Vkorc1l1 (vitamin K epoxide reductase complex, subunit 1-like 1) - Rat Genome Database

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Gene: Vkorc1l1 (vitamin K epoxide reductase complex, subunit 1-like 1) Rattus norvegicus
Analyze
Symbol: Vkorc1l1
Name: vitamin K epoxide reductase complex, subunit 1-like 1
RGD ID: 1303249
Description: Enables vitamin-K-epoxide reductase (warfarin-sensitive) activity. Involved in vitamin K metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of RNA polymerase III complex. Orthologous to human VKORC1L1 (vitamin K epoxide reductase complex subunit 1 like 1); INTERACTS WITH 2,2',5,5'-tetrachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103693015; vitamin K epoxide reductase complex subunit 1-like protein 1; VKORC1-like protein 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21226,717,959 - 26,768,193 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1226,623,976 - 26,768,225 (-)Ensembl
Rnor_6.01230,218,825 - 30,268,990 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl816,287,804 - 16,333,603 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1230,222,701 - 30,268,990 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0816,361,530 - 16,411,734 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41227,764,873 - 27,813,093 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11227,628,088 - 27,676,309 (-)NCBI
Celera1228,435,669 - 28,481,785 (-)NCBICelera
Cytogenetic Map12q12-q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. VKORC1L1, an enzyme rescuing the vitamin K 2,3-epoxide reductase activity in some extrahepatic tissues during anticoagulation therapy. Hammed A, etal., J Biol Chem. 2013 Oct 4;288(40):28733-42. doi: 10.1074/jbc.M113.457119. Epub 2013 Aug 8.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Rost S, etal., Nature 2004 Feb 5;427(6974):537-41.
Additional References at PubMed
PMID:21367861   PMID:24532791  


Genomics

Comparative Map Data
Vkorc1l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21226,717,959 - 26,768,193 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl1226,623,976 - 26,768,225 (-)Ensembl
Rnor_6.01230,218,825 - 30,268,990 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl816,287,804 - 16,333,603 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl1230,222,701 - 30,268,990 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0816,361,530 - 16,411,734 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41227,764,873 - 27,813,093 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11227,628,088 - 27,676,309 (-)NCBI
Celera1228,435,669 - 28,481,785 (-)NCBICelera
Cytogenetic Map12q12-q13NCBI
VKORC1L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38765,865,772 - 65,959,558 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl765,873,074 - 65,959,563 (+)EnsemblGRCh38hg38GRCh38
GRCh37765,338,061 - 65,424,545 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36764,975,692 - 65,057,237 (+)NCBINCBI36hg18NCBI36
Build 34764,782,406 - 64,863,950NCBI
Celera766,693,876 - 66,775,381 (-)NCBI
Cytogenetic Map7q11.21NCBI
HuRef761,525,480 - 61,607,209 (+)NCBIHuRef
CHM1_1765,433,455 - 65,515,064 (+)NCBICHM1_1
T2T-CHM13v2.0767,095,208 - 67,181,682 (+)NCBI
CRA_TCAGchr7v2764,675,776 - 64,757,319 (+)NCBI
Vkorc1l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395129,970,950 - 130,015,533 (+)NCBIGRCm39mm39
GRCm39 Ensembl5129,970,811 - 130,015,533 (+)Ensembl
GRCm385129,942,109 - 129,986,692 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5129,941,970 - 129,986,692 (+)EnsemblGRCm38mm10GRCm38
MGSCv375130,417,983 - 130,458,761 (+)NCBIGRCm37mm9NCBIm37
MGSCv365128,365,952 - 128,407,011 (+)NCBImm8
MGSCv365130,226,816 - 130,267,594 (+)NCBImm8
Celera5126,981,358 - 126,985,732 (+)NCBICelera
Cytogenetic Map5G1.3NCBI
Vkorc1l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554568,356,208 - 8,374,898 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554568,316,107 - 8,374,898 (+)NCBIChiLan1.0ChiLan1.0
VKORC1L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1764,702,962 - 64,720,313 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0760,111,428 - 60,196,412 (-)NCBIMhudiblu_PPA_v0panPan3
VKORC1L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.16661,690 - 728,813 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl6660,365 - 725,756 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha62,362,342 - 2,429,440 (+)NCBI
ROS_Cfam_1.06467,059 - 534,229 (+)NCBI
UMICH_Zoey_3.16410,520 - 477,612 (+)NCBI
UNSW_CanFamBas_1.06404,868 - 471,978 (+)NCBI
UU_Cfam_GSD_1.06575,779 - 642,971 (+)NCBI
Vkorc1l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344126,282,506 - 126,302,445 (+)NCBI
SpeTri2.0NW_0049365437,733,420 - 7,775,691 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VKORC1L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl316,688,898 - 16,764,251 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1316,691,143 - 16,764,097 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2316,941,581 - 17,016,787 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VKORC1L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1281,535,346 - 1,617,484 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607015,030,003 - 15,110,314 (-)NCBIVero_WHO_p1.0
Vkorc1l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247408,322,077 - 8,388,939 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247408,322,329 - 8,388,939 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
RH142529  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21226,725,634 - 26,725,746 (-)MAPPERmRatBN7.2
mRatBN7.21226,725,634 - 26,725,746 (+)MAPPERmRatBN7.2
Rnor_6.01230,226,501 - 30,226,612NCBIRnor6.0
Rnor_6.0816,330,142 - 16,330,253NCBIRnor6.0
Rnor_5.0816,403,949 - 16,404,060UniSTSRnor5.0
Rnor_5.01232,163,437 - 32,163,548UniSTSRnor5.0
RGSC_v3.41227,769,545 - 27,769,656UniSTSRGSC3.4
Celera1228,439,460 - 28,439,571UniSTS
RH 3.4 Map12446.6UniSTS
Cytogenetic Map12q13UniSTS
UniSTS:489243  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.4814,632,003 - 14,632,641UniSTSRGSC3.4
Celera815,750,715 - 15,751,353UniSTS
Cytogenetic Map8q12UniSTS
Cytogenetic Map12q13UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)122423477731894213Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:46
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000024691
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 4 26 16 9 16 1 1 74 18 33 10 1
Low 2 39 31 25 10 25 7 10 17 8 1 7
Below cutoff 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024691   ⟹   ENSRNOP00000024691
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl816,287,804 - 16,333,603 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000079546   ⟹   ENSRNOP00000070920
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1230,222,701 - 30,268,990 (-)Ensembl
RefSeq Acc Id: NM_203338   ⟹   NP_976083
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21226,721,835 - 26,768,114 (-)NCBI
Rnor_6.01230,222,701 - 30,268,990 (-)NCBI
Rnor_5.0816,361,530 - 16,411,734 (+)NCBI
RGSC_v3.41227,764,873 - 27,813,093 (-)RGD
Celera1228,435,669 - 28,481,785 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598418   ⟹   XP_017453907
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21226,717,959 - 26,768,193 (-)NCBI
Rnor_6.01230,218,825 - 30,268,983 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039089657   ⟹   XP_038945585
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21226,717,959 - 26,768,191 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_976083   ⟸   NM_203338
- UniProtKB: Q6TEK3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017453907   ⟸   XM_017598418
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000070920   ⟸   ENSRNOT00000079546
RefSeq Acc Id: XP_038945585   ⟸   XM_039089657
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000024691   ⟸   ENSRNOT00000024691
Protein Domains
RPOL4c

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6TEK3-F1-model_v2 AlphaFold Q6TEK3 1-176 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
8 16361655 16361656 A C snv FHH/EurMcwi (MCW), GH/OmrMcwi (MCW), KFRS3B/Kyo (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU), DOB/Oda (KyushuU), F344/Jcl (KyushuU), LEC/Tj (KyushuU), SBN/Ygl (MCW), F344/DuCrlCrlj (KyushuU), BDIX/NemOda (KyushuU), ZFDM (KyushuU), SR/JrHsd (MCW), IS/Kyo (KyushuU), BUF/MNa (KyushuU), NIG-III/Hok (KyushuU), LE/Stm (KyushuU), HTX/Kyo (KyushuU), F344/NSlc (KyushuU), BN/SsNSlc (KyushuU), RCS/Kyo (KyushuU), IS-Tlk/Kyo (KyushuU), F344/Stm (KyushuU), HWY/Slc (KyushuU)
8 16361686 16361687 G C snv ZFDM (KyushuU), LEC/Tj (KyushuU), LE/Stm (KyushuU), BUF/MNa (KyushuU)
8 16361719 16361720 G A snv LE/Stm (KyushuU), LEC/Tj (KyushuU)
8 16361750 16361751 G C snv GH/OmrMcwi (MCW), SBN/Ygl (MCW), IS/Kyo (KyushuU), BUF/MNa (KyushuU), NIG-III/Hok (KyushuU), F344/DuCrlCrlj (KyushuU), LE/Stm (KyushuU), HTX/Kyo (KyushuU), F344/NSlc (KyushuU), RCS/Kyo (KyushuU), IS-Tlk/Kyo (KyushuU), F344/Stm (KyushuU), LEC/Tj (KyushuU), F344/Jcl (KyushuU), BDIX/NemOda (KyushuU), DOB/Oda (KyushuU), ZFDM (KyushuU), ZF (KyushuU), COP/CrCrl (MCW & UW), FHL/EurMcwi (MCW), SBH/Ygl (MCW), SS/JrHsdMcwi (MCW)
8 16407238 16407239 C T snv ZFDM (KyushuU), BDIX.Cg-Tal/NemOda (KyushuU), BN/SsNSlc (KyushuU)
8 16407312 16407313 A T snv BUF/MNa (KyushuU), ZFDM (KyushuU)
8 16407327 16407328 T C snv RCS/Kyo (KyushuU), F344/Stm (KyushuU)
8 16407352 16407353 A C snv NIG-III/Hok (KyushuU), IS/Kyo (KyushuU), ZF (KyushuU), F344/Jcl (KyushuU), HTX/Kyo (KyushuU), F344/Stm (KyushuU), IS-Tlk/Kyo (KyushuU), RCS/Kyo (KyushuU), LEC/Tj (KyushuU)
8 16407376 16407377 C T snv NIG-III/Hok (KyushuU), IS/Kyo (KyushuU), LE/Stm (KyushuU), HTX/Kyo (KyushuU), ZF (KyushuU), F344/Jcl (KyushuU), HWY/Slc (KyushuU), F344/Stm (KyushuU), IS-Tlk/Kyo (KyushuU), F344/NSlc (KyushuU), BN/SsNSlc (KyushuU), RCS/Kyo (KyushuU)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303249 AgrOrtholog
BioCyc Gene G2FUF-19512 BioCyc
Ensembl Genes ENSRNOG00000000901 Ensembl, UniProtKB/TrEMBL
  ENSRNOG00000018291 Ensembl
  ENSRNOG00000058750 Ensembl
Ensembl Protein ENSRNOP00000001202.6 UniProtKB/TrEMBL
  ENSRNOP00000070920.2 UniProtKB/TrEMBL
  ENSRNOP00000073151.2 UniProtKB/TrEMBL
  ENSRNOP00000077096.1 UniProtKB/TrEMBL
  ENSRNOP00000078246.1 UniProtKB/TrEMBL
  ENSRNOP00000083764.1 UniProtKB/TrEMBL
  ENSRNOP00000095977.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000001202.8 UniProtKB/TrEMBL
  ENSRNOT00000079176.2 UniProtKB/TrEMBL
  ENSRNOT00000079546.2 UniProtKB/TrEMBL
  ENSRNOT00000104408.1 UniProtKB/TrEMBL
  ENSRNOT00000109091.1 UniProtKB/TrEMBL
  ENSRNOT00000112952.1 UniProtKB/TrEMBL
  ENSRNOT00000119276.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.40 UniProtKB/TrEMBL
  1.20.1440.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro HRDC-like_sf UniProtKB/TrEMBL
  RNA_pol_Rpb4/RPC9_core UniProtKB/TrEMBL
  RPB4/RPC9 UniProtKB/TrEMBL
  Rpb4/RPC9_sf UniProtKB/TrEMBL
  RPC9 UniProtKB/TrEMBL
  VKOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VKOR_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VKORC1/VKORC1L1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:399684 UniProtKB/Swiss-Prot
NCBI Gene 399684 ENTREZGENE
PANTHER PTHR14519 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15561 UniProtKB/TrEMBL
Pfam RNA_pol_Rpb4 UniProtKB/TrEMBL
  VKOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Vkorc1l1 PhenoGen
SMART RPOL4c UniProtKB/TrEMBL
  VKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47819 UniProtKB/TrEMBL
UniProt A0A0G2K4S3_RAT UniProtKB/TrEMBL
  A0A8I5XVS4_RAT UniProtKB/TrEMBL
  A0A8I5ZKI4_RAT UniProtKB/TrEMBL
  A0A8I5ZWM1_RAT UniProtKB/TrEMBL
  A0A8I6APU2_RAT UniProtKB/TrEMBL
  A0A8L2UQ18_RAT UniProtKB/TrEMBL
  F8WFG9_RAT UniProtKB/TrEMBL
  Q6TEK3 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Vkorc1l1  vitamin K epoxide reductase complex, subunit 1-like 1  LOC103693015  vitamin K epoxide reductase complex subunit 1-like protein 1  Data Merged 737654 PROVISIONAL
2014-08-25 LOC103693015  vitamin K epoxide reductase complex subunit 1-like protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Vkorc1l1  vitamin K epoxide reductase complex, subunit 1-like 1      Symbol and Name status set to approved 1299863 APPROVED
2005-07-14 Vkorc1l1  vitamin K epoxide reductase complex, subunit 1-like 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_drugs mutations are associated with warfarin-resistant strains 1303972
gene_product putative subunit of vitamin K epoxide reductase complex required for blood coagulation 1303972