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Gene: Pole (DNA polymerase epsilon, catalytic subunit) Rattus norvegicus
Symbol: Pole
Name: DNA polymerase epsilon, catalytic subunit
RGD ID: 1594540
Description: Exhibits DNA-directed DNA polymerase activity. Involved in DNA biosynthetic process and embryonic organ development. Predicted to localize to epsilon DNA polymerase complex; nucleoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human POLE (DNA polymerase epsilon, catalytic subunit); PARTICIPATES IN nucleotide excision repair pathway; base excision repair pathway; DNA replication pathway; INTERACTS WITH (+)-schisandrin B; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA polymerase epsilon; DNA polymerase epsilon catalytic subunit A; DNA-directed DNA polymerase epsilon; POLE1; Pole_mapped; polymerase (DNA directed), epsilon; polymerase (DNA directed), epsilon (mapped); polymerase (DNA directed), epsilon, catalytic subunit; polymerase (DNA) epsilon, catalytic subunit
Homo sapiens (human) : POLE (DNA polymerase epsilon, catalytic subunit)  HGNC  Alliance
Mus musculus (house mouse) : Pole (polymerase (DNA directed), epsilon)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pole (DNA polymerase epsilon, catalytic subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : POLE (DNA polymerase epsilon, catalytic subunit)
Canis lupus familiaris (dog) : POLE (DNA polymerase epsilon, catalytic subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pole (DNA polymerase epsilon, catalytic subunit)
Sus scrofa (pig) : POLE (DNA polymerase epsilon, catalytic subunit)
Chlorocebus sabaeus (African green monkey) : POLE (DNA polymerase epsilon, catalytic subunit)
Heterocephalus glaber (naked mole-rat) : Pole (DNA polymerase epsilon, catalytic subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01252,403,533 - 52,452,075 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1252,403,529 - 52,452,040 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01254,138,907 - 54,187,430 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41246,491,498 - 46,539,988 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1247,901,862 - 47,950,299 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Pole
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1594540
Created: 2006-11-20
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.