Gene: Pole (DNA polymerase epsilon, catalytic subunit) Rattus norvegicus
Symbol: Pole
Name: DNA polymerase epsilon, catalytic subunit
Description: ENCODES a protein that exhibits DNA-directed DNA polymerase activity; chromatin binding (ortholog); DNA binding (ortholog); INVOLVED IN DNA biosynthetic process; embryonic organ development; base-excision repair, gap-filling (ortholog); PARTICIPATES IN nucleotide excision repair pathway; base excision repair pathway; DNA replication pathway; ASSOCIATED WITH breast cancer (ortholog); Breast Neoplasms (ortholog); colon cancer (ortholog); FOUND IN epsilon DNA polymerase complex (ortholog); nucleoplasm (ortholog); nucleus (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 6-propyl-2-thiouracil; acrylamide
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA polymerase epsilon; DNA polymerase epsilon catalytic subunit A; DNA-directed DNA polymerase epsilon; POLE1; Pole_mapped; polymerase (DNA directed), epsilon; polymerase (DNA directed), epsilon (mapped); polymerase (DNA directed), epsilon, catalytic subunit; polymerase (DNA) epsilon, catalytic subunit
Homo sapiens (human) : POLE (DNA polymerase epsilon, catalytic subunit)  HGNC  Alliance
Mus musculus (house mouse) : Pole (polymerase (DNA directed), epsilon)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pole (DNA polymerase epsilon, catalytic subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : POLE (DNA polymerase epsilon, catalytic subunit)
Canis lupus familiaris (dog) : POLE (DNA polymerase epsilon, catalytic subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pole (DNA polymerase epsilon, catalytic subunit)
Sus scrofa (pig) : POLE (DNA polymerase epsilon, catalytic subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01252,403,533 - 52,452,075 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01254,138,907 - 54,187,430 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41246,491,498 - 46,539,988 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1247,901,862 - 47,950,299 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pole
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1594540
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2019-01-30
Status: ACTIVE