Mdh2 (malate dehydrogenase 2) - Rat Genome Database

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Gene: Mdh2 (malate dehydrogenase 2) Rattus norvegicus
Symbol: Mdh2
Name: malate dehydrogenase 2
RGD ID: 619719
Description: Enables L-malate dehydrogenase (NAD+) activity; L-malate dehydrogenase (NADP+) activity; and identical protein binding activity. Involved in NADH metabolic process and malate metabolic process. Located in mitochondrial matrix. Used to study brain ischemia; congestive heart failure; and myocardial infarction. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2); PARTICIPATES IN citric acid cycle pathway; fructose-1,6-bisphosphatase deficiency pathway; fumaric aciduria pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 2,2,2-tetramine.
Type: protein-coding
Previously known as: malate dehydrogenase 2, NAD (mitochondrial); malate dehydrogenase, mitochondrial; Mor1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81226,530,886 - 26,543,841 (-)NCBIGRCr8
mRatBN7.21220,894,269 - 20,907,225 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,894,262 - 20,907,271 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,036,216 - 22,049,189 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,648,634 - 22,661,607 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,715,096 - 21,728,069 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01223,941,451 - 23,954,406 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,941,448 - 23,954,431 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,938,703 - 25,951,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,021,302 - 22,034,257 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11222,008,565 - 22,021,518 (-)NCBI
Celera1222,657,034 - 22,669,988 (-)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (EXP)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2,2-tetramine  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acrolein  (EXP)
acrylamide  (EXP)
amitrole  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
Brodifacoum  (EXP)
caffeine  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
cisplatin  (EXP,ISO)
clobetasol  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
D-gluconic acid  (EXP)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
dinophysistoxin 1  (ISO)
Diosbulbin B  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
etoposide  (ISO)
fenbendazole  (ISO)
fenofibrate  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (EXP,ISO)
FR900359  (ISO)
gedunin  (ISO)
hydrogen peroxide  (EXP)
indometacin  (EXP)
inulin  (ISO)
ivermectin  (ISO)
linalool  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
mitoxantrone  (ISO)
Monobutylphthalate  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
nickel dichloride  (ISO)
nicotine  (EXP)
ouabain  (ISO)
ozone  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
pirinixic acid  (ISO)
Propiverine  (EXP)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
streptozocin  (EXP)
sunitinib  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (ISO)
thimerosal  (ISO)
thiram  (ISO)
tributylstannane  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
trovafloxacin  (EXP)
uranium atom  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
membrane  (ISO)
mitochondrial matrix  (IDA,ISO)
mitochondrion  (IBA,ISO)


References - curated
# Reference Title Reference Citation
1. Nardilysin facilitates complex formation between mitochondrial malate dehydrogenase and citrate synthase. Chow KM, etal., Biochim Biophys Acta. 2005 May 25;1723(1-3):292-301. Epub 2005 Mar 10.
2. Effects of ischemia and pharmacological treatment on subcellular fractions from neonatal rat brain. Curti D, etal., Farmaco Sci. 1982 Apr;37(4):275-82.
3. Cross-linking of mitochondrial matrix proteins in situ. D'Souza SF and Srere PA, Biochim Biophys Acta. 1983 Jul 29;724(1):40-51.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Adriamycin induced myocardial failure in rats: Protective role of Centella asiatica. Gnanapragasam A, etal., Mol Cell Biochem. 2006 Jun 20;.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Isolation and nucleotide sequence of a cDNA clone encoding rat mitochondrial malate dehydrogenase. Grant PM, etal., Nucleic Acids Res 1986 Aug 11;14(15):6053-66.
8. Effect of alpha-tocopherol on mitochondrial electron transport in experimental myocardial infarction in rats. Ithayarasi AP and Shyamala Devi C, Indian J Biochem Biophys. 1998 Apr;35(2):115-9.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. Preparation and properties of mitochondria derived from synaptosomes. Lai JC and Clark JB, Biochem J. 1976 Feb 15;154(2):423-32.
11. Malonaldehyde acts as a mitochondrial toxin: Inhibitory effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Long J, etal., Life Sci. 2006 Sep 5;79(15):1466-72. Epub 2006 May 7.
12. Purification and properties of the cytosolic and mitochondrial forms of aspartate aminotransferase and malate dehydrogenase from rat heart. Mavrides C and Nadeau G, Biochem Cell Biol. 1987 Mar;65(3):239-44.
13. Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools. McKenna MC, etal., Biochem Pharmacol. 2006 Feb 14;71(4):399-407. Epub 2005 Dec 20.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
18. GOA pipeline RGD automated data pipeline
19. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
20. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
21. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22. Role of NADH shuttles in glucose-induced insulin secretion from fetal beta-cells. Tan C, etal., Diabetes. 2002 Oct;51(10):2989-96.
23. Rat liver mitochondrial malate dehydrogenase: purification, kinetic properties, and role in ethanol metabolism. Wiseman MS, etal., Arch Biochem Biophys. 1991 Oct;290(1):191-6.
24. NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Ying W Antioxid Redox Signal. 2008 Feb;10(2):179-206.
Additional References at PubMed
PMID:3828294   PMID:5496232   PMID:6576816   PMID:8117664   PMID:12865426   PMID:14651853   PMID:15489334   PMID:16740313   PMID:16751257   PMID:17603759   PMID:17634366   PMID:18614015  
PMID:19056867   PMID:19717454   PMID:20080761   PMID:20167786   PMID:20458337   PMID:20833797   PMID:21630459   PMID:22082260   PMID:22658674   PMID:22681889   PMID:23376485   PMID:23533145  
PMID:23602810   PMID:26316108   PMID:27989324   PMID:29476059  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr81226,530,886 - 26,543,841 (-)NCBIGRCr8
mRatBN7.21220,894,269 - 20,907,225 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,894,262 - 20,907,271 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1222,036,216 - 22,049,189 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01222,648,634 - 22,661,607 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01221,715,096 - 21,728,069 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01223,941,451 - 23,954,406 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1223,941,448 - 23,954,431 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,938,703 - 25,951,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,021,302 - 22,034,257 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11222,008,565 - 22,021,518 (-)NCBI
Celera1222,657,034 - 22,669,988 (-)NCBICelera
Cytogenetic Map12q12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38776,048,106 - 76,067,508 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl776,048,051 - 76,067,508 (+)EnsemblGRCh38hg38GRCh38
GRCh37775,677,424 - 75,696,826 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36775,515,329 - 75,533,867 (+)NCBINCBI36Build 36hg18NCBI36
Build 34775,322,043 - 75,340,579NCBI
Celera770,545,928 - 70,564,452 (+)NCBICelera
Cytogenetic Map7q11.23NCBI
HuRef770,763,958 - 70,782,483 (+)NCBIHuRef
CHM1_1775,607,380 - 75,625,901 (+)NCBICHM1_1
T2T-CHM13v2.0777,335,642 - 77,355,027 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2775,010,457 - 75,028,995 (+)NCBI
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm395135,807,503 - 135,819,240 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5135,807,334 - 135,819,252 (+)EnsemblGRCm39 Ensembl
GRCm385135,778,649 - 135,790,386 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5135,778,480 - 135,790,398 (+)EnsemblGRCm38mm10GRCm38
MGSCv375136,254,519 - 136,266,256 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365136,063,276 - 136,075,013 (+)NCBIMGSCv36mm8
Celera5132,786,019 - 132,797,756 (+)NCBICelera
Cytogenetic Map5G2NCBI
cM Map575.4NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495545614,819,406 - 14,837,142 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545614,819,406 - 14,833,547 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v2693,888,151 - 93,906,812 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17142,152,789 - 142,171,414 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0767,953,759 - 67,973,270 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1782,497,799 - 82,517,411 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl782,497,800 - 82,516,526 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.167,389,266 - 7,405,311 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha69,085,235 - 9,101,096 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.067,209,447 - 7,225,514 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl67,209,439 - 7,225,504 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.167,178,719 - 7,194,795 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.067,142,165 - 7,158,017 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.067,305,587 - 7,321,452 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024409344131,827,961 - 131,842,493 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365432,194,032 - 2,208,651 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365432,194,074 - 2,208,626 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl310,120,083 - 10,132,752 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1310,120,121 - 10,132,705 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.239,953,279 - 9,965,866 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.12810,294,021 - 10,313,079 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2810,294,021 - 10,313,970 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660706,107,854 - 6,127,132 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_00462474014,837,023 - 14,850,988 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474014,837,699 - 14,850,126 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Mdh2
78 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:126
Count of miRNA genes:105
Interacting mature miRNAs:112
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1302792Scl21Serum cholesterol level QTL 213.80.0011blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)12719673046669029Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382545055165Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
1300157Rf21Renal function QTL 214.4renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)12931821632103380Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961088935682913Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121047413746669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
1331755Bp219Blood pressure QTL 2193.041arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121107382528064557Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121983578938193007Rat
2306789Ean6Experimental allergic neuritis QTL 64.9nervous system integrity trait (VT:0010566)experimental autoimmune neuritis severity score (CMO:0001528)121961087024139202Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122032881946669029Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121961087042828880Rat
1549912Bp268Blood pressure QTL 268arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)101318273646669029Rat
2302060Pia37Pristane induced arthritis QTL 376.10.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)121319815746669029Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121281238546669029Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
1549902Bp269Blood pressure QTL 269arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121318273646669029Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121235161946669029Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121107382524234895Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121047413746669029Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
61416Pia4Pristane induced arthritis QTL 48.4joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)121363552330827399Rat
631521Pia12Pristane induced arthritis QTL 128.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)122025941723672083Rat
61421Cia12Collagen induced arthritis QTL 124.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)121363552335682913Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121281238546669029Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
2293086Iddm30Insulin dependent diabetes mellitus QTL 303.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12844949028302290Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)121555082638478808Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,894,380 - 20,894,469 (+)MAPPERmRatBN7.2
Rnor_6.01223,941,563 - 23,941,651NCBIRnor6.0
Rnor_5.01225,938,815 - 25,938,903UniSTSRnor5.0
RGSC_v3.41222,021,414 - 22,021,502UniSTSRGSC3.4
RGSC_v3.41222,021,413 - 22,021,502RGDRGSC3.4
RGSC_v3.11222,008,677 - 22,008,766RGD
Celera1222,657,146 - 22,657,234UniSTS
RH 3.4 Map12299.1UniSTS
RH 3.4 Map12299.1RGD
RH 2.0 Map12221.8RGD
Cytogenetic Map12q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,895,923 - 20,896,126 (+)MAPPERmRatBN7.2
Rnor_6.01223,943,106 - 23,943,308NCBIRnor6.0
Rnor_5.01225,940,358 - 25,940,560UniSTSRnor5.0
RGSC_v3.41222,022,957 - 22,023,159UniSTSRGSC3.4
Celera1222,658,689 - 22,658,891UniSTS
RH 3.4 Map12302.2UniSTS
Cytogenetic Map12q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,894,449 - 20,894,990 (+)MAPPERmRatBN7.2
Rnor_6.01223,941,632 - 23,942,172NCBIRnor6.0
Rnor_5.01225,938,884 - 25,939,424UniSTSRnor5.0
RGSC_v3.41222,021,483 - 22,022,023UniSTSRGSC3.4
Celera1222,657,215 - 22,657,755UniSTS
RH 3.4 Map12301.31UniSTS
Cytogenetic Map12q12UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,894,295 - 20,894,468 (+)MAPPERmRatBN7.2
Rnor_6.01223,941,478 - 23,941,650NCBIRnor6.0
Rnor_5.01225,938,730 - 25,938,902UniSTSRnor5.0
RGSC_v3.41222,021,329 - 22,021,501UniSTSRGSC3.4
Celera1222,657,061 - 22,657,233UniSTS
Cytogenetic Map12q12UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 12 1
Medium 3 31 57 41 19 41 8 10 74 35 41 11 8
Below cutoff


RefSeq Acc Id: ENSRNOT00000001958   ⟹   ENSRNOP00000001958
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1220,894,262 - 20,907,271 (-)Ensembl
Rnor_6.0 Ensembl1223,941,448 - 23,954,431 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112030   ⟹   ENSRNOP00000090657
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1220,894,262 - 20,901,591 (-)Ensembl
RefSeq Acc Id: NM_031151   ⟹   NP_112413
Rat AssemblyChrPosition (strand)Source
GRCr81226,530,886 - 26,543,841 (-)NCBI
mRatBN7.21220,894,269 - 20,907,225 (-)NCBI
Rnor_6.01223,941,451 - 23,954,406 (-)NCBI
Rnor_5.01225,938,703 - 25,951,658 (-)NCBI
RGSC_v3.41222,021,302 - 22,034,257 (-)RGD
Celera1222,657,034 - 22,669,988 (-)RGD
RefSeq Acc Id: NP_112413   ⟸   NM_031151
- Peptide Label: precursor
- UniProtKB: Q6GSM4 (UniProtKB/Swiss-Prot),   P04636 (UniProtKB/Swiss-Prot),   A6J0B0 (UniProtKB/TrEMBL),   A0A8I6ABC9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000001958   ⟸   ENSRNOT00000001958
RefSeq Acc Id: ENSRNOP00000090657   ⟸   ENSRNOT00000112030
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04636-F1-model_v2 AlphaFold P04636 1-338 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698547
Promoter ID:EPDNEW_R9070
Type:initiation region
Description:malate dehydrogenase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01223,954,387 - 23,954,447EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:619719 AgrOrtholog
BioCyc Gene G2FUF-19631 BioCyc
BioCyc Pathway MALATE-ASPARTATE-SHUTTLE-PWY [malate/L-aspartate shuttle pathway] BioCyc
  PWY-5690 [TCA cycle II (plants and fungi)] BioCyc
  PWY66-399 [gluconeogenesis III] BioCyc
  PWY-5690 BioCyc
  PWY66-399 BioCyc
Ensembl Genes ENSRNOG00000001440 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055000334 UniProtKB/Swiss-Prot
  ENSRNOG00060010793 UniProtKB/Swiss-Prot
  ENSRNOG00065001791 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001958 ENTREZGENE
  ENSRNOT00000001958.5 UniProtKB/Swiss-Prot
  ENSRNOT00000112030.1 UniProtKB/TrEMBL
  ENSRNOT00055000587 UniProtKB/Swiss-Prot
  ENSRNOT00060018290 UniProtKB/Swiss-Prot
  ENSRNOT00065002403 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-binding Rossmann-like Domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro L-lactate/malate_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lactate/malate_DH_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lactate/malate_DH_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lactate_DH/Glyco_Ohase_4_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Malate_DH_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Malate_DH_type1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81829 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ldh_1_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ldh_1_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mdh2 PhenoGen
PIRSF Lac_mal_DH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000001440 RatGTEx
  ENSRNOG00055000334 RatGTEx
  ENSRNOG00060010793 RatGTEx
  ENSRNOG00065001791 RatGTEx
Superfamily-SCOP SSF51735 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56327 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt Secondary Q6GSM4 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-10 Mdh2  malate dehydrogenase 2  Mdh2  malate dehydrogenase 2, NAD (mitochondrial)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-10 Mdh2  malate dehydrogenase 2, NAD (mitochondrial)  Mor1  malate dehydrogenase, mitochondrial  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2003-04-09 Mor1  malate dehydrogenase, mitochondrial      Symbol and Name updated 629477 APPROVED
2003-03-12 Mor1  malate dehydrogenase, mitochondrial  Mdh2  malate dehydrogenase 2  Data merged from RGD:3071 628472 PROVISIONAL
2002-11-06 Mdh2  malate dehydrogenase 2    Malate dehydrogenase 2, NAD (mitochondrial)  Name updated 625702 APPROVED
2002-08-07 Mor1  malate dehydrogenase mitochondrial      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Mdh2  Malate dehydrogenase 2, NAD (mitochondrial)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a mitochondrial import sequence 633303