Epo (erythropoietin) - Rat Genome Database
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Gene: Epo (erythropoietin) Rattus norvegicus
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Symbol: Epo
Name: erythropoietin
RGD ID: 2559
Description: Predicted to have cytokine activity; erythropoietin receptor binding activity; and protein kinase activator activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of activated T cell proliferation; and response to dexamethasone. Localizes to cell body and extracellular space. Used to study retinal detachment and visual epilepsy. Biomarker of cholangiocarcinoma; eye disease (multiple); transient cerebral ischemia; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic angiopathy; familial erythrocytosis 5; ischemia (multiple); and neurodegenerative disease (multiple). Orthologous to human EPO (erythropoietin); PARTICIPATES IN erythropoietin signaling pathway; hypoxia inducible factor pathway; cytokine mediated signaling pathway; INTERACTS WITH (+)-pilocarpine; 1H-indole; 2-methoxy-17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01222,274,828 - 22,278,268 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,274,828 - 22,278,266 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,291,481 - 24,294,921 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41219,551,768 - 19,555,208 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11219,541,291 - 19,544,730 (-)NCBI
Celera1221,009,353 - 21,012,793 (+)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
Acute-Phase Reaction  (IEP)
AIDS Dementia Complex  (ISO)
Albuminuria  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
Anastomotic Leak  (ISO)
anemia  (ISO)
beta thalassemia  (ISO)
Brain Hypoxia  (ISO)
Brain Injuries  (IEP,ISO)
breast cancer  (ISO)
calcinosis  (ISO)
Cardiogenic Shock  (ISO)
cardiomyopathy  (ISO)
central nervous system disease  (ISO)
cholangiocarcinoma  (IEP)
cognitive disorder  (ISO)
congenital diaphragmatic hernia  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
diabetic angiopathy  (ISO)
Diabetic Nephropathies  (ISO)
diabetic neuropathy  (ISO)
diabetic retinopathy  (ISO)
Diamond-Blackfan Anemia-Like  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Autoimmune Neuritis  (IEP)
Experimental Diabetes Mellitus  (IEP)
Experimental Sarcoma  (ISO)
familial erythrocytosis 5  (ISO)
Fatigue  (ISO)
Fetal Distress  (IEP)
gastric ulcer  (ISO)
glaucoma  (IEP,ISO)
heart disease  (ISO)
hemolytic anemia  (ISO)
hemolytic-uremic syndrome  (ISO)
Hemorrhagic Shock  (ISO)
hypertension  (ISO)
hypoglycemia  (ISO)
Hypoxia-Ischemia, Brain  (IEP,ISO)
Inflammation  (ISO)
kidney disease  (ISO)
kidney failure  (ISO)
Kidney Reperfusion Injury  (ISO)
Knee Osteoarthritis  (ISO)
Limb Ischemia  (ISO)
Liver Reperfusion Injury  (ISO)
macular retinal edema  (ISO)
malignant glioma  (ISO)
Mammary Neoplasms, Experimental  (IMP)
melanoma  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
middle cerebral artery infarction  (ISO)
myelodysplastic syndrome  (ISO)
myocardial infarction  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
Neoplasm Metastasis  (ISO)
nephrotic syndrome  (ISO)
Nerve Degeneration  (ISO)
neurodegenerative disease  (ISO)
pancytopenia  (ISO)
Paraneoplastic Syndromes  (ISO)
Parkinson's disease  (ISO)
placental insufficiency  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Poisoning  (ISO)
polyneuropathy  (ISO)
porphyria  (ISO)
Pregnancy Complications  (ISO)
pulmonary embolism  (ISO)
pulmonary hypertension  (ISO)
retinal degeneration  (ISO)
retinal detachment  (IDA,IEP)
retinopathy of prematurity  (IEP)
severe combined immunodeficiency  (ISO)
Spinal Cord Compression  (IEP)
Spinal Cord Injuries  (ISO)
status epilepticus  (ISO)
Subarachnoid Hemorrhage  (ISO)
Subdural Hematoma, Acute  (ISO)
thrombocytopenia  (ISO)
thrombosis  (ISO)
Thyroid Neoplasms  (ISO)
transient cerebral ischemia  (IEP,ISO)
Tubulointerstitial Fibrosis  (ISO)
type 2 diabetes mellitus  (ISO)
uremia  (ISO)
vascular dementia  (IEP)
vascular disease  (ISO)
Venous Thrombosis  (ISO)
Ventricular Fibrillation  (ISO)
ventricular septal defect  (ISO)
Ventricular Tachycardia  (ISO)
visual epilepsy  (IDA)
Weight Loss  (ISO)
Wounds, Penetrating  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(R)-noradrenaline  (ISO)
(S)-nicotine  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
1H-indole  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methoxy-17beta-estradiol  (EXP)
2-naphthylamine  (ISO)
3',5'-cyclic AMP  (EXP)
3',5'-cyclic GMP  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
5,6,7,8-tetrahydrobiopterin  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (EXP,ISO)
7,12-dimethyltetraphene  (ISO)
acetylcholine  (ISO)
Actein  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (EXP,ISO)
amitrole  (ISO)
ammonium chloride  (EXP)
amphotericin B  (EXP,ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (ISO)
BQ 123  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calycosin  (ISO)
calycosin-7-O-beta-D-glucoside  (ISO)
carbamazepine  (ISO)
carbon monoxide  (EXP)
carboplatin  (EXP)
ceftriaxone  (EXP)
cisplatin  (EXP,ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (ISO)
cytochalasin B  (ISO)
D-glucose  (ISO)
dacarbazine  (ISO)
decabromodiphenyl ether  (EXP)
dehydroepiandrosterone  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (EXP,ISO)
doxorubicin  (EXP,ISO)
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor  (ISO)
enalapril  (EXP,ISO)
etoposide  (ISO)
fenoterol  (ISO)
formaldehyde  (ISO)
formononetin  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glutathione  (EXP,ISO)
haloperidol  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroxyurea  (ISO)
indometacin  (EXP)
indoxyl sulfate  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) citrate  (ISO)
kainic acid  (ISO)
ketoconazole  (ISO)
L-erythro-7,8-dihydrobiopterin  (ISO)
lipopolysaccharide  (ISO)
LY294002  (EXP,ISO)
malonaldehyde  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
menadione  (ISO)
mercury dichloride  (ISO)
methylmercury chloride  (EXP)
microcystin-LR  (ISO)
monosodium L-glutamate  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
neopterin  (ISO)
nicotine  (ISO)
nitric oxide  (EXP)
nitrites  (ISO)
nitrofen  (EXP)
nitroprusside  (ISO)
Nonidet P-40  (ISO)
ochratoxin A  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
phenobarbital  (ISO)
phenylhydrazine  (EXP)
pirinixic acid  (ISO)
pyrogallol  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (EXP,ISO)
resveratrol  (ISO)
ribavirin  (ISO)
salubrinal  (ISO)
sapropterin  (ISO)
simvastatin  (EXP)
sodium stibogluconate  (ISO)
staurosporine  (EXP)
streptozocin  (EXP)
superoxide  (ISO)
testosterone  (ISO)
urethane  (ISO)
zidovudine  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of protein kinase activity  (IEA)
acute-phase response  (IEP)
aging  (IEP)
apoptotic process  (ISO)
cellular hyperosmotic response  (ISO)
embryo implantation  (ISO)
erythrocyte differentiation  (ISO,ISS)
erythrocyte maturation  (IEA)
erythropoietin-mediated signaling pathway  (IBA,ISO,ISS)
hemoglobin biosynthetic process  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of calcium ion transport into cytosol  (ISO)
negative regulation of cation channel activity  (ISO)
negative regulation of erythrocyte apoptotic process  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress  (ISO)
negative regulation of myeloid cell apoptotic process  (ISO)
negative regulation of neuron death  (IDA)
negative regulation of transcription by RNA polymerase II  (ISO)
peptidyl-serine phosphorylation  (ISO)
positive regulation of activated T cell proliferation  (IDA)
positive regulation of cell population proliferation  (IBA,IMP,ISO)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of neuron differentiation  (IDA)
positive regulation of neuron projection development  (IDA)
positive regulation of protein kinase activity  (ISO)
positive regulation of Ras protein signal transduction  (IBA,ISO)
positive regulation of transcription, DNA-templated  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to axon injury  (IEP)
response to dexamethasone  (IEP)
response to electrical stimulus  (IEP)
response to estrogen  (IEP)
response to hyperoxia  (IEP)
response to hypoxia  (IEP,ISO,TAS)
response to interleukin-1  (IEP)
response to lipopolysaccharide  (IEP)
response to nutrient  (IEP)
response to salt stress  (IEP)
response to testosterone  (IEP)
response to vitamin A  (IEP)

Cellular Component
cell body  (IDA)
cell surface  (ISO)
extracellular space  (IBA,IDA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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Additional References at PubMed
PMID:9722506   PMID:12381912   PMID:12584724   PMID:12927817   PMID:13129593   PMID:14569084   PMID:14706194   PMID:15016652   PMID:15050726   PMID:15084469   PMID:15167538   PMID:15249201  
PMID:15262216   PMID:15591122   PMID:15686664   PMID:15879293   PMID:16282136   PMID:16417583   PMID:16497104   PMID:17300687   PMID:17560935   PMID:17634394   PMID:17981124   PMID:18174394  
PMID:18352839   PMID:18845609   PMID:19536483   PMID:19695235   PMID:19705458   PMID:19779256   PMID:20104680   PMID:20167254   PMID:20204781   PMID:21095239   PMID:21410687   PMID:21443457  
PMID:21461559   PMID:21707946   PMID:21722091   PMID:22294054   PMID:22495316   PMID:22659586   PMID:22766248   PMID:23728385   PMID:23821361   PMID:23971737   PMID:24524370   PMID:24685074  
PMID:24763928   PMID:24832733   PMID:24928528   PMID:24998947   PMID:25283246   PMID:25464888   PMID:25767056   PMID:25935977   PMID:26178913   PMID:26561638   PMID:26777998   PMID:26852593  
PMID:27521836   PMID:27959434   PMID:28087117   PMID:28189515   PMID:28282554   PMID:28283061   PMID:29395333   PMID:29436578   PMID:29443550   PMID:30146260   PMID:31689455   PMID:31929736  
PMID:32124933  


Genomics

Candidate Gene Status
Epo is a candidate Gene for QTL Edcs2
Comparative Map Data
Epo
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01222,274,828 - 22,278,268 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1222,274,828 - 22,278,266 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01224,291,481 - 24,294,921 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41219,551,768 - 19,555,208 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11219,541,291 - 19,544,730 (-)NCBI
Celera1221,009,353 - 21,012,793 (+)NCBICelera
Cytogenetic Map12q12NCBI
EPO
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7100,720,468 - 100,723,700 (+)EnsemblGRCh38hg38GRCh38
GRCh387100,720,468 - 100,723,700 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377100,318,423 - 100,321,323 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,156,359 - 100,159,259 (+)NCBINCBI36hg18NCBI36
Build 34799,963,073 - 99,965,972NCBI
Celera795,048,997 - 95,051,893 (+)NCBI
Cytogenetic Map7q22.1NCBI
HuRef794,949,230 - 94,952,126 (+)NCBIHuRef
CHM1_17100,248,723 - 100,251,623 (+)NCBICHM1_1
CRA_TCAGchr7v2799,678,028 - 99,680,928 (+)NCBI
Epo
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395137,481,282 - 137,484,078 (-)NCBIGRCm39mm39
GRCm385137,483,020 - 137,485,816 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5137,483,020 - 137,533,242 (-)EnsemblGRCm38mm10GRCm38
MGSCv375137,924,248 - 137,927,044 (-)NCBIGRCm37mm9NCBIm37
MGSCv365137,712,873 - 137,715,533 (-)NCBImm8
Celera5134,466,358 - 134,469,154 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map576.5NCBI
Epo
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955573203,441 - 206,355 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955573203,875 - 206,078 (-)NCBIChiLan1.0ChiLan1.0
EPO
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.17106,148,062 - 106,150,974 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7106,148,062 - 106,150,974 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0792,747,671 - 92,750,886 (+)NCBIMhudiblu_PPA_v0panPan3
EPO
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl68,994,211 - 8,996,144 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.168,994,211 - 8,995,954 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Epo
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936543742,722 - 745,332 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPO
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl38,620,508 - 8,622,936 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.138,620,508 - 8,622,936 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.238,014,859 - 8,017,287 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPO
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2812,489,766 - 12,491,908 (-)Ensembl
ChlSab1.12812,487,222 - 12,491,986 (-)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12122650917Rat
10450854Stl34Serum triglyceride level QTL 343.50.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)12122853017Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12123035872Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123758197Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12130749723Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12136919844Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12138334225Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)1215081045150810Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1215081045150810Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)1215081045150810Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1215081045150810Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1215081045150810Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1215081045150810Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)1215081045150810Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)1249257845492578Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12247568747475687Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12251344247513442Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12251344247513442Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12421005149210051Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12895459327911196Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6922362652716770Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12922362652716770Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12922362652716770Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12922362652716770Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12922362652716770Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12922362652716770Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12922363052716770Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12978983452716770Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121017588931975590Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)121025689031723732Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)121176499537522089Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121312721127285590Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121312721131723688Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121312721150320041Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121441977552716770Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121502198652716770Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121508558522283507Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121571460935964508Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121571460941291738Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121590890052716770Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121590890052716770Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121711477023839390Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121718558044098244Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121796086538409001Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121834247752716770Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121834247752716770Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121872904352716770Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121875259352716770Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101875259352716770Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:136
Count of miRNA genes:97
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000001914
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 4 4 4
Low 24 24 24 10 6 22
Below cutoff 4 2 1 1 2 2 16 27 10 7 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001914   ⟹   ENSRNOP00000001914
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1222,274,828 - 22,278,266 (+)Ensembl
RefSeq Acc Id: NM_017001   ⟹   NP_058697
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01222,274,828 - 22,278,268 (+)NCBI
Rnor_5.01224,291,481 - 24,294,921 (+)NCBI
RGSC_v3.41219,551,768 - 19,555,208 (-)RGD
Celera1221,009,353 - 21,012,793 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249101   ⟹   XP_006249163
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01222,275,249 - 22,278,268 (+)NCBI
Rnor_5.01224,291,481 - 24,294,921 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_058697 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249163 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41126 (Get FASTA)   NCBI Sequence Viewer  
  BAA01593 (Get FASTA)   NCBI Sequence Viewer  
  EDM13263 (Get FASTA)   NCBI Sequence Viewer  
  P29676 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_058697   ⟸   NM_017001
- Peptide Label: precursor
- UniProtKB: P29676 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006249163   ⟸   XM_006249101
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000001914   ⟸   ENSRNOT00000001914

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2559 AgrOrtholog
Ensembl Genes ENSRNOG00000001412 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000001914 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001914 ENTREZGENE, UniProtKB/Swiss-Prot
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  EPO/TPO_CS UniProtKB/Swiss-Prot
  EPO_TPO UniProtKB/Swiss-Prot
  Erythroptn UniProtKB/Swiss-Prot
KEGG Report rno:24335 UniProtKB/Swiss-Prot
NCBI Gene 24335 ENTREZGENE
PANTHER PTHR10370 UniProtKB/Swiss-Prot
Pfam EPO_TPO UniProtKB/Swiss-Prot
PhenoGen Epo PhenoGen
PIRSF EPO UniProtKB/Swiss-Prot
PRINTS ERYTHROPTN UniProtKB/Swiss-Prot
PROSITE EPO_TPO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniGene Rn.11365 ENTREZGENE
UniProt EPO_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P70504 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Epo  Erythropoietin      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in the brain and in cultured cortical neurons 628490
gene_function glycoprotein hormone 628490
gene_pathway protective effect may act through the anti-apoptotic signaling cascades 628490
gene_process mediates paracrine neuroprotection of ischemic preconditioning (IP) 628490
gene_process activates the neuronal EPO receptor, subsequently JAK-2 and PI3K 628490
gene_regulation expression is regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1) and mRNA is induced by low oxygen tension 628490