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Gene: Tbc1d4 (TBC1 domain family, member 4) Rattus norvegicus
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Symbol: Tbc1d4
Name: TBC1 domain family, member 4
Description: Predicted to have GTPase activator activity and Rab GTPase binding activity. Involved in cellular response to insulin stimulus and negative regulation of vesicle fusion. Localizes to the vesicle. Human ortholog(s) of this gene implicated in acanthosis nigricans. Orthologous to human TBC1D4 (TBC1 domain family member 4); PARTICIPATES IN altered insulin responsive facilitative sugar transporter mediated glucose transport pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; Rab family mediated signaling pathway; INTERACTS WITH (S)-colchicine; 6-propyl-2-thiouracil; arotinoid acid.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC306117; LOW QUALITY PROTEIN: TBC1 domain family member 4; RGD1561609; similar to TBC1 domain family member 4; similar to TBC1 domain family member 4 (Akt substrate of 160 kDa) (AS160); TBC1 domain family member 4
Orthologs:
Homo sapiens (human) : TBC1D4 (TBC1 domain family member 4)  HGNC  Alliance
Mus musculus (house mouse) : Tbc1d4 (TBC1 domain family, member 4)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tbc1d4 (TBC1 domain family member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : TBC1D4 (TBC1 domain family member 4)
Canis lupus familiaris (dog) : TBC1D4 (TBC1 domain family member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tbc1d4 (TBC1 domain family member 4)
Sus scrofa (pig) : TBC1D4 (TBC1 domain family member 4)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01585,927,978 - 86,105,829 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01589,695,614 - 89,871,879 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41585,359,159 - 85,561,229 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1577,452,014 - 77,628,396 (-)NCBICelera
Cytogenetic Map15q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Tbc1d4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1561609
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.