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Gene: Ankle2 (ankyrin repeat and LEM domain containing 2) Rattus norvegicus
Symbol: Ankle2
Name: ankyrin repeat and LEM domain containing 2
Description: Predicted to have protein phosphatase 2A binding activity. Predicted to be involved in several processes, including mitotic nuclear envelope reassembly; negative regulation of apoptotic process; and regulation of phosphate metabolic process. Predicted to localize to the integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly 16. Orthologous to human ANKLE2 (ankyrin repeat and LEM domain containing 2); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 2,2',4,4'-Tetrabromodiphenyl ether; acrylamide.
Type: protein-coding
Also known as: Ab2-034; ankyrin repeat and LEM domain-containing protein 2; LEM domain-containing protein 4; liver regeneration-related protein LRRG057; LOC360829; RGD1310191; similar to Ab2-034
Homo sapiens (human) : ANKLE2 (ankyrin repeat and LEM domain containing 2)  HGNC  Alliance
Mus musculus (house mouse) : Ankle2 (ankyrin repeat and LEM domain containing 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ankle2 (ankyrin repeat and LEM domain containing 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ANKLE2 (ankyrin repeat and LEM domain containing 2)
Canis lupus familiaris (dog) : ANKLE2 (ankyrin repeat and LEM domain containing 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ankle2 (ankyrin repeat and LEM domain containing 2)
Sus scrofa (pig) : ANKLE2 (ankyrin repeat and LEM domain containing 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01252,475,862 - 52,507,126 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01254,212,228 - 54,242,961 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41246,563,828 - 46,595,794 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11246,432,677 - 46,462,726 (-)NCBI
Celera1247,974,120 - 48,005,270 (-)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Ankle2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1310191
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.