Tbx5 (T-box transcription factor 5) - Rat Genome Database

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Gene: Tbx5 (T-box transcription factor 5) Rattus norvegicus
Analyze
Symbol: Tbx5
Name: T-box transcription factor 5
RGD ID: 1305702
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in transdifferentiation. Located in nucleus. Used to study myocardial infarction. Human ortholog(s) of this gene implicated in Holt-Oram syndrome. Orthologous to human TBX5 (T-box transcription factor 5); INTERACTS WITH bisphenol A; dibutyl phthalate; graphite.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC304514; T-box 5; T-box protein 5; T-box transcription factor TBX5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21236,686,344 - 36,739,253 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1236,688,014 - 36,734,885 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1237,865,094 - 37,912,212 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01238,478,894 - 38,526,001 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01237,531,397 - 37,578,508 (-)NCBIRnor_WKY
Rnor_6.01242,059,688 - 42,148,226 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1242,097,626 - 42,148,146 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,909,016 - 43,998,121 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41237,956,658 - 38,004,255 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11237,820,045 - 37,867,643 (-)NCBI
Celera1238,362,373 - 38,409,445 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ development  (ISS)
atrial septum development  (ISO)
atrial septum morphogenesis  (IEA,ISO)
atrioventricular bundle cell differentiation  (IEA,ISO)
atrioventricular node cell development  (IEA,ISO)
atrioventricular node cell fate commitment  (IEA,ISO)
atrioventricular valve morphogenesis  (IEA,ISO)
bundle of His cell to Purkinje myocyte communication by electrical coupling  (IEA,ISO)
bundle of His development  (ISO)
cardiac left ventricle formation  (IBA,IEA,ISO)
cardiac muscle cell differentiation  (ISO)
cardiac muscle cell proliferation  (IEA,ISO)
cell fate specification  (IBA)
cell-cell signaling  (ISO,ISS)
cell-cell signaling involved in cardiac conduction  (IEA,ISO)
DNA-templated transcription  (ISO)
DNA-templated transcription elongation  (ISO)
embryonic forelimb morphogenesis  (IEA,ISO,ISS)
embryonic limb morphogenesis  (ISO,ISS)
endocardial cushion development  (IEA,ISO)
forelimb morphogenesis  (ISO)
heart development  (ISO,ISS)
lung development  (IEA,ISO)
morphogenesis of an epithelium  (IEA,ISO)
negative regulation of cardiac muscle cell proliferation  (IEA,ISO,ISS)
negative regulation of cell migration  (IEA,ISO,ISS)
negative regulation of cell population proliferation  (ISO,ISS)
pattern specification process  (IBA,IEA,ISO)
pericardium development  (IEA,ISO,ISS)
positive regulation of cardiac conduction  (IEA,ISO)
positive regulation of cardiac muscle cell proliferation  (IEA,ISO)
positive regulation of cardioblast differentiation  (IEA,ISO,ISS)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of gap junction assembly  (IEA,ISO)
positive regulation of secondary heart field cardioblast proliferation  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
regulation of atrial cardiac muscle cell membrane depolarization  (IEA,ISO)
regulation of DNA-templated transcription  (ISO)
regulation of transcription by RNA polymerase II  (IBA)
sinoatrial node development  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
transdifferentiation  (IMP)
ventricular cardiac muscle tissue development  (ISO)
ventricular septum development  (IEA,ISO)

Cellular Component
cytoplasm  (IEA,ISO,ISS)
nucleus  (IDA,IEA,ISO,ISS)
protein-containing complex  (ISO,ISS)
protein-DNA complex  (IEA,ISO,ISS)
transcription regulator complex  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Mutations in human TBX5 cause limb and cardiac malformation in Holt-Oram syndrome. Basson CT, etal., Nat Genet. 1997 Jan;15(1):30-5.
2. Functional analysis of novel TBX5 T-box mutations associated with Holt-Oram syndrome. Boogerd CJ, etal., Cardiovasc Res. 2010 Oct 1;88(1):130-9. doi: 10.1093/cvr/cvq178. Epub 2010 Jun 2.
3. A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Bruneau BG, etal., Cell. 2001 Sep 21;106(6):709-21.
4. T-box gene products are required for mesenchymal induction of epithelial branching in the embryonic mouse lung. Cebra-Thomas JA, etal., Dev Dyn. 2003 Jan;226(1):82-90.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Characterization of the TBX5 binding site and analysis of mutations that cause Holt-Oram syndrome. Ghosh TK, etal., Hum Mol Genet. 2001 Sep 1;10(18):1983-94.
7. Cloning of TBX5, a key gene during heart formation and its expression in rat embryonic heart. Gong LG, etal., Yi Chuan Xue Bao. 2006 Mar;33(3):199-205.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10. Ng JK, etal., Development. 2002 Nov;129(22):5161-70.
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. A gain-of-function TBX5 mutation is associated with atypical Holt-Oram syndrome and paroxysmal atrial fibrillation. Postma AV, etal., Circ Res. 2008 Jun 6;102(11):1433-42. doi: 10.1161/CIRCRESAHA.107.168294. Epub 2008 May 1.
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis. Takeuchi JK, etal., Development. 2003 Dec;130(24):5953-64. Epub 2003 Oct 22.
17. Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling. Zhang Y, etal., Aquat Toxicol. 2013 Jul 29;142-143C:26-32. doi: 10.1016/j.aquatox.2013.07.014.
Additional References at PubMed
PMID:8988164   PMID:11161571   PMID:11431700   PMID:12237100   PMID:12490567   PMID:12499378   PMID:12736217   PMID:12845333   PMID:14519429   PMID:14550786   PMID:14978031   PMID:15138308  
PMID:15289437   PMID:15621531   PMID:15843409   PMID:16183809   PMID:16332960   PMID:16380715   PMID:16684884   PMID:16870172   PMID:17604724   PMID:18285513   PMID:19084512   PMID:19204083  
PMID:19727199   PMID:20691899   PMID:22898775   PMID:24565863   PMID:25963046   PMID:26100648   PMID:26926761   PMID:27035640   PMID:27833996   PMID:28100873   PMID:29174768   PMID:30720154  
PMID:31265161  


Genomics

Comparative Map Data
Tbx5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21236,686,344 - 36,739,253 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1236,688,014 - 36,734,885 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1237,865,094 - 37,912,212 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01238,478,894 - 38,526,001 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01237,531,397 - 37,578,508 (-)NCBIRnor_WKY
Rnor_6.01242,059,688 - 42,148,226 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1242,097,626 - 42,148,146 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01243,909,016 - 43,998,121 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41237,956,658 - 38,004,255 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11237,820,045 - 37,867,643 (-)NCBI
Celera1238,362,373 - 38,409,445 (-)NCBICelera
Cytogenetic Map12q16NCBI
TBX5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812114,353,911 - 114,408,442 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl12114,353,911 - 114,408,442 (-)EnsemblGRCh38hg38GRCh38
GRCh3712114,791,716 - 114,846,247 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612113,276,118 - 113,330,630 (-)NCBINCBI36Build 36hg18NCBI36
Celera12114,419,103 - 114,473,633 (-)NCBICelera
Cytogenetic Map12q24.21NCBI
HuRef12111,801,135 - 111,855,628 (-)NCBIHuRef
CHM1_112114,759,933 - 114,814,388 (-)NCBICHM1_1
T2T-CHM13v2.012114,330,644 - 114,385,180 (-)NCBIT2T-CHM13v2.0
Tbx5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395119,934,581 - 120,023,285 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5119,970,733 - 120,023,284 (+)EnsemblGRCm39 Ensembl
GRCm385119,796,514 - 119,885,220 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5119,832,668 - 119,885,219 (+)EnsemblGRCm38mm10GRCm38
MGSCv375120,284,672 - 120,335,227 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365120,095,280 - 120,145,092 (+)NCBIMGSCv36mm8
Celera5116,903,647 - 116,978,836 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map560.42NCBI
Tbx5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545516,132,975 - 16,217,953 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545516,133,130 - 16,217,894 (+)NCBIChiLan1.0ChiLan1.0
TBX5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.112115,336,267 - 115,389,739 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12115,333,609 - 115,389,739 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v012111,954,222 - 112,009,261 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TBX5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12611,462,541 - 11,549,699 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2611,463,653 - 11,506,446 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2611,520,894 - 11,607,938 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02611,714,458 - 11,801,523 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2611,714,461 - 11,760,667 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12611,682,098 - 11,768,911 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02611,744,240 - 11,831,307 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02611,794,191 - 11,881,084 (-)NCBIUU_Cfam_GSD_1.0
Tbx5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118152,025,875 - 152,066,905 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365587,408,222 - 7,454,901 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365587,408,229 - 7,454,897 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TBX5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1437,774,171 - 37,825,401 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11437,772,205 - 37,826,015 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21440,161,963 - 40,260,936 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TBX5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111109,638,694 - 109,696,619 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11109,638,715 - 109,689,177 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037135,422,975 - 135,477,375 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tbx5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474718,307,294 - 18,348,040 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474718,307,294 - 18,348,040 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tbx5
319 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:30
Count of miRNA genes:28
Interacting mature miRNAs:29
Transcripts:ENSRNOT00000001893
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)122860752637691617Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 36 11
Low 7 14 6 3 6 1 11
Below cutoff 2 21 13 15 13 8 11 12 14 16 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001893   ⟹   ENSRNOP00000001893
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1236,688,014 - 36,734,885 (-)Ensembl
Rnor_6.0 Ensembl1242,097,626 - 42,148,146 (+)Ensembl
RefSeq Acc Id: NM_001009964   ⟹   NP_001009964
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21236,688,014 - 36,734,885 (-)NCBI
Rnor_6.01242,099,833 - 42,146,841 (+)NCBI
Rnor_5.01243,909,016 - 43,998,121 (+)NCBI
RGSC_v3.41237,956,658 - 38,004,255 (-)RGD
Celera1238,362,373 - 38,409,445 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249387   ⟹   XP_006249449
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21236,686,344 - 36,737,323 (-)NCBI
Rnor_6.01242,097,735 - 42,148,226 (+)NCBI
Rnor_5.01243,909,016 - 43,998,121 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006249390   ⟹   XP_006249452
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21236,686,344 - 36,737,324 (-)NCBI
Rnor_6.01242,097,735 - 42,148,226 (+)NCBI
Rnor_5.01243,909,016 - 43,998,121 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006249391   ⟹   XP_006249453
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21236,686,344 - 36,735,633 (-)NCBI
Rnor_6.01242,099,333 - 42,148,226 (+)NCBI
Rnor_5.01243,909,016 - 43,998,121 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008769230   ⟹   XP_008767452
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21236,686,344 - 36,739,253 (-)NCBI
Rnor_6.01242,095,407 - 42,148,226 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598339   ⟹   XP_017453828
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21236,686,344 - 36,739,249 (-)NCBI
Rnor_6.01242,095,407 - 42,148,226 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089491   ⟹   XP_038945419
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21236,686,344 - 36,739,253 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001009964   ⟸   NM_001009964
- UniProtKB: Q5I2P1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006249452   ⟸   XM_006249390
- Peptide Label: isoform X1
- UniProtKB: G3V657 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249449   ⟸   XM_006249387
- Peptide Label: isoform X1
- UniProtKB: G3V657 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249453   ⟸   XM_006249391
- Peptide Label: isoform X1
- UniProtKB: G3V657 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008767452   ⟸   XM_008769230
- Peptide Label: isoform X1
- UniProtKB: G3V657 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017453828   ⟸   XM_017598339
- Peptide Label: isoform X1
- UniProtKB: G3V657 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001893   ⟸   ENSRNOT00000001893
RefSeq Acc Id: XP_038945419   ⟸   XM_039089491
- Peptide Label: isoform X1
- UniProtKB: G3V657 (UniProtKB/TrEMBL)
Protein Domains
T-box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5I2P1-F1-model_v2 AlphaFold Q5I2P1 1-517 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305702 AgrOrtholog
BioCyc Gene G2FUF-19150 BioCyc
Ensembl Genes ENSRNOG00000001399 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000001893 ENTREZGENE
  ENSRNOP00000001893.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001893 ENTREZGENE
  ENSRNOT00000001893.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-box_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  T-box_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_T-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_T-box_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:304514 UniProtKB/Swiss-Prot
NCBI Gene 304514 ENTREZGENE
PANTHER PTHR11267 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam T-box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tbx5 PhenoGen
PRINTS TBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE TBOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TBOX_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TBOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49417 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt G3V657 ENTREZGENE, UniProtKB/TrEMBL
  Q5I2P1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-05 Tbx5  T-box transcription factor 5  Tbx5  T-box 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Tbx5  T-box 5  Tbx5_predicted  T-box 5 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Tbx5_predicted  T-box 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED