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Gene: Sh2b3 (SH2B adaptor protein 3) Rattus norvegicus
Symbol: Sh2b3
Name: SH2B adaptor protein 3
Description: Exhibits phosphate ion binding activity. Involved in negative regulation of sprouting angiogenesis and regulation of regulatory T cell differentiation. Predicted to localize to plasma membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in essential thrombocythemia; familial erythrocytosis 1; and myelofibrosis. Orthologous to human SH2B3 (SH2B adaptor protein 3); PARTICIPATES IN erythropoietin signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH 3H-1,2-dithiole-3-thione; bisphenol A; cobalt dichloride.
Type: protein-coding
Also known as: linker of T-cell receptor pathways; Lnk; lymphocyte adapter protein; lymphocyte-specific adapter protein Lnk; SH2B adapter protein 3; signal transduction protein Lnk
Homo sapiens (human) : SH2B3 (SH2B adaptor protein 3)  HGNC  Alliance
Mus musculus (house mouse) : Sh2b3 (SH2B adaptor protein 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh2b3 (SH2B adaptor protein 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SH2B3 (SH2B adaptor protein 3)
Canis lupus familiaris (dog) : SH2B3 (SH2B adaptor protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh2b3 (SH2B adaptor protein 3)
Sus scrofa (pig) : SH2B3 (SH2B adaptor protein 3)
Chlorocebus sabaeus (African green monkey) : SH2B3 (SH2B adaptor protein 3)
Heterocephalus glaber (naked mole-rat) : Sh2b3 (SH2B adaptor protein 3)
more info ...
Allele / Splice: Sh2b3em1Mcwi   Sh2b3em2Mcwi  
Genetic Models: SS-Sh2b3em1Mcwi SS-Sh2b3em2Mcwi SS-Sh2b3em2Mcwi-/- SS-Sh2b3em1Mcwi-/+ SS-Sh2b3em1Mcwi-/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01240,261,990 - 40,265,757 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,244,081 - 40,265,757 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,132,947 - 42,136,714 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,954,679 - 35,958,446 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11235,818,066 - 35,821,834 (+)NCBI
Celera1236,414,671 - 36,418,438 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Sh2b3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68411
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.