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Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | P2RX4 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | P2RX4 (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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# | Reference Title | Reference Citation |
1. | Regulation of neuronal type genes in congestive heart failure rats. | Andersson KB, etal., Acta Physiol (Oxf). 2006 Jan;186(1):17-27. |
2. | Identification of P2X2/P2X4/P2X6 heterotrimeric receptors using atomic force microscopy (AFM) imaging. | Antonio LS, etal., FEBS Lett. 2014 Jun 5;588(12):2125-8. doi: 10.1016/j.febslet.2014.04.048. Epub 2014 May 8. |
3. | Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes. | Aschrafi A, etal., J Mol Biol. 2004 Sep 3;342(1):333-43. |
4. | Electron microscopic localisation of P2X4 receptor subunit immunoreactivity to pre- and post-synaptic neuronal elements and glial processes in the dorsal vagal complex of the rat. | Ashour F and Deuchars J, Brain Res. 2004 Nov 5;1026(1):44-55. |
5. | A P2X purinoceptor cDNA conferring a novel pharmacological profile. | Bo X, etal., FEBS Lett 1995 Nov 13;375(1-2):129-33. |
6. | An antagonist-insensitive P2X receptor expressed in epithelia and brain. | Buell G, etal., EMBO J 1996 Jan 2;15(1):55-62. |
7. | Up-regulation of P2X2, P2X4 receptor and ischemic cell death: prevention by P2 antagonists. | Cavaliere F, etal., Neuroscience. 2003;120(1):85-98. |
8. | Histidine 140 plays a key role in the inhibitory modulation of the P2X4 nucleotide receptor by copper but not zinc. | Coddou C, etal., J Biol Chem. 2003 Sep 19;278(38):36777-85. Epub 2003 Jun 20. |
9. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
10. | Evidence for functional P2X4/P2X7 heteromeric receptors. | Guo C, etal., Mol Pharmacol. 2007 Dec;72(6):1447-56. Epub 2007 Sep 4. |
11. | P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH. | Huang P, etal., J Biol Chem. 2014 Jun 20;289(25):17658-67. doi: 10.1074/jbc.M114.552158. Epub 2014 May 9. |
12. | ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4. | Inoue K, etal., J Pharmacol Sci. 2004 Feb;94(2):112-4. |
13. | Characterization of three types of ATP-activated current in relation to P2X subunits in rat trigeminal ganglion neurons. | Luo J, etal., Brain Res. 2006 Oct 18;1115(1):9-15. Epub 2006 Aug 24. |
14. | Microglial P2X4R-evoked pain hypersensitivity is sexually dimorphic in rats. | Mapplebeck JCS, etal., Pain. 2018 Sep;159(9):1752-1763. doi: 10.1097/j.pain.0000000000001265. |
15. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
16. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
17. | Involvement of P2X4 and P2Y12 receptors in ATP-induced microglial chemotaxis. | Ohsawa K, etal., Glia. 2007 Apr 15;55(6):604-16. doi: 10.1002/glia.20489. |
18. | KEGG Annotation Import Pipeline | Pipeline to import KEGG annotations from KEGG into RGD |
19. | GOA pipeline | RGD automated data pipeline |
20. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
21. | Distinct Localization of P2X receptors at excitatory postsynaptic specializations. | Rubio ME and Soto F, J Neurosci. 2001 Jan 15;21(2):641-53. |
22. | A novel neuronal P2x ATP receptor ion channel with widespread distribution in the brain. | Seguela P, etal., J Neurosci 1996 Jan 15;16(2):448-55. |
23. | Direct observation of ATP-induced conformational changes in single P2X(4) receptors. | Shinozaki Y, etal., PLoS Biol. 2009 May;7(5):e1000103. doi: 10.1371/journal.pbio.1000103. Epub 2009 May 5. |
24. | P2X4: an ATP-activated ionotropic receptor cloned from rat brain. | Soto F, etal., Proc Natl Acad Sci U S A 1996 Apr 16;93(8):3684-8. |
25. | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11. |
26. | Functional properties of internalization-deficient P2X4 receptors reveal a novel mechanism of ligand-gated channel facilitation by ivermectin. | Toulme E, etal., Mol Pharmacol. 2006 Feb;69(2):576-87. Epub 2005 Nov 10. |
27. | P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. | Tsuda M, etal., Nature. 2003 Aug 14;424(6950):778-83. doi: 10.1038/nature01786. |
28. | Cloning and pharmacological characterization of a fourth P2X receptor subtype widely expressed in brain and peripheral tissues including various endocrine tissues. | Wang CZ, etal., Biochem Biophys Res Commun 1996 Mar 7;220(1):196-202. |
PMID:9016352 | PMID:10515189 | PMID:10899068 | PMID:10969036 | PMID:11606481 | PMID:12077178 | PMID:12088286 | PMID:12105201 | PMID:12600825 | PMID:12788520 | PMID:15081800 | PMID:15130891 |
PMID:15489334 | PMID:15528255 | PMID:15795310 | PMID:15885321 | PMID:15890753 | PMID:15985462 | PMID:16327800 | PMID:16534777 | PMID:16943557 | PMID:16949036 | PMID:16973131 | PMID:17264311 |
PMID:17560948 | PMID:17897319 | PMID:17918263 | PMID:17940064 | PMID:17990272 | PMID:18427835 | PMID:18675255 | PMID:18837052 | PMID:18938136 | PMID:19056867 | PMID:19084381 | PMID:19283779 |
PMID:19295157 | PMID:19298529 | PMID:19304656 | PMID:19351603 | PMID:19447505 | PMID:19562525 | PMID:19767540 | PMID:19946888 | PMID:20009029 | PMID:20026202 | PMID:20056605 | PMID:20406028 |
PMID:20407394 | PMID:20590593 | PMID:21106936 | PMID:21378451 | PMID:21482824 | PMID:21844344 | PMID:21907716 | PMID:22053919 | PMID:22222817 | PMID:22230887 | PMID:22393055 | PMID:22785548 |
PMID:23220420 | PMID:23303206 | PMID:23524095 | PMID:23533145 | PMID:23555667 | PMID:23771671 | PMID:24254916 | PMID:24569146 | PMID:24798490 | PMID:24943126 | PMID:24997270 | PMID:25070962 |
PMID:25074385 | PMID:25398027 | PMID:25662851 | PMID:25680470 | PMID:26481522 | PMID:26946358 | PMID:27506813 | PMID:27545450 | PMID:28306606 | PMID:28461136 | PMID:29973381 | PMID:29997254 |
PMID:30306657 | PMID:30507759 | PMID:30537520 | PMID:32198702 | PMID:32428626 | PMID:32979222 | PMID:33398365 | PMID:33639220 | PMID:33966147 | PMID:34638832 | PMID:35218450 | PMID:35290938 |
PMID:35594248 |
P2rx4 (Rattus norvegicus - Norway rat) |
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P2RX4 (Homo sapiens - human) |
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P2rx4 (Mus musculus - house mouse) |
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P2rx4 (Chinchilla lanigera - long-tailed chinchilla) |
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P2RX4 (Pan paniscus - bonobo/pygmy chimpanzee) |
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P2RX4 (Canis lupus familiaris - dog) |
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P2rx4 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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P2RX4 (Sus scrofa - pig) |
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P2RX4 (Chlorocebus sabaeus - green monkey) |
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P2rx4 (Heterocephalus glaber - naked mole-rat) |
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Variants in P2rx4
218 total Variants ![]() |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
RH137366 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 13 | 57 | 41 | 19 | 41 | 26 | 29 | 37 | 11 | |||
Low | 30 | 8 | 11 | 48 | 6 | 4 | 8 | ||||||
Below cutoff |
RefSeq Transcripts | NM_031594 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_039089300 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039089302 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039089303 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | BC078792 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
CH473973 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JACYVU010000228 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
U32497 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
U47031 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
X87763 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
X91200 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
X93565 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000001752 ⟹ ENSRNOP00000001752 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000098463 ⟹ ENSRNOP00000084396 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000102812 ⟹ ENSRNOP00000092796 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000110480 ⟹ ENSRNOP00000086475 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_031594 ⟹ NP_113782 | ||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039089300 ⟹ XP_038945228 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_039089302 ⟹ XP_038945230 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_039089303 ⟹ XP_038945231 | ||||||||
Type: | CODING | ||||||||
Position: |
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Protein RefSeqs | NP_113782 | (Get FASTA) | NCBI Sequence Viewer |
XP_038945228 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038945230 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038945231 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAA99777 | (Get FASTA) | NCBI Sequence Viewer |
AAC52380 | (Get FASTA) | NCBI Sequence Viewer | |
AAH78792 | (Get FASTA) | NCBI Sequence Viewer | |
CAA61037 | (Get FASTA) | NCBI Sequence Viewer | |
CAA62607 | (Get FASTA) | NCBI Sequence Viewer | |
CAA63778 | (Get FASTA) | NCBI Sequence Viewer | |
EDM13668 | (Get FASTA) | NCBI Sequence Viewer | |
EDM13669 | (Get FASTA) | NCBI Sequence Viewer | |
EDM13670 | (Get FASTA) | NCBI Sequence Viewer | |
EDM13671 | (Get FASTA) | NCBI Sequence Viewer | |
EDM13672 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000001752 | ||
ENSRNOP00000084396.1 | |||
ENSRNOP00000086475.1 | |||
ENSRNOP00000092796.1 | |||
GenBank Protein | P51577 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_113782 ⟸ NM_031594 |
- UniProtKB: | P51577 (UniProtKB/Swiss-Prot), A6J182 (UniProtKB/TrEMBL), A6J181 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000001752 ⟸ ENSRNOT00000001752 |
RefSeq Acc Id: | XP_038945230 ⟸ XM_039089302 |
- Peptide Label: | isoform X2 |
RefSeq Acc Id: | XP_038945228 ⟸ XM_039089300 |
- Peptide Label: | isoform X1 |
RefSeq Acc Id: | XP_038945231 ⟸ XM_039089303 |
- Peptide Label: | isoform X3 |
RefSeq Acc Id: | ENSRNOP00000086475 ⟸ ENSRNOT00000110480 |
RefSeq Acc Id: | ENSRNOP00000084396 ⟸ ENSRNOT00000098463 |
RefSeq Acc Id: | ENSRNOP00000092796 ⟸ ENSRNOT00000102812 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P51577-F1-model_v2 | AlphaFold | P51577 | 1-388 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13698641 | ||||||||
Promoter ID: | EPDNEW_R9164 | ||||||||
Type: | initiation region | ||||||||
Name: | P2rx4_1 | ||||||||
Description: | purinergic receptor P2X 4 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:62073 | AgrOrtholog |
BioCyc Gene | G2FUF-19267 | BioCyc |
Ensembl Genes | ENSRNOG00000001300 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000001752 | ENTREZGENE, UniProtKB/Swiss-Prot |
ENSRNOT00000098463.1 | UniProtKB/TrEMBL | |
ENSRNOT00000102812.1 | UniProtKB/TrEMBL | |
ENSRNOT00000110480.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 2.60.490.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
atp-gated p2x4 ion channel | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
IMAGE_CLONE | IMAGE:7123247 | IMAGE-MGC_LOAD |
InterPro | P2X4_purnocptor | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
P2X_extracellular_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
P2X_purnocptor | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:29659 | UniProtKB/Swiss-Prot |
MGC_CLONE | MGC:93356 | IMAGE-MGC_LOAD |
NCBI Gene | 29659 | ENTREZGENE |
PANTHER | P2X PURINOCEPTOR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
P2X PURINOCEPTOR 4 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | P2X_receptor | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PhenoGen | P2rx4 | PhenoGen |
PIRSF | P2X_purinoceptor | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PRINTS | P2X4RECEPTOR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
P2XRECEPTOR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PROSITE | P2X_RECEPTOR | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
RatGTEx | ENSRNOG00000001300 | RatGTEx |
UniProt | A0A8I5ZYY2_RAT | UniProtKB/TrEMBL |
A0A8I6A3Q3_RAT | UniProtKB/TrEMBL | |
A0A8I6GKC6_RAT | UniProtKB/TrEMBL | |
A6J179_RAT | UniProtKB/TrEMBL | |
A6J180_RAT | UniProtKB/TrEMBL | |
A6J181 | ENTREZGENE, UniProtKB/TrEMBL | |
A6J182 | ENTREZGENE, UniProtKB/TrEMBL | |
A6J183_RAT | UniProtKB/TrEMBL | |
P2RX4_RAT | UniProtKB/Swiss-Prot, ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
---|---|---|---|---|---|---|---|
2016-02-11 | P2rx4 | purinergic receptor P2X 4 | P2rx4 | purinergic receptor P2X, ligand-gated ion channel 4 | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2002-06-10 | P2rx4 | purinergic receptor P2X, ligand-gated ion channel, 4 | Name updated | 70584 | APPROVED |
Note Type | Note | Reference |
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gene_expression | expressed in pancreatic islet cells | 729194 |
gene_regulation | channel is highly permeable to Ca2+ and is modulated by extracellular Zn2+ | 729054 |