Gene: Sh2b3 (SH2B adaptor protein 3) Rattus norvegicus
Symbol: Sh2b3
Name: SH2B adaptor protein 3
Description: ENCODES a protein that exhibits phosphate ion binding; protein-containing complex binding; INVOLVED IN negative regulation of sprouting angiogenesis; regulation of regulatory T cell differentiation; cell differentiation (ortholog); PARTICIPATES IN erythropoietin signaling pathway; neurotrophic factor signaling pathway; ASSOCIATED WITH decreased susceptibility to hypertension; decreased urine albumin level; decreased ventricle muscle contractility; ASSOCIATED WITH albuminuria; Hypertension; Myocardial Reperfusion Injury; FOUND IN intracellular (inferred); INTERACTS WITH 3H-1,2-dithiole-3-thione; bisphenol A; cobalt dichloride
Type: protein-coding
Also known as: linker of T-cell receptor pathways; Lnk; lymphocyte adapter protein; lymphocyte-specific adapter protein Lnk; SH2B adapter protein 3; signal transduction protein Lnk
Homo sapiens (human) : SH2B3 (SH2B adaptor protein 3)  HGNC  Alliance
Mus musculus (house mouse) : Sh2b3 (SH2B adaptor protein 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh2b3 (SH2B adaptor protein 3)
Canis lupus familiaris (dog) : SH2B3 (SH2B adaptor protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh2b3 (SH2B adaptor protein 3)
more info ...
Allele / Splice: Sh2b3em1Mcwi   Sh2b3em2Mcwi  
Genetic Models: SS-Sh2b3em1Mcwi SS-Sh2b3em2Mcwi SS-Sh2b3em2Mcwi-/- SS-Sh2b3em1Mcwi-/+ SS-Sh2b3em1Mcwi-/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01240,261,990 - 40,265,757 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01242,132,947 - 42,136,714 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,954,679 - 35,958,446 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11235,818,066 - 35,821,834 (+)NCBI
Celera1236,414,671 - 36,418,438 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
QTLs in Region (Rnor_6.0)
Genetic Models
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Sh2b3
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68411
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2018-03-13
Status: ACTIVE