Aldh2 (aldehyde dehydrogenase 2 family member) - Rat Genome Database

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Gene: Aldh2 (aldehyde dehydrogenase 2 family member) Rattus norvegicus
Analyze
Symbol: Aldh2
Name: aldehyde dehydrogenase 2 family member
RGD ID: 69219
Description: Enables NADH binding activity; aldehyde dehydrogenase (NAD+) activity; and identical protein binding activity. Involved in several processes, including behavioral response to ethanol; cellular response to resveratrol; and response to ischemia. Located in mitochondrial matrix. Used to study metabolic dysfunction and alcohol associated liver disease. Biomarker of heart disease. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to human ALDH2 (aldehyde dehydrogenase 2 family member); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aldehyde dehydrogenase 2; aldehyde dehydrogenase 2 family (mitochondrial); aldehyde dehydrogenase 2 mitochondrial; aldehyde dehydrogenase 2, mitochondrial; aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDH1; mitochondrial aldehyde dehydrogenase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Aldh2em2Mcwi  
Genetic Models: SS-Aldh2em2Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,610,244 - 40,643,220 (+)NCBIGRCr8
mRatBN7.21234,949,549 - 34,982,527 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,901,219 - 34,982,521 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,122,427 - 36,155,172 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,733,638 - 36,766,383 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,786,091 - 35,818,829 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,466,418 - 40,498,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,466,495 - 40,498,752 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,334,057 - 42,366,049 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,081,778 - 36,116,445 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11235,945,165 - 35,979,833 (+)NCBI
Celera1236,614,188 - 36,647,218 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,5-trimethylbenzene  (ISO)
1,3-dinitrobenzene  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrabromodibenzodioxine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2,5-dihydroxybenzaldehyde  (ISO)
2-ethoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
3',5'-cyclic GMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-dihydroxyphenylacetaldehyde  (EXP)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-hydroxybenzaldehyde  (ISO)
3-hydroxypyruvic acid  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-(diethylamino)benzaldehyde  (ISO)
4-dimethylaminocinnamaldehyde  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxynon-2-enal  (ISO)
4-nitrophenyl acetate  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetaldehyde  (EXP,ISO)
acetamide  (EXP)
acetophenone  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
aniline  (EXP)
antimycin A  (ISO)
aristolochic acid A  (ISO)
atrazine  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (ISO)
benomyl  (EXP,ISO)
benzaldehyde  (ISO)
benzaldehydes  (ISO)
benzbromarone  (EXP)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzyl isothiocyanate  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
butanal  (ISO)
butane-2,3-diol  (ISO)
cadmium atom  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
captan  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celecoxib  (EXP)
CGP 52608  (ISO)
chloral hydrate  (EXP,ISO)
chloroacetaldehyde  (ISO)
chloroethene  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
choline  (EXP,ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
cocaine  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
Cuprizon  (EXP)
cyanamide  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
D-glucose  (EXP)
D-glyceraldehyde  (EXP)
daidzein 7-O-beta-D-glucoside  (ISO)
decanal  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (EXP)
diallyl disulfide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
Dicyclohexyl phthalate  (EXP)
diethyl maleate  (EXP,ISO)
diethylstilbestrol  (ISO)
diisobutyl phthalate  (EXP)
dimethoate  (ISO)
dimethylarsinous acid  (ISO)
disulfiram  (EXP,ISO)
diuron  (EXP)
dopamine  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
enilconazole  (ISO)
epoxiconazole  (ISO)
EPTC  (ISO)
ethanol  (EXP,ISO)
flavonoids  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
folpet  (ISO)
formaldehyde  (EXP,ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glucose  (EXP)
glyceraldehyde  (EXP)
glycine betaine  (ISO)
glycolaldehyde  (EXP)
glyoxal  (EXP)
GW 4064  (ISO)
hemin  (EXP)
hexanal  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
indometacin  (EXP)
iprodione  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
L-methionine  (EXP,ISO)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
m-xylene  (ISO)
magnesium atom  (EXP,ISO)
malonaldehyde  (ISO)
mancozeb  (EXP,ISO)
maneb  (EXP,ISO)
menadione  (ISO)
menthofuran  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
methylglyoxal  (EXP)
mitoxantrone  (ISO)
molinate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
N-nitrosomorpholine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP)
NAD zwitterion  (EXP,ISO)
NAD(+)  (EXP,ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naphthalene  (ISO)
nitrates  (ISO)
nitric oxide  (ISO)
nitroglycerin  (EXP,ISO)
norlaudanosoline  (EXP)
omeprazole  (EXP)
Oxadiazon  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
pentaerythritol tetranitrate  (EXP,ISO)
pentrinitrol  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP)
phenacyl bromide  (ISO)
phenobarbital  (ISO)
PhIP  (EXP)
phlorizin  (ISO)
phosphorothioate oligonucleotide  (EXP)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
propanal  (ISO)
propiconazole  (ISO)
prunetin  (EXP)
pyrimidifen  (ISO)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sodium fluoride  (ISO)
streptozocin  (EXP)
sulfasalazine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (ISO)
taraxerone  (ISO)
tert-butyl ethyl ether  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
ubiquinones  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway  (ISO)
3-hydroxyisobutyric aciduria pathway  (ISO)
3-methylcrotonyl CoA carboxylase 1 deficiency pathway  (ISO)
3-methylglutaconic aciduria type 1 pathway  (ISO)
3-methylglutaconic aciduria type 3 pathway  (ISO)
arginine and proline metabolic pathway  (IEA)
ascorbate and aldarate metabolic pathway  (IEA)
beta-alanine metabolic pathway  (IEA,ISO)
carnosinemia pathway  (ISO)
dihydropyrimidine dehydrogenase deficiency pathway  (ISO)
dimethylglycine dehydrogenase deficiency pathway  (ISO)
disulfiram pharmacodynamics pathway  (ISO)
fatty acid metabolic pathway  (IEA)
GABA aminotransferase deficiency pathway   (ISO)
gluconeogenesis pathway  (IEA)
glycerolipid metabolic pathway   (IEA)
glycolysis pathway  (IEA)
glycolysis/gluconeogenesis pathway  (IEA)
histidine metabolic pathway  (IEA,ISO)
histidinemia pathway  (ISO)
isobutyryl-CoA dehydrogenase deficiency pathway  (ISO)
isovaleric acidemia pathway  (ISO)
Leigh disease pathway  (ISO)
lysine degradation pathway  (IEA)
maple syrup urine disease pathway  (ISO)
methylmalonate semialdehyde dehydrogenase deficiency pathway  (ISO)
methylmalonic acidemia pathway  (ISO)
nonketotic hyperglycinemia pathway  (ISO)
pentose and glucuronate interconversion pathway  (IEA)
primary hyperoxaluria type 2 pathway  (ISO)
propanoate metabolic pathway  (IEA)
propionic acidemia pathway  (ISO)
pyruvate decarboxylase deficiency pathway  (ISO)
pyruvate dehydrogenase E1 deficiency pathway  (ISO)
pyruvate kinase deficiency of red cells pathway   (ISO)
pyruvate metabolic pathway  (IEA,ISO)
sarcosinemia pathway  (ISO)
tryptophan metabolic pathway  (IEA,ISO)
valine, leucine and isoleucine degradation pathway  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Aldehyde dehydrogenase 2 polymorphism for development to hepatocellular carcinoma in East Asian alcoholic liver cirrhosis. Abe H, etal., J Gastroenterol Hepatol. 2015 Sep;30(9):1376-83. doi: 10.1111/jgh.12948.
2. Epidemiologic study of the association of low-Km mitochondrial acetaldehyde dehydrogenase genotypes with blood pressure level and the prevalence of hypertension in a general population. Amamoto K, etal., Hypertens Res. 2002 Nov;25(6):857-64.
3. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
4. Estrogen regulation of the rat anterior pituitary gland proteome. Blake CA, etal., Exp Biol Med (Maywood). 2005 Dec;230(11):800-7.
5. Increase in class 2 aldehyde dehydrogenase expression by arachidonic acid in rat hepatoma cells. Canuto RA, etal., Biochem J. 2001 Aug 1;357(Pt 3):811-8.
6. Association Between Aldehyde Dehydrogenase 2 Glu504Lys Polymorphism and Alcoholic Liver Disease. Chang B, etal., Am J Med Sci. 2018 Jul;356(1):10-14. doi: 10.1016/j.amjms.2018.03.012. Epub 2018 Mar 20.
7. Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis. Chao YC, etal., Am J Gastroenterol. 2000 Oct;95(10):2958-64. doi: 10.1111/j.1572-0241.2000.02328.x.
8. ALDH2 Deficiency Promotes Ethanol-Induced Gut Barrier Dysfunction and Fatty Liver in Mice. Chaudhry KK, etal., Alcohol Clin Exp Res. 2015 Aug;39(8):1465-75. doi: 10.1111/acer.12777. Epub 2015 Jul 14.
9. Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Chen CH, etal., Science. 2008 Sep 12;321(5895):1493-5. doi: 10.1126/science.1158554.
10. Proteomic alteration of mitochondrial aldehyde dehydrogenase 2 in sepsis regulated by heat shock response. Chen HW, etal., Shock. 2007 Dec;28(6):710-6. doi: 10.1097/shk.0b013e318050c8c2.
11. Vinyl chloride-induced interaction of nonalcoholic and toxicant-associated steatohepatitis: Protection by the ALDH2 activator Alda-1. Chen L, etal., Redox Biol. 2019 Jun;24:101205. doi: 10.1016/j.redox.2019.101205. Epub 2019 Apr 19.
12. Hormonal and chemical influences on the expression of class 2 aldehyde dehydrogenases in rat H4IIEC3 and human HuH7 hepatoma cells. Crabb DW, etal., Alcohol Clin Exp Res. 1995 Dec;19(6):1414-9.
13. Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk of primary hepatocellular carcinoma in a Chinese population. Ding J, etal., Asian Pac J Cancer Prev. 2008 Jan-Mar;9(1):31-5.
14. Genotyping of the aldehyde dehydrogenase 2 (ALDH2) gene using the polymerase chain reaction: evidence for single point mutation in the ALDH2 gene of ALDH2-deficiency. Enomoto N, etal., Gastroenterol Jpn. 1991 Aug;26(4):440-7.
15. Sequence of the signal peptide for rat liver mitochondrial aldehyde dehydrogenase. Farres J, etal., Biochem Biophys Res Commun 1988 Feb 15;150(3):1083-7.
16. Primary structures of rat and bovine liver mitochondrial aldehyde dehydrogenases deduced from cDNA sequences. Farres J, etal., Eur J Biochem 1989 Mar 1;180(1):67-74.
17. Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids. Gao Y, etal., Gut. 2019 Jul;68(7):1311-1322. doi: 10.1136/gutjnl-2018-316221. Epub 2018 Aug 18.
18. Eliciting the low-activity aldehyde dehydrogenase Asian phenotype by an antisense mechanism results in an aversion to ethanol. Garver E, etal., J Exp Med. 2001 Sep 3;194(5):571-80. doi: 10.1084/jem.194.5.571.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
21. NADH fluorescence lifetime analysis of the effect of magnesium ions on ALDH2. Gonnella TP, etal., Chem Biol Interact. 2011 May 30;191(1-3):147-52. doi: 10.1016/j.cbi.2011.01.023. Epub 2011 Jan 27.
22. Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagy. Guo R, etal., J Hepatol. 2015 Mar;62(3):647-56. doi: 10.1016/j.jhep.2014.10.009. Epub 2014 Oct 20.
23. Mitochondria-targeted ubiquinone (MitoQ) enhances acetaldehyde clearance by reversing alcohol-induced posttranslational modification of aldehyde dehydrogenase 2: A molecular mechanism of protection against alcoholic liver disease. Hao L, etal., Redox Biol. 2018 Apr;14:626-636. doi: 10.1016/j.redox.2017.11.005. Epub 2017 Nov 11.
24. Aldehyde dehydrogenase-2 (ALDH2) opposes hepatocellular carcinoma progression by regulating AMP-activated protein kinase signaling in mice. Hou G, etal., Hepatology. 2017 May;65(5):1628-1644. doi: 10.1002/hep.29006. Epub 2017 Mar 31.
25. Altered profile of gene expression in rat hearts induced by chronic nicotine consumption. Hu D, etal., Biochem Biophys Res Commun. 2002 Oct 4;297(4):729-36.
26. Change of components of the metabolic syndrome in a workers' health checkup after five years--relation with elevated liver enzymes, gene polymorphisms for ALDH 2, beta3-AR and lifestyle. Ishikawa N, etal., Nippon Koshu Eisei Zasshi. 2005 Nov;52(11):979-86.
27. Purification and characterization of catalytically active precursor of rat liver mitochondrial aldehyde dehydrogenase expressed in Escherichia coli. Jeng JJ and Weiner H, Arch Biochem Biophys. 1991 Sep;289(2):214-22.
28. ALDH2(E487K) mutation increases protein turnover and promotes murine hepatocarcinogenesis. Jin S, etal., Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9088-93. doi: 10.1073/pnas.1510757112. Epub 2015 Jul 6.
29. Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in Japanese. Kanda J, etal., Cancer Sci. 2008 Dec 4.
30. Genetic polymorphisms of aldehyde dehydrogenase 2, cytochrome p450 2E1 for liver cancer risk in HCV antibody-positive japanese patients and the variations of CYP2E1 mRNA expression levels in the liver due to its polymorphism. Kato S, etal., Scand J Gastroenterol. 2003 Aug;38(8):886-93.
31. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
32. Gender differences in the genetic risk for alcohol dependence--the results of a pharmacogenetic study in Korean alcoholics. Kim SG, Nihon Arukoru Yakubutsu Igakkai Zasshi. 2009 Dec;44(6):680-5.
33. Aldehyde dehydrogenase 2 deficiency ameliorates alcoholic fatty liver but worsens liver inflammation and fibrosis in mice. Kwon HJ, etal., Hepatology. 2014 Jul;60(1):146-57. doi: 10.1002/hep.27036. Epub 2014 May 28.
34. Isoflurane Preconditioning Confers Cardioprotection by Activation of ALDH2. Lang XE, etal., PLoS One. 2013;8(2):e52469. doi: 10.1371/journal.pone.0052469. Epub 2013 Feb 28.
35. Alda-1 Ameliorates Liver Ischemia-Reperfusion Injury by Activating Aldehyde Dehydrogenase 2 and Enhancing Autophagy in Mice. Li M, etal., J Immunol Res. 2018 Dec 24;2018:9807139. doi: 10.1155/2018/9807139. eCollection 2018.
36. [Activation of mitochondrial aldehyde dehydrogenase 2 and inhibition of mitochondrial permeability transition pore involved in cardioprotection of ethanol postconditioning]. Li ZH, etal., Zhejiang Da Xue Xue Bao Yi Xue Ban. 2010 Nov;39(6):566-71.
37. Alcohol Drinking Mediates the Association between Polymorphisms of ADH1B and ALDH2 and Hepatitis B-Related Hepatocellular Carcinoma. Liu J, etal., Cancer Epidemiol Biomarkers Prev. 2016 Apr;25(4):693-9. doi: 10.1158/1055-9965.EPI-15-0961. Epub 2016 Jan 31.
38. Resveratrol attenuates excessive ethanol exposure induced insulin resistance in rats via improving NAD+ /NADH ratio. Luo G, etal., Mol Nutr Food Res. 2017 Nov;61(11). doi: 10.1002/mnfr.201700087. Epub 2017 Aug 15.
39. Signal recognition initiates reorganization of the presequence translocase during protein import. Lytovchenko O, etal., EMBO J. 2013 Mar 20;32(6):886-98. doi: 10.1038/emboj.2013.23. Epub 2013 Feb 12.
40. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
41. Inactive aldehyde dehydrogenase-2 increased the risk of pancreatic cancer among smokers in a Japanese male population. Miyasaka K, etal., Pancreas. 2005 Mar;30(2):95-8.
42. Inactivation of oxidized and S-nitrosylated mitochondrial proteins in alcoholic fatty liver of rats. Moon KH, etal., Hepatology. 2006 Nov;44(5):1218-30.
43. Meta-analysis of three diabetes population studies: association of inactive ALDH2 genotype with maternal inheritance of diabetes. Murata C, etal., Diabetes Res Clin Pract. 2004 Dec;66 Suppl 1:S145-7.
44. A polymorphism of the aldehyde dehydrogenase 2 gene is a risk factor for multiple lacunar infarcts in Japanese men: the Takahata Study. Nagasawa H, etal., Eur J Neurol. 2007 Apr;14(4):428-34.
45. Assessment of a difference in ALDH2 heterozygotes and alcoholic liver injury. Nagata N, etal., Alcohol Clin Exp Res. 2002 Aug;26(8 Suppl):11S-14S. doi: 10.1097/01.ALC.0000027923.82434.7F.
46. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
47. Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population. Nishizawa D, etal., Neuropsychobiology. 2006;53(3):137-41. doi: 10.1159/000093099. Epub 2006 May 4.
48. Mitochondrial ALDH2 deficiency as an oxidative stress. Ohta S, etal., Ann N Y Acad Sci. 2004 Apr;1011:36-44.
49. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
50. The longitudinal effect of the aldehyde dehydrogenase 2*2 allele on the risk for nonalcoholic fatty liver disease. Oniki K, etal., Nutr Diabetes. 2016 May 23;6:e210. doi: 10.1038/nutd.2016.17.
51. Analysis of genes differentially expressed in astrocytes stimulated with lipopolysaccharide using cDNA arrays. Pang Y, etal., Brain Res. 2001 Sep 28;914(1-2):15-22.
52. Aldehyde Dehydrogenase 2 (ALDH2) in Rat Fatty Liver Cold Ischemia Injury. Panisello-Roselló A, etal., Int J Mol Sci. 2018 Aug 22;19(9). pii: ijms19092479. doi: 10.3390/ijms19092479.
53. Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians. Peng GS, etal., Pharmacogenetics 1999 Aug;9(4):463-76.
54. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
55. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
56. Polymorphisms in the mitochondrial aldehyde dehydrogenase gene (Aldh2) determine peak blood acetaldehyde levels and voluntary ethanol consumption in rats. Quintanilla ME, etal., Pharmacogenet Genomics. 2005 Jun;15(6):427-31.
57. GOA pipeline RGD automated data pipeline
58. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
59. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
60. Comprehensive gene review and curation RGD comprehensive gene curation
61. Genotypes of alcohol-metabolizing enzymes in Japanese with alcohol liver diseases: a strong association of the usual Caucasian-type aldehyde dehydrogenase gene (ALDH1(2)) with the disease. Shibuya A and Yoshida A, Am J Hum Genet. 1988 Nov;43(5):744-8.
62. Mitochondrial aldehyde dehydrogenase activation by Alda-1 inhibits atherosclerosis and attenuates hepatic steatosis in apolipoprotein E-knockout mice. Stachowicz A, etal., J Am Heart Assoc. 2014 Nov 12;3(6):e001329. doi: 10.1161/JAHA.114.001329.
63. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
64. ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes. Suzuki Y, etal., Alcohol Clin Exp Res. 2004 Aug;28(8 Suppl Proceedings):111S-116S.
65. Aldehyde dehydrogenase 2 genotype in type 1 diabetes mellitus. Suzuki Y, etal., Diabetes Res Clin Pract. 2003 May;60(2):139-41.
66. The aldehyde dehydrogenase 2 gene is a risk factor for hypertension in Japanese but does not alter the sensitivity to pressor effects of alcohol: the Suita study. Takagi S, etal., Hypertens Res. 2001 Jul;24(4):365-70.
67. Aldehyde dehydrogenase 2 gene is a risk factor for myocardial infarction in Japanese men. Takagi S, etal., Hypertens Res. 2002 Sep;25(5):677-81.
68. Relationship between alcohol drinking, ADH2 and ALDH2 genotypes, and risk for hepatocellular carcinoma in Japanese. Takeshita T, etal., Cancer Lett. 2000 Feb 28;149(1-2):69-76. doi: 10.1016/s0304-3835(99)00343-2.
69. Effects of the Nonsteroidal Anti-inflammatory Drug Celecoxib on Mitochondrial Function. Tatematsu Y, etal., Biol Pharm Bull. 2018;41(3):319-325. doi: 10.1248/bpb.b17-00527.
70. The subcellular distribution and properties of aldehyde dehydrogenases in rat liver. Tottmar SO, etal., Biochem J. 1973 Dec;135(4):577-86.
71. Inhibition of aldehyde dehydrogenase 2 by oxidative stress is associated with cardiac dysfunction in diabetic rats. Wang J, etal., Mol Med. 2011 Mar-Apr;17(3-4):172-9. doi: 10.2119/molmed.2010.00114. Epub 2010 Oct 15.
72. The aldehyde dehydrogenase 2 gene is associated with heroin dependence. Wang TY, etal., Drug Alcohol Depend. 2012 Jan 1;120(1-3):220-4. doi: 10.1016/j.drugalcdep.2011.06.008. Epub 2011 Jul 1.
73. Identification of liver proteins and their roles associated with carbon tetrachloride-induced hepatotoxicity. Wong LL, etal., Hum Exp Toxicol. 2011 Sep;30(9):1369-81. doi: 10.1177/0960327110391388. Epub 2010 Dec 7.
74. Mitochondrial aldehyde dehydrogenase attenuates hyperoxia-induced cell death through activation of ERK/MAPK and PI3K-Akt pathways in lung epithelial cells. Xu D, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Nov;291(5):L966-75. Epub 2006 Jun 16.
75. Genetic variants of ALDH2-rs671 and CYP2E1-rs2031920 contributed to risk of hepatocellular carcinoma susceptibility in a Chinese population. Ye X, etal., Cancer Manag Res. 2018 May 4;10:1037-1050. doi: 10.2147/CMAR.S162105. eCollection 2018.
76. Genetic polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and liver cirrhosis, chronic calcific pancreatitis, diabetes mellitus, and hypertension among Japanese alcoholic men. Yokoyama A, etal., Alcohol Clin Exp Res. 2013 Aug;37(8):1391-401. doi: 10.1111/acer.12108. Epub 2013 Mar 29.
77. Slow-metabolizing ADH1B and inactive heterozygous ALDH2 increase vulnerability to fatty liver in Japanese men with alcohol dependence. Yokoyama A, etal., J Gastroenterol. 2018 May;53(5):660-669. doi: 10.1007/s00535-017-1402-6. Epub 2017 Oct 23.
78. Developmental expression of aldehyde dehydrogenase in rat: a comparison of liver and lung development. Yoon M, etal., Toxicol Sci. 2006 Feb;89(2):386-98. Epub 2005 Nov 16.
79. Preconditioning with physiological levels of ethanol protect kidney against ischemia/reperfusion injury by modulating oxidative stress. Yuan Q, etal., PLoS One. 2011;6(10):e25811. doi: 10.1371/journal.pone.0025811. Epub 2011 Oct 12.
80. Inhibition of aldehyde dehydrogenase 2 activity enhances antimycin-induced rat cardiomyocytes apoptosis through activation of MAPK signaling pathway. Zhang P, etal., Biomed Pharmacother. 2011 Dec;65(8):590-3. doi: 10.1016/j.biopha.2009.12.001. Epub 2009 Dec 30.
81. Alda-1, an ALDH2 activator, protects against hepatic ischemia/reperfusion injury in rats via inhibition of oxidative stress. Zhang T, etal., Free Radic Res. 2018 Jun;52(6):629-638. doi: 10.1080/10715762.2018.1459042. Epub 2018 Apr 13.
Additional References at PubMed
PMID:18196   PMID:1699808   PMID:4015840   PMID:4065146   PMID:10721992   PMID:12893989   PMID:14651853   PMID:14690875   PMID:15489334   PMID:17102135   PMID:17493633   PMID:18614015  
PMID:19056867   PMID:19506075   PMID:20361289   PMID:20543077   PMID:20729865   PMID:21130747   PMID:21506955   PMID:22117533   PMID:22214999   PMID:22430940   PMID:22445980   PMID:22737913  
PMID:22761303   PMID:23376485   PMID:23500772   PMID:24164360   PMID:24571199   PMID:24817685   PMID:25163478   PMID:25351957   PMID:25629048   PMID:26172086   PMID:26254233   PMID:26886786  
PMID:27736868   PMID:28038474   PMID:29129988   PMID:29574217   PMID:29767275   PMID:30837397   PMID:31140414   PMID:31883320   PMID:33360016   PMID:34203800   PMID:34725563   PMID:34800366  
PMID:35503616   PMID:35567426   PMID:36720319  


Genomics

Comparative Map Data
Aldh2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81240,610,244 - 40,643,220 (+)NCBIGRCr8
mRatBN7.21234,949,549 - 34,982,527 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,901,219 - 34,982,521 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1236,122,427 - 36,155,172 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,733,638 - 36,766,383 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,786,091 - 35,818,829 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,466,418 - 40,498,813 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,466,495 - 40,498,752 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,334,057 - 42,366,049 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41236,081,778 - 36,116,445 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11235,945,165 - 35,979,833 (+)NCBI
Celera1236,614,188 - 36,647,218 (+)NCBICelera
Cytogenetic Map12q16NCBI
ALDH2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812111,766,933 - 111,817,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12111,766,887 - 111,817,532 (+)EnsemblGRCh38hg38GRCh38
GRCh3712112,204,737 - 112,255,336 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612110,688,729 - 110,732,167 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412110,667,065 - 110,710,502NCBI
Celera12111,829,810 - 111,873,247 (+)NCBICelera
Cytogenetic Map12q24.12NCBI
HuRef12109,218,289 - 109,261,129 (+)NCBIHuRef
CHM1_112112,172,628 - 112,215,725 (+)NCBICHM1_1
T2T-CHM13v2.012111,743,846 - 111,794,443 (+)NCBIT2T-CHM13v2.0
Aldh2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,704,090 - 121,731,887 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,704,090 - 121,731,887 (-)EnsemblGRCm39 Ensembl
GRCm385121,566,027 - 121,593,824 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,566,027 - 121,593,824 (-)EnsemblGRCm38mm10GRCm38
MGSCv375122,017,696 - 122,043,833 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365121,828,319 - 121,854,203 (-)NCBIMGSCv36mm8
Celera5118,657,638 - 118,683,765 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.86NCBI
Aldh2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554828,352,569 - 8,384,899 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554828,352,569 - 8,383,097 (+)NCBIChiLan1.0ChiLan1.0
ALDH2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210119,836,914 - 119,879,015 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112119,833,358 - 119,875,410 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012109,343,020 - 109,385,060 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112112,734,243 - 112,776,471 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12112,734,243 - 112,776,471 (+)Ensemblpanpan1.1panPan2
ALDH2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,319,109 - 9,361,021 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,481,407 - 9,518,893 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,578,697 - 9,616,338 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,578,446 - 9,619,768 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,534,133 - 9,571,615 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0269,596,947 - 9,634,535 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0269,550,188 - 9,587,685 (+)NCBIUU_Cfam_GSD_1.0
Aldh2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118155,091,721 - 155,116,690 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365584,362,654 - 4,390,414 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365584,362,693 - 4,387,705 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ALDH2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1439,896,565 - 39,933,124 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11439,902,317 - 39,933,113 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21442,378,891 - 42,409,676 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ALDH2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111107,019,015 - 107,060,784 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11107,019,111 - 107,060,374 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037138,033,968 - 138,076,544 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aldh2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474720,403,717 - 20,438,690 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474720,407,190 - 20,438,605 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Aldh2
322 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:164
Count of miRNA genes:133
Interacting mature miRNAs:143
Transcripts:ENSRNOT00000001816
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)122860752637691617Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134043551788Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12136247923Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat

Markers in Region
RH131450  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21234,943,346 - 34,943,540 (+)MAPPERmRatBN7.2
Rnor_6.01240,460,227 - 40,460,420NCBIRnor6.0
Rnor_5.01242,327,854 - 42,328,047UniSTSRnor5.0
RGSC_v3.41236,075,510 - 36,075,703UniSTSRGSC3.4
Celera1236,607,917 - 36,608,110UniSTS
RH 3.4 Map12615.8UniSTS
Cytogenetic Map12q16UniSTS
BI278447  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81240,642,992 - 40,643,153 (+)Marker Load Pipeline
mRatBN7.21234,982,299 - 34,982,460 (+)MAPPERmRatBN7.2
Rnor_6.01240,498,586 - 40,498,746NCBIRnor6.0
Rnor_5.01242,365,822 - 42,365,982UniSTSRnor5.0
RGSC_v3.41236,116,273 - 36,116,433UniSTSRGSC3.4
Celera1236,647,046 - 36,647,206UniSTS
RH 3.4 Map12615.8UniSTS
Cytogenetic Map12q16UniSTS


Genetic Models
This gene Aldh2 is modified in the following models/strains:
SS-Aldh2em2Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000001816   ⟹   ENSRNOP00000001816
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,949,520 - 34,982,521 (+)Ensembl
Rnor_6.0 Ensembl1240,466,495 - 40,498,752 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000057435   ⟹   ENSRNOP00000054244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,901,219 - 34,943,681 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000073125   ⟹   ENSRNOP00000065002
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,901,219 - 34,943,681 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000095373   ⟹   ENSRNOP00000088376
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,906,018 - 34,943,681 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096999   ⟹   ENSRNOP00000097994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,901,219 - 34,943,686 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099715   ⟹   ENSRNOP00000092375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,901,219 - 34,982,521 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104824   ⟹   ENSRNOP00000092331
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,906,002 - 34,942,349 (+)Ensembl
RefSeq Acc Id: NM_032416   ⟹   NP_115792
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81240,610,244 - 40,643,220 (+)NCBI
mRatBN7.21234,949,549 - 34,982,527 (+)NCBI
Rnor_6.01240,466,495 - 40,498,758 (+)NCBI
Rnor_5.01242,334,057 - 42,366,049 (+)NCBI
RGSC_v3.41236,081,778 - 36,116,445 (+)RGD
Celera1236,614,188 - 36,647,218 (+)RGD
Sequence:
RefSeq Acc Id: NP_115792   ⟸   NM_032416
- Peptide Label: precursor
- UniProtKB: Q91ZD7 (UniProtKB/Swiss-Prot),   Q8K3V8 (UniProtKB/Swiss-Prot),   Q6Q290 (UniProtKB/Swiss-Prot),   Q6Q289 (UniProtKB/Swiss-Prot),   Q6Q288 (UniProtKB/Swiss-Prot),   P11884 (UniProtKB/Swiss-Prot),   F1LN88 (UniProtKB/TrEMBL),   A6J1D5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001816   ⟸   ENSRNOT00000001816
Ensembl Acc Id: ENSRNOP00000088376   ⟸   ENSRNOT00000095373
Ensembl Acc Id: ENSRNOP00000092331   ⟸   ENSRNOT00000104824
Ensembl Acc Id: ENSRNOP00000097994   ⟸   ENSRNOT00000096999
Ensembl Acc Id: ENSRNOP00000092375   ⟸   ENSRNOT00000099715
Ensembl Acc Id: ENSRNOP00000054244   ⟸   ENSRNOT00000057435
Ensembl Acc Id: ENSRNOP00000065002   ⟸   ENSRNOT00000073125
Protein Domains
Acyl-CoA dehydrogenase/oxidase C-terminal   Acyl-CoA dehydrogenase/oxidase N-terminal   Acyl-CoA oxidase/dehydrogenase middle   Aldehyde dehydrogenase   Aminoglycoside phosphotransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11884-F1-model_v2 AlphaFold P11884 1-519 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698654
Promoter ID:EPDNEW_R9179
Type:initiation region
Name:Aldh2_1
Description:aldehyde dehydrogenase 2 family
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01240,466,447 - 40,466,507EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69219 AgrOrtholog
BioCyc Gene G2FUF-19216 BioCyc
BioCyc Pathway PWY-0 [putrescine degradation III] BioCyc
  PWY66-162 [ethanol degradation IV] BioCyc
  PWY66-21 [ethanol degradation II] BioCyc
BioCyc Pathway Image PWY-0 BioCyc
  PWY66-162 BioCyc
  PWY66-21 BioCyc
Ensembl Genes ENSRNOG00000001344 Ensembl
  ENSRNOG00000037815 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001816.7 UniProtKB/TrEMBL
  ENSRNOT00000073125.4 UniProtKB/TrEMBL
  ENSRNOT00000099715.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.540.10 UniProtKB/TrEMBL
  2.40.110.10 UniProtKB/TrEMBL
  3.40.50.1000 UniProtKB/TrEMBL
  3.90.1200.10 UniProtKB/TrEMBL
  Aldehyde Dehydrogenase, Chain A, domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde Dehydrogenase, Chain A, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Butyryl-CoA Dehydrogenase, subunit A, domain 3 UniProtKB/TrEMBL
  Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Putative phosphatase, domain 2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621229 IMAGE-MGC_LOAD
InterPro ACAD10-like UniProtKB/TrEMBL
  ACAD10_11_N UniProtKB/TrEMBL
  Acyl-CoA_Oxase/DH_cen-dom UniProtKB/TrEMBL
  Acyl-CoA_Oxase/DH_mid-dom_sf UniProtKB/TrEMBL
  AcylCo_DH-like_C UniProtKB/TrEMBL
  AcylCo_DH/oxidase_C UniProtKB/TrEMBL
  AcylCoA_DH/ox_N UniProtKB/TrEMBL
  AcylCoA_DH/ox_N_sf UniProtKB/TrEMBL
  AcylCoA_DH/oxidase_NM_dom UniProtKB/TrEMBL
  Ald_DH/histidinol_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_CS_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_CS_GLU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ald_DH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aldehyde_DH_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Aminoglycoside_PTrfase UniProtKB/TrEMBL
  HAD-like_sf UniProtKB/TrEMBL
  HAD-SF_hydro_IA UniProtKB/TrEMBL
  HAD-SF_ppase_IA/epoxid_hydro_N UniProtKB/TrEMBL
  HAD_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PGP-like_dom2 UniProtKB/TrEMBL
KEGG Report rno:29539 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72375 IMAGE-MGC_LOAD
NCBI Gene 29539 ENTREZGENE
PANTHER ALDEHYDE DEHYDROGENASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
  HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED UniProtKB/TrEMBL
Pfam Acyl-CoA_dh_1 UniProtKB/TrEMBL
  Acyl-CoA_dh_M UniProtKB/TrEMBL
  Acyl-CoA_dh_N UniProtKB/TrEMBL
  Aldedh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APH UniProtKB/TrEMBL
  Hydrolase UniProtKB/TrEMBL
PharmGKB ALDH2 RGD
PhenoGen Aldh2 PhenoGen
PRINTS HADHALOGNASE UniProtKB/TrEMBL
PROSITE ALDEHYDE_DEHYDR_CYS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALDEHYDE_DEHYDR_GLU UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001344 RatGTEx
  ENSRNOG00000037815 RatGTEx
Superfamily-SCOP SSF47203 UniProtKB/TrEMBL
  SSF53720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
  SSF56645 UniProtKB/TrEMBL
  SSF56784 UniProtKB/TrEMBL
UniProt A0A8I6AVL2_RAT UniProtKB/TrEMBL
  A6J1D5 ENTREZGENE, UniProtKB/TrEMBL
  ALDH2_RAT UniProtKB/Swiss-Prot
  F1LN88 ENTREZGENE, UniProtKB/TrEMBL
  M0R6F2_RAT UniProtKB/TrEMBL
  P11884 ENTREZGENE
  Q2QAI2_RAT UniProtKB/TrEMBL
  Q6Q288 ENTREZGENE
  Q6Q289 ENTREZGENE
  Q6Q290 ENTREZGENE
  Q8K3V8 ENTREZGENE
  Q91ZD7 ENTREZGENE
UniProt Secondary Q6Q288 UniProtKB/Swiss-Prot
  Q6Q289 UniProtKB/Swiss-Prot
  Q6Q290 UniProtKB/Swiss-Prot
  Q8K3V8 UniProtKB/Swiss-Prot
  Q91ZD7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Aldh2  aldehyde dehydrogenase 2 family (mitochondrial)  Aldh2  aldehyde dehydrogenase 2, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Aldh2  aldehyde dehydrogenase 2, mitochondrial  Aldh2  aldehyde dehydrogenase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Aldh2  aldehyde dehydrogenase 2      Name updated 70584 APPROVED