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Gene: Mdh2 (malate dehydrogenase 2) Rattus norvegicus
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Symbol: Mdh2
Name: malate dehydrogenase 2
Description: Exhibits L-malate dehydrogenase activity; malate dehydrogenase (NADP+) activity; and protein self-association. Involved in NADH metabolic process; dicarboxylic acid metabolic process; and tricarboxylic acid cycle. Localizes to the mitochondrial matrix. Used to study brain ischemia; congestive heart failure; and myocardial infarction. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 51. Orthologous to human MDH2 (malate dehydrogenase 2); PARTICIPATES IN citric acid cycle pathway; fructose-1,6-bisphosphatase deficiency pathway; fumaric aciduria pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: malate dehydrogenase 2, NAD (mitochondrial); malate dehydrogenase, mitochondrial; Mor1
Orthologs:
Homo sapiens (human) : MDH2 (malate dehydrogenase 2)  HGNC  Alliance
Mus musculus (house mouse) : Mdh2 (malate dehydrogenase 2, NAD (mitochondrial))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mdh2 (malate dehydrogenase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MDH2 (malate dehydrogenase 2)
Canis lupus familiaris (dog) : MDH2 (malate dehydrogenase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mdh2 (malate dehydrogenase 2)
Sus scrofa (pig) : MDH2 (malate dehydrogenase 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01223,941,451 - 23,954,406 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01225,938,703 - 25,951,658 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41222,021,302 - 22,034,257 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11222,008,565 - 22,021,518 (-)NCBI
Celera1222,657,034 - 22,669,988 (-)NCBICelera
Cytogenetic Map12q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Mdh2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 619719
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.