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Gene: Atp6v0a2 (ATPase H+ transporting V0 subunit a2) Rattus norvegicus

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Symbol:

Atp6v0a2 (Ensembl: Dnah10)

Name:

ATPase H+ transporting V0 subunit a2 (Ensembl:dynein, axonemal, heavy chain 10)

RGD ID:

621006

Description:

Predicted to enable proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in cellular response to increased oxygen levels and intracellular iron ion homeostasis. Predicted to be located in several cellular components, including acrosomal vesicle; focal adhesion; and perinuclear region of cytoplasm. Predicted to be part of proton-transporting V-type ATPase, V0 domain. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIA and wrinkly skin syndrome. Orthologous to human ATP6V0A2 (ATPase H+ transporting V0 subunit a2); PARTICIPATES IN oxidative phosphorylation pathway; phagocytosis pathway; rheumatoid arthritis pathway; INTERACTS WITH 6-propyl-2-thiouracil; ammonium chloride; amphetamine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

ATPase, H+ transporting, lysosomal V0 subunit a isoform 2; ATPase, H+ transporting, lysosomal V0 subunit A2; Cc1-3; J6b7; LOC304467; T-cell expressing clone j6; Tj6; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a 2; V-type proton ATPase 116 kDa subunit a isoform 2; V-type proton ATPase 116 kDa subunit a2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	37,608,211 - 37,640,860 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	37,472,813 - 37,640,860 (-)	Ensembl				GRCr8
mRatBN7.2	12	31,947,220 - 31,979,875 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	31,822,733 - 32,007,069 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	33,129,001 - 33,158,515 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	33,740,320 - 33,769,838 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	32,792,188 - 32,821,709 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	37,368,321 - 37,398,233 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	37,363,906 - 37,425,596 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	39,238,423 - 39,269,298 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	33,061,611 - 33,092,421 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	33,639,711 - 33,670,024 (-)	NCBI		Celera
RGSC_v3.1	12	32,941,066 - 32,949,116 (-)	NCBI
Cytogenetic Map	12	q15	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Autosomal Recessive Cutis Laxa (ISO)

autosomal recessive cutis laxa type IIA (ISO)

congenital disorder of glycosylation Il (ISO)

cutis laxa (ISO)

genetic disease (ISO)

Joubert syndrome (ISO)

Joubert syndrome 24 (ISO)

Meckel syndrome (ISO)

Meckel syndrome 8 (ISO)

short chain acyl-CoA dehydrogenase deficiency (ISO)

wrinkly skin syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

Azoxymethane (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

caffeine (ISO)

clofibrate (ISO)

cobalt dichloride (EXP)

coumarin (ISO)

cyclosporin A (ISO)

daidzein (ISO)

dextran sulfate (ISO)

diazinon (ISO)

diquat (ISO)

dorsomorphin (ISO)

entinostat (ISO)

epoxiconazole (ISO)

ethanol (ISO)

folic acid (ISO)

FR900359 (ISO)

genistein (EXP,ISO)

glycitein (ISO)

glyphosate (ISO)

hydroxyurea (ISO)

inulin (ISO)

lead(0) (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

N,N-diethyl-m-toluamide (EXP)

nitrates (ISO)

osimertinib (EXP)

panobinostat (ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (EXP)

phenobarbital (ISO)

pirinixic acid (ISO)

poly(I:C) (ISO)

Pyridostigmine bromide (EXP)

quinolin-8-ol (ISO)

rac-lactic acid (ISO)

rotenone (ISO)

sarin (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tamibarotene (ISO)

temozolomide (ISO)

testosterone (ISO)

thapsigargin (ISO)

titanium dioxide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to increased oxygen levels (ISO)

intracellular iron ion homeostasis (ISO)

monoatomic ion transport (IEA)

proton transmembrane transport (IEA)

Cellular Component

acrosomal vesicle (ISO)

focal adhesion (ISO)

membrane (IEA)

perinuclear region of cytoplasm (ISO)

plasma membrane (ISO)

proton-transporting V-type ATPase complex (ISO)

proton-transporting V-type ATPase, V0 domain (IEA,ISO)

vacuolar proton-transporting V-type ATPase, V0 domain (IEA)

Molecular Function

protein binding (ISO)

proton-transporting ATPase activity, rotational mechanism (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

oxidative phosphorylation pathway (IEA)

phagocytosis pathway (IEA)

rheumatoid arthritis pathway (IEA)

tuberculosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	Immunization with an antigen identified by cytokine tumor vaccine-assisted SEREX (CAS) suppressed growth of the rat 9L glioma in vivo.	Okada H, etal., Cancer Res 2001 Mar 15;61(6):2625-31.
5.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
6.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11872743	PMID:12477932	PMID:12672822	PMID:15326124	PMID:16621796	PMID:17897319	PMID:19549681	PMID:21795392	PMID:28296633

Genomics

Comparative Map Data

Atp6v0a2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	37,608,211 - 37,640,860 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	12	37,472,813 - 37,640,860 (-)	Ensembl				GRCr8
mRatBN7.2	12	31,947,220 - 31,979,875 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	31,822,733 - 32,007,069 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	12	33,129,001 - 33,158,515 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	33,740,320 - 33,769,838 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	32,792,188 - 32,821,709 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	37,368,321 - 37,398,233 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	37,363,906 - 37,425,596 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	12	39,238,423 - 39,269,298 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	12	33,061,611 - 33,092,421 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	12	33,639,711 - 33,670,024 (-)	NCBI		Celera
RGSC_v3.1	12	32,941,066 - 32,949,116 (-)	NCBI
Cytogenetic Map	12	q15	NCBI

ATP6V0A2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	123,712,353 - 123,761,755 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	123,712,353 - 123,761,755 (+)	Ensembl			hg38	GRCh38
GRCh37	12	124,196,900 - 124,246,302 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	122,762,818 - 122,810,394 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	12	122,721,744 - 122,769,321	NCBI
Celera	12	123,793,121 - 123,842,693 (+)	NCBI		Celera
Cytogenetic Map	12	q24.31	NCBI
HuRef	12	121,158,054 - 121,207,491 (+)	NCBI		HuRef
CHM1_1	12	124,017,815 - 124,067,195 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	123,711,219 - 123,760,679 (+)	NCBI		T2T-CHM13v2.0

Atp6v0a2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	124,767,117 - 124,801,519 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	124,766,641 - 124,801,519 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	124,629,052 - 124,724,455 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	124,628,576 - 124,724,455 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	125,192,573 - 125,202,524 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv37	5	125,079,648 - 125,097,437 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	125,001,189 - 125,011,627 (+)	NCBI		MGSCv36	mm8
Celera	5	121,704,480 - 121,735,509 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	63.7	NCBI

Atp6v0a2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	5,311,434 - 5,337,697 (-)	Ensembl
ChiLan1.0	NW_004955482	5,311,434 - 5,337,684 (-)	NCBI	ChiLan1.0	ChiLan1.0

ATP6V0A2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	131,787,497 - 131,834,937 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	131,783,904 - 131,831,213 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	121,297,959 - 121,343,294 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	125,522,886 - 125,569,858 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	125,522,886 - 125,569,858 (+)	Ensembl			panPan2	panpan1.1

ATP6V0A2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	5,911,319 - 5,952,773 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	5,912,887 - 5,952,306 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	6,074,169 - 6,115,619 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	6,161,361 - 6,202,794 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	6,162,010 - 6,229,946 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	6,094,884 - 6,136,318 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	6,187,243 - 6,228,453 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	6,140,432 - 6,181,874 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Atp6v0a2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	158,344,853 - 158,374,799 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936558	1,103,135 - 1,134,573 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936558	1,104,627 - 1,138,487 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ATP6V0A2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	29,250,405 - 29,297,683 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	29,250,400 - 29,297,697 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	30,944,213 - 30,989,982 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ATP6V0A2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	119,042,465 - 119,095,380 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	119,042,525 - 119,097,450 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666037	126,179,187 - 126,233,498 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Atp6v0a2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	23,471,403 - 23,504,576 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624747	23,471,697 - 23,501,018 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Atp6v0a2
309 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	255
Count of miRNA genes:	160
Interacting mature miRNAs:	183
Transcripts:	ENSRNOT00000001349, ENSRNOT00000049316, ENSRNOT00000057966
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	24805022	52308831	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	11200494	52308831	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
8693635	Alc28	Alcohol consumption QTL 28	2.7	0.439	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	50386405	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	25989355	52308831	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	3489416	48489416	Rat
1331739	Hrtrt14	Heart rate QTL 14	3.56232		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	12	1	38687564	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	18473041	52308831	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200497	52308831	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	15264248	52308831	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	11743528	52308831	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	11200494	52308831	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	1	38635130	Rat
70169	Eae13	Experimental allergic encephalomyelitis QTL 13		0.032	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	12	29775522	42298555	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	17464979	46784661	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	33700432	46784661	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	33700432	51558799	Rat
631829	Alc6	Alcohol consumption QTL 6	4.7		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	34243475	43352593	Rat
1331786	Kidm11	Kidney mass QTL 11	3.571		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	12	16187438	52308831	Rat
8693658	Alc33	Alcohol consumption QTL 33	2.1	0.68	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	12	28717718	49212240	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	16135029	52308831	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	16187438	51213550	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	11200494	52308831	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	11200494	52308831	Rat
7387292	Kidm42	Kidney mass QTL 42	3.03	0.0004	kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	12	1	41361854	Rat
1300157	Rf21	Renal function QTL 21	4.4		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	12	29636637	37764351	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	2747694	47747694	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	18473041	52308831	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	3087180	48087180	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat
7243862	Mcs30	Mammary carcinoma susceptibility QTL 30	8.62		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	12	5633306	50633306	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	16135029	52308831	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	11200494	52308831	Rat

Markers in Region

BF395959

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	31,986,499 - 31,986,623 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	37,404,956 - 37,405,079	NCBI	Rnor6.0
Rnor_5.0	12	39,276,021 - 39,276,144	UniSTS	Rnor5.0
RGSC_v3.4	12	33,099,144 - 33,099,267	UniSTS	RGSC3.4
Celera	12	33,676,746 - 33,676,869	UniSTS
RH 3.4 Map	12	550.9	UniSTS
Cytogenetic Map	12	q15	UniSTS

RH141592

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	31,947,277 - 31,947,462 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	37,365,736 - 37,365,920	NCBI	Rnor6.0
Rnor_5.0	12	39,235,838 - 39,236,022	UniSTS	Rnor5.0
RGSC_v3.4	12	33,059,026 - 33,059,210	UniSTS	RGSC3.4
Celera	12	33,637,126 - 33,637,310	UniSTS
RH 3.4 Map	12	558.8	UniSTS
Cytogenetic Map	12	q15	UniSTS

BE110564

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	31,949,576 - 31,949,736 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	37,368,035 - 37,368,194	NCBI	Rnor6.0
Rnor_5.0	12	39,238,137 - 39,238,296	UniSTS	Rnor5.0
RGSC_v3.4	12	33,061,325 - 33,061,484	UniSTS	RGSC3.4
Celera	12	33,639,425 - 33,639,584	UniSTS
RH 3.4 Map	12	568.11	UniSTS
Cytogenetic Map	12	q15	UniSTS

RH141862

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	31,949,162 - 31,949,361 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	37,367,621 - 37,367,819	NCBI	Rnor6.0
Rnor_5.0	12	39,237,723 - 39,237,921	UniSTS	Rnor5.0
RGSC_v3.4	12	33,060,911 - 33,061,109	UniSTS	RGSC3.4
Celera	12	33,639,011 - 33,639,209	UniSTS
RH 3.4 Map	12	565.9	UniSTS
Cytogenetic Map	12	q15	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
10	12	61	133	57	60	41	86	41	298	168	11	124	71	73	19	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053775	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC127646	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF118854	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098791	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC168659	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ286425	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DV216525	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000083401 ⟹ ENSRNOP00000068905

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	37,608,211 - 37,640,860 (-)	Ensembl
mRatBN7.2 Ensembl	12	31,949,022 - 31,979,862 (-)	Ensembl
Rnor_6.0 Ensembl	12	37,367,474 - 37,398,329 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000084553 ⟹ ENSRNOP00000072568

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	31,982,730 - 32,007,050 (-)	Ensembl
Rnor_6.0 Ensembl	12	37,401,186 - 37,425,596 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000087698 ⟹ ENSRNOP00000073487

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	31,946,465 - 32,007,069 (-)	Ensembl
Rnor_6.0 Ensembl	12	37,363,906 - 37,411,525 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106066 ⟹ ENSRNOP00000084529

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	12	37,472,813 - 37,607,921 (-)	Ensembl
mRatBN7.2 Ensembl	12	31,823,454 - 31,993,069 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106704 ⟹ ENSRNOP00000097523

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	31,822,733 - 31,993,069 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000108577 ⟹ ENSRNOP00000095339

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	31,822,880 - 32,007,069 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000110165 ⟹ ENSRNOP00000093343

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	31,982,730 - 32,007,050 (-)	Ensembl

RefSeq Acc Id:

NM_053775 ⟹ NP_446227

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	37,608,211 - 37,640,860 (-)	NCBI
mRatBN7.2	12	31,947,220 - 31,979,875 (-)	NCBI
Rnor_6.0	12	37,368,321 - 37,398,233 (-)	NCBI
Rnor_5.0	12	39,238,423 - 39,269,298 (-)	NCBI
RGSC_v3.4	12	33,061,611 - 33,092,421 (-)	RGD
Celera	12	33,639,711 - 33,670,024 (-)	RGD

Sequence:

show sequence

ATGGGCTCCCTCTTCCGTAGCGAGAGCATGTGCCTGGCGCAGCTCTTCCTGCAGTCGGGCACGG
CCTACGAGTGTCTGAGCGCGCTTGGCGAGAAGGGCCTGGTGCAGTTCCGAGACCTCAACCAAAA
TGTAAGTTCTTTCCAAAGAAAATTCGTTGGTGAGGTAAAGAGGTGTGAAGAACTAGAACGAATA
TTGGTGTACCTGGTGCAGGAAATCACCAGAGCTGATATTCCCCTGCCTGAGGGAGAGGCCAGTC
CTCCCGCACCACCTGTTAAACATGTTCTAGAAATGCAGGAGCAGCTGCAGAAGCTCGAGGTGGA
GCTCAGAGAAGTCACCAAGAACAAGGAGAAGCTGAGGAAGAACCTGCTGGAGCTGGTGGAGTAT
ACCCACATGCTGAGGGTCACCAAGACCTTCCTTAAACGGAACGTGGAGTTTGAGCCAACTTACG
AAGAGTTCCCCGCCTTAGAGAGCGACTCTCTGTTGGACTACAGCTGCATGCAGCGGCTGGGCGC
CAAGCTGGGATTCGTTTCTGGCCTGATTCAGCAAGGCAAAGTGGAAGCATTTGAAAGAATGCTG
TGGCGGGCCTGCAAAGGGTACACCATTGTGACCTATGCAGAGCTGGACGAGGCCCTGGAAGACC
CTGAGACGGGTGAAGTCATAAAGTGGTATGTGTTCCTGATCTCGTTTTGGGGAGAGCAGATTGG
CCACAAGGTTAAGAAGATCTGTGACTGTTACCACTGCCACATCTACCCGTATCCAAACACGGCC
GAGGAGCGCAGGGAGATCCAGGAGGGGCTCAATACTCGGATCCAAGACCTTTACACTGTGCTGC
ACAAAACGGAGGACTACCTGCGGCAAGTGCTGTGCAAGGCTGCCGAGTCCGTGTGCAGCCGTGT
GATACAGGTGCGGAAGATGAAAGCCATCTACCACATGCTCAACATGTGCAGCTTTGACGTCACC
AACAAGTGCCTCATAGCTGAGGTCTGGTGCCCCGAGGTGGACCTGCCCGGCTTGCGCAGAGCGC
TGGAGGAAGGCTCGAGAGAAAGTGGAGCTACAATCCCCTCGTTCATGAACACAATCCCTACGAA
AGAAACGCCGCCCACTCTGATCCGCACCAACAAATTCACTGAAGGTTTCCAGAACATCGTGGAT
GCCTACGGTGTTGGGAGCTACAGAGAAGTGAACCCAGCTTTGTTCACCATCATCACCTTCCCGT
TCCTGTTTGGCGTGATGTTTGGTGACTTGGGGCACGGCTTTGTCATGTTCCTGTTTGCCCTCTT
ACTGGTGTTGAATGAGAATCACCCCAGACTAAGCCAGTCACAGGAGATCCTTAGGATGTTCTTT
GATGGCCGATATATCCTGCTGCTGATGGGGCTGTTCTCCGTGTACACCGGCCTCATCTACAACG
ACTGCTTCTCCAAGTCCCTGAACCTCTTTGGCTCTGGGTGGAACGTGTCTGCCATGTACAGTTC
CAGCCACTCCCCAGAGGAGCAAAGGAAAATGGTGCTTTGGAATGACAGCACCATCAGGCACAGC
AGGACGCTGCAGCTGGACCCAAACATCCCTGGAGTTTTCCGAGGCCCCTACCCTTTCGGCATCG
ATCCTATTTGGAACCTGGCCACAAATCGCCTCACGTTCCTCAACTCCTTCAAGATGAAGATGTC
TGTGATTTTAGGAATTTTTCACATGACCTTTGGTGTCATTCTGGGAATATTTAACCACTTGCAC
TTCAGGAAGAAGTTCAACATCTACCTGGTCTCGGTCCCCGAGATCCTGTTTATGCTCTGCATCT
TTGGGTACCTGATTTTCATGATCATCTACAAGTGGCTGGCGTACTCGGCAGAGACCTCCAGAGA
GGCCCCCAGCATCCTCATCGAGTTCATTAACATGTTCCTGTTCCCGTCCAGTGAGACACACGGC
CTCTACCCGGGGCAGGCACACGTCCAGAAGGTGTTGTTGGCTCTCACCGTGCTGGCTGTCCCTG
TGCTCTTCTTGGGAAAGCCGCTCTTTCTGCTGTGGCTGCACAATGGGCGCAGTTGCTTCGGCGT
GAGCCGGAGCGGCTACACGCTCGTGAGGAAGGACAGCGAGGAAGAGGTGTCTCTCCTAGGCAGC
CAGGACATAGAGGAGGGGAACAACCGCATGGAAGAGGGCTGCCGAGAAATGACCTGTGAGGAGT
TTAACTTCGGGGAGATCCTGATGACTCAGGCCATCCACTCCATCGAGTACTGCCTTGGCTGCAT
CTCCAACACTGCGTCCTACCTGAGGCTTTGGGCTCTCAGCCTGGCACACGCACAGCTCTCGGAT
GTGCTGTGGGCCATGCTGATGCGTGTAGGCCTGCGTGTGGACAACACTTACGGGGTCCTGCTGC
TGCTGCCCGTCATGACTTTCTTTGCAGTTCTGACCGTTTTTATCCTTCTGGTCATGGAAGGGCT
TTCTGCATTTCTCCACGCCATCCGGCTTCACTGGGTAGAATTTCAGAACAAATTCTACGTTGGT
GCAGGTACCAAATTCGTTCCTTTCTCCTTCAGTCTGCTGTCCTCCAAGTTCAGTAAAGATGACA
GCATAGCATGA

hide sequence

Protein Sequences


Protein RefSeqs	NP_446227	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD45408	(Get FASTA)	NCBI Sequence Viewer
	AAH98791	(Get FASTA)	NCBI Sequence Viewer
	AAI68659	(Get FASTA)	NCBI Sequence Viewer
	ABB91444	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000068905
	ENSRNOP00000068905.1
	ENSRNOP00000073487.2
	ENSRNOP00000095339.1

RefSeq Acc Id:

NP_446227 ⟸ NM_053775

- UniProtKB:

Q2I6B1 (UniProtKB/TrEMBL), F1LQ38 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MGSLFRSESMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELERI
LVYLVQEITRADIPLPEGEASPPAPPVKHVLEMQEQLQKLEVELREVTKNKEKLRKNLLELVEY
THMLRVTKTFLKRNVEFEPTYEEFPALESDSLLDYSCMQRLGAKLGFVSGLIQQGKVEAFERML
WRACKGYTIVTYAELDEALEDPETGEVIKWYVFLISFWGEQIGHKVKKICDCYHCHIYPYPNTA
EERREIQEGLNTRIQDLYTVLHKTEDYLRQVLCKAAESVCSRVIQVRKMKAIYHMLNMCSFDVT
NKCLIAEVWCPEVDLPGLRRALEEGSRESGATIPSFMNTIPTKETPPTLIRTNKFTEGFQNIVD
AYGVGSYREVNPALFTIITFPFLFGVMFGDLGHGFVMFLFALLLVLNENHPRLSQSQEILRMFF
DGRYILLLMGLFSVYTGLIYNDCFSKSLNLFGSGWNVSAMYSSSHSPEEQRKMVLWNDSTIRHS
RTLQLDPNIPGVFRGPYPFGIDPIWNLATNRLTFLNSFKMKMSVILGIFHMTFGVILGIFNHLH
FRKKFNIYLVSVPEILFMLCIFGYLIFMIIYKWLAYSAETSREAPSILIEFINMFLFPSSETHG
LYPGQAHVQKVLLALTVLAVPVLFLGKPLFLLWLHNGRSCFGVSRSGYTLVRKDSEEEVSLLGS
QDIEEGNNRMEEGCREMTCEEFNFGEILMTQAIHSIEYCLGCISNTASYLRLWALSLAHAQLSD
VLWAMLMRVGLRVDNTYGVLLLLPVMTFFAVLTVFILLVMEGLSAFLHAIRLHWVEFQNKFYVG
AGTKFVPFSFSLLSSKFSKDDSIA

hide sequence

Ensembl Acc Id:

ENSRNOP00000072568 ⟸ ENSRNOT00000084553

Ensembl Acc Id:

ENSRNOP00000073487 ⟸ ENSRNOT00000087698

Ensembl Acc Id:

ENSRNOP00000068905 ⟸ ENSRNOT00000083401

Ensembl Acc Id:

ENSRNOP00000095339 ⟸ ENSRNOT00000108577

Ensembl Acc Id:

ENSRNOP00000093343 ⟸ ENSRNOT00000110165

Ensembl Acc Id:

ENSRNOP00000084529 ⟸ ENSRNOT00000106066

Ensembl Acc Id:

ENSRNOP00000097523 ⟸ ENSRNOT00000106704

Protein Domains

Tectonic

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698605

Promoter ID:

EPDNEW_R9129

Type:

multiple initiation site

Name:

Tctn2_1

Description:

tectonic family member 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_R9130

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	37,398,331 - 37,398,391	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621006	AgrOrtholog
BioCyc Gene	G2FUF-19365	BioCyc
BioCyc Pathway	PWY-7980 [ATP biosynthesis]	BioCyc
BioCyc Pathway Image	PWY-7980	BioCyc
Ensembl Genes	ENSRNOG00000052704	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000083401	ENTREZGENE
	ENSRNOT00000083401.2	UniProtKB/TrEMBL
	ENSRNOT00000087698.2	UniProtKB/TrEMBL
	ENSRNOT00000108577.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7375616	IMAGE-MGC_LOAD
InterPro	ATPase_V0/A0-cplx_116kDa_su	UniProtKB/TrEMBL
	DUF1619	UniProtKB/TrEMBL
	V-type_ATPase_116kDa_su_euka	UniProtKB/TrEMBL
KEGG Report	rno:116455	UniProtKB/TrEMBL
MGC_CLONE	MGC:112832	IMAGE-MGC_LOAD
NCBI Gene	116455	ENTREZGENE
PANTHER	ATPase_V0/A0_116	UniProtKB/TrEMBL
	V-TYPE PROTON ATPASE 116 KDA SUBUNIT A2	UniProtKB/TrEMBL
Pfam	DUF1619	UniProtKB/TrEMBL
	V_ATPase_I	UniProtKB/TrEMBL
PhenoGen	Atp6v0a2	PhenoGen
PIRSF	ATP6V0A1	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000052704	RatGTEx
UniProt	A0A0G2K5M9_RAT	UniProtKB/TrEMBL
	F1LQ38	ENTREZGENE
	Q2I6B1	ENTREZGENE, UniProtKB/TrEMBL
	Q4G036_RAT	UniProtKB/TrEMBL
	Q7TP16_RAT	UniProtKB/TrEMBL
UniProt Secondary	F1LQ38	UniProtKB/TrEMBL
	F1LR83	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-17	Atp6v0a2	ATPase H+ transporting V0 subunit a2	Atp6v0a2	ATPase, H+ transporting, lysosomal V0 subunit A2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-02-22	Atp6v0a2	ATPase, H+ transporting, lysosomal V0 subunit A2	Atp6v0a2	ATPase, H+ transporting, lysosomal V0 subunit a isoform 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-29	Atp6v0a2	ATPase, H+ transporting, lysosomal V0 subunit a isoform 2	Atp6v0a2_predicted	ATPase, H+ transporting, lysosomal V0 subunit a isoform 2 (predicted)	Data merged from RGD:1310125	737654	APPROVED
2005-07-08	Atp6v0a2	ATPase, H+ transporting, lysosomal V0 subunit a isoform 2	Tj6	T-cell expressing clone j6	Symbol and Name updated	1299863	APPROVED
2005-01-12	Atp6v0a2_predicted	ATPase, H+ transporting, lysosomal V0 subunit a isoform 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED
2002-08-07	Tj6	T-cell expressing clone j6			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

BioCyc Pathways