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Pathways
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Gene: Sh2b3 (SH2B adaptor protein 3) Rattus norvegicus
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Symbol: Sh2b3
Name: SH2B adaptor protein 3
Description: Exhibits phosphate ion binding activity. Involved in negative regulation of sprouting angiogenesis and regulation of regulatory T cell differentiation. Predicted to localize to the plasma membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in essential thrombocythemia; familial erythrocytosis 1; and myelofibrosis. Orthologous to human SH2B3 (SH2B adaptor protein 3); PARTICIPATES IN erythropoietin signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH 3H-1,2-dithiole-3-thione; bisphenol A; cobalt dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: linker of T-cell receptor pathways; Lnk; lymphocyte adapter protein; lymphocyte-specific adapter protein Lnk; SH2B adapter protein 3; signal transduction protein Lnk
Orthologs:
Homo sapiens (human) : SH2B3 (SH2B adaptor protein 3)  HGNC  Alliance
Mus musculus (house mouse) : Sh2b3 (SH2B adaptor protein 3)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh2b3 (SH2B adaptor protein 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SH2B3 (SH2B adaptor protein 3)
Canis lupus familiaris (dog) : SH2B3 (SH2B adaptor protein 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh2b3 (SH2B adaptor protein 3)
Sus scrofa (pig) : SH2B3 (SH2B adaptor protein 3)
more info ...
Allele / Splice: Sh2b3em1Mcwi   Sh2b3em2Mcwi  
Genetic Models: SS-Sh2b3em1Mcwi SS-Sh2b3em2Mcwi SS-Sh2b3em2Mcwi-/- SS-Sh2b3em1Mcwi-/+ SS-Sh2b3em1Mcwi-/-
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01240,261,990 - 40,265,757 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01242,132,947 - 42,136,714 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41235,954,679 - 35,958,446 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11235,818,066 - 35,821,834 (+)NCBI
Celera1236,414,671 - 36,418,438 (+)NCBICelera
Cytogenetic Map12q16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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QTLs in Region (Rnor_6.0)
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Sequence

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Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

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Nomenclature History
RGD Curation Notes
  
More on Sh2b3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 68411
Created: 2001-07-11
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.