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Gene: Aldh2 (aldehyde dehydrogenase 2 family member) Rattus norvegicus
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Symbol: Aldh2
Name: aldehyde dehydrogenase 2 family member
Description: Exhibits NADH binding activity; aldehyde dehydrogenase (NAD) activity; and identical protein binding activity. Involved in several processes, including response to estradiol; response to progesterone; and response to testosterone. Localizes to the mitochondrion. Biomarker of heart disease. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; artery disease (multiple); brain infarction; diabetes mellitus (multiple); and diabetic neuropathy. Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH (+)-menthofuran; (S)-norlaudanosoline; 1,3-dinitrobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: aldehyde dehydrogenase 2; aldehyde dehydrogenase 2 family (mitochondrial); aldehyde dehydrogenase 2 mitochondrial; aldehyde dehydrogenase 2, mitochondrial; aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDH1; mitochondrial aldehyde dehydrogenase
Orthologs:
Homo sapiens (human) : ALDH2 (aldehyde dehydrogenase 2 family member)  HGNC  Alliance
Mus musculus (house mouse) : Aldh2 (aldehyde dehydrogenase 2, mitochondrial)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aldh2 (aldehyde dehydrogenase 2 family member)
Pan paniscus (bonobo/pygmy chimpanzee) : ALDH2 (aldehyde dehydrogenase 2 family member)
Canis lupus familiaris (dog) : ALDH2 (aldehyde dehydrogenase 2 family member)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aldh2 (aldehyde dehydrogenase 2 family member)
Sus scrofa (pig) : ALDH2 (aldehyde dehydrogenase 2 family member)
more info ...
Allele / Splice: Aldh2em2Mcwi  
Genetic Models: SS-Aldh2em2Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01240,466,418 - 40,498,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01242,334,057 - 42,366,049 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,081,778 - 36,116,445 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11235,945,165 - 35,979,833 (+)NCBI
Celera1236,614,188 - 36,647,218 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Aldh2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69219
Created: 2001-11-13
Species: Rattus norvegicus
Last Modified: 2019-04-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.