Ywhag (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma) - Rat Genome Database

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Gene: Ywhag (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma) Rattus norvegicus
Analyze
Symbol: Ywhag
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
RGD ID: 62002
Description: Enables receptor tyrosine kinase binding activity. Involved in cellular response to insulin stimulus. Located in vesicle. Is active in presynapse. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 56. Orthologous to human YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; interleukin-3 signaling pathway; mTOR signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 14-3-3 protein gamma; 14-3-3 protein gamma-subtype; 14-3-3G; 3-monooxygenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein gamma; tryosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein gamma polypeptide; tryosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein gamma polypeptide; tyrosine 3/tryptophan 5 -monooxygenase activation protein, gamma polypeptide
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,381,106 - 26,409,466 (+)NCBIGRCr8
mRatBN7.21220,744,500 - 20,772,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,744,535 - 20,772,827 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1221,886,692 - 21,914,903 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,499,081 - 22,527,298 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,564,574 - 21,592,894 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01223,789,547 - 23,817,884 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,789,638 - 23,817,883 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,788,140 - 25,816,532 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41221,859,804 - 21,888,050 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11221,847,105 - 21,875,295 (+)NCBI
Celera1222,507,939 - 22,536,185 (+)NCBICelera
RH 3.4 Map12300.5RGD
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-nitrophenol  (ISO)
4-vinylcyclohexene dioxide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
amiodarone  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
chromium(6+)  (ISO)
clofibrate  (EXP)
clofibric acid  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
CU-O LINKAGE  (ISO)
diarsenic trioxide  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichlorine  (EXP)
dioxygen  (ISO)
doxorubicin  (EXP)
enniatin  (EXP)
epoxiconazole  (ISO)
ethanol  (EXP)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fumagillin  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
glutathione  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hydrogen cyanide  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
L-ethionine  (EXP)
L-glutamic acid  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (ISO)
mercury dichloride  (EXP)
methimazole  (EXP)
microcystin RR  (ISO)
microcystin-LR  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nefazodone  (EXP)
omeprazole  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
PCB138  (EXP)
pentachlorophenol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
propiconazole  (ISO)
prostaglandin F2alpha  (EXP)
quercetin  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
T-2 toxin  (EXP)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISS)
presynapse  (IDA)
synapse  (IDA,IEP)
vesicle  (IDA)

References

References - curated
# Reference Title Reference Citation
1. Diagnostic value of surrogate CSF biomarkers for Creutzfeldt-Jakob disease in the era of RT-QuIC. Abu-Rumeileh S, etal., J Neurol. 2019 Dec;266(12):3136-3143. doi: 10.1007/s00415-019-09537-0. Epub 2019 Sep 20.
2. Inhibition of calcium/calmodulin-dependent protein kinase kinase by protein 14-3-3. Davare MA, etal., J Biol Chem. 2004 Dec 10;279(50):52191-9. Epub 2004 Oct 6.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. 14-3-3 Proteins directly regulate Ca(2+)/calmodulin-dependent protein kinase kinase alpha through phosphorylation-dependent multisite binding. Ichimura T, etal., FEBS Lett. 2008 Mar 5;582(5):661-5. doi: 10.1016/j.febslet.2008.01.037. Epub 2008 Jan 31.
5. Cerebrospinal fluid neurofilament light in suspected sporadic Creutzfeldt-Jakob disease. Kanata E, etal., J Clin Neurosci. 2019 Feb;60:124-127. doi: 10.1016/j.jocn.2018.09.031. Epub 2018 Oct 9.
6. AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane. Koumanov F, etal., J Biol Chem. 2011 May 13;286(19):16574-82. doi: 10.1074/jbc.M111.226092. Epub 2011 Mar 17.
7. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
8. Modulation of inactivation properties of CaV2.2 channels by 14-3-3 proteins. Li Y, etal., Neuron. 2006 Sep 21;51(6):755-71. doi: 10.1016/j.neuron.2006.08.014.
9. Subcellular localisation of 14-3-3 isoforms in rat brain using specific antibodies. Martin H, etal., J Neurochem. 1994 Dec;63(6):2259-65.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3. Muda K, etal., Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E34-43. doi: 10.1073/pnas.1312701111. Epub 2013 Dec 18.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Neurofilaments in blood and CSF for diagnosis and prediction of onset in Creutzfeldt-Jakob disease. Steinacker P, etal., Sci Rep. 2016 Dec 8;6:38737. doi: 10.1038/srep38737.
18. 14-3-3 gamma associates with muscle specific kinase and regulates synaptic gene transcription at vertebrate neuromuscular synapse. Strochlic L, etal., Proc Natl Acad Sci U S A. 2004 Dec 28;101(52):18189-94. Epub 2004 Dec 16.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Molecular cloning of rat cDNAs for beta and gamma subtypes of 14-3-3 protein and developmental changes in expression of their mRNAs in the nervous system. Watanabe M, etal., Brain Res Mol Brain Res 1993 Jan;17(1-2):135-46.
21. Molecular cloning of rat cDNAs for the zeta and theta subtypes of 14-3-3 protein and differential distributions of their mRNAs in the brain. Watanabe M, etal., Brain Res Mol Brain Res 1994 Aug;25(1-2):113-21.
Additional References at PubMed
PMID:10433554   PMID:11824616   PMID:12446771   PMID:12477932   PMID:12482592   PMID:12650640   PMID:15677482   PMID:16854843   PMID:17085597   PMID:17634366   PMID:19056867   PMID:19199708  
PMID:19946888   PMID:20458337   PMID:20639859   PMID:21423176   PMID:22658674   PMID:22871113   PMID:23432726   PMID:24743739   PMID:26316108   PMID:29476059   PMID:30093406   PMID:30478609  
PMID:32357304   PMID:35352799   PMID:36427097  


Genomics

Comparative Map Data
Ywhag
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81226,381,106 - 26,409,466 (+)NCBIGRCr8
mRatBN7.21220,744,500 - 20,772,828 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,744,535 - 20,772,827 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1221,886,692 - 21,914,903 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,499,081 - 22,527,298 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,564,574 - 21,592,894 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01223,789,547 - 23,817,884 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,789,638 - 23,817,883 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,788,140 - 25,816,532 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41221,859,804 - 21,888,050 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11221,847,105 - 21,875,295 (+)NCBI
Celera1222,507,939 - 22,536,185 (+)NCBICelera
RH 3.4 Map12300.5RGD
Cytogenetic Map12q12NCBI
YWHAG
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38776,326,799 - 76,358,991 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl776,326,799 - 76,358,991 (-)EnsemblGRCh38hg38GRCh38
GRCh37775,956,116 - 75,988,308 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36775,794,052 - 75,826,252 (-)NCBINCBI36Build 36hg18NCBI36
Build 34775,600,767 - 75,632,967NCBI
Celera770,824,607 - 70,856,862 (-)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef771,042,455 - 71,074,829 (-)NCBIHuRef
CHM1_1775,886,202 - 75,918,463 (-)NCBICHM1_1
T2T-CHM13v2.0777,614,271 - 77,646,485 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2775,289,172 - 75,321,406 (-)NCBI
Ywhag
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395135,937,233 - 135,963,495 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,937,263 - 135,963,470 (-)EnsemblGRCm39 Ensembl
GRCm385135,908,379 - 135,934,641 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,908,409 - 135,934,616 (-)EnsemblGRCm38mm10GRCm38
MGSCv375136,384,249 - 136,410,511 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365136,193,036 - 136,219,151 (-)NCBIMGSCv36mm8
Celera5132,916,950 - 132,946,032 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.53NCBI
Ywhag
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545614,939,084 - 14,970,248 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545614,939,130 - 14,970,248 (-)NCBIChiLan1.0ChiLan1.0
YWHAG
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2693,594,488 - 93,627,035 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17141,859,428 - 141,891,673 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0767,661,589 - 67,693,814 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1782,773,779 - 82,777,252 (-)NCBIpanpan1.1PanPan1.1panPan2
YWHAG
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.167,504,834 - 7,548,097 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl67,507,608 - 7,532,409 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha69,200,437 - 9,228,221 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.067,325,329 - 7,353,135 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl67,325,457 - 7,353,171 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.167,294,343 - 7,322,128 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.067,257,314 - 7,285,076 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.067,420,808 - 7,448,168 (-)NCBIUU_Cfam_GSD_1.0
Ywhag
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344131,940,360 - 131,974,428 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,061,794 - 2,096,525 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365432,062,137 - 2,096,207 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
YWHAG
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.139,994,802 - 10,023,296 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.239,882,655 - 9,911,118 (+)NCBISscrofa10.2Sscrofa10.2susScr3
YWHAG
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12810,462,984 - 10,494,500 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2810,462,859 - 10,494,457 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660705,923,909 - 5,955,125 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ywhag
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474014,959,089 - 14,995,548 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474014,960,105 - 14,995,522 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ywhag
186 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:369
Count of miRNA genes:219
Interacting mature miRNAs:260
Transcripts:ENSRNOT00000001954
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
61443Btemp2Thermal response to stress QTL 23.30.000094body temperature trait (VT:0005535)core body temperature (CMO:0001036)121502518320794014Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)121961087024139202Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
631521Pia12Pristane induced arthritis QTL 128.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)122025941723672083Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat

Markers in Region
BE098443  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,771,063 - 20,771,237 (+)MAPPERmRatBN7.2
Rnor_6.01223,816,120 - 23,816,293NCBIRnor6.0
Rnor_5.01225,814,768 - 25,814,941UniSTSRnor5.0
RGSC_v3.41221,886,286 - 21,886,459UniSTSRGSC3.4
Celera1222,534,421 - 22,534,594UniSTS
RH 3.4 Map12301.7UniSTS
Cytogenetic Map12q12UniSTS
RH142408  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,771,298 - 20,771,491 (+)MAPPERmRatBN7.2
Rnor_6.01223,816,355 - 23,816,547NCBIRnor6.0
Rnor_5.01225,815,003 - 25,815,195UniSTSRnor5.0
RGSC_v3.41221,886,521 - 21,886,713UniSTSRGSC3.4
Celera1222,534,656 - 22,534,848UniSTS
RH 3.4 Map12300.5UniSTS
Cytogenetic Map12q12UniSTS
RH137270  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,771,291 - 20,771,490 (+)MAPPERmRatBN7.2
Rnor_6.01223,816,348 - 23,816,546NCBIRnor6.0
Rnor_5.01225,814,996 - 25,815,194UniSTSRnor5.0
RGSC_v3.41221,886,514 - 21,886,712UniSTSRGSC3.4
Celera1222,534,649 - 22,534,847UniSTS
RH 3.4 Map12298.6UniSTS
Cytogenetic Map12q12UniSTS
BF417900  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,764,953 - 20,765,155 (+)MAPPERmRatBN7.2
Rnor_6.01223,810,010 - 23,810,211NCBIRnor6.0
Rnor_5.01225,808,658 - 25,808,859UniSTSRnor5.0
RGSC_v3.41221,880,176 - 21,880,377UniSTSRGSC3.4
Celera1222,528,311 - 22,528,512UniSTS
RH 3.4 Map12300.61UniSTS
Cytogenetic Map12q12UniSTS
SSC3D06  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,772,547 - 20,772,744 (+)MAPPERmRatBN7.2
Rnor_6.01223,817,604 - 23,817,800NCBIRnor6.0
Rnor_5.01225,816,252 - 25,816,448UniSTSRnor5.0
RGSC_v3.41221,887,770 - 21,887,966UniSTSRGSC3.4
Celera1222,535,905 - 22,536,101UniSTS
Cytogenetic Map12q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 16
Medium 3 43 57 41 19 41 8 11 58 35 39 11 8
Low 2
Below cutoff

Sequence


Ensembl Acc Id: ENSRNOT00000001954   ⟹   ENSRNOP00000001954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1220,744,535 - 20,772,827 (+)Ensembl
Rnor_6.0 Ensembl1223,789,638 - 23,817,883 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000084730   ⟹   ENSRNOP00000069671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1220,744,567 - 20,772,825 (+)Ensembl
Rnor_6.0 Ensembl1223,789,675 - 23,817,865 (+)Ensembl
RefSeq Acc Id: NM_019376   ⟹   NP_062249
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81226,381,219 - 26,409,466 (+)NCBI
mRatBN7.21220,744,580 - 20,772,828 (+)NCBI
Rnor_6.01223,789,638 - 23,817,884 (+)NCBI
Rnor_5.01225,788,140 - 25,816,532 (+)NCBI
RGSC_v3.41221,859,804 - 21,888,050 (+)RGD
Celera1222,507,939 - 22,536,185 (+)RGD
Sequence:
RefSeq Acc Id: XM_006249184   ⟹   XP_006249246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81226,381,106 - 26,409,466 (+)NCBI
mRatBN7.21220,744,500 - 20,772,828 (+)NCBI
Rnor_6.01223,789,547 - 23,817,884 (+)NCBI
Rnor_5.01225,788,140 - 25,816,532 (+)NCBI
Sequence:
RefSeq Acc Id: NP_062249   ⟸   NM_019376
- UniProtKB: A0JPM0 (UniProtKB/Swiss-Prot),   P61983 (UniProtKB/Swiss-Prot),   A6J0A1 (UniProtKB/TrEMBL),   A0A8L2R1A5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249246   ⟸   XM_006249184
- Peptide Label: isoform X1
- UniProtKB: A0JPM0 (UniProtKB/Swiss-Prot),   P61983 (UniProtKB/Swiss-Prot),   A6J0A1 (UniProtKB/TrEMBL),   A0A8L2R1A5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069671   ⟸   ENSRNOT00000084730
Ensembl Acc Id: ENSRNOP00000001954   ⟸   ENSRNOT00000001954
Protein Domains
14-3-3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P61983-F1-model_v2 AlphaFold P61983 1-247 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698545
Promoter ID:EPDNEW_R9068
Type:initiation region
Name:Ywhag_1
Description:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activationprotein, gamma
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01223,789,595 - 23,789,655EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62002 AgrOrtholog
BioCyc Gene G2FUF-19639 BioCyc
Ensembl Genes ENSRNOG00000001436 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055000321 UniProtKB/Swiss-Prot
  ENSRNOG00060010383 UniProtKB/Swiss-Prot
  ENSRNOG00065001781 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001954.4 UniProtKB/Swiss-Prot
  ENSRNOT00000084730.2 UniProtKB/TrEMBL
  ENSRNOT00055000561 UniProtKB/Swiss-Prot
  ENSRNOT00060017554 UniProtKB/Swiss-Prot
  ENSRNOT00065002381 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.190.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:8372306 IMAGE-MGC_LOAD
InterPro 14-3-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  14-3-3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:56010 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:156653 IMAGE-MGC_LOAD
NCBI Gene 56010 ENTREZGENE
PANTHER 14-3-3 PROTEIN GAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18860 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 14-3-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ywhag PhenoGen
PIRSF 14-3-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS 1433ZETA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE 1433_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1433_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001436 RatGTEx
  ENSRNOG00055000321 RatGTEx
  ENSRNOG00060010383 RatGTEx
  ENSRNOG00065001781 RatGTEx
SMART 14_3_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48445 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC228360
UniProt 1433G_RAT UniProtKB/Swiss-Prot
  A0A8L2R1A5 ENTREZGENE, UniProtKB/TrEMBL
  A0JPM0 ENTREZGENE
  A6J0A1 ENTREZGENE, UniProtKB/TrEMBL
  P61983 ENTREZGENE
UniProt Secondary A0JPM0 UniProtKB/Swiss-Prot
  O70457 UniProtKB/Swiss-Prot
  P35214 UniProtKB/Swiss-Prot
  Q9UDP2 UniProtKB/Swiss-Prot
  Q9UN99 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-12-11 Ywhag  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma  Ywhag  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27     Ywhag  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ywhag  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide    tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide   Name updated 1299863 APPROVED
2002-06-10 Ywhag  tyrosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide       Name updated 70584 APPROVED
2002-01-14 Ywhag  tryosine 3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide      correction to spelling of name 68926 APPROVED
2001-10-22 Ywhag  tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, gamma      Name updated 68913 WITHDRAWN
2001-10-22 Ywhag  tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, gamma polypeptide      Name updated 68913 APPROVED
2001-07-23 Ywhag  tryosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, gamma      Name updated to reflect Human and Mouse nomenclature 67952 APPROVED
2001-07-23 Ywhag  3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide      Name withdrawn 67952 WITHDRAWN

RGD Curation Notes
Note Type Note Reference
gene_evolution 14-3-3 family of proteins is highly conserved among both plants and animals 61782
gene_homology protein shares 100% sequence identity with human ywhag 61782