Tmed2 (transmembrane p24 trafficking protein 2) - Rat Genome Database

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Gene: Tmed2 (transmembrane p24 trafficking protein 2) Rattus norvegicus
Analyze
Symbol: Tmed2
Name: transmembrane p24 trafficking protein 2
RGD ID: 69243
Description: Predicted to enable frizzled binding activity and smoothened binding activity. Predicted to be involved in several processes, including labyrinthine layer blood vessel development; maternal placenta development; and negative regulation of GTPase activity. Predicted to act upstream of or within several processes, including PERK-mediated unfolded protein response; chordate embryonic development; and regulation of signal transduction. Located in COPI-coated vesicle and zymogen granule membrane. Orthologous to human TMED2 (transmembrane p24 trafficking protein 2); INTERACTS WITH 2-ethoxyethanol; 2-methoxyethanol; 5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: coated vesicle membrane protein; COPI-coated vesicle membrane protein p24; membrane protein p24A; MGC72390; p24 family protein beta-1; p24beta1; RNP21.4; Rnp24; transmembrane emp24 domain trafficking protein 2; transmembrane emp24 domain-containing protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,713,522 - 37,722,606 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1237,713,529 - 37,722,606 (-)EnsemblGRCr8
mRatBN7.21232,052,542 - 32,061,628 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1232,052,543 - 32,071,903 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1233,231,743 - 33,240,850 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,843,066 - 33,852,174 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,894,932 - 32,904,047 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01237,471,259 - 37,480,344 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1237,471,260 - 37,480,297 (-)Ensemblrn6Rnor6.0
Rnor_5.01239,342,087 - 39,351,163 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41233,165,291 - 33,174,326 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1233,742,602 - 33,751,640 (-)NCBICelera
RGSC_v3.11233,028,678 - 33,037,714 (-)NCBI
Cytogenetic Map12q15NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2-ethoxyethanol  (EXP)
2-methoxyethanol  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acrolein  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
alpha-pinene  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsenite(3-)  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
carbon nanotube  (ISO)
chloropicrin  (ISO)
clofibrate  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cypermethrin  (EXP)
dibenzo[a,l]pyrene  (ISO)
dimethylarsinous acid  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
erlotinib hydrochloride  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
hypochlorous acid  (ISO)
ivermectin  (ISO)
L-ethionine  (EXP)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
monocrotaline  (ISO)
N-nitrosodimethylamine  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
omeprazole  (EXP)
ozone  (EXP,ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
pinosylvin  (ISO)
pirinixic acid  (EXP)
pyrimidifen  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium chloride  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trans-pinosylvin  (ISO)
tunicamycin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
allantois development  (IEA,ISO)
branching involved in labyrinthine layer morphogenesis  (IEA,ISO)
chorion development  (IEA,ISO)
dorsal/ventral neural tube patterning  (IEA)
embryonic morphogenesis  (IEA,ISO)
embryonic placenta development  (IEA,ISO)
endoplasmic reticulum membrane organization  (IEA,ISO)
endoplasmic reticulum organization  (IEA,ISO)
endoplasmic reticulum to Golgi vesicle-mediated transport  (IBA)
Golgi organization  (IBA,ISO,ISS)
heart looping  (IEA,ISO)
in utero embryonic development  (IEA,ISO)
inflammatory response  (IEA,ISO)
intracellular protein localization  (IEA,ISO)
intracellular protein transport  (IBA,ISO,NAS)
labyrinthine layer blood vessel development  (IEA,ISO)
maintenance of protein localization in organelle  (IEA,ISO)
maternal placenta development  (IEA,ISO)
multicellular organism growth  (IEA,ISO)
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation  (ISO)
negative regulation of GTPase activity  (ISO,ISS)
negative regulation of protein localization to plasma membrane  (IEA,ISO)
negative regulation of smoothened signaling pathway  (IEA,ISO)
neural tube closure  (IEA,ISO)
PERK-mediated unfolded protein response  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
post-anal tail morphogenesis  (IEA,ISO)
protein localization to plasma membrane  (ISO,ISS)
protein secretion  (IEA,ISO)
protein transport  (IEA)
regulation of SREBP signaling pathway  (IEA,ISO)
somite rostral/caudal axis specification  (IEA,ISO)
somitogenesis  (IEA,ISO)
vesicle targeting  (NAS)
vesicle-mediated transport  (IEA)

Molecular Function
frizzled binding  (IEA,ISO)
protein binding  (IPI,ISO)
smoothened binding  (IEA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Golgi matrix proteins interact with p24 cargo receptors and aid their efficient retention in the Golgi apparatus. Barr FA, etal., J Cell Biol. 2001 Dec 10;155(6):885-91. Epub 2001 Dec 10.
2. Tmp21 and p24A, two type I proteins enriched in pancreatic microsomal membranes, are members of a protein family involved in vesicular trafficking. Blum R, etal., J Biol Chem 1996 Jul 19;271(29):17183-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. p24 and p23, the major transmembrane proteins of COPI-coated transport vesicles, form hetero-oligomeric complexes and cycle between the organelles of the early secretory pathway. Gommel D, etal., FEBS Lett. 1999 Mar 26;447(2-3):179-85.
5. p24A, a type I transmembrane protein, controls ARF1-dependent resensitization of protease-activated receptor-2 by influence on receptor trafficking. Luo W, etal., J Biol Chem. 2007 Oct 12;282(41):30246-55. Epub 2007 Aug 10.
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:9472029   PMID:10761932   PMID:11748249   PMID:12237308   PMID:12477932   PMID:15489334   PMID:20178780   PMID:20361938   PMID:20427317   PMID:25002582   PMID:28797121  


Genomics

Comparative Map Data
Tmed2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81237,713,522 - 37,722,606 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1237,713,529 - 37,722,606 (-)EnsemblGRCr8
mRatBN7.21232,052,542 - 32,061,628 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1232,052,543 - 32,071,903 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1233,231,743 - 33,240,850 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01233,843,066 - 33,852,174 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01232,894,932 - 32,904,047 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01237,471,259 - 37,480,344 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1237,471,260 - 37,480,297 (-)Ensemblrn6Rnor6.0
Rnor_5.01239,342,087 - 39,351,163 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41233,165,291 - 33,174,326 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1233,742,602 - 33,751,640 (-)NCBICelera
RGSC_v3.11233,028,678 - 33,037,714 (-)NCBI
Cytogenetic Map12q15NCBI
TMED2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812123,584,552 - 123,598,582 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12123,584,526 - 123,598,582 (+)Ensemblhg38GRCh38
GRCh3712124,069,099 - 124,083,129 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612122,635,029 - 122,648,641 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3412122,594,040 - 122,607,561NCBI
Celera12123,665,514 - 123,679,126 (+)NCBICelera
Cytogenetic Map12q24.31NCBI
HuRef12121,030,441 - 121,044,052 (+)NCBIHuRef
CHM1_112123,890,022 - 123,903,633 (+)NCBICHM1_1
T2T-CHM13v2.012123,583,417 - 123,597,447 (+)NCBIT2T-CHM13v2.0
Tmed2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395124,678,835 - 124,688,566 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5124,678,758 - 124,688,569 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385124,540,791 - 124,550,503 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5124,540,695 - 124,550,506 (+)Ensemblmm10GRCm38
MGSCv375124,990,800 - 125,000,512 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365124,801,409 - 124,811,121 (+)NCBIMGSCv36mm8
Celera5121,616,969 - 121,626,684 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map563.65NCBI
Tmed2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554825,404,739 - 5,415,243 (-)Ensembl
ChiLan1.0NW_0049554825,404,739 - 5,415,243 (-)NCBIChiLan1.0ChiLan1.0
TMED2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210131,656,040 - 131,673,075 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112131,655,269 - 131,669,897 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012121,169,915 - 121,183,524 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112125,397,391 - 125,410,799 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12125,397,391 - 125,410,794 (+)EnsemblpanPan2panpan1.1
TMED2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1266,039,046 - 6,047,490 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl266,039,405 - 6,047,459 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha266,200,941 - 6,210,349 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0266,288,140 - 6,297,554 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl266,287,725 - 6,297,549 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1266,221,613 - 6,231,022 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0266,314,000 - 6,323,406 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0266,267,212 - 6,276,621 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmed2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118158,247,895 - 158,256,138 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365581,223,114 - 1,231,479 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365581,223,114 - 1,258,699 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMED2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1429,390,335 - 29,400,440 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11429,390,903 - 29,400,454 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21431,082,626 - 31,092,755 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMED2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111118,913,145 - 118,927,335 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11118,913,078 - 118,928,281 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037126,348,858 - 126,363,072 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmed2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474723,389,262 - 23,399,955 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474723,389,262 - 23,399,962 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmed2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11629,322,546 - 29,331,540 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmed2
76 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:641
Count of miRNA genes:287
Interacting mature miRNAs:359
Transcripts:ENSRNOT00000001397
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12138687564Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)12138635130Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122977552242298555Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)123424347543352593Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
7387292Kidm42Kidney mass QTL 423.030.0004kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)12141361854Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)122963663737764351Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat

Markers in Region
RH125644  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21232,052,579 - 32,052,813 (+)MAPPERmRatBN7.2
Rnor_6.01237,471,297 - 37,471,530NCBIRnor6.0
Rnor_5.01239,342,125 - 39,342,358UniSTSRnor5.0
RGSC_v3.41233,165,326 - 33,165,559UniSTSRGSC3.4
Celera1233,742,637 - 33,742,870UniSTS
Cytogenetic Map12q15UniSTS
RH124557  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21232,052,572 - 32,052,747 (+)MAPPERmRatBN7.2
Rnor_6.01237,471,290 - 37,471,464NCBIRnor6.0
Rnor_5.01239,342,118 - 39,342,292UniSTSRnor5.0
RGSC_v3.41233,165,319 - 33,165,493UniSTSRGSC3.4
Celera1233,742,630 - 33,742,804UniSTS
Cytogenetic Map12q15UniSTS
Tmed2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2757,769,129 - 57,769,525 (+)MAPPERmRatBN7.2
Rnor_6.0764,327,639 - 64,328,034NCBIRnor6.0
Rnor_5.0764,548,640 - 64,549,035UniSTSRnor5.0
Celera754,951,202 - 54,951,597UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map12q15UniSTS
Tmed2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2757,769,182 - 57,769,564 (+)MAPPERmRatBN7.2
Rnor_6.0764,327,692 - 64,328,073NCBIRnor6.0
Rnor_5.0764,548,693 - 64,549,074UniSTSRnor5.0
Celera754,951,255 - 54,951,636UniSTS
Cytogenetic Map7q22UniSTS
Cytogenetic Map12q15UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001397   ⟹   ENSRNOP00000001397
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1237,713,529 - 37,722,606 (-)Ensembl
mRatBN7.2 Ensembl1232,052,543 - 32,071,903 (-)Ensembl
Rnor_6.0 Ensembl1237,471,260 - 37,480,297 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105841   ⟹   ENSRNOP00000077165
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1237,713,529 - 37,722,606 (-)Ensembl
mRatBN7.2 Ensembl1232,052,543 - 32,071,903 (-)Ensembl
RefSeq Acc Id: NM_001393805   ⟹   NP_001380734
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81237,713,522 - 37,722,606 (-)NCBI
mRatBN7.21232,052,542 - 32,061,628 (-)NCBI
RefSeq Acc Id: NM_031722   ⟹   NP_113910
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81237,713,522 - 37,722,606 (-)NCBI
mRatBN7.21232,052,542 - 32,061,628 (-)NCBI
Rnor_6.01237,471,262 - 37,480,297 (-)NCBI
Rnor_5.01239,342,087 - 39,351,163 (-)NCBI
RGSC_v3.41233,165,291 - 33,174,326 (-)RGD
Celera1233,742,602 - 33,751,640 (-)RGD
Sequence:
RefSeq Acc Id: NP_113910   ⟸   NM_031722
- Peptide Label: isoform 2 precursor
- UniProtKB: Q63524 (UniProtKB/Swiss-Prot),   A6J0Y7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001397   ⟸   ENSRNOT00000001397
Ensembl Acc Id: ENSRNOP00000077165   ⟸   ENSRNOT00000105841
RefSeq Acc Id: NP_001380734   ⟸   NM_001393805
- Peptide Label: isoform 1 precursor
- UniProtKB: A0A8I5Y5Z9 (UniProtKB/TrEMBL),   A6J0Y8 (UniProtKB/TrEMBL)
Protein Domains
GOLD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63524-F1-model_v2 AlphaFold Q63524 1-201 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698609
Promoter ID:EPDNEW_R9134
Type:multiple initiation site
Name:Tmed2_1
Description:transmembrane p24 trafficking protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01237,480,334 - 37,480,394EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69243 AgrOrtholog
BioCyc Gene G2FUF-19358 BioCyc
Ensembl Genes ENSRNOG00000001053 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001397 ENTREZGENE
  ENSRNOT00000001397.5 UniProtKB/Swiss-Prot
  ENSRNOT00000105841 ENTREZGENE
IMAGE_CLONE IMAGE:5623841 IMAGE-MGC_LOAD
InterPro GOLD_dom UniProtKB/Swiss-Prot
  GOLD_dom_sf UniProtKB/Swiss-Prot
  TMP21-related UniProtKB/Swiss-Prot
KEGG Report rno:65165 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72390 IMAGE-MGC_LOAD
NCBI Gene 65165 ENTREZGENE
PANTHER PTHR22811 UniProtKB/Swiss-Prot
Pfam EMP24_GP25L UniProtKB/Swiss-Prot
PhenoGen Tmed2 PhenoGen
PROSITE GOLD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001053 RatGTEx
SMART EMP24_GP25L UniProtKB/Swiss-Prot
Superfamily-SCOP SSF101576 UniProtKB/Swiss-Prot
TIGR TC206186
UniProt A0A8I5Y5Z9 ENTREZGENE, UniProtKB/TrEMBL
  A6J0Y7 ENTREZGENE, UniProtKB/TrEMBL
  A6J0Y8 ENTREZGENE, UniProtKB/TrEMBL
  Q63524 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-19 Tmed2  transmembrane p24 trafficking protein 2  Tmed2  transmembrane emp24 domain trafficking protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Tmed2  transmembrane emp24 domain trafficking protein 2  Rnp24  coated vesicle membrane protein  Symbol and Name updated 1299863 APPROVED
2002-06-10 Rnp24  coated vesicle membrane protein      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference