392888913951760Rat
1311349IqceIQ motif containing E121394329013982708Rat
1309549Ttyh3tweety family member 3121399683114025457Rat
620587LfngLFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase121403055114038996Rat
71055Grifingalectin-related inter-fiber protein121408017014082892Rat
1308214Chst12carbohydrate sulfotransferase 12121411063114129099Rat
1598146Kif19bkinesin family member 19B121414416314196259Rat
41188349LOC120095895uncharacterized LOC120095895121414908814152690Rat
41182922LOC120096093U6 spliceosomal RNA121416998914170094Rat
1309018Eif3beukaryotic translation initiation factor 3, subunit B121419640314220865Rat
11502171LOC108352425uncharacterized LOC108352425121422308014265458Rat
1305791Snx8sorting nexin 8121425182914300435Rat

1 to 20 of 732 rows
1 to 20 of 1052 rows
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Expected Size
Chr
Start
Stop
Species
Match
10125DXMgh7230123381916733819400Ratregion
10888D12Wox1089122089438020894469Ratregion
10990D12Mco2242123871454038714782Ratregion
11051D12Mit2217121961087019611091Ratregion
11052D12Wox11200121961088619611090Ratregion
11053D12Wox12202121961088919611095Ratregion
33955D1Mit22124123140994231410080Ratregion
33963D12Mit4198123819280938193007Ratregion
34017D12Mit9142122184936621849508Ratregion
34070D12Mgh7138123569808835698226Ratregion
34086D12Mgh9135124021838040218516Ratregion
34246D12Mgh3118122423477724234895Ratregion
34389D12Mgh10132123769148537691617Ratregion
34417D12Mgh2163121983578919835952Ratregion
34729D12Mgh5124122806443328064557Ratregion
11281D12Wox15157123609153336091690Ratregion
11282D12Arb7340123609137936091727Ratregion
11396D12Mgh11150124164428741644437Ratregion
11449D12Wox14158122200342822003586Ratregion
11450D12Mgh12140122199658621996726Ratregion
1 to 20 of 1052 rows

Peak: (D12Rat52)
Rat AssemblyChrPosition (strand)Source
GRCr81240,972,969 - 40,973,114 (+)Marker Load Pipeline
mRatBN7.21235,312,313 - 35,312,458 (+)MAPPER
Rnor_6.01240,842,405 - 40,842,549NCBI
Rnor_5.01242,709,520 - 42,709,664UniSTS
RGSC_v3.41236,448,697 - 36,448,841RGD
RGSC_v3.41236,448,698 - 36,448,842UniSTS
RGSC_v3.11236,312,085 - 36,312,229RGD
Celera1236,976,786 - 36,976,930UniSTS
RH 3.4 Map12613.1UniSTS
RH 3.4 Map12613.1RGD
RH 2.0 Map12529.4RGD
SHRSP x BN Map1244.35RGD
Cytogenetic Map12q16UniSTS


1 to 10 of 70 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12931821612829686Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat

1 to 10 of 70 rows


Note Type Note Reference
qtl_cross_type intercross  
qtl_general males scored approximetely twice in the loss of righting reflex test than females 1334439
qtl_general software package used: Map Manager QTX 1334439
qtl_general number of animals used: 70 days old 413 F2 rats inducing agent: intraperitoneal administration of alcohol 3.5 g/kg 1334439
qtl_general measurement method: after alcohol administration, animals were placed on their back and the time at when they no longer right themselves was recorded; the lapse time at which they could right themselves was taken as loss of righting reflex (LORR) 1334439
qtl_statistics Likelihood Ratio: 11.1 1334439