P2rx4 (purinergic receptor P2X 4) - Rat Genome Database

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Gene: P2rx4 (purinergic receptor P2X 4) Rattus norvegicus
Symbol: P2rx4
Name: purinergic receptor P2X 4
RGD ID: 62073
Description: Enables several functions, including ATP binding activity; ligand-gated monoatomic cation channel activity; and transition metal ion binding activity. Involved in several processes, including cellular response to zinc ion; neuronal action potential; and positive regulation of microglial cell migration. Located in several cellular components, including dendritic spine; lysosomal membrane; and neuronal cell body. Biomarker of congestive heart failure. Orthologous to human P2RX4 (purinergic receptor P2X 4); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amphetamine.
Type: protein-coding
Previously known as: ATP receptor; P2X purinoceptor 4; P2X4; purinergic receptor P2X ligand-gated ion channel 4; purinergic receptor P2X, ligand-gated ion channel 4
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21233,844,609 - 33,862,265 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,844,396 - 33,862,253 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1235,022,338 - 35,040,001 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01235,633,773 - 35,651,436 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01234,686,065 - 34,703,728 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01239,308,022 - 39,325,673 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,308,025 - 39,325,673 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01241,196,777 - 41,214,428 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41234,943,900 - 34,961,551 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11234,807,290 - 34,824,939 (-)NCBI
Celera1235,521,444 - 35,539,095 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
Benzo[k]fluoranthene  (ISO)
benzoates  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
cobalt atom  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
diclofenac  (EXP)
dieldrin  (EXP)
disodium selenite  (ISO)
dorsomorphin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
ginsenoside C-K  (ISO)
ginsenoside Rb1  (ISO)
ginsenoside Rd  (ISO)
heptachlor  (EXP)
hydroquinone  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lead diacetate  (EXP)
lipopolysaccharide  (ISO)
luteolin  (EXP)
mercury atom  (EXP)
mercury(0)  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nitrogen dioxide  (ISO)
ozone  (ISO)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
propiconazole  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
toluene 2,4-diisocyanate  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
valproic acid  (ISO)
XL147  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic signaling pathway  (ISO)
behavioral response to pain  (IMP)
calcium ion transmembrane transport  (IBA,IDA,ISO)
calcium ion transport  (ISO)
calcium-mediated signaling  (IEA)
cellular response to ATP  (IDA,IMP,ISO,ISS)
cellular response to zinc ion  (IDA)
clathrin-dependent endocytosis  (IMP)
excitatory postsynaptic potential  (IEA,ISO)
inorganic cation transmembrane transport  (IDA)
membrane depolarization  (ISO)
monoatomic cation transmembrane transport  (IEA)
monoatomic ion transmembrane transport  (ISO)
negative regulation of cardiac muscle hypertrophy  (ISO)
neuronal action potential  (IDA)
nitric oxide biosynthetic process  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of calcium ion transport into cytosol  (ISO)
positive regulation of calcium-mediated signaling  (ISO)
positive regulation of endothelial cell chemotaxis  (ISO)
positive regulation of microglial cell migration  (IMP)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IMP)
purinergic nucleotide receptor signaling pathway  (IEA,ISO)
regulation of blood pressure  (ISO)
regulation of cardiac muscle contraction  (ISO)
regulation of chemotaxis  (IMP)
regulation of response to drug  (IMP)
regulation of ruffle assembly  (IMP)
regulation of sodium ion transport  (IDA)
relaxation of cardiac muscle  (ISO)
response to ATP  (IEA,ISO)
response to axon injury  (IMP)
response to fluid shear stress  (ISO)
response to ischemia  (IMP)
sensory perception of pain  (IMP)
sensory perception of touch  (IMP)
signal transduction  (ISO)
vasodilation  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Regulation of neuronal type genes in congestive heart failure rats. Andersson KB, etal., Acta Physiol (Oxf). 2006 Jan;186(1):17-27.
2. Identification of P2X2/P2X4/P2X6 heterotrimeric receptors using atomic force microscopy (AFM) imaging. Antonio LS, etal., FEBS Lett. 2014 Jun 5;588(12):2125-8. doi: 10.1016/j.febslet.2014.04.048. Epub 2014 May 8.
3. Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes. Aschrafi A, etal., J Mol Biol. 2004 Sep 3;342(1):333-43.
4. Electron microscopic localisation of P2X4 receptor subunit immunoreactivity to pre- and post-synaptic neuronal elements and glial processes in the dorsal vagal complex of the rat. Ashour F and Deuchars J, Brain Res. 2004 Nov 5;1026(1):44-55.
5. A P2X purinoceptor cDNA conferring a novel pharmacological profile. Bo X, etal., FEBS Lett 1995 Nov 13;375(1-2):129-33.
6. An antagonist-insensitive P2X receptor expressed in epithelia and brain. Buell G, etal., EMBO J 1996 Jan 2;15(1):55-62.
7. Up-regulation of P2X2, P2X4 receptor and ischemic cell death: prevention by P2 antagonists. Cavaliere F, etal., Neuroscience. 2003;120(1):85-98.
8. Histidine 140 plays a key role in the inhibitory modulation of the P2X4 nucleotide receptor by copper but not zinc. Coddou C, etal., J Biol Chem. 2003 Sep 19;278(38):36777-85. Epub 2003 Jun 20.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Evidence for functional P2X4/P2X7 heteromeric receptors. Guo C, etal., Mol Pharmacol. 2007 Dec;72(6):1447-56. Epub 2007 Sep 4.
11. P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH. Huang P, etal., J Biol Chem. 2014 Jun 20;289(25):17658-67. doi: 10.1074/jbc.M114.552158. Epub 2014 May 9.
12. ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4. Inoue K, etal., J Pharmacol Sci. 2004 Feb;94(2):112-4.
13. Characterization of three types of ATP-activated current in relation to P2X subunits in rat trigeminal ganglion neurons. Luo J, etal., Brain Res. 2006 Oct 18;1115(1):9-15. Epub 2006 Aug 24.
14. Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats. Mapplebeck JCS, etal., Pain. 2018 Sep;159(9):1752-1763. doi: 10.1097/j.pain.0000000000001265.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis. Ohsawa K, etal., Glia. 2007 Apr 15;55(6):604-16. doi: 10.1002/glia.20489.
18. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
19. GOA pipeline RGD automated data pipeline
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Distinct Localization of P2X receptors at excitatory postsynaptic specializations. Rubio ME and Soto F, J Neurosci. 2001 Jan 15;21(2):641-53.
22. A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain. Seguela P, etal., J Neurosci 1996 Jan 15;16(2):448-55.
23. Direct observation of ATP-induced conformational changes in single P2X(4) receptors. Shinozaki Y, etal., PLoS Biol. 2009 May;7(5):e1000103. doi: 10.1371/journal.pbio.1000103. Epub 2009 May 5.
24. P2X4: an ATP-activated ionotropic receptor cloned from rat brain. Soto F, etal., Proc Natl Acad Sci U S A 1996 Apr 16;93(8):3684-8.
25. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
26. Functional properties of internalization-deficient P2X4 receptors reveal a novel mechanism of ligand-gated channel facilitation by ivermectin. Toulme E, etal., Mol Pharmacol. 2006 Feb;69(2):576-87. Epub 2005 Nov 10.
27. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Tsuda M, etal., Nature. 2003 Aug 14;424(6950):778-83. doi: 10.1038/nature01786.
28. Cloning and pharmacological characterization of a fourth P2X receptor subtype widely expressed in brain and peripheral tissues including various endocrine tissues. Wang CZ, etal., Biochem Biophys Res Commun 1996 Mar 7;220(1):196-202.
Additional References at PubMed
PMID:9016352   PMID:10515189   PMID:10899068   PMID:10969036   PMID:11606481   PMID:12077178   PMID:12088286   PMID:12105201   PMID:12600825   PMID:12788520   PMID:15081800   PMID:15130891  
PMID:15489334   PMID:15528255   PMID:15795310   PMID:15885321   PMID:15890753   PMID:15985462   PMID:16327800   PMID:16534777   PMID:16943557   PMID:16949036   PMID:16973131   PMID:17264311  
PMID:17560948   PMID:17897319   PMID:17918263   PMID:17940064   PMID:17990272   PMID:18427835   PMID:18675255   PMID:18837052   PMID:18938136   PMID:19056867   PMID:19084381   PMID:19283779  
PMID:19295157   PMID:19298529   PMID:19304656   PMID:19351603   PMID:19447505   PMID:19562525   PMID:19767540   PMID:19946888   PMID:20009029   PMID:20026202   PMID:20056605   PMID:20406028  
PMID:20407394   PMID:20590593   PMID:21106936   PMID:21378451   PMID:21482824   PMID:21844344   PMID:21907716   PMID:22053919   PMID:22222817   PMID:22230887   PMID:22393055   PMID:22785548  
PMID:23220420   PMID:23303206   PMID:23524095   PMID:23533145   PMID:23555667   PMID:23771671   PMID:24254916   PMID:24569146   PMID:24798490   PMID:24943126   PMID:24997270   PMID:25070962  
PMID:25074385   PMID:25398027   PMID:25662851   PMID:25680470   PMID:26481522   PMID:26946358   PMID:27506813   PMID:27545450   PMID:28306606   PMID:28461136   PMID:29973381   PMID:29997254  
PMID:30306657   PMID:30507759   PMID:30537520   PMID:32198702   PMID:32428626   PMID:32979222   PMID:33398365   PMID:33639220   PMID:33966147   PMID:34638832   PMID:35218450   PMID:35290938  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21233,844,609 - 33,862,265 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1233,844,396 - 33,862,253 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1235,022,338 - 35,040,001 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01235,633,773 - 35,651,436 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01234,686,065 - 34,703,728 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01239,308,022 - 39,325,673 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1239,308,025 - 39,325,673 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01241,196,777 - 41,214,428 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41234,943,900 - 34,961,551 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11234,807,290 - 34,824,939 (-)NCBI
Celera1235,521,444 - 35,539,095 (-)NCBICelera
Cytogenetic Map12q16NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh3812121,210,129 - 121,234,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12121,210,065 - 121,234,106 (+)EnsemblGRCh38hg38GRCh38
GRCh3712121,647,932 - 121,671,909 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612120,132,047 - 120,156,292 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412120,110,383 - 120,134,627NCBI
Celera12121,285,420 - 121,309,664 (+)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12118,657,246 - 118,681,512 (+)NCBIHuRef
CHM1_112121,616,508 - 121,640,746 (+)NCBICHM1_1
T2T-CHM13v2.012121,200,899 - 121,224,872 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm395122,845,581 - 122,867,802 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5122,845,607 - 122,867,801 (+)EnsemblGRCm39 Ensembl
GRCm385122,707,518 - 122,729,739 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5122,707,544 - 122,729,738 (+)EnsemblGRCm38mm10GRCm38
MGSCv375123,157,566 - 123,179,053 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365122,968,240 - 122,989,661 (+)NCBIMGSCv36mm8
Celera5119,785,375 - 119,806,787 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map562.53NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554827,031,874 - 7,039,220 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554827,031,874 - 7,039,026 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan112129,291,253 - 129,315,419 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012118,807,961 - 118,832,267 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112122,178,668 - 122,202,959 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12122,178,672 - 122,202,959 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1267,897,528 - 7,914,279 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl267,898,015 - 7,914,234 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha268,062,300 - 8,079,042 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0268,155,694 - 8,172,441 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl268,155,705 - 8,172,399 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1268,115,630 - 8,132,371 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0268,174,205 - 8,190,943 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0268,130,559 - 8,147,306 (-)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024405118156,402,015 - 156,417,147 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365583,059,886 - 3,077,451 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365583,062,279 - 3,077,493 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1431,368,303 - 31,387,905 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11431,368,542 - 31,387,960 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21433,232,162 - 33,251,989 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.111116,585,276 - 116,609,401 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11116,585,586 - 116,609,511 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037128,472,594 - 128,496,813 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474721,783,381 - 21,796,260 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474721,783,445 - 21,796,501 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in P2rx4
218 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:246
Count of miRNA genes:170
Interacting mature miRNAs:197
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)122860752637691617Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21233,844,643 - 33,844,833 (+)MAPPERmRatBN7.2
Rnor_6.01239,308,055 - 39,308,244NCBIRnor6.0
Rnor_5.01241,196,810 - 41,196,999UniSTSRnor5.0
RGSC_v3.41234,943,933 - 34,944,122UniSTSRGSC3.4
Celera1235,521,477 - 35,521,666UniSTS
RH 3.4 Map12595.6UniSTS
Cytogenetic Map12q16UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 13 57 41 19 41 26 29 37 11
Low 30 8 11 48 6 4 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000001752   ⟹   ENSRNOP00000001752
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,844,613 - 33,862,253 (-)Ensembl
Rnor_6.0 Ensembl1239,308,025 - 39,325,673 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098463   ⟹   ENSRNOP00000084396
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,844,396 - 33,862,234 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000102812   ⟹   ENSRNOP00000092796
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,844,613 - 33,862,253 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000110480   ⟹   ENSRNOP00000086475
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1233,844,616 - 33,862,234 (-)Ensembl
RefSeq Acc Id: NM_031594   ⟹   NP_113782
Rat AssemblyChrPosition (strand)Source
mRatBN7.21233,844,611 - 33,862,265 (-)NCBI
Rnor_6.01239,308,022 - 39,325,673 (-)NCBI
Rnor_5.01241,196,777 - 41,214,428 (-)NCBI
RGSC_v3.41234,943,900 - 34,961,551 (-)RGD
Celera1235,521,444 - 35,539,095 (-)RGD
RefSeq Acc Id: XM_039089300   ⟹   XP_038945228
Rat AssemblyChrPosition (strand)Source
mRatBN7.21233,844,609 - 33,853,812 (-)NCBI
RefSeq Acc Id: XM_039089302   ⟹   XP_038945230
Rat AssemblyChrPosition (strand)Source
mRatBN7.21233,844,609 - 33,853,812 (-)NCBI
RefSeq Acc Id: XM_039089303   ⟹   XP_038945231
Rat AssemblyChrPosition (strand)Source
mRatBN7.21233,844,609 - 33,851,353 (-)NCBI
RefSeq Acc Id: NP_113782   ⟸   NM_031594
- UniProtKB: P51577 (UniProtKB/Swiss-Prot),   A6J182 (UniProtKB/TrEMBL),   A6J181 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001752   ⟸   ENSRNOT00000001752
RefSeq Acc Id: XP_038945230   ⟸   XM_039089302
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038945228   ⟸   XM_039089300
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038945231   ⟸   XM_039089303
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000086475   ⟸   ENSRNOT00000110480
RefSeq Acc Id: ENSRNOP00000084396   ⟸   ENSRNOT00000098463
RefSeq Acc Id: ENSRNOP00000092796   ⟸   ENSRNOT00000102812

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P51577-F1-model_v2 AlphaFold P51577 1-388 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698641
Promoter ID:EPDNEW_R9164
Type:initiation region
Description:purinergic receptor P2X 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01239,325,605 - 39,325,665EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62073 AgrOrtholog
BioCyc Gene G2FUF-19267 BioCyc
Ensembl Genes ENSRNOG00000001300 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001752 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000098463.1 UniProtKB/TrEMBL
  ENSRNOT00000102812.1 UniProtKB/TrEMBL
  ENSRNOT00000110480.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.490.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  atp-gated p2x4 ion channel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro P2X4_purnocptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X_extracellular_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2X_purnocptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29659 UniProtKB/Swiss-Prot
  P2X PURINOCEPTOR 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam P2X_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen P2rx4 PhenoGen
PIRSF P2X_purinoceptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2XRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001300 RatGTEx
  A6J179_RAT UniProtKB/TrEMBL
  A6J180_RAT UniProtKB/TrEMBL
  A6J183_RAT UniProtKB/TrEMBL
  P2RX4_RAT UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 P2rx4  purinergic receptor P2X 4  P2rx4  purinergic receptor P2X, ligand-gated ion channel 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 P2rx4  purinergic receptor P2X, ligand-gated ion channel, 4       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in pancreatic islet cells 729194
gene_regulation channel is highly permeable to Ca2+ and is modulated by extracellular Zn2+ 729054