Enables several functions, including ATP binding activity; ligand-gated monoatomic cation channel activity; and transition metal ion binding activity. Involved in several processes, including cellular response to zinc ion; neuronal action potential; and positive regulation of microglial cell migration. Located in several cellular components, including dendritic spine; lysosomal membrane; and neuronal cell body. Biomarker of congestive heart failure. Orthologous to human P2RX4 (purinergic receptor P2X 4); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; amphetamine.
[Cadmium co-treated with Zinc] promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein] and Cadmium promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of P2RX4 mRNA
[ginsenoside M1 co-treated with Adenosine Triphosphate] results in increased activity of P2RX4 protein and ginsenoside M1 promotes the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]
[resveratrol co-treated with Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX4 mRNA and [resveratrol co-treated with Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased expression of P2RX4 protein
[Mercury co-treated with Copper] inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein] and Mercury inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]
[Mercury co-treated with Copper] inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein] and Mercury inhibits the reaction [Adenosine Triphosphate results in increased activity of P2RX4 protein]
1-((3-benzyl-3-methyl-2 and 3-dihydro-1-benzofuran-6-yl)carbonyl)piperidine inhibits the reaction [Paclitaxel results in increased expression of P2RX4 protein]
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of P2RX4 mRNA
[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of P2RX4 mRNA
Electron microscopic localisation of P2X4 receptor subunit immunoreactivity to pre- and post-synaptic neuronal elements and glial processes in the dorsal vagal complex of the rat.
Cloning and pharmacological characterization of a fourth P2X receptor subtype widely expressed in brain and peripheral tissues including various endocrine tissues.
