Cyp2w1 (cytochrome P450, family 2, subfamily w, polypeptide 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Cyp2w1 (cytochrome P450, family 2, subfamily w, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp2w1
Name: cytochrome P450, family 2, subfamily w, polypeptide 1
RGD ID: 1305193
Description: Predicted to enable several functions, including heme binding activity; retinoic acid 4-hydroxylase activity; and retinoid binding activity. Predicted to be involved in several processes, including aflatoxin metabolic process; phospholipid metabolic process; and retinoic acid catabolic process. Predicted to be located in cell surface and endoplasmic reticulum lumen. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Orthologous to human CYP2W1 (cytochrome P450 family 2 subfamily W member 1); INTERACTS WITH bisphenol A; 2,3,7,8-tetrachlorodibenzodioxine (ortholog); 4,4'-sulfonyldiphenol (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cytochrome P450 2W1; LOC288517
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21215,291,552 - 15,296,421 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,291,704 - 15,296,421 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01217,382,749 - 17,387,909 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,383,159 - 17,387,879 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,367,866 - 19,374,746 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,792,480 - 15,797,202 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11215,822,407 - 15,827,127 (-)NCBI
Celera1217,045,261 - 17,050,420 (-)NCBICelera
Cytogenetic Map12q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
3. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:16426568   PMID:16551781   PMID:20805301   PMID:22591743   PMID:26936974  


Genomics

Comparative Map Data
Cyp2w1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21215,291,552 - 15,296,421 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1215,291,704 - 15,296,421 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01217,382,749 - 17,387,909 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,383,159 - 17,387,879 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01219,367,866 - 19,374,746 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41215,792,480 - 15,797,202 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11215,822,407 - 15,827,127 (-)NCBI
Celera1217,045,261 - 17,050,420 (-)NCBICelera
Cytogenetic Map12q11NCBI
CYP2W1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387983,181 - 989,640 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7983,181 - 989,640 (+)EnsemblGRCh38hg38GRCh38
GRCh3771,022,817 - 1,029,276 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367989,361 - 995,802 (+)NCBINCBI36Build 36hg18NCBI36
Build 347796,234 - 802,517NCBI
Celera7990,578 - 996,997 (+)NCBICelera
Cytogenetic Map7p22.3NCBI
HuRef7939,494 - 945,913 (+)NCBIHuRef
CHM1_171,021,926 - 1,028,345 (+)NCBICHM1_1
T2T-CHM13v2.071,088,177 - 1,094,636 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v271,077,465 - 1,083,884 (+)NCBI
Cyp2w1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395139,338,371 - 139,345,362 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5139,338,372 - 139,342,788 (+)EnsemblGRCm39 Ensembl
GRCm385139,352,616 - 139,359,607 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5139,352,617 - 139,357,033 (+)EnsemblGRCm38mm10GRCm38
MGSCv375139,828,571 - 139,832,987 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365139,606,259 - 139,610,675 (+)NCBIMGSCv36mm8
Celera5136,406,834 - 136,411,079 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map578.44NCBI
LOC102016571
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554608,705,068 - 8,712,121 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554608,705,068 - 8,711,266 (+)NCBIChiLan1.0ChiLan1.0
CYP2W1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1754,252,914 - 54,259,930 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v071,140,855 - 1,147,788 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.171,353,510 - 1,369,487 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl71,353,510 - 1,362,781 (+)Ensemblpanpan1.1panPan2
CYP2W1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1615,883,248 - 15,889,508 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl615,881,636 - 15,889,186 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha617,354,512 - 17,362,330 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0616,012,124 - 16,019,942 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl616,012,367 - 16,019,917 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1615,814,985 - 15,822,771 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0615,741,518 - 15,749,310 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0616,029,717 - 16,037,535 (-)NCBIUU_Cfam_GSD_1.0
LOC101970215
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344143,793,867 - 143,807,376 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367541,203,017 - 1,208,131 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367541,203,004 - 1,208,131 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP2W1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3642,471 - 648,909 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13641,997 - 649,313 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23744,864 - 752,709 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CYP2W1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12820,580,272 - 20,592,771 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2820,582,287 - 20,591,497 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660901,103,793 - 1,111,633 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101698313
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474026,544,715 - 26,549,433 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474026,545,725 - 26,551,906 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cyp2w1
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:108
Count of miRNA genes:90
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000031264
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121300829619212979Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2
Low 3 2
Below cutoff 26 19 3 14 3 5 6 12 11 18 9 5

Sequence


RefSeq Acc Id: ENSRNOT00000091003   ⟹   ENSRNOP00000075407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1215,291,704 - 15,296,421 (-)Ensembl
Rnor_6.0 Ensembl1217,383,159 - 17,387,879 (-)Ensembl
RefSeq Acc Id: XM_039089972   ⟹   XP_038945900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21215,291,552 - 15,296,421 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414598 (Get FASTA)   NCBI Sequence Viewer  
  XP_038945900 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL89769 (Get FASTA)   NCBI Sequence Viewer  
  EDL89770 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075407
  ENSRNOP00000075407.2
RefSeq Acc Id: ENSRNOP00000075407   ⟸   ENSRNOT00000091003
RefSeq Acc Id: XP_038945900   ⟸   XM_039089972
- UniProtKB: A0A0G2KAI3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2KAI3-F1-model_v2 AlphaFold A0A0G2KAI3 1-492 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305193 AgrOrtholog
BioCyc Gene G2FUF-19889 BioCyc
Ensembl Genes ENSRNOG00000051770 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091003 ENTREZGENE
  ENSRNOT00000091003.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
NCBI Gene 288517 ENTREZGENE
PANTHER CYTOCHROME P450 2W1 UniProtKB/TrEMBL
  CYTOCHROME P450 508A4-RELATED UniProtKB/TrEMBL
Pfam p450 UniProtKB/TrEMBL
PharmGKB CYP2W1 RGD
PhenoGen Cyp2w1 PhenoGen
PRINTS EP450I UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000051770 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A0G2KAI3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp2w1  cytochrome P450, family 2, subfamily w, polypeptide 1  Cyp2w1  cytochrome P450, family 2, subfamily W, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Cyp2w1  cytochrome P450, family 2, subfamily W, polypeptide 1   Cyp2w1_predicted  cytochrome P450, family 2, subfamily W, polypeptide 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cyp2w1_predicted  cytochrome P450, family 2, subfamily W, polypeptide 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED