Sh2b3 (SH2B adaptor protein 3) - Rat Genome Database

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Gene: Sh2b3 (SH2B adaptor protein 3) Rattus norvegicus
Analyze
Symbol: Sh2b3
Name: SH2B adaptor protein 3
RGD ID: 68411
Description: Enables phosphate ion binding activity. Involved in negative regulation of sprouting angiogenesis and regulation of regulatory T cell differentiation. Used to study hypertension. Human ortholog(s) of this gene implicated in colorectal cancer; essential thrombocythemia; familial erythrocytosis 1; myelofibrosis; and type 1 diabetes mellitus. Orthologous to human SH2B3 (SH2B adaptor protein 3); PARTICIPATES IN erythropoietin signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: linker of T-cell receptor pathways; Lnk; lymphocyte adapter protein; lymphocyte-specific adapter protein Lnk; SH2B adapter protein 3; signal transduction protein Lnk
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Sh2b3em1Mcwi   Sh2b3em2Mcwi  
Genetic Models: SS-Sh2b3em1Mcwi SS-Sh2b3em2Mcwi SS-Sh2b3em2Mcwi-/- SS-Sh2b3em1Mcwi-/+ SS-Sh2b3em1Mcwi-/-
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21234,731,934 - 34,753,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,731,911 - 34,753,616 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1235,904,822 - 35,926,500 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,516,036 - 36,537,714 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,568,505 - 35,590,183 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,261,990 - 40,265,757 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,244,081 - 40,265,757 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,132,947 - 42,136,714 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,954,679 - 35,958,446 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11235,818,066 - 35,821,834 (+)NCBI
Celera1236,414,671 - 36,418,438 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-methylcholine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
hexachlorobenzene  (EXP)
indometacin  (ISO)
inulin  (ISO)
isobutanol  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
prothioconazole  (ISO)
quercetin  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
Soman  (EXP)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis. Flister MJ, etal., Circ Cardiovasc Genet. 2015 Apr;8(2):294-304. doi: 10.1161/CIRCGENETICS.114.000527. Epub 2015 Jan 27.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Genetic analysis of adult-onset autoimmune diabetes. Howson JM, etal., Diabetes. 2011 Oct;60(10):2645-53. Epub 2011 Aug 26.
4. Cloning and characterization of Lnk, a signal transduction protein that links T-cell receptor activation signal to phospholipase C gamma 1, Grb2, and phosphatidylinositol 3-kinase. Huang X, etal., Proc Natl Acad Sci U S A 1995 Dec 5;92(25):11618-22.
5. Rat messenger RNA for the retinal pigment epithelium-specific protein RPE65 gradually accumulates in two weeks from late embryonic days. Manes G, etal., FEBS Lett 1998 Feb 20;423(2):133-7.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. LNK protein: Low expression in human colorectal carcinoma and relationship with tumor invasion. Pan J, etal., Biomed Pharmacother. 2020 Jan;121:109467. doi: 10.1016/j.biopha.2019.109467. Epub 2019 Nov 6.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
12. Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases. Plagnol V, etal., PLoS Genet. 2011 Aug;7(8):e1002216. doi: 10.1371/journal.pgen.1002216. Epub 2011 Aug 4.
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Mutation of SH2B3 (LNK), a genome-wide association study candidate for hypertension, attenuates Dahl salt-sensitive hypertension via inflammatory modulation. Rudemiller NP, etal., Hypertension. 2015 May;65(5):1111-7. doi: 10.1161/HYPERTENSIONAHA.114.04736. Epub 2015 Mar 16.
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Recurrent Coding Sequence Variation Explains Only A Small Fraction of the Genetic Architecture of Colorectal Cancer. Timofeeva MN, etal., Sci Rep. 2015 Nov 10;5:16286. doi: 10.1038/srep16286.
19. Creation and preliminary characterization of a leptin knockout rat. Vaira S, etal., Endocrinology. 2012 Nov;153(11):5622-8. doi: 10.1210/en.2012-1462. Epub 2012 Sep 4.
Additional References at PubMed
PMID:11805142   PMID:14612394   PMID:15337790   PMID:20404132   PMID:22028877   PMID:26101343   PMID:27430239   PMID:31799683  


Genomics

Comparative Map Data
Sh2b3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21234,731,934 - 34,753,617 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1234,731,911 - 34,753,616 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1235,904,822 - 35,926,500 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,516,036 - 36,537,714 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01235,568,505 - 35,590,183 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,261,990 - 40,265,757 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,244,081 - 40,265,757 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01242,132,947 - 42,136,714 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,954,679 - 35,958,446 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11235,818,066 - 35,821,834 (+)NCBI
Celera1236,414,671 - 36,418,438 (+)NCBICelera
Cytogenetic Map12q16NCBI
SH2B3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812111,404,730 - 111,451,623 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12111,405,923 - 111,451,623 (+)EnsemblGRCh38hg38GRCh38
GRCh3712111,843,727 - 111,889,427 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612110,328,135 - 110,373,810 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412110,306,471 - 110,352,146NCBI
Celera12111,470,186 - 111,515,861 (+)NCBICelera
Cytogenetic Map12q24.12NCBI
HuRef12108,858,506 - 108,903,968 (+)NCBIHuRef
CHM1_112111,811,712 - 111,857,391 (+)NCBICHM1_1
T2T-CHM13v2.012111,385,588 - 111,432,181 (+)NCBIT2T-CHM13v2.0
Sh2b3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395121,953,544 - 121,975,706 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5121,953,551 - 121,975,709 (-)EnsemblGRCm39 Ensembl
GRCm385121,815,481 - 121,837,645 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5121,815,488 - 121,837,646 (-)EnsemblGRCm38mm10GRCm38
MGSCv375122,267,224 - 122,286,810 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365122,077,832 - 122,097,418 (-)NCBIMGSCv36mm8
Celera5118,907,377 - 118,942,299 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map561.99NCBI
Sh2b3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554828,096,160 - 8,097,765 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554828,079,905 - 8,100,791 (+)NCBIChiLan1.0ChiLan1.0
SH2B3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan112119,467,715 - 119,514,391 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012108,977,344 - 109,024,029 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112112,371,797 - 112,418,746 (+)NCBIpanpan1.1PanPan1.1panPan2
SH2B3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1269,033,851 - 9,073,095 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl269,005,281 - 9,070,204 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha269,206,973 - 9,235,670 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0269,303,831 - 9,332,542 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl269,292,891 - 9,329,651 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1269,259,823 - 9,288,511 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0269,322,052 - 9,350,491 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0269,275,536 - 9,304,251 (+)NCBIUU_Cfam_GSD_1.0
Sh2b3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118155,352,543 - 155,375,181 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365584,104,534 - 4,123,869 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365584,103,898 - 4,126,883 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SH2B3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1432,623,286 - 32,664,606 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11432,623,286 - 32,664,606 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21434,618,865 - 34,660,151 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SH2B3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111106,657,601 - 106,703,940 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11106,670,685 - 106,700,619 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037138,394,084 - 138,440,116 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sh2b3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474720,730,751 - 20,759,625 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474720,729,142 - 20,759,631 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sh2b3
29 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1318
Count of miRNA genes:274
Interacting mature miRNAs:359
Transcripts:ENSRNOT00000030583, ENSRNOT00000073611, ENSRNOT00000075776
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)122806443340130419Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)122806443345899022Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)122806443346669029Rat
1331787Rf41Renal function QTL 412.998kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)122806455740218380Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)122860752637691617Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123210317445899022Rat


Genetic Models
This gene Sh2b3 is modified in the following models/strains:
SS-Sh2b3em1Mcwi     SS-Sh2b3em2Mcwi     SS-Sh2b3em2Mcwi-/-     SS-Sh2b3em1Mcwi-/+     SS-Sh2b3em1Mcwi-/-    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 43 50 34 19 34 6 9 52 34 41 11 6
Low 1 7 7 7 2 2 22 1 2
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000030583   ⟹   ENSRNOP00000038125
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1234,731,911 - 34,753,616 (+)Ensembl
Rnor_6.0 Ensembl1240,244,081 - 40,265,757 (+)Ensembl
RefSeq Acc Id: NM_001402348   ⟹   NP_001389277
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21234,731,934 - 34,753,617 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000038125   ⟸   ENSRNOT00000030583
RefSeq Acc Id: NP_001389277   ⟸   NM_001402348
- UniProtKB: D4ABY6 (UniProtKB/TrEMBL),   A6J1C7 (UniProtKB/TrEMBL),   A6J1C5 (UniProtKB/TrEMBL),   A6J1C6 (UniProtKB/TrEMBL)
Protein Domains
SH2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P50745-F1-model_v2 AlphaFold P50745 1-368 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:68411 AgrOrtholog
BioCyc Gene G2FUF-19221 BioCyc
Ensembl Genes ENSRNOG00000028198 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030583 ENTREZGENE
  ENSRNOT00000030583.5 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  6.10.140.110 UniProtKB/TrEMBL
InterPro PH-like_dom_sf UniProtKB/TrEMBL
  Phe_ZIP UniProtKB/TrEMBL
  Phe_ZIP_sf UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2B3_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:58838 UniProtKB/Swiss-Prot
NCBI Gene 58838 ENTREZGENE
PANTHER PTHR10872 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10872:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Phe_ZIP UniProtKB/TrEMBL
  SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Sh2b3 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000028198 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF109805 UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC229436
UniProt A6J1C5 ENTREZGENE, UniProtKB/TrEMBL
  A6J1C6 ENTREZGENE, UniProtKB/TrEMBL
  A6J1C7 ENTREZGENE, UniProtKB/TrEMBL
  D4ABY6 ENTREZGENE
  P50745 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary D4ABY6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Sh2b3  SH2B adaptor protein 3  Lnk  linker of T-cell receptor pathways  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Lnk  linker of T-cell receptor pathways      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a Src homology 2 (SH2) domain and a tyrosine phosphorylation site 68272
gene_function interacts with phospholipase C gamma 1, phosphatidylinositol 3-kinase, and Grb-2 in activated T-cells 68272