Nudt1 (nudix hydrolase 1) - Rat Genome Database

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Gene: Nudt1 (nudix hydrolase 1) Rattus norvegicus
Analyze
Symbol: Nudt1
Name: nudix hydrolase 1
RGD ID: 621080
Description: Predicted to enable nucleoside triphosphate diphosphatase activity and snoRNA binding activity. Involved in male gonad development and response to cadmium ion. Located in acrosomal vesicle; extracellular space; and nuclear membrane. Biomarker of hypertension. Orthologous to human NUDT1 (nudix hydrolase 1); INTERACTS WITH ammonium chloride; bisphenol A; flavonoids.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2-hydroxy-dATP diphosphatase; 7,8-dihydro-8-oxoguanine triphosphatase; 8-oxo-dGTPase; methylated purine nucleoside triphosphate hydrolase; Mth1; mutT (E. coli) human homolog (8-oxo-dGTPase); mutT human homolog (8-oxo-dGTPase); nucleoside diphosphate-linked moiety X motif 1; nudix (nucleoside diphosphate linked moiety X)-type motif 1; nudix motif 1; nudix-type motif 1; oxidized purine nucleoside triphosphate hydrolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81219,416,411 - 19,423,448 (-)NCBIGRCr8
mRatBN7.21214,302,514 - 14,309,559 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1214,302,694 - 14,305,826 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,110,350 - 15,113,649 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,733,848 - 15,737,147 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01214,760,555 - 14,763,860 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,391,578 - 16,398,771 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,391,578 - 16,395,029 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01218,384,329 - 18,391,351 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41214,775,536 - 14,778,845 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11214,805,463 - 14,808,773 (-)NCBI
Celera1216,061,302 - 16,064,584 (-)NCBICelera
Cytogenetic Map12q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
beauvericin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dimethyl sulfoxide  (ISO)
dioxygen  (ISO)
enniatin  (ISO)
Enterolactone  (ISO)
epoxiconazole  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen peroxide  (ISO)
imiquimod  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
methapyrilene  (ISO)
N,N-diethyl-m-toluamide  (EXP)
nitrogen dioxide  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
Pyridostigmine bromide  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
tremolite asbestos  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
acrosomal vesicle  (IDA)
cytoplasm  (IBA,ISO,ISS)
cytosol  (IEA,ISO)
extracellular space  (IDA)
mitochondrial matrix  (ISO,ISS)
mitochondrion  (ISO,ISS)
nuclear membrane  (IDA)
nucleus  (ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents occurrence of spontaneous mutations due to oxidation of guanine nucleotides. Cai JP, etal., Carcinogenesis 1995 Oct;16(10):2343-50.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Ontogeny and regulation of variant thyroid hormone receptor isoforms in developing rat testis. Jannini EA, etal., J Endocrinol Invest. 1999 Dec;22(11):843-8.
5. Intracellular distribution of the antimutagenic enzyme MTH1 in the liver, kidney and testis of F344 rats and its modulation by cadmium. Kasprzak KS, etal., Exp Toxicol Pathol 2001 Oct;53(5):325-35.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. Accumulation of 8-oxo-deoxyguanosine in cardiovascular tissues with the development of hypertension. Ohtsubo T, etal., DNA Repair (Amst). 2007 Jun 1;6(6):760-9. Epub 2007 Feb 5.
9. The absence of Mth1 inactivation and DNA polymerase kappa overexpression in rat mammary carcinomas with frequent A:T to C:G transversions. Okochi E, etal., Jpn J Cancer Res 2002 May;93(5):501-6.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Oxidative damage to RNA and expression patterns of MTH1 in the hippocampi of senescence-accelerated SAMP8 mice and Alzheimer's disease patients. Song XN, etal., Neurochem Res. 2011 Aug;36(8):1558-65. doi: 10.1007/s11064-011-0484-4. Epub 2011 May 3.
14. Immunohistochemical detection of 8-hydroxy-2'-deoxyguanosine in paraffin-embedded sections of rat liver after carbon tetrachloride treatment. Takahashi S, etal., Toxicol Pathol. 1998 Mar-Apr;26(2):247-52.
Additional References at PubMed
PMID:7592783   PMID:7782328   PMID:8226881   PMID:10373420   PMID:10608900   PMID:11139615   PMID:11756418   PMID:12857738   PMID:15133035   PMID:21070968   PMID:22556419   PMID:23376485  
PMID:28261604   PMID:33021405  


Genomics

Comparative Map Data
Nudt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81219,416,411 - 19,423,448 (-)NCBIGRCr8
mRatBN7.21214,302,514 - 14,309,559 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1214,302,694 - 14,305,826 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1215,110,350 - 15,113,649 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01215,733,848 - 15,737,147 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01214,760,555 - 14,763,860 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01216,391,578 - 16,398,771 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1216,391,578 - 16,395,029 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01218,384,329 - 18,391,351 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41214,775,536 - 14,778,845 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11214,805,463 - 14,808,773 (-)NCBI
Celera1216,061,302 - 16,064,584 (-)NCBICelera
Cytogenetic Map12q11NCBI
NUDT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3872,242,226 - 2,251,145 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl72,242,226 - 2,251,146 (+)EnsemblGRCh38hg38GRCh38
GRCh3772,281,861 - 2,290,780 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3672,248,383 - 2,257,306 (+)NCBINCBI36Build 36hg18NCBI36
Build 3472,055,780 - 2,064,021NCBI
Celera72,251,549 - 2,260,471 (+)NCBICelera
Cytogenetic Map7p22.3NCBI
HuRef72,201,140 - 2,210,062 (+)NCBIHuRef
CHM1_172,281,464 - 2,290,386 (+)NCBICHM1_1
T2T-CHM13v2.072,355,644 - 2,364,561 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v272,330,533 - 2,339,455 (+)NCBI
Nudt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395140,307,375 - 140,323,892 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5140,307,411 - 140,323,892 (+)EnsemblGRCm39 Ensembl
GRCm385140,321,622 - 140,338,137 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5140,321,656 - 140,338,137 (+)EnsemblGRCm38mm10GRCm38
MGSCv375140,807,876 - 140,814,089 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365140,584,396 - 140,590,609 (+)NCBIMGSCv36mm8
Celera5137,390,656 - 137,396,879 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map578.94NCBI
Nudt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554609,678,270 - 9,689,106 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554609,678,270 - 9,689,106 (+)NCBIChiLan1.0ChiLan1.0
NUDT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v267,207,982 - 7,217,192 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1755,532,679 - 55,541,894 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v072,511,573 - 2,520,643 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.172,613,207 - 2,622,141 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl72,614,005 - 2,621,997 (+)Ensemblpanpan1.1panPan2
NUDT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1614,874,459 - 14,881,517 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl614,859,518 - 14,882,704 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha616,336,737 - 16,343,817 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0615,000,839 - 15,007,880 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1614,804,097 - 14,811,136 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0614,731,016 - 14,738,104 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0615,018,707 - 15,025,800 (-)NCBIUU_Cfam_GSD_1.0
Nudt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344143,029,319 - 143,044,461 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049368237,099 - 18,677 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049368237,104 - 22,083 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUDT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl31,566,915 - 1,576,234 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.131,567,417 - 1,575,801 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NUDT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12819,332,014 - 19,340,538 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2819,327,393 - 19,338,665 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660902,380,158 - 2,394,282 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nudt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474027,528,548 - 27,541,001 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474027,528,428 - 27,538,406 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nudt1
75 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:217
Count of miRNA genes:158
Interacting mature miRNAs:176
Transcripts:ENSRNOT00000001700
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1600391Edcs2Endometrial carcinoma susceptibility QTL23.50.01uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)12683319017870186Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7204484Bp358Blood pressure QTL 3580.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121300829619212979Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat

Markers in Region
RH141672  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map12q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 24 20 14 9 14 34 20 26
Low 2 19 37 27 10 27 8 11 40 15 15 11 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000001700   ⟹   ENSRNOP00000001700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1214,302,694 - 14,305,826 (-)Ensembl
Rnor_6.0 Ensembl1216,391,578 - 16,395,029 (-)Ensembl
RefSeq Acc Id: NM_057120   ⟹   NP_476461
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81219,416,411 - 19,419,720 (-)NCBI
mRatBN7.21214,302,514 - 14,305,826 (-)NCBI
Rnor_6.01216,391,578 - 16,395,029 (-)NCBI
Rnor_5.01218,384,329 - 18,391,351 (-)NCBI
RGSC_v3.41214,775,536 - 14,778,845 (-)RGD
Celera1216,061,302 - 16,064,584 (-)RGD
Sequence:
RefSeq Acc Id: XM_006248911   ⟹   XP_006248973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81219,416,625 - 19,423,448 (-)NCBI
mRatBN7.21214,302,728 - 14,309,559 (-)NCBI
Rnor_6.01216,391,792 - 16,398,771 (-)NCBI
Rnor_5.01218,384,329 - 18,391,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039089035   ⟹   XP_038944963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81219,416,625 - 19,423,374 (-)NCBI
mRatBN7.21214,302,728 - 14,309,440 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_476461   ⟸   NM_057120
- UniProtKB: P53369 (UniProtKB/Swiss-Prot),   A6K1T0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006248973   ⟸   XM_006248911
- Peptide Label: isoform X1
- UniProtKB: P53369 (UniProtKB/Swiss-Prot),   A6K1T0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001700   ⟸   ENSRNOT00000001700
RefSeq Acc Id: XP_038944963   ⟸   XM_039089035
- Peptide Label: isoform X1
- UniProtKB: P53369 (UniProtKB/Swiss-Prot),   A6K1T0 (UniProtKB/TrEMBL)
Protein Domains
Nudix hydrolase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P53369-F1-model_v2 AlphaFold P53369 1-156 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621080 AgrOrtholog
BioCyc Gene G2FUF-19912 BioCyc
BioCyc Pathway PWY-6502 [8-oxo-(d)GTP detoxification I] BioCyc
BioCyc Pathway Image PWY-6502 BioCyc
Ensembl Genes ENSRNOG00000001260 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055011717 UniProtKB/Swiss-Prot
  ENSRNOG00060029637 UniProtKB/Swiss-Prot
  ENSRNOG00065000132 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001700 ENTREZGENE
  ENSRNOT00000001700.7 UniProtKB/Swiss-Prot
  ENSRNOT00055019902 UniProtKB/Swiss-Prot
  ENSRNOT00060051463 UniProtKB/Swiss-Prot
  ENSRNOT00065000229 UniProtKB/Swiss-Prot
Gene3D-CATH Nucleoside Triphosphate Pyrophosphohydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 8ODP UniProtKB/TrEMBL
  Nudix_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUDIX_hydrolase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUDIX_hydrolase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUDIX_hydrolase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OxG-triPHTase UniProtKB/Swiss-Prot
KEGG Report rno:117260 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 117260 ENTREZGENE
PANTHER 7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE UniProtKB/Swiss-Prot
  7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE UniProtKB/Swiss-Prot
  7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE UniProtKB/TrEMBL
  7,8-DIHYDRO-8-OXOGUANINE TRIPHOSPHATASE UniProtKB/TrEMBL
Pfam NUDIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nudt1 PhenoGen
PRINTS 8OXTPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUDIXFAMILY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NUDIX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUDIX_BOX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001260 RatGTEx
  ENSRNOG00055011717 RatGTEx
  ENSRNOG00060029637 RatGTEx
  ENSRNOG00065000132 RatGTEx
Superfamily-SCOP Nudix UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt 8ODP_RAT UniProtKB/Swiss-Prot
  A6K1S8_RAT UniProtKB/TrEMBL
  A6K1T0 ENTREZGENE, UniProtKB/TrEMBL
  P53369 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-10 Nudt1  nudix hydrolase 1  Nudt1  nudix (nucleoside diphosphate linked moiety X)-type motif 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Nudt1  nudix (nucleoside diphosphate linked moiety X)-type motif 1  Mth1  mutT (E. coli) human homolog (8-oxo-dGTPase)  Symbol and Name updated 1299863 APPROVED
2002-08-07 Mth1  mutT (E. coli) human homolog (8-oxo-dGTPase)      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_protein 156 amino acids; 18 kDa 633231