Il3ra (interleukin 3 receptor subunit alpha)

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Gene: Il3ra (interleukin 3 receptor subunit alpha) Rattus norvegicus

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Symbol:

Il3ra

Name:

interleukin 3 receptor subunit alpha

RGD ID:

628728

Description:

Predicted to enable cytokine binding activity and interleukin-3 receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to act upstream of or within interleukin-3-mediated signaling pathway. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Orthologous to human IL3RA (interleukin 3 receptor subunit alpha); PARTICIPATES IN interleukin-3 signaling pathway; apoptotic cell death pathway; cytokine mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

Cyrl; cytokine receptor-like protein CYRL; interleukin 3 receptor, alpha; interleukin 3 receptor, alpha chain; interleukin-3 receptor subunit alpha

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	21,431,848 - 21,437,336 (-)	NCBI		GRCr8
mRatBN7.2	12	16,318,081 - 16,323,781 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	16,318,081 - 16,323,484 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	17,135,140 - 17,140,539 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	17,758,865 - 17,764,264 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	16,821,662 - 16,827,061 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	18,534,762 - 18,542,508 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	18,534,767 - 18,540,166 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	20,519,720 - 20,527,317 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	16,825,702 - 16,830,035 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	16,855,630 - 16,859,963 (-)	NCBI
Celera	12	18,067,830 - 18,073,220 (-)	NCBI		Celera
Cytogenetic Map	12	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

(S)-nicotine (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-naphthylamine (ISO)

4,4'-sulfonyldiphenol (EXP)

acetamide (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

antimycin A (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

butanal (ISO)

cadmium dichloride (EXP,ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

D-penicillamine (EXP)

dextran sulfate (ISO)

diarsenic trioxide (ISO)

dioxygen (ISO)

disodium selenite (ISO)

formaldehyde (ISO)

furan (EXP)

hydroquinone O-beta-D-glucopyranoside (ISO)

lipopolysaccharide (ISO)

MeIQx (ISO)

mercury atom (ISO)

mercury(0) (ISO)

nicotine (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

rotenone (ISO)

Soman (EXP)

sulforaphane (ISO)

tacedinaline (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tributylstannane (ISO)

trichloroethene (ISO)

triphenyl phosphate (ISO)

urethane (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to interleukin-3 (IEA)

cytokine-mediated signaling pathway (IBA)

interleukin-3-mediated signaling pathway (ISO)

Cellular Component

external side of plasma membrane (IBA)

receptor complex (IBA)

Molecular Function

cytokine binding (IBA)

cytokine receptor activity (IBA)

interleukin-3 receptor activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

apoptotic cell death pathway (IEA)

cytokine mediated signaling pathway (IEA)

interleukin-3 signaling pathway (ISO)

Jak-Stat signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	CYRL, a novel cytokine receptor-like protein expressed in testis, lung, and spleen.	Chritton SL and Sheng M, Biochem Biophys Res Commun 2000 Jan 27;267(3):697-702.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	PID Annotation Import Pipeline	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
8.	Information Derived from GenBank Report	RGD, Sept. 2003

Additional References at PubMed

PMID:19109256

Genomics

Comparative Map Data

Il3ra
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	21,431,848 - 21,437,336 (-)	NCBI		GRCr8
mRatBN7.2	12	16,318,081 - 16,323,781 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	16,318,081 - 16,323,484 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	17,135,140 - 17,140,539 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	17,758,865 - 17,764,264 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	16,821,662 - 16,827,061 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	18,534,762 - 18,542,508 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	18,534,767 - 18,540,166 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	20,519,720 - 20,527,317 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	16,825,702 - 16,830,035 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	16,855,630 - 16,859,963 (-)	NCBI
Celera	12	18,067,830 - 18,073,220 (-)	NCBI		Celera
Cytogenetic Map	12	q11	NCBI

IL3RA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	1,336,785 - 1,382,689 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38	Y	1,336,785 - 1,382,689 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	Y	1,336,616 - 1,382,689 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p14 Ensembl	X	1,336,616 - 1,382,689 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	1,455,678 - 1,501,582 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	Y	1,405,678 - 1,451,582 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	Y	1,415,509 - 1,461,582 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 36	X	1,415,509 - 1,461,582 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	Y	1,499,187 - 1,545,408	NCBI
Celera	X	5,763,883 - 5,782,916 (+)	NCBI		Celera
Cytogenetic Map	X	;Y	NCBI
CHM1_1	X	1,486,100 - 1,532,170 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	Y	1,201,550 - 1,246,464 (+)	NCBI		T2T-CHM13v2.0
T2T-CHM13v2.0	X	1,187,106 - 1,226,335 (+)	NCBI		T2T-CHM13v2.0

Il3ra
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	8,114,270 - 8,123,851 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	8,113,752 - 8,123,488 (-)	Ensembl		GRCm39 Ensembl
GRCm38	14	14,345,912 - 14,355,493 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	14,346,275 - 14,356,011 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	15,179,009 - 15,188,004 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	13,139,762 - 13,148,757 (+)	NCBI		MGSCv36	mm8
Celera	14	10,023,172 - 10,032,166 (+)	NCBI		Celera
Cytogenetic Map	14	A1	NCBI
cM Map	14	7.08	NCBI

Il3ra
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955499	1,004,432 - 1,011,950 (+)	NCBI	ChiLan1.0	ChiLan1.0

IL3RA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	894,590 - 912,213 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	894,552 - 911,556 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	835,696 - 852,616 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	805,892 - 822,821 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	X	797,886 - 814,855 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	814,528 - 831,515 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	850,504 - 867,235 (+)	NCBI		UU_Cfam_GSD_1.0

Il3ra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404953	572,452 - 578,962 (+)	NCBI		HiC_Itri_2

IL3RA
(Sus scrofa - pig)

No map positions available.

IL3RA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Vero_WHO_p1.0	NW_023666056	1,314,792 - 1,364,886 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Il3ra
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624834	641,018 - 653,906 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Il3ra
18 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	75
Count of miRNA genes:	67
Interacting mature miRNAs:	70
Transcripts:	ENSRNOT00000001792
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2312418	Kidm41	Kidney mass QTL 41	3.7	0.0001	kidney mass (VT:0002707)	single kidney wet weight to body weight ratio (CMO:0000622)	12	1	19611090	Rat
61443	Btemp2	Thermal response to stress QTL 2	3.3	0.000094	body temperature trait (VT:0005535)	core body temperature (CMO:0001036)	12	15025183	20794014	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
2302060	Pia37	Pristane induced arthritis QTL 37	6.1	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	13198157	46669029	Rat
1549912	Bp268	Blood pressure QTL 268			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	13182736	46669029	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	12812385	46669029	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	9603277	46669029	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564498	46669029	Rat
61331	Eau2	Experimental allergic uveoretinitis QTL 2		0.0005	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	12	8525423	28064601	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	6107579	46669029	Rat
1581516	Cm56	Cardiac mass QTL 56	4.2	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	1	29333307	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	15872653	32974238	Rat
6893681	Bw109	Body weight QTL 109	2.3	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	12	1	23297788	Rat
1549902	Bp269	Blood pressure QTL 269			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	13182736	46669029	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	7196730	46669029	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	12351619	46669029	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	11073825	24234895	Rat
1598855	Bp294	Blood pressure QTL 294	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	1	34851688	Rat
1600391	Edcs2	Endometrial carcinoma susceptibility QTL2	3.5	0.01	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	12	6833190	17870186	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	10474137	46669029	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	45055165	Rat
10755457	Coatc14	Coat color QTL 14		0.01759	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	12	1	22591684	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
61416	Pia4	Pristane induced arthritis QTL 4	8.4		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	12	13635523	30827399	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7204484	Bp358	Blood pressure QTL 358		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	13008296	19212979	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	5564495	46669029	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	13635523	35682913	Rat
1300157	Rf21	Renal function QTL 21	4.4		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	12	9318216	32103380	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	12812385	46669029	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	10474137	46669029	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
2293086	Iddm30	Insulin dependent diabetes mellitus QTL 30	3.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	8449490	28302290	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	15550826	38478808	Rat
1331755	Bp219	Blood pressure QTL 219	3.041		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	28064557	Rat

Markers in Region

RH128686

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	16,317,924 - 16,318,074 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	18,534,606 - 18,534,755	NCBI	Rnor6.0
Rnor_5.0	12	20,519,560 - 20,519,709	UniSTS	Rnor5.0
RGSC_v3.4	12	16,825,542 - 16,825,691	UniSTS	RGSC3.4
Celera	12	18,067,674 - 18,067,823	UniSTS
RH 3.4 Map	12	256.3	UniSTS
Cytogenetic Map	12	q11	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_139260	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006248989	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005491596	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF030243	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BP475867	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BP502982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM042837	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM046911	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214452	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000001792 ⟹ ENSRNOP00000001792

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	16,318,081 - 16,323,484 (-)	Ensembl
Rnor_6.0 Ensembl	12	18,534,767 - 18,540,166 (-)	Ensembl

RefSeq Acc Id:

NM_139260 ⟹ NP_640353

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	21,431,848 - 21,437,250 (-)	NCBI
mRatBN7.2	12	16,318,081 - 16,323,484 (-)	NCBI
Rnor_6.0	12	18,534,762 - 18,540,166 (-)	NCBI
Rnor_5.0	12	20,519,720 - 20,527,317 (-)	NCBI
RGSC_v3.4	12	16,825,702 - 16,830,035 (-)	RGD
Celera	12	18,067,830 - 18,073,220 (-)	NCBI

Sequence:

show sequence

GTCTGTGGACTCTGCTGGGGTCGGCAGAGAGCGAGCGAGGTCCGTGCGTGGATTTGGGGTCCGG
GATCAGGCGGTGGTCACTCTGTGTCTCAGGGAACACTGAGAGCAGGAACGGAAGATAACAGCCC
AGGGTGAGGCTGACTCTGACCACCACCACTGGACAGATACGTTCGGATCCGGTTCCCACGGCCA
TCATGGCTGCCGGAGTGTGGCTGCTGCTGTCGGTTACTATGTTCGAGGCGATGTCAGAACGGGG
AGTCCATATGGAGGCCCCACCTCTGACACCGCCCATCAGGAACCTAAGCATCGACCCCGCCCAG
CGCAGGCTGACGTGGGAGTGGGGCGGGGGCGGGACCAGGGCAGAGGGCGGGGCCTTGGGTCCCA
GGTTCCTGTGCAGAAAGGAGGGGCGGGACCCTGTGCGGGCGGACCCTGCAGGTCATTCCTGCTC
CTTCCCTGCCCTTTCCCACTGTCACGTAACCAACTTCACTGTCTTCCCCGAGGGGCAAGAGAAG
GATGCGGCCCACCTGTGCTTCCAGCCCCGTGACCCCAACAGGGCGGCTGCCGCCCGCAACCTGC
ACTGCTGGGTGCACGACGTGGATTGGCTGAGTTGCCGCTGGGGTCGGGGCCCTGGGGCAACACG
GGATGTGCGATACAGAATGTTCCTGCGAGATGCAAGGCACAGCCCAGACCACGACCGTGAGTGC
CCGAGGTACGAGGTTGACTCCCAAGGGTCGCGCGTGGGCTGTGCGGTGGGTGAGGCTGGGACCC
TGGCCTCCCTCATCACAGTGACGGTGAACGGCAGTGGTGGCGCCCATGGGGTCCACGCGCCCGT
GTCTTGTACCGACGCGGATATCGACATGGCTGCCGTGGAGGTCCTGGCCCCGCCCGTGCTGACA
GCTGAATGCGAAAGCACCGGGGCCCGTGTGAGGTGGGCGCCGCAGAGCCGGTTCCAGACGGCCT
TCGTGTTCACTCTGCAGATCAACCAGAGTTCACAGACAGAGCCAAAGCTTGAGATGGTATATGA
GACAGAATTCAAGGTCCCGACCCTGGACACGGTTTCTGTGCGTGTCAAGGCCACAGCCCTGGAC
TCGGGCGTGGAGAGCGACTGGAGCAAGGCCTGGAGCCTGGACTGTGGCCCCACAGCGACTCTGG
CAACCCCGATGACATCGCTGCTCCTGGCGGGGGCGGGCGCGGTGCTCACAGTGATGGCTGTGCT
GCTGCTGTGCTGGAGGAAGTCGCTGCTGAGCCGCCTGTTCCCACCCATCCCAAGGATGAGAGTC
CTACCTGGGCCAGAGATGGTTGCATGGGTCGAGGCACCTGAGAACTGCGAGGTGACGCTGGTGA
CAGACAACTGAGCCCTGCCCCCAGCACGGACCCCAATAAACCAACCCCTTGCCACTCTGAGAAA

hide sequence

RefSeq Acc Id:

XM_006248989 ⟹ XP_006249051

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	21,431,848 - 21,437,292 (-)	NCBI
mRatBN7.2	12	16,318,081 - 16,323,776 (-)	NCBI
Rnor_6.0	12	18,534,762 - 18,542,508 (-)	NCBI
Rnor_5.0	12	20,519,720 - 20,527,317 (-)	NCBI

Sequence:

show sequence

CTAAAAAATTCTTCAAATTTTTTCTGAATCATTTTGTGTCTATTATATTCAGAATTATTTTCCT
GCACCTATAGCCCTGTAGTTGTCCTGCACTTGTAGAACTGCACCTACCCTGCACCTGAATCCTT
GTACGTGTTGCTCCACACCTGCATCTCTGTACCTGCAGCCTTGTACCTCCTGCTCTGTACCGCA
GCCCTGAGCCTGTTGCCCTGTACCTGCAGGCCTGAACCTGGAGCCATGTACTTGACCTGCACCT
GTAGCCCTGTACCTGCAGTCCTATACCTTCTACCGTGTACTTGCAGCCCAGCACCTGCAGCCCT
GTACTTGTCCTGTACCTGCAGCCTTGTACCTGTTGCCCTGCATCTGCAGGCTTTGTACCTGCTG
CCCTGCACCTGTACTTGCCCTGTACTTGCCCTGTGCCTGCTGTACTGCACTTGCAGCCCTGCAA
CTGCAGAGCTGCACCTGCCTGGCACCTGCAGCCTTGTATTTGATGCCCTGCACCTGCTGCCCTT
CACCTACAGCCCTGTACCTGAATCCCTTTACGTGCTGCTCTACACCTGCATCTCTGTACGTGCA
GCCCTGTACCTCCTGCTCTGTACCTGCAGTCCTGAGCCTGCTGCCATGCACCTGCAACCCTGAA
TTTTCAGCCCTGTACTTGCAGCCCTGCACCTGCAGGCCTATACCTGCCTTGCACCTGCTGCCCT
GCATCTGCAGCCCTGTACGTGATTCTCTTTACCTGCAGCACTGTACCTACAGCACTGTACCTGC
AGCACTGTACTTGCCCTGCACGTGCAGCCCTGCACCCGGAGCCTTGTACCTGCTGCCCTTCACC
TGCAGCCCTGGACCTGCCCTGCACTGCAGTCGTGCACCTGCTGCTCTGTACCTGTAACCCTGTA
CATGCAGCCCTGCACCTGCAGCCATGAACCTTCTGCTCTGGACCTGCAGCCCTGCACTTAACCT
GCACCTGCAGTCCTGCACTTGTCCTATACCTGCTTCCCTGCACCTGCAGCCCTATAACTGCAGC
CATGCACTTGTAGCCCTACACCTACAGCCCTGTATCTGCAGCTATGAACCTACAGCCATGCACC
TGCTGCTCTGTACATGTCCTGCCCCTGCAGTCCTGTATTTGCCTTGCACCTGCAGCCCTGTACC
TGCAGCCTTGTACCTGGTGCCCTGCACCTGCAGGCCTATACTTGCCCTGAACCTGAAGCCCTGT
ATTTGCCCTGCACTGCAGCCCTGCACCTGAAGCCCTGCACCTGCTCCTCTGTACCTGCAACCCT
GCACTTGCTCTGTACCTGCAGCCCTGTACCTGATGCTTTGTACTTGCATCCCTGCACCTGAAGT
CCTGTACCTACAGAACTATACCTCCAGCCCTGTCCTAGCAAGGCACCTACAGCCCTATACCTGC
AGCCCTGTATTTGCTTGCTCTGTACCTGCTTCCCTGCACCTGCAACCCTGAACGTGCTTGTATG
TACCTACAGTCTTGCACCTGCAACCCTGCACCTGCTGCTCTGTGCCTTCAGCCTTTTACTTGCT
GCTCTGTACATGCAGCCCTATACCTGCTGATCTGTACTTGCAGCCCTGCACCTGCGACCCTTGT
ACTTGCACTGCACTTACAGCCCTCCAACTGCAGGCCTGTATCTGCAGCCCTATATCTGCAACCC
TGCATCTTCAGCCTTTTATCAGTAGACCTGTACCTGTAGCCCTGTACTTGCCTTGCACCTGCAG
CCCTGCACCTGCAGCCCTGCACCTGCAGCCTTGTACCTGCAGCCCTGTACCTGCGACCCTCGAA
CTTGCACTGCACTTACAACCCTCCATCTGCAGGCCTTTACCTGCAGCTCTATATCTGCAACCCA
GCACCTTCAGCCCTTTACCTCCAGACCTGCACCTGCAGCCCTGTACTTGCCCTGAACCTGCAAT
CTTGTACCTGCACTGTGTTGTGATCGCCCTTCTCCAGGGCTGTCAATCACCGCTGTGTCAGTTA
GTCCCGCCCCCTACTTCCAAACCATACCCCAACTACCGGTGCTCCGCGCCATCCCCCTGCCTCA
GCGACCCGAGCTCCAGGGCGGCGACCACATCATGATCGCAACCCAGGCATATCCTGCGCTCGGC
CACACCCACAACATGGATGCCGCTGTGCAGGTTTCTCGTTTCCGGACCCCAGGGCGCGGCCGGG
GGGCGTGGCCTGGGCGACCCGCAAATCCCCCCACTACCCAAGAGACTACGCAGGCCCCGCCCTC
CCTGGCCAGGCGACAGCCTCAGATAATTGCTCAACACTGGATGCGGCCACTTGGGGCGGGGCCT
GCGGAGTCACAGGGTCGCGGCTAGACCTGGGCTTTGAGGTCTGTGGACTCTGCTGGGGTCGGCA
GAGAGCGAGCGAGGTCCGTGCGTGGATTTGGGGTCCGGGATCAGGCGGTGGTCACTCTGTGTCT
CAGGGAACACTGAGAGCAGGAACGGAAGATAACAATACGTTCGGATCCGGTTCCCACGGCCATC
ATGGCTGCCGGAGTGTGGCTGCTGCTGTCGGTTACTATGTTCGAGGCGATGTCAGAACGGGGAG
TCCATATGGAGGCCCCACCTCTGACACCGCCCATCAGGAACCTAAGCATCGACCCCGCCCAGCG
CAGGCTGACGTGGGAGTGGGGCGGGGGCGGGACCAGGGCAGAGGGCGGGGCCTTGGGTCCCAGG
TTCCTGTGCAGAAAGGAGGGGCGGGACCCTGTGCGGGCGGACCCTGCAGGTCATTCCTGCTCCT
TCCCTGCCCTTTCCCACTGTCACGTAACCAACTTCACTGTCTTCCCCGAGGGGCAAGAGAAGGA
TGCGGCCCACCTGTGCTTCCAGCCCCGTGACCCCAACAGGGCGGCTGCCGCCCGCAACCTGCAC
TGCTGGGTGCACGACGTGGATTGGCTGAGTTGCCGCTGGGGTCGGGGCCCTGGGGCAACACGGG
ATGTGCGATACAGAATGTTCCTGCGAGATGCAAGGCACAGCCCAGACCACGACCGTGAGTGCCC
GAGGTACGAGGTTGACTCCCAAGGGTCGCGCGTGGGCTGTGCGGTGGGTGAGGCTGGGACCCTG
GCCTCCCTCATCACAGTGACGGTGAACGGCAGTGGTGGCGCCCATGGGGTCCACGCGCCCGTGT
CTTGTACCGACGCGGATATCGACATGGCTGCCGTGGAGGTCCTGGCCCCGCCCGTGCTGACAGC
TGAATGCGAAAGCACCGGGGCCCGTGTGAGGTGGGCGCCGCAGAGCCGGTTCCAGACGGCCTTC
GTGTTCACTCTGCAGATCAACCAGAGTTCACAGACAGAGCCAAAGCTTGAGATGGTATATGAGA
CAGAATTCAAGGTCCCGACCCTGGACACGGTTTCTGTGCGTGTCAAGGCCACAGCCCTGGACTC
GGGCGTGGAGAGCGACTGGAGCAAGGCCTGGAGCCTGGACTGTGGCCCCACAGCGACTCTGGCA
ACCCCGATGACATCGCTGCTCCTGGCGGGGGCGGGCGCGGTGCTCACAGTGATGGCTGTGCTGC
TGCTGTGCTGGAGGAAGTCGCTGCTGAGCCGCCTGTTCCCACCCATCCCAAGGATGAGAGTCCT
ACCTGGGCCAGAGATGGTTGCATGGGTCGAGGCACCTGAGAACTGCGAGGTGACGCTGGTGACA
GACAACTGAGCCCTGCCCCCAGCACGGACCCCAATAAACCAACCCCTTGCCACTCTGAGAAA

hide sequence

RefSeq Acc Id:

XR_005491596

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	21,431,848 - 21,437,336 (-)	NCBI
mRatBN7.2	12	16,318,081 - 16,323,781 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_640353	(Get FASTA)	NCBI Sequence Viewer
	XP_006249051	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF37356	(Get FASTA)	NCBI Sequence Viewer
	EDL89818	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001792.4

RefSeq Acc Id:	NP_640353 ⟸ NM_139260
- Peptide Label:	precursor
- UniProtKB:	E9PSX4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAGVWLLLSVTMFEAMSERGVHMEAPPLTPPIRNLSIDPAQRRLTWEWGGGGTRAEGGALGPR FLCRKEGRDPVRADPAGHSCSFPALSHCHVTNFTVFPEGQEKDAAHLCFQPRDPNRAAAARNLH CWVHDVDWLSCRWGRGPGATRDVRYRMFLRDARHSPDHDRECPRYEVDSQGSRVGCAVGEAGTL ASLITVTVNGSGGAHGVHAPVSCTDADIDMAAVEVLAPPVLTAECESTGARVRWAPQSRFQTAF VFTLQINQSSQTEPKLEMVYETEFKVPTLDTVSVRVKATALDSGVESDWSKAWSLDCGPTATLA TPMTSLLLAGAGAVLTVMAVLLLCWRKSLLSRLFPPIPRMRVLPGPEMVAWVEAPENCEVTLVT DN hide sequence

RefSeq Acc Id:	XP_006249051 ⟸ XM_006248989
- Peptide Label:	isoform X1
- UniProtKB:	E9PSX4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAGVWLLLSVTMFEAMSERGVHMEAPPLTPPIRNLSIDPAQRRLTWEWGGGGTRAEGGALGPR FLCRKEGRDPVRADPAGHSCSFPALSHCHVTNFTVFPEGQEKDAAHLCFQPRDPNRAAAARNLH CWVHDVDWLSCRWGRGPGATRDVRYRMFLRDARHSPDHDRECPRYEVDSQGSRVGCAVGEAGTL ASLITVTVNGSGGAHGVHAPVSCTDADIDMAAVEVLAPPVLTAECESTGARVRWAPQSRFQTAF VFTLQINQSSQTEPKLEMVYETEFKVPTLDTVSVRVKATALDSGVESDWSKAWSLDCGPTATLA TPMTSLLLAGAGAVLTVMAVLLLCWRKSLLSRLFPPIPRMRVLPGPEMVAWVEAPENCEVTLVT DN hide sequence

Ensembl Acc Id:

ENSRNOP00000001792 ⟸ ENSRNOT00000001792

Protein Domains

Type I cytokine receptor cytokine-binding

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-E9PSX4-F1-model_v2	AlphaFold	E9PSX4	1-386	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698487

Promoter ID:

EPDNEW_R9011

Type:

initiation region

Name:

Il3ra_1

Description:

interleukin 3 receptor subunit alpha

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	18,540,169 - 18,540,229	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:628728	AgrOrtholog
BioCyc Gene	G2FUF-19846	BioCyc
Ensembl Genes	ENSRNOG00000001325	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000001792.5	UniProtKB/TrEMBL
Gene3D-CATH	2.60.40.10	UniProtKB/TrEMBL
	2.60.40.3850	UniProtKB/TrEMBL
InterPro	FN3_sf	UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/TrEMBL
	IL6_recept-bd	UniProtKB/TrEMBL
	Short_hematopoietin_rcpt_2_CS	UniProtKB/TrEMBL
KEGG Report	rno:246144	UniProtKB/TrEMBL
NCBI Gene	246144	ENTREZGENE
Pfam	IL6Ra-bind	UniProtKB/TrEMBL
PhenoGen	Il3ra	PhenoGen
PROSITE	HEMATOPO_REC_S_F2	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001325	RatGTEx
Superfamily-SCOP	FN_III-like	UniProtKB/TrEMBL
UniProt	A6K210_RAT	UniProtKB/TrEMBL
	E9PSX4	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-02	Il3ra	interleukin 3 receptor subunit alpha	Il3ra	interleukin 3 receptor, alpha	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-11-06	Il3ra	interleukin 3 receptor, alpha	Il3ra	interleukin 3 receptor, alpha chain	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	Il3ra	interleukin 3 receptor, alpha chain	Cyrl	cytokine receptor-like protein CYRL	Symbol and Name updated	1299863	APPROVED
2003-02-27	Cyrl	cytokine receptor-like protein CYRL			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)