Strain Report - Rat Genome Database

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Strain: LAS1

Symbol: LAS1
Strain: LAS
Full Name: Low Alcohol Sensitive strain 1
RGD ID: 1578696
Citation ID: RRID:RRRC_00080
Ontology ID: RS:0001326
Previously known as: ILAS1
Type: inbred
Source: Rat Resource and Research Center
Origin: Selectively bred for 24 generations for low sensitivity to ethanol then inbred.
Genetic Markers: Hooded
Coat Color: Brown
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm






References

References - curated
# Reference Title Reference Citation
1. Selective breeding of rats differing in sensitivity to the effects of acute ethanol administration. Draski LJ, etal., Alcohol Clin Exp Res. 1992 Feb;16(1):48-54.
2. Developmental alterations of ethanol sensitivity in selectively bred high and low alcohol sensitive rats. Draski LJ, etal., Pharmacol Biochem Behav. 2001 Oct-Nov;70(2-3):387-96.
3. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
4. Quantitative trait Loci mapping for ethanol sensitivity and neurotensin receptor density in an F2 intercross derived from inbred high and low alcohol sensitivity selectively bred rat lines. Radcliffe RA, etal., Alcohol Clin Exp Res 2004 Dec;28(12):1796-804.
5. Confirmation of quantitative trait loci for ethanol sensitivity and neurotensin receptor density in crosses derived from the inbred high and low alcohol sensitive selectively bred rat lines. Radcliffe RA, etal., Psychopharmacology (Berl). 2006 Oct;188(3):343-54. Epub 2006 Sep 5.
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Strain QTL Data
Symbol Name Trait
Alcrsp1 Alcohol response QTL 1 response to alcohol trait   (VT:0010489)    
Alcrsp10 Alcohol response QTL 10 alcohol metabolism trait   (VT:0015089)    
Alcrsp11 Alcohol response QTL 11 alcohol metabolism trait   (VT:0015089)    
Alcrsp12 Alcohol response QTL 12 response to alcohol trait   (VT:0010489)    
Alcrsp13 Alcohol response QTL 13 response to alcohol trait   (VT:0010489)    
Alcrsp14 Alcohol response QTL 14 response to alcohol trait   (VT:0010489)    
Alcrsp15 Alcohol response QTL 16 alcohol metabolism trait   (VT:0015089)    
Alcrsp16 Alcohol response QTL 16 alcohol metabolism trait   (VT:0015089)    
Alcrsp2 Alcohol response QTL 2 response to alcohol trait   (VT:0010489)    
Alcrsp3 Alcohol response QTL 3 response to alcohol trait   (VT:0010489)    
Alcrsp4 Alcohol response QTL 4 response to alcohol trait   (VT:0010489)    
Alcrsp5 Alcohol response QTL 5 response to alcohol trait   (VT:0010489)    
Alcrsp6 Alcohol response QTL 6 response to alcohol trait   (VT:0010489)    
Alcrsp7 Alcohol response QTL 7 response to alcohol trait   (VT:0010489)    
Alcrsp8 Alcohol response QTL 8 alcohol metabolism trait   (VT:0015089)    
Alcrsp9 Alcohol response QTL 9 alcohol metabolism trait   (VT:0015089)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other Contributes to low sensitivity to high dose ethanol hypnosis 1578559

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-04-18 LAS1  Low Alcohol Sensitive strain 1  LAS1  Low Alcohol Sensitive strain 1  Name updated 68913 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00080 RGD